Article
Immunology
Qingwei Lai, Qingyun Li, Xinyu Li, Heng Wang, Wei Zhang, Xiaotao Song, Peng Hu, Ruiqin Yao, Hongbin Fan, Xingshun Xu
Summary: This study evaluated the clinical significance of GluR3B antibody level as a biomarker for the prognosis of drug-resistant epilepsy (DRE). The results showed that elevated GluR3B antibody levels can predict the risk of developing DRE and have good clinical predictive ability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Udaya Seneviratne, Harry Christie, Wendyl D'Souza, Mark Cook
Summary: This study aimed to investigate the differences in focal semiologic features between generalized-onset bilateral tonic-clonic seizures (GBTCS) and focal-onset bilateral tonic-clonic seizures (FBTCS). The results revealed that head version, preceding automatisms, eye version, unilateral facial clonic activity, and mouth deviation were more frequent in FBTCS. Additionally, longer seizure duration favored FBTCS, while shorter time to head version from the ictal onset indicated GBTCS. Therefore, careful evaluation of semiology can help clinicians distinguish between FBTCS and GBTCS.
EPILEPSY & BEHAVIOR
(2022)
Article
Neurosciences
Qiang Xu, Qirui Zhang, Fang Yang, Yifei Weng, Xinyu Xie, Jingru Hao, Rongfeng Qi, Valentina Gumenyuk, Steven M. Stufflebeam, Boris C. Bernhardt, Guangming Lu, Zhiqiang Zhang
Summary: This study explored the brain network changes in patients with generalized tonic-clonic seizures (GTCS) and focal epilepsy associated with focal to bilateral tonic-clonic seizure (FE-FBTS) using structural covariance analysis, revealing differences between the two syndromes. Patients showed increased connectivity within the striatum and thalamus relative to healthy controls, with connectivity changes increasing as a function of epilepsy duration. FE-FBTS presented more severe network disruption compared to GE-GTCS.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Wesley T. Kerr, Christian Brandt, Leock Y. Ngo, Anna Patten, Jocelyn Y. Cheng, Lynn Kramer, Jacqueline A. French
Summary: The study evaluated the exploratory time to exceed pre-randomization seizure count (T-PSC) in participants with primary generalized tonic-clonic seizures. The results showed that perampanel demonstrated effectiveness in a shorter duration of monitoring. Therefore, T-PSC may be considered as a viable alternative trial endpoint.
Article
Clinical Neurology
Christina Maher, Arkiev D'Souza, Rui Zeng, Michael Barnett, Omid Kavehei, Armin Nikpour, Chenyu Wang
Summary: We compared white matter differences between patients with and without focal to bilateral tonic-clonic seizures (FBTCS) and control participants using a neural network based tract segmentation model. We found significant alterations in white matter regions of patients with focal epilepsy compared to controls. Patients without FBTCS showed increased disruption in specific white matter tracts, while the FBTCS group had measurements more similar to healthy controls. These findings help identify specific tracts that may serve as predictive biomarkers for patients likely to develop FBTCS.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xin Li, Zhongyuan Wang, Qian Chen, Xiaoyun Wang, Zhao Qing, Wen Zhang, Jiaming Lu, Junxia Wang, Xin Zhang, Jiani Liu, Zhengge Wang, Baoxin Li, Bing Zhang
Summary: This study identified focal atrophy in the basolateral region of the left amygdala in drug-resistant IGE patients, suggesting it may aid in predicting drug responses and identifying potential therapeutic targets.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Behavioral Sciences
Harry Christie, Wendyl D'Souza, Mark Cook, Udaya Seneviratne
Summary: This review examined the presence of focal signs in generalized-onset tonic-clonic seizures (GOTCS) and the utility of semiology in differentiating those from focal to bilateral tonic-clonic seizures (FBTCS). Focal signs are often evident in GOTCS, but the observation of multiple focal signs within a given seizure may be more indicative of FBTCS. However, caution is advised against differentiating between the two seizure types based solely on semiology due to significant overlap in focal features.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Michael Tan, Neil Pearce, Aurelio Tobias, Mark J. Cook, Wendyl J. D'Souza
Summary: This study aims to determine the contribution of comorbidities to excess psychogenic nonepileptic seizures (PNES) mortality. A retrospective cohort study was conducted to investigate the relationship between comorbidities and PNES mortality. The importance of this study lies in better understanding and managing the bidirectional relationship between these wider somatic treatments and PNES, which could potentially reduce the risk of death.
Article
Clinical Neurology
Renee Proost, Jaiver Macea, Lieven Lagae, Wim Van Paesschen, Katrien Jansen
Summary: This study investigated the performance of a multimodal wearable device for offline detection of tonic seizures in pediatric epilepsy patients. It found that the device had good performance in detecting nightly tonic seizures and outperformed seizure diaries.
Article
Veterinary Sciences
Junya Hirashima, Miyoko Saito, Tsukasa Kuriyama, Taketo Akamatsu, Minoru Yokomori
Summary: This study aimed to establish a wearable seizure detection system using acceleration data and the Mahalanobis distance, and preliminarily investigate its feasibility among dogs. The results showed that the system effectively identified seizures and non-seizure activities, and the feasibility test in dogs with epilepsy was successful.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Behavioral Sciences
Kiran M. Kanth, Christopher S. Zimmerman, Sheela C. Toprani, Masud Seyal
Summary: This study aimed to analyze the effects of seizure characteristics on postictal recovery of awareness following bilateral tonic-clonic seizures (BTCS). The results showed that patient age was an important factor affecting the time to recovery of awareness, with younger patients having a shorter recovery time. Additionally, postictal agitation was more common in males. The study also found that focal seizures may impair awareness by inhibiting subcortical arousal mechanisms. Therefore, age and seizure characteristics play an important role in the recovery of awareness after BTCS.
EPILEPSY & BEHAVIOR
(2022)
Review
Behavioral Sciences
Gianni Cutillo, Hatem Tolba, Lawrence J. Hirsch
Summary: The systematic review examined the efficacy of anti-seizure medications for controlling focal to bilateral tonic-clonic seizures. Topiramate, tiagabine, brivaracetam, and lamotrigine showed promising results, while data for other medications were limited. Specific data on nocturnal FBTCS were never reported.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Ting Li, Shaowei Niu, Xiang Qiu, Zhaohua Zhai, Lin Yang, Li Chen, Xiao Ming Zhang
Summary: Voxel-based analysis of 3D PCASL imaging can sensitively detect brain perfusion differences in GTCS patients. The decrease in CBF in the right temporal pole of the middle temporal gyrus may be associated with disease onset. These findings may offer new perspectives on the pathogenesis of GTCS and the underlying pathophysiological changes associated with perfusion.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Jacqueline A. French, Robert T. Wechsler, Eugen Trinka, Christian Brandt, Terence J. O'Brien, Anna Patten, Alejandro Salah, Manoj Malhotra
Summary: The study assesses the long-term efficacy and safety of perampanel as an adjunctive treatment for patients with generalized tonic-clonic seizures. The results show that perampanel can maintain seizure control for at least 2 years, with a high retention rate and a common daily dose range of 4-8 mg. This study demonstrates that perampanel is a viable long-term treatment option for patients aged 12 years and above with GTC seizures.
Article
Neurosciences
Dimitrios Pitetzis, Christos Frantzidis, Elizabeth Psoma, Georgia Deretzi, Anna Kalogera-Fountzila, Panagiotis D. D. Bamidis, Martha Spilioti
Summary: This study identified the network involved in the formation of spike-wave discharges in patients with generalized tonic-clonic seizures alone. It found that certain brain areas acted as generators of the discharges, while others had a significant influence on the entire network.
Article
Neurosciences
Damon P. Cardenas, Eric R. Muir, Shiliang Huang, Angela Boley, Daniel Lodge, Timothy Q. Duong
Article
Neurosciences
Eric R. Muir, Damon P. Cardenas, Timothy Q. Duong
Article
Biophysics
Damon P. Cardenas, Eric R. Muir, Timothy Q. Duong
NMR IN BIOMEDICINE
(2016)
Article
Clinical Neurology
Jonathan J. Halford, Michael R. Sperling, Dileep R. Nair, Dennis J. Dlugos, William O. Tatum, Jay Harvey, Jacqueline A. French, John R. Pollard, Edward Faught, Katherine H. Noe, Thomas R. Henry, Gina M. Jetter, Octavian V. Lie, Lola C. Morgan, Michael R. Girouard, Damon P. Cardenas, Luke E. Whitmire, Jose E. Cavazos
Article
Physiology
Matthew J. McHale, Zaheer U. Sarwar, Damon P. Cardenas, Laurel Porter, Anna S. Salinas, Joel E. Michalek, Linda M. McManus, Paula K. Shireman
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2012)
Article
Biochemical Research Methods
Adrien Ponticorvo, Damon Cardenas, Andrew K. Dunn, Daniel Ts'o, Timothy Q. Duong
JOURNAL OF BIOMEDICAL OPTICS
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric R. Muir, Damon Cardenas, Shiliang Huang, John Roby, Guang Li, Timothy Q. Duong
MAGNETIC RESONANCE IN MEDICINE
(2014)
Article
Clinical Neurology
Damon P. Cardenas, Jonathan J. Halford, Luke E. Whitmire, Lola C. Morgan, Octavian V. Lie, Gina M. Jetter, Jose E. Cavazos
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Clinical Neurology
Anca A. Arbune, Isa Conradsen, Damon P. Cardenas, Luke E. Whitmire, Shannon R. Voyles, Peter Wolf, Samden Lhatoo, Philippe Ryvlin, Sandor Beniczky
Article
Clinical Neurology
Christoph Baumgartner, Luke E. Whitmire, Shannon R. Voyles, Damon P. Cardenas
Summary: Accurate characterization and quantification of seizure types are essential for optimal pharmacotherapy in epilepsy patients. This study demonstrates that continuous monitoring of sEMG data can provide an objective measure to evaluate motor seizure activity, particularly tonic-clonic and tonic seizures. The combination of automated classification methods and expert review shows promising results in accurately classifying motor seizure events.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Ophthalmology
Guang Li, Jeffrey W. Kiel, Damon P. Cardenas, Bryan H. De La Garza, Timothy Q. Duong
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2013)