Article
Cell Biology
Yan Xie, Li Rong, Min He, Yuyou Jiang, Haiyu Li, Li Mai, Fangzhou Song
Summary: High expression of SNHG3 in gastric cancer is correlated with tumor clinical stage and patient survival rate, while knocking down SNHG3 can inhibit the proliferation, migration, and invasion of GC cells. SNHG3 binds and sequesters miR-139-5p to indirectly promote the upregulation of the miR139-5p target gene MYB, driving the oncogenic activities of GC.
Article
Oncology
Li Zhang, Guihua Li, Xiuzhen Wang, Youli Zhang, Xia Huang, Huazhen Wu
Summary: The study revealed that SNHG3 accelerates the proliferation and migration of ovarian cancer cells by regulating miR-139-5p and Notch1.
Article
Gastroenterology & Hepatology
Zeng-Peng Sun, Zhi-Guo Tan, Chuang Peng, Wei-Min Yi
Summary: The oncogenic lncRNA SNHG3 is upregulated in cholangiocarcinoma cells and its knockdown inhibits proliferation and migration by sponging miR-3173-5p to release suppression of ERG. This suggests a potential therapeutic target for CCA by targeting the SNHG3/miR-3173-5p/ERG axis.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Cell Biology
Jiangning Zhao, Huanrong Lin, Kunsong Huang, Shen Li
Summary: In this study, it was found that cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) carrying SNHG3 can promote colorectal cancer (CRC) cell proliferation through the miR-34b-5p/HuR/HOXC6 axis. These findings reveal the important role of CAFs-EVs in CRC progression.
CELL DEATH DISCOVERY
(2022)
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Immunology
Guo Ji, Xiu Wang, Hao Xi
Summary: This study reveals that METTL3-mediated m(6)A modification of lncRNA SNHG3 accelerates gastric cancer progression by modulating the miR-186-5p/cyclinD2 axis.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Pengxu Shi, Yueting Li, Qingsheng Guo
Summary: The study identified the critical role of circular RNA circPIP5K1A in the stemness of osteosarcoma cells, with enhanced expression in clinical tissues. Knockdown of circPIP5K1A inhibited cell viabilities, induced apoptosis, and reduced invasion and migration capabilities. Mechanistically, circPIP5K1A enhanced YAP expression by targeting miR-515-5p, affecting the stemness of osteosarcoma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Jinbo Xie, Jinliang Ni, Huajuan Shi, Keyi Wang, Xiaoying Ma, Wei Li, Bo Peng
Summary: This study confirmed the upregulation of lncRNA SNHG3 in nonmuscle-invasive bladder cancer, and suggested that the SNHG3/c-MYC/BMI1 axis may be a novel target for regulating tumor growth and metastasis in this disease.
Article
Cell & Tissue Engineering
Shaojun Chu, Yulong Li, Baojin Wu, Guo Rong, Qiang Hou, Qin Zhou, Dexiang Du, Yufei Li
Summary: Accumulating evidence suggests that METTL3 plays a significant role in melanoma, but its specific function and mechanism are still unclear. This study analyzed the association of METTL3 and lncRNA SNHG3 with clinicopathological characteristics and prognosis in melanoma patients. The findings demonstrated that METTL3-mediated m(6)A modification of lncRNA SNHG3 promoted the growth and invasion of melanoma cells by regulating the miR-330-5p/CNBP axis.
CELL TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Y. Zhang, L. Li, K-X Lu, L-B Yu, J. Meng, C-Y Liu
Summary: This study demonstrates that lncRNA SNHG3 promotes the proliferation and invasion of colorectal cancer (CRC) by regulating the miR-370-5p/EZH1 axis. The upregulation of SNHG3 is associated with advanced tumor staging, positive lymph node metastasis, and poor prognosis in CRC. Knockdown of SNHG3 inhibits proliferation and invasion of CRC cells, indicating its potential therapeutic target in CRC.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Wenjie Luo, Jun Wang, Wenhao Xu, Chunguang Ma, Fangning Wan, Yongqiang Huang, Mengfei Yao, Hailiang Zhang, Yuanyuan Qu, Dingwei Ye, Yiping Zhu
Summary: The lncRNA RP11-89 promotes cell proliferation, migration, tumorigenesis and inhibits cell cycle arrest through the miR-129-5p/PROM2 axis in bladder cancer. RP11-89 acts as a sponge for miR-129-5p, upregulating PROM2 and activating iron export, leading to attenuation of ferroptosis. RP11-89 is a novel tumorigenic regulator that may serve as a potential biomarker for targeted therapy in bladder cancer.
CELL DEATH & DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Feng Gao, Xiao-Chen Wang, Zhi-Dan Luo, Guang-Quan Hu, Meng-Qing Ma, Yi Liang, Bang-Long Xu, Xian-He Lin
Summary: In this study, the researchers investigated the role of long non-coding RNA HOXA11-AS in atherosclerosis. They found that HOXA11-AS contributed to atherosclerotic injuries by directly regulating the miR-515-5p/ROCK1 axis. This study provides new evidence that HOXA11-AS could be a potential candidate for atherosclerosis therapy.
Article
Biotechnology & Applied Microbiology
Yudong Tian, Yanbin Guan, Yang Su, Tao Yang, Haizhou Yu
Summary: This study revealed that TRPM2-AS is significantly upregulated in BLCA tissues and cell lines, with its knockdown inhibiting cell viability, proliferation, and colony formation while promoting apoptosis. miR-22-3p, a downstream target of TRPM2-AS, showed lower expression in BLCA and its inhibition enhanced cell phenotypes. Additionally, GINS2 mRNA, a downstream target of miR-22-3p, was upregulated in BLCA and its knockdown suppressed cell phenotypes, suggesting a novel interactome in BLCA with potential therapeutic implications.
ONCOTARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yaxuan Zhang, Yin Zhang, Sen Wang, Qingquan Li, Boqiang Cao, Baosheng Huang, Tianlu Wang, Ruijuan Guo, Ning Liu
Summary: ZFPM2-AS1 is a highly-expressed lncRNA in glioma tissues and cells, and its silencing suppresses cell proliferation, cell cycle, and promotes cell apoptosis. SP1 interacts with the ZFPM2-AS1 promoter to transcriptionally activate ZFPM2-AS1 expression, and ZFPM2-AS1 functions as a ceRNA for miR-515-5p to target SOD2 in glioma cells. This study highlights the regulatory mechanism of the SP1/ZFPM2-AS1/miR-515-5p/SOD2 axis in glioma and suggests that targeting ZFPM2-AS1 could be an effective treatment strategy for glioma.
Article
Cell Biology
Peng Wu, Chunxiang Li, Dong mei Ye, Kenan Yu, Yuxuan Li, Hailin Tang, Gaoshen Xu, Shuijing Yi, Zhiwei Zhan
Summary: In this study, circEPSTI1 was found to be significantly upregulated in cervical cancer and shown to impact cell ferroptosis. The circEPSTI1-miR-375/409-3P/515-5p-SLC7A11 axis was identified to affect proliferation in cervical cancer through the ceRNA mechanism and was linked to ferroptosis. The findings suggest circEPSTI1 as a potential new biomarker for monitoring and targeting treatment in cervical cancer.
Article
Nanoscience & Nanotechnology
Tianyi Kang, Yang Li, Yong Wang, Jiao Zhu, Ling Yang, Yulan Huang, Meimei Xiong, Jinlu Liu, Shuai Wang, Meijuan Huang, Xiawei Wei, Maling Gou
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Biotechnology & Applied Microbiology
Chenglu Wang, Shuang Yang, Lu Jin, Guangcheng Dai, Qiu Yao, Han Xiang, Yongsheng Zhang, Xiaolong Liu, Boxin Xue
ONCOTARGETS AND THERAPY
(2020)
Article
Medicine, Research & Experimental
Ming Xu, Lu Jin, Yuxi Shan, Jin Zhu, Boxin Xue
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Medicine, Research & Experimental
Jin Zhu, Lu Jin, Aili Zhang, Peng Gao, Guangcheng Dai, Ming Xu, Lijun Xu, Dongrong Yang
MEDICAL SCIENCE MONITOR
(2020)
Article
Biotechnology & Applied Microbiology
Guangcheng Dai, Chenglu Wang, Wei Tang, Jiangyun Liu, Boxin Xue
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Engineering, Biomedical
Lu Jin, Lei Yao, Feng Yuan, Guangcheng Dai, Boxin Xue
Summary: A new type of biodegradable ureteral stents made from degradable polyurethane and magnesium alloys was developed and tested for its biocompatibility and degradation properties. The study confirmed the good biocompatibility of the biodegradable stents and their ability to completely degrade within 4 weeks, providing better drainage than conventional stents and potentially reducing the need for secondary procedures and stent-related infections.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Oncology
Lixia Wang, Chuanlai Yang, Man Chu, Zhi-wei Wang, Boxin Xue
Summary: The study investigated the molecular mechanisms underlying radioresistance in bladder cancer, revealing elevated Cdc20 expression in IR cells and its role in governing IR-mediated EMT by regulating FoxO1 degradation. Therefore, inhibiting Cdc20 or activating FoxO1 may be potential strategies to overcome radioresistance in bladder cancer.
Article
Oncology
Lu Jin, Yibin Zhou, Guangqiang Chen, Guangcheng Dai, Kai Fu, Dongrong Yang, Jin Zhu
Summary: TROAP is overexpressed in prostate cancer and is associated with tumor progression and poor patient survival. Knockdown of TROAP inhibits proliferation and invasion of DU145 and PC3 cells, potentially through modulation of MMP-9 and E-Cadherin. TROAP is identified as a driver of prostate cancer development and progression, providing a new target for treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Lu Jin, Wei Zhang, Ming-Yu Yao, Ye Tian, Bo-xin Xue, Wei Tao
Summary: GNE-493 is a novel PI3K/mTOR dual inhibitor that effectively inhibits the growth and migration of prostate cancer cells through Akt-mTOR-dependent and -independent mechanisms.
CELL DEATH DISCOVERY
(2022)
Article
Plant Sciences
Lu Jin, Yingxue Guo, Weiye Mao, Jingwei Wang, Lushuai Jin, Xia Liu, Qiyang Shou, Huiying Fu
Summary: In this study, it was found that total glucosides of paeony (TGP) can improve the inflammatory microenvironment of tumors by inhibiting the release of inflammatory factors, thereby suppressing tumor growth and metastasis. TGP reduces the infiltration of tumor-associated macrophages (TAMs), promotes T cell infiltration, and regulates the levels of inflammatory factors to achieve these effects.
Article
Medicine, General & Internal
Qunli Xiong, Zhiwei Zhang, Yang Yang, Yongfeng Xu, Ying Zhou, Su Zhang, Jinlu Liu, Ying Zheng, Qing Zhu
Summary: This study investigates the role of KLF6 in pancreatic cancer (PAAD). The results show that KLF6 is downregulated in pancreatic cancer tissues and is associated with poor survival. Overexpression of KLF6 inhibits proliferation, metastasis, and epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. It is discovered that KLF6 upregulates activating transcription factor 3 (ATF3) in PAAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Lu Jin, Jin Zhu, Linya Yao, Gang Shen, Bo-xin Xue, Wei Tao
Summary: This study found that SphK1 and SphK2 are upregulated in human prostate cancer tissues. The use of SKI-178 effectively inhibits the growth and migration of prostate cancer cells, exerting cytotoxic effects through the inhibition of SphK activity and induction of ceramide production.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Fang Nie, Jianguo Cao, Jinlu Tong, Mingming Zhu, Yuan Gao, Zhihua Ran
JOURNAL OF BIOMEDICAL SCIENCE
(2015)