Article
Endocrinology & Metabolism
Eleftherios P. Paschalis, David W. Dempster, Sonja Gamsjaeger, Stamatia Rokidi, Norbert Hassler, Wolfgang Brozek, Faye W. Chan-Diehl, Klaus Klaushofer, Kathleen A. Taylor
Summary: The study investigates the early effects of TPTD and ZOL on the material properties of newly formed bone in postmenopausal women with osteoporosis. Results indicate that the two drugs have differential effects on material properties at individual remodeling sites, highlighting their different mechanisms of action.
Article
Endocrinology & Metabolism
Seunghyun Lee, Namki Hong, Kyoung Jin Kim, Chung Hyun Park, Jooyeon Lee, Yumie Rhee
Summary: This retrospective cohort study found that treatment with teriparatide (TPTD) in premenopausal women with pregnancy- and lactation-associated osteoporosis (PLO) can effectively maintain bone mineral density (BMD) without the need for sequential antiresorptive therapy (ART).
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Geriatrics & Gerontology
Gustavo Duque, Sandra Iuliano, Jacqueline C. T. Close, Mizhgan Fatima, Kirtan Ganda, Stefanie Bird, Ben Kirk, Mary Levidiotis, Catherine M. Said, Alexandra Papaioannou, Charles A. Inderjeeth
Summary: Osteoporosis is often overlooked and undertreated in people living in Residential Aged Care Facilities, despite their higher risk of fractures compared to community-dwelling individuals. In Australia, a series of Consensus Conferences have been held to update guidelines and provide valuable guidance for healthcare practitioners working in RACFs.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Melanie Schorr Haines, Allison Kimball, Erinne Meenaghan, Katherine N. Bachmann, Kate Santoso, Kamryn T. Eddy, Vibha Singhal, Seda Ebrahimi, Esther Dechant, Thomas Weigel, Lori Ciotti, Robert J. Keane, Suzanne Gleysteen, Diane Mickley, Miriam A. Bredella, Can Ozan Tan, Rajiv Gupta, Madhusmita Misra, David Schoenfeld, Anne Klibanski, Karen K. Miller
Summary: The study showed that sequential therapy with recombinant human IGF-1 followed by risedronate can increase lateral lumbar spine areal bone mineral density more than risedronate or placebo in women with anorexia nervosa. Strategies combining anabolic and antiresorptive treatments may be effective at improving bone mineral density in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Alvaro del Real, Carmen Valero, Jose M. Olmos, Jose L. Hernandez, Jose A. Riancho
Summary: Common genetic variants in the mevalonate and oestrogen pathways are associated with changes in bone mineral density in response to antiresorptive drugs, providing insights for predicting drug responses and making personalized therapeutic choices.
Article
Endocrinology & Metabolism
Kenneth E. S. Poole, Graham M. Treece, Rose A. Pearson, Andrew H. Gee, Michael A. Bolognese, Jacques P. Brown, Stefan Goemaere, Andreas Grauer, David A. Hanley, Carlos Mautalen, Chris Recknor, Yu-Ching Yang, Maria Rojeski, Cesar Libanati, Tristan Whitmarsh
Summary: This study analyzed the impact of romosozumab and teriparatide on vertebral bone accrual, showing significant improvements with romosozumab in all parameters compared to teriparatide. While there was no significant difference in Cn.BMD gains between the two treatments, both were significantly better than the placebo group.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ian R. Reid, Anne M. Horne, Borislav Mihov, Sonja Bastin, Gregory D. Gamble
Summary: Bisphosphonates are commonly used for osteoporosis prevention and treatment, while NSAIDs are widely used by older adults at high fracture risk. A study reanalyzed data from a clinical trial of zoledronate and found that NSAID use did not affect the bone density or fracture risk reduction effects of zoledronate. The study concluded that NSAIDs do not interfere with the efficacy of potent bisphosphonates in terms of bone density or fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Michael Bruce, Mary L. Bouxsein, Joy N. Tsai, Benjamin Z. Leder
Summary: The effectiveness of a single dose of zoledronic acid in maintaining improvements in peripheral bone density and microarchitecture achieved with the combination of denosumab and teriparatide was investigated. The results showed gradual decreases in total and cortical bone density, but remains above baseline, and no significant changes in trabecular parameters. Further research is needed to explore alternative therapeutic approaches for fully maintaining improvements in peripheral bone parameters.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Richard Eastell, Joy N. Tsai, Benjamin Z. Leder
Summary: Combination therapy of teriparatide and denosumab can significantly increase bone mineral density, while discontinuation of denosumab may lead to bone loss and increased fracture risk. A single dose of zoledronic acid effectively maintains the BMD improvements achieved with the combination therapy for at least 27 months. Spine BMD was largely preserved during this period as well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Felicia Cosman, Didier Hans, Enisa Shevroja, Yamei Wang, Bruce Mitlak
Summary: Although bone mineral density (BMD) is a predictor of fracture, many fractures occur in women with T-scores > -2.5. Bone microarchitecture, assessed by trabecular bone score (TBS), predicts fracture risk independent of BMD. We evaluated whether abaloparatide improves TBS and whether TBS trends were associated with vertebral fracture risk reduction.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
David W. Dempster, Hua Zhou, Sudhaker D. Rao, Chris Recknor, Paul D. Miller, Benjamin Z. Leder, Miriam Annett, Michael S. Ominsky, Bruce H. Mitlak
Summary: After 3 months of abaloparatide treatment, there was significant improvement in bone formation on cancellous, endocortical, intracortical, and periosteal surfaces in postmenopausal women with osteoporosis. Both modeling-based formation (MBF) and remodeling-based formation (RBF) contributed to this increase in bone formation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Alexander H. Seeto, Bo Abrahamsen, Peter R. Ebeling, Alexander J. Rodriguez
Summary: The study evaluated the cardiovascular safety of denosumab through a systematic review of randomized controlled trials. It found that postmenopausal women treated with denosumab had a higher risk of cardiovascular adverse events compared to those treated with bisphosphonates, but no significant difference was observed compared to placebo. Future trials should focus on standardized reporting of cardiovascular adverse events to better understand the effects of bone active medications.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Piet Geusens, Robert Feldman, Mary Oates, Thierry Thomas, Polyzois Makras, Franz Jakob, Bente Langdahl, Zhenxun Wang, Maria Rojeski, Cesar Libanati
Summary: The study demonstrates that romosozumab can reduce the incidence of fractures, whether in patients receiving placebo or alendronate. This treatment effect is independent of the baseline presence and severity of fractures and is sustained after transitioning to other medications.
Article
Endocrinology & Metabolism
Jae-Won Shin, Quen He, Yong June Suk, Sang-Ho Kim, Hak-Sun Kim
Summary: The study found that short-term teriparatide use before denosumab treatment was more effective in reducing fragility fracture risk compared to denosumab monotherapy.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Richard Eastell, Eric Vittinghoff, Li-Yung Lui, Susan K. Ewing, Ann Schwartz, Douglas C. Bauer, Dennis M. Black, Mary L. Bouxsein
Summary: The study aimed to determine the impact of type 2 diabetes on the efficacy of antiresorptive treatment for osteoporosis. The results showed that bisphosphonates and most antiresorptive drugs are effective in reducing fracture risk and increasing bone mineral density regardless of diabetes status.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Benjamin Z. Leder, Carol Zapalowski, Ming-Yi Hu, Gary Hattersley, Nancy E. Lane, Andrea J. Singer, Robin K. Dore
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Editorial Material
Endocrinology & Metabolism
Benjamin Z. Leder
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Benjamin Z. Leder, Joy N. Tsai
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Benjamin Z. Leder, Bruce Mitlak, Ming-Yi Hu, Gary Hattersley, Richard S. Bockman
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
David W. Dempster, Hua Zhou, Sudhaker D. Rao, Chris Recknor, Paul D. Miller, Benjamin Z. Leder, Miriam Annett, Michael S. Ominsky, Bruce H. Mitlak
Summary: After 3 months of abaloparatide treatment, there was significant improvement in bone formation on cancellous, endocortical, intracortical, and periosteal surfaces in postmenopausal women with osteoporosis. Both modeling-based formation (MBF) and remodeling-based formation (RBF) contributed to this increase in bone formation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Richard Eastell, Joy N. Tsai, Benjamin Z. Leder
Summary: Combination therapy of teriparatide and denosumab can significantly increase bone mineral density, while discontinuation of denosumab may lead to bone loss and increased fracture risk. A single dose of zoledronic acid effectively maintains the BMD improvements achieved with the combination therapy for at least 27 months. Spine BMD was largely preserved during this period as well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Michael Bruce, Mary L. Bouxsein, Joy N. Tsai, Benjamin Z. Leder
Summary: The effectiveness of a single dose of zoledronic acid in maintaining improvements in peripheral bone density and microarchitecture achieved with the combination of denosumab and teriparatide was investigated. The results showed gradual decreases in total and cortical bone density, but remains above baseline, and no significant changes in trabecular parameters. Further research is needed to explore alternative therapeutic approaches for fully maintaining improvements in peripheral bone parameters.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Joy N. Tsai, Hang Lee, Grace Sassana-Khadka, Mackenzie Jordan, Savannah Ryan, Benjamin Z. Leder
Summary: Discontinuing denosumab results in accelerated bone remodeling, decreased bone mineral density, and increased risk of fractures. This study evaluated the comparative efficacy of alendronate and raloxifene in preventing post-denosumab high-turnover bone loss. The results showed that after one year of denosumab, one year of alendronate is more effective in maintaining bone remodeling inhibition and bone mineral density gains compared to raloxifene.
OSTEOPOROSIS INTERNATIONAL
(2023)