Article
Oncology
Makoto Yamasaki, Hiroshi Miyata, Kotaro Yamashita, Takuya Hamakawa, Koji Tanaka, Keijiro Sugimura, Tomoki Makino, Atsushi Takeno, Osamu Shiraishi, Masaaki Motoori, Yutaka Kimura, Motohiro Hirao, Kazumasa Fujitani, Takusi Yasuda, Masahiko Yano, Hidetoshi Eguchi, Yuichiro Doki
Summary: This study compared the long-term effects of chemoradiotherapy and triplet chemotherapy as initial therapy for T4b esophageal cancer. The results showed that the 2-year survival rate was higher in the chemoradiotherapy group (55.1%) compared to the chemotherapy group (34.7%), although the difference was not significant. In patients undergoing R0 resection, the local and regional lymph node recurrence rate was significantly lower in the chemoradiotherapy group compared to the chemotherapy group.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Magnus Nilsson, Halla Olafsdottir, Gabriella Alexandersson von Doebeln, Fernanda Villegas, Giovanna Gagliardi, Mats Hellstroem, Qiao-Li Wang, Hemming Johansson, Val Gebski, Jakob Hedberg, Fredrik Klevebro, Sheraz Markar, Elizabeth Smyth, Pernilla Lagergren, Ghazwan Al-Haidari, Lars Cato Rekstad, Eirik Kjus Aahlin, Bengt Wallner, David Edholm, Jan Johansson, Eva Szabo, John V. Reynolds, C. S. Pramesh, Naveen Mummudi, Amit Joshi, Lorenzo Ferri, Rebecca K. S. Wong, Chris O'Callaghan, Jelena Lukovic, Kelvin K. W. Chan, Trevor Leong, Andrew Barbour, Mark Smithers, Yin Li, Xiaozheng Kang, Feng-Ming Kong, Yin-Kai Chao, Tom Crosby, Christiane Bruns, Hanneke van Laarhoven, Mark van Berge Henegouwen, Richard van Hillegersberg, Riccardo Rosati, Guillaume Piessen, Giovanni de Manzoni, Florian Lordick
Summary: This study aims to compare the overall survival and quality of life between neoadjuvant chemoradiotherapy (nCRT) followed by surgery and definitive chemoradiotherapy (dCRT) followed by surveillance and salvage esophagectomy, in patients with operable, locally advanced esophageal squamous cell carcinoma (ESCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shu-An Wang, Fuchao Li, Jiayu Zhu, Xiaotian Chen, Wei Ren, Bo Gao
Summary: This study aimed to investigate the effects of multidisciplinary whole-course nutrition management on the nutritional status and complications during the treatment of patients with esophageal cancer undergoing chemoradiotherapy. The results showed that multidisciplinary whole-course nutrition management can maintain the nutritional status of patients, reduce complications, shorten hospital stays, and reduce in-patient expenses.
Article
Biochemistry & Molecular Biology
Jun Yin, Jingnan Yuan, Yunjin Li, Yong Fang, Ruoxi Wang, Heng Jiao, Han Tang, Shaoyuan Zhang, Siyun Lin, Feng Su, Jianmin Gu, Tian Jiang, Dong Lin, Zhiliang Huang, Chaoxiang Du, Kui Wu, Lijie Tan, Qing Zhou
Summary: This study reported a phase 1b trial of neoadjuvant PD-L1 blockade with adebrelimab in resectable esophageal squamous cell carcinoma (ESCC). The results showed that the use of adebrelimab was safe and feasible, with some patients achieving a complete pathologic response. Responsive patients had an improved immune microenvironment at baseline.
Article
Oncology
Yujin Xu, Baiqiang Dong, Weiguo Zhu, Jiancheng Li, Rong Huang, Zongwen Sun, Xinmei Yang, Liping Liu, Han He, Zhongxing Liao, Ni Guan, Yue Kong, Wanwei Wang, Jianxiang Chen, Huijuan He, Guoqin Qiu, Ming Zeng, Juan Pu, Wangyuan Hu, Yong Bao, Zhigang Liu, Jun Ma, Hao Jiang, Xianghui Du, Jin Hu, Tingting Zhuang, Jing Cai, Jin Huang, Hua Tao, Yuan Liu, Xiaodong Liang, Juying Zhou, Guangzhou Tao, Xiao Zheng, Ming Chen
Summary: This study evaluated the efficacy and safety of different radiation doses in patients with ESCC and found that 60 Gy and 50 Gy had similar survival outcomes, but the 60 Gy group had a higher incidence of severe pneumonitis.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Karyn A. Goodman, Fang-Shu Ou, Nathan C. Hall, Tanios Bekaii-Saab, Briant Fruth, Erin Twohy, Michael O. Meyers, Daniel J. Boffa, Kisha Mitchell, Wendy L. Frankel, Donna Niedzwiecki, Anne Noonan, Yelena Y. Janjigian, Paul J. Thurmes, Alan P. Venook, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, David H. Ilson
Summary: The study evaluated the use of early assessment of chemotherapy responsiveness by PET imaging to tailor therapy for patients with esophageal and esophagogastric junction adenocarcinoma. Results showed improved pathologic complete response rates in PET nonresponders, with PET responders to FOLFOX achieving a promising 5-year overall survival of 53%.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Yanxiao Liu, Zhiyong Zheng, Minghao Li, Yaowen Zhang, Fujun Zhao, Heyi Gong, Haiqun Lin, Wei Huang, Xiangming Chen, Zhiqiao Xu, Xiaomin Li, Wenzhi Liu, Yanhui Cui, Anping Zheng, Baosheng Li
Summary: This phase II clinical trial compared the safety and efficacy of concurrent chemoradiotherapy using S-1 with radiotherapy alone for elderly patients with locally advanced esophageal squamous cell carcinoma. The study found that concurrent chemoradiotherapy with S-1 had tolerable adverse effects and improved overall response rate and progression-free survival compared to radiotherapy alone.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
H. Tang, H. Wang, Y. Fang, J. Y. Zhu, J. Yin, Y. X. Shen, Z. C. Zeng, D. X. Xiang, Y. Y. Hou, M. Du, C. H. Lian, Q. Zhao, H. J. Jiang, L. Gong, Z. G. Li, J. Liu, D. Y. Xie, W. F. Li, C. Chen, B. Zheng, K. N. Chen, L. Dai, Y. D. Liao, K. Li, H. C. Li, N. Q. Zhao, L. J. Tan
Summary: This study aimed to evaluate the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) versus neoadjuvant chemotherapy (nCT) followed by minimally invasive esophagectomy (MIE) for locally advanced esophageal squamous cell carcinoma (ESCC). The results showed that nCRT did not significantly improve overall survival compared to nCT.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Maarten C. C. M. Hulshof, Elisabeth D. Geijsen, Tom Rozema, Vera Oppedijk, Jeroen Buijsen, Karen J. Neelis, Joost J. M. E. Nuyttens, Maurice J. C. van der Sangen, Paul M. Jeene, Jannie G. Reinders, Mark I. van Berge Henegouwen, Adriana Thano, Jeanin E. van Hooft, Hanneke W. M. van Laarhoven, Ate van der Gaast
Summary: In definitive chemoradiation for esophageal cancer, escalating radiation dose up to 61.6 Gy to the primary tumor did not significantly improve local tumor control compared to 50.4 Gy. The absence of a dose-effect was observed in both adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Swetha Sridharan, Fiona Day, Jasmin Loh, James Lynam, Joanne Smart, Brandan Holt, Hiren Mandaliya, Anthony Bonaventura, Mahesh Kumar, Jarad Martin
Summary: The study aimed to assess the safety and efficacy of using hypofractionated radiotherapy with concurrent carboplatin and paclitaxel chemotherapy in patients with esophageal cancer and dysphagia. The results showed that this treatment approach was well tolerated and improved dysphagia symptoms in patients.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Yongling Ji, Xianghui Du, Weiguo Zhu, Yanguang Yang, Jun Ma, Li Zhang, Jiancheng Li, Hua Tao, Jianhong Xia, Haihua Yang, Jin Huang, Yong Bao, Dexi Du, Degan Liu, Xiusheng Wang, Chaoming Li, Xinmei Yang, Ming Zeng, Zhigang Liu, Wen Zheng, Juan Pu, Jun Chen, Wangyuan Hu, Peijing Li, Jin Wang, Yujin Xu, Xiao Zheng, Jianxiang Chen, Wanwei Wang, Guangzhou Tao, Jing Cai, Jizhong Zhao, Jun Zhu, Ming Jiang, Yan Yan, Guoping Xu, Shanshan Bu, Binbin Song, Ke Xie, Shan Huang, Yuanda Zheng, Liming Sheng, Xiaojing Lai, Ying Chen, Lei Cheng, Xiao Hu, Wenhao Ji, Min Fang, Yue Kong, Xiaofu Yu, Huizhang Li, Runhua Li, Lei Shi, Wei Shen, Chaonan Zhu, Junwei Lv, Rong Huang, Han He, Ming Chen
Summary: In this phase 3 randomized clinical trial, CCRT with S-1 was found to be well-tolerated and significantly improved overall survival rate compared to radiotherapy alone in older patients with esophageal cancer. The CCRT group had a higher complete response rate and 2-year overall survival rate, although there were slightly higher incidence of grade 3 or higher leukopenia in the CCRT group.
Article
Oncology
Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Helene Lozano, Abdoulkader Soumai Alloh, Catherine Cornu, Magali Herve, Zohra Akkal, Michel Lievre, Valerie Plattner, Francesca Valvo, Cristina Bono, Maria Rosaria Fiore, Viviana Vitolo, Barbara Vischioni, Stephanie Patin, Hubert Allemand, Francois Gueyffier, Jennifer Margier, Pascale Guerre, Sylvie Chabaud, Roberto Orecchia, Pascal Pommier
Summary: This study aims to compare the effectiveness of carbon ion therapy with photon or proton radiotherapy for the treatment of radioresistant tumors. So far, no similar studies have shown the superiority of carbon ion therapy.
Article
Oncology
ShanBing Wang, Jiapei Liu, Kaijian Lei, Yuming Jia, Chunxiu Wang, Xia Zhang, Ting Li
Summary: This study aimed to test the efficacy of SPECT-defined ABMS VMAT in reducing grade 3+ acute HT in locally advanced cervical cancer patients treated with chemoradiotherapy. The results showed that ABMS VMAT significantly reduced the incidence of grade 3+ acute HT and improved chemotherapy delivery. However, there was weak evidence of the effect on distant metastasis.
Article
Surgery
Hong Yang, Hui Liu, Yuping Chen, Chengchu Zhu, Wentao Fang, Zhentao Yu, Weimin Mao, Jiaqing Xiang, Yongtao Han, Zhijian Chen, Haihua Yang, Jiaming Wang, Qingsong Pang, Xiao Zheng, Huanjun Yang, Tao Li, Xu Zhang, Qun Li, Geng Wang, Baofu Chen, Teng Mao, Min Kong, Xufeng Guo, Ting Lin, Mengzhong Liu, Jianhua Fu
Summary: The study found that neoadjuvant chemoradiotherapy (NCRT) followed by surgery significantly improved long-term overall survival and disease-free survival in patients with locally advanced esophageal squamous cell carcinoma (ESCC).