Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction

Mitophagy Directs Muscle-Adipose Crosstalk to Alleviate Dietary Obesity

(2018) Tingting Fu et al.   Cell Reports

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells

(2018) Kaixiang Cao et al.   Science Advances

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

(2018) Younghoon Jang et al.   NUCLEIC ACIDS RESEARCH

H3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability

(2017) Younghoon Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription

(2017) Shu-Ping Wang et al.   MOLECULAR CELL

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis

(2017) Binbin Lai et al.   NUCLEIC ACIDS RESEARCH

KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation

(2016) Siang-Yun Ang et al.   DEVELOPMENT

Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit

(2016) Jing Liu et al.   EMBO Molecular Medicine

Electrophysiological and histological changes of paraspinal muscles in adolescent idiopathic scoliosis

(2016) I. Stetkarova et al.   EUROPEAN SPINE JOURNAL

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle

(2016) Xijun Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition

(2016) Chaochen Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Roles of the Histone Methyltransferase MLL4/KMT2D in Murine Hepatic Steatosis Directed by ABL1 and PPARγ2

(2016) Dae-Hwan Kim et al.   Cell Reports

Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits

(2015) P. Darrell Neufer et al.   Cell Metabolism

The selection and function of cell type-specific enhancers

(2015) Sven Heinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism

(2015) Kevin Y. Lee et al.   Nature Communications

Alternative Splicing of MEF2C pre-mRNA Controls Its Activity in Normal Myogenesis and Promotes Tumorigenicity in Rhabdomyosarcoma Cells

(2014) Meiling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation

(2013) S. Sebastian et al.   GENES & DEVELOPMENT

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

(2013) D. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Modification of Enhancer Chromatin: What, How, and Why?

(2013) Eliezer Calo et al.   MOLECULAR CELL

De novo mutations in histone-modifying genes in congenital heart disease

(2013) Samir Zaidi et al.   NATURE

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

(2013) Ji-Eun Lee et al.   eLife

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

(2011) Vihang A. Narkar et al.   Cell Metabolism

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

Diet-induced Lethality Due to Deletion of theHdac3Gene in Heart and Skeletal Muscle

(2011) Zheng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6

(2011) D. Quiat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle dysfunction and exercise limitation in adolescent idiopathic scoliosis

(2010) J. Martinez-Llorens et al.   EUROPEAN RESPIRATORY JOURNAL

Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle

(2010) Zhen Yan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification

(2010) Youji He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

(2010) Shamina M. Rangwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL