Review
Nutrition & Dietetics
Jorge B. Cannata-Andia, Natalia Carrillo-Lopez, Osvaldo D. Messina, Neveen A. T. Hamdy, Sara Panizo, Serge L. Ferrari
Summary: Vascular calcification, low bone mass, and fragility fractures are frequently observed in ageing subjects, with potential common mechanisms that need further research to understand their interplay.
Review
Medicine, General & Internal
Alexandra-Ioana Trandafir, Oana-Claudia Sima, Ana-Maria Gheorghe, Adrian Ciuche, Anca-Pati Cucu, Claudiu Nistor, Mara Carsote
Summary: Bone fragility is a complication of type 2 diabetes mellitus (T2DM) that has been identified in recent decades. Trabecular bone score (TBS) appears to be more accurate than bone mineral density (BMD) in diabetic bone disease, particularly in menopausal women with T2DM, to independently capture the fracture risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Qing-Chang Chen, Yan Zhang
Summary: Bone diseases are the main causes of disability and impaired quality of life. Neuropeptide Y plays important roles in bone tissue by regulating bone metabolism and disease progression through its receptors. This review provides a brief overview of recent progress in understanding the regulatory mechanism of bone physiology and pathological metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei, Wen-Cheng Xiong
Summary: Patients with Parkinson's disease exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. Understanding the relationship between peripheral tissue deficits and brain pathology in PD development is still at an early stage, highlighting the complex interaction of genetic and environmental risk factors. Genetic mutations in various genes have been identified in PD patients, some of which are involved in regulation of bone metabolism, indicating potential links between PD risk genes and bone health.
CELL AND BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Oscar Fonseca, Maria Salome Gomes, Maria Adelina Amorim, Ana Cordeiro Gomes
Summary: Cystic fibrosis, a monogenic disease, has a diverse clinical presentation involving chronic lung infection, inflammation, and reduced bone mass. The underlying mechanisms of reduced bone mass in cystic fibrosis patients are still unclear. This review explores the relationship between CFTR dysfunction and intrinsic bone defects, as well as the impact of the proinflammatory environment and chronic infection on bone mass maintenance in CF patients.
Article
Endocrinology & Metabolism
Yujuan Ouyang, Yingping Quan, Chengyi Guo, Songlin Xie, Changxiong Liu, Xiongjie Huang, Xinfeng Huang, Yanming Chen, Xiangjun Xiao, Nengqian Ma, Ruijie Xie
Summary: This study found a significant positive and saturated association between BMI and BMD in adolescents aged 8-19 years. Maintaining BMI at saturation values may reduce other adverse effects while achieving optimal BMD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Angela Sheu, Dana Bliuc, Thach Tran, Christopher P. White, Jacqueline R. Center
Summary: The study found that individuals with type 2 diabetes have a significantly increased mortality risk following fractures. This risk is particularly high for those with diabetes duration of more than 5 years and experiencing hip/vertebral fractures (in men) or non-hip non-vertebral fractures (in women). Therefore, careful monitoring and management after fractures are crucial for individuals with type 2 diabetes.
Review
Medicine, Research & Experimental
Xiaodan Ou, Mingguang Chen, Lizhen Xu, Wei Lin, Huibin Huang, Gang Chen, Junping Wen
Summary: Bariatric surgery has a certain impact on bone density, especially in patients over 40 years of age and individuals with a postsurgical time of greater than 12 months. It is important for these patients to pay attention to bone density screening and osteoporosis prevention. Further research is needed to analyze longer-term changes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Alexandra-Cristina Burdusel, Ecaterina Andronescu
Summary: Lipid nanoparticles and liposomes are important tools widely used in drug delivery systems, with potential applications in the treatment of bone diseases.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: This study aimed to investigate the risk of major osteoporotic fractures in diabetes patients initiated with alendronate and denosumab. Results showed that the risk of incident major osteoporotic fractures among subjects with diabetes was similar between those initially treated with alendronate and denosumab, suggesting both treatments are equally effective in preventing osteoporotic fractures in subjects with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Miao Zhang, Yuexuan Li, Lifei Liu, Mei Huang, Miao Wang, Jun Zou
Summary: Exercise therapy and key regulators of bone quality have anti-hyperglycemic effects on T2DM mice. The correlation between exercise and bone quality improvement in T2DM mice, as well as the relationship between nonlinear optical properties of bone and crystal structure changes, are still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nancy Martini, Lucas Streckwall, Antonio Desmond Mccarthy
Summary: In post-menopausal women, aged individuals, and patients with diabetes mellitus or chronic renal disease, bone mineral density decreases while arterial calcifications accumulate. Patients with low BMD and/or fragility fractures have an increased risk for coronary and cerebrovascular events. Similarly, patients with abdominal aorta calcifications show decreased BMD in bones irrigated by branches of the abdominal aorta.
ENDOCRINE CONNECTIONS
(2023)
Article
Orthopedics
Rui Lin, Bilian Xu, Zhiqiang Ye, Yin Gao, Haiping Fang, Jintong Song, Dahong Liang, Lingna Liu, Zilong Hu, Min Zhang, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Yanzhi Liu
Summary: This study demonstrated that metformin significantly attenuated osteopenia and improved bone microarchitecture in T2DM rat models. It also promoted stem cell osteogenic differentiation under high glucose conditions. The effects of metformin on bone metabolism are closely associated with the suppression of the RAGE-JAK2STAT1 signaling axis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Multidisciplinary Sciences
Subin Hwang, Kyungho Lee, Jeeeun Park, Do Hee Kim, Junseok Jeon, Hye Ryoun Jang, Kyu Yeon Hur, Jae Hyeon Kim, Wooseong Huh, Yoon-Goo Kim, Jung Eun Lee
Summary: It is uncertain whether albuminuria can identify elderly patients with diabetes at high risk of ESKD or mortality. The study found that both microalbuminuria and macroalbuminuria are risk factors for incident ESKD and mortality in elderly patients with diabetes.
SCIENTIFIC REPORTS
(2023)
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Rheumatology
Samanan Intongkam, Parinya Samakarnthai, Rattapol Pakchotanon, Pongthorn Narongroeknawin, Paijit Assavatanabodee, Sumapa Chaiamnuay
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2019)
Review
Surgery
Veeravich Jaruvongvanich, Nicha Wongjarupong, Kornpong Vantanasiri, Parinya Samakkarnthai, Patompong Ungprasert
Review
Endocrinology & Metabolism
Sundeep Khosla, Parinya Samakkarnthai, David G. Monroe, Joshua N. Farr
Summary: Increased fracture risk in patients with type 2 diabetes mellitus may be due to impairments in bone material properties and increases in cortical porosity, highlighting potential areas for therapeutic intervention.
NATURE REVIEWS ENDOCRINOLOGY
(2021)