Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation)

A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

(2019) Brecht Guillemyn et al.   HUMAN MOLECULAR GENETICS

Overlapping and differential functions of ATF6α versus ATF6β in the mouse heart

(2019) Robert N. Correll et al.   Scientific Reports

Identification of residues critical for topology inversion of the transmembrane protein TM4SF20 through regulated alternative translocation

(2019) Jingcheng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum

(2019) Tamas Balla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Regulating G protein-coupled receptors by topological inversion

(2019) Bray Denard et al.   eLife

Substrate recognition and processing by γ-secretase

(2019) Michael S. Wolfe   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The first family with adult osteogenesis imperfecta caused by a novel homozygous mutation in CREB3L1

(2019) Ferdy K. Cayami et al.   Molecular Genetics & Genomic Medicine

Homozygosity for CREB3L1 premature stop codon in first case of recessive osteogenesis imperfecta associated with OASIS-deficiency to survive infancy

(2018) Katarina Lindahl et al.   BONE

Paradoxical roles of ATF6α and ATF6β in modulating disease severity caused by mutations in collagen X

(2018) M. Forouhan et al.   MATRIX BIOLOGY

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

(2018) Russell A. DeBose-Boyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy

(2018) Bray Denard et al.   BMC CANCER

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

(2018) Arvin B. Tam et al.   DEVELOPMENTAL CELL

UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage–specific manner

(2017) Tokiro Ishikawa et al.   JOURNAL OF CELL BIOLOGY

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Role of lipoprotein lipase in lipid metabolism

(2016) Gunilla Olivecrona   CURRENT OPINION IN LIPIDOLOGY

Very Low Density Lipoprotein Assembly Is Required for cAMP-responsive Element-binding Protein H Processing and Hepatic Apolipoprotein A-IV Expression

(2016) Dongmei Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix

(2016) Qiuyue Chen et al.   MOLECULAR CELL

PARL: The mitochondrial rhomboid protease

(2016) Marco Spinazzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta

(2016) Uschi Lindert et al.   Nature Communications

Glucagon regulates hepatic lipid metabolism via cAMP and Insig-2 signaling: implication for the pathogenesis of hypertriglyceridemia and hepatic steatosis

(2016) Hai Wang et al.   Scientific Reports

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

(2016) Yoshimi Nakagawa et al.   Scientific Reports

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

(2015) Joseph L. Goldstein et al.   CELL

Identification of CREB3L1 as a Biomarker Predicting Doxorubicin Treatment Outcome

(2015) Bray Denard et al.   PLoS One

Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21

(2014) Hyunbae Kim et al.   ENDOCRINOLOGY

Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH

(2014) Xu Xu et al.   JOURNAL OF LIPID RESEARCH

Sustained Induction of Collagen Synthesis by TGF-β Requires Regulated Intramembrane Proteolysis of CREB3L1

(2014) Qiuyue Chen et al.   PLoS One

The site-2 protease

(2013) Robert B. Rawson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Doxorubicin, DNA torsion, and chromatin dynamics

(2013) Fan Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

(2013) Atsushi Saito et al.   MOLECULAR CELL

Deficiency for the ER-stress transducer OASIS causes severe recessive osteogenesis imperfecta in humans

(2013) Sofie Symoens et al.   Orphanet Journal of Rare Diseases

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

(2012) Bray Denard et al.   eLife

The Membrane-Bound Transcription Factor CREB3L1 Is Activated in Response to Virus Infection to Inhibit Proliferation of Virus-Infected Cells

(2011) Bray Denard et al.   Cell Host & Microbe

FUS-CREB3L2/L1-Positive Sarcomas Show a Specific Gene Expression Profile with Upregulation of CD24 and FOXL1

(2011) E. Moller et al.   CLINICAL CANCER RESEARCH

Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis

(2011) Massoud Motamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

(2011) Jung Hoon Lee et al.   NATURE MEDICINE

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Regulation of Cholesterol and Fatty Acid Synthesis

(2011) J. Ye et al.   Cold Spring Harbor Perspectives in Biology

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells

(2010) Ravi N. Vellanki et al.   ENDOCRINOLOGY

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

(2010) J. N. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFAP Syndrome Is Caused by Deficiency in MBTPS2, an Intramembrane Zinc Metalloprotease Essential for Cholesterol Homeostasis and ER Stress Response

(2009) Frank Oeffner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

(2009) Tomohiko Murakami et al.   NATURE CELL BIOLOGY

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

VLDL exits from the endoplasmic reticulum in a specialized vesicle, the VLDL transport vesicle, in rat primary hepatocytes

(2008) Shadab A. Siddiqi   BIOCHEMICAL JOURNAL

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

(2008) Joon No Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The concept of translocational regulation

(2008) Ramanujan S. Hegde et al.   JOURNAL OF CELL BIOLOGY

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

(2008) Michael S. Brown et al.   JOURNAL OF LIPID RESEARCH