Article
Microbiology
Karolina Plaskowska, Lukasz Makowski, Agnieszka Strzalka, Jolanta Zakrzewska-Czerwinska
Summary: Most eukaryotic and bacterial cells divide by binary fission, while some bacteria can also divide by nonbinary fission. The predatory bacterium Bdellovibrio bacteriovorus exhibits bimodal fission, with the mode of division depending on the size of the prey bacterium. This finding provides insights into the proliferation and elimination strategies of antibiotic-resistant pathogens.
Article
Chemistry, Multidisciplinary
Yan Liu, Wanting Guo, Wanmei Wang, Hui Zhang, Yiguang Jin
Summary: The development of potent bactericidal antibiotic alternatives is crucial to address the current antibiotic crisis. This study constructed a B. bacteriovorus in situ forming hydrogel (BIG) for the local treatment of drug-resistant bacterial ocular infection. BIG not only preserved the activity of B. bacteriovorus but also remained on the ocular surface for a prolonged period.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Camila Maurmann de Souza, Osmel Fleitas Martinez, Harry Morales Duque, Octavio Luiz Franco
Summary: Novel treatments are needed to combat resistant Gram-negative bacteria and predatory bacteria have emerged as a potential solution. However, the efficacy of predatory bacteria alone is limited, leading to the investigation of combination therapies with other agents. This article discusses recent advancements in the use of predatory bacteria for infections and proposes novel combination strategies with antivirulence compounds.
DRUG DISCOVERY TODAY
(2023)
Article
Microbiology
Yuki Hoshiko, Yoshito Nishiyama, Tae Moriya, Kiwao Kadokami, Luis Esau Lopez-Jacome, Ryutaro Hirano, Rodolfo Garcia-Contreras, Toshinari Maeda
Summary: The study found that the pqs QS system of P. aeruginosa inhibits the predatory activity of B. bacteriovorus, while the predatory activity of B. bacteriovorus increases when using pqs QS system mutant strains.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Christian Mariel Saenz-Santos, Omotayo Opemipo Oyedara, Yunia Veronica Garcia-Tejeda, Claudia A. Romero-Bastida, Esperanza Milagros Garcia-Oropesa, Eduardo Villalobo, Mario A. Rodriguez-Perez
Summary: The study evaluated the viability of Bdellovibrio bacteriovorus in biopolymeric films, with CA-S film showing less reduction in bacterial viability. This suggests that CA-S could be a better agent for immobilization and preservation of B. bacteriovorus for enhanced predatory activities against Escherichia coli.
Editorial Material
Microbiology
R. Elizabeth Sockett
Summary: Liz Sockett describes the lessons she learned from studying Bdellovibrio bacteriovorus, a single-celled predator that invades and kills Gram-negative bacteria from within.
NATURE MICROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ying Tang, Qian-Xiao Huang, Di-Wei Zheng, Yang Chen, Li Ma, Cui Huang, Xian-Zheng Zhang
Summary: By utilizing a material-assisted micro-organism (MAMO) strategy with ZnO nanorods engineered Bdellovibrio (ZnO@Bdello), the biofilm composed of Gram-negative bacteria can be effectively eradicated. This strategy demonstrates superior competence in alleviating inflammation and inhibiting bone resorption.
Review
Microbiology
Ting F. Lai, Rhian M. Ford, Simona G. Huwiler
Summary: Since its discovery, the predatory bacterium Bdellovibrio bacteriovorus has attracted attention as a potential solution to antibiotic resistance. This review provides a comprehensive historical overview and discusses the advancements in microscopy and molecular mechanisms. Recent findings in cryo-electron tomography have revealed intricate molecular details of the predatory life cycle, and new imaging technologies and quantitative advances are expected to unravel remaining unanswered questions in the future.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Engineering, Environmental
Megan Kode, Monique Waso-Reyneke, Brandon Reyneke, Julia Denissen, Tanya Clements-Decker, Benjamin Havenga, Sehaam Khan, Wesaal Khan
Summary: This study investigated the reduction of antibiotic resistant Klebsiella pneumoniae and Pseudomonas aeruginosa using combination treatments of Bdellovibrio bacteriovorus, solar disinfection, and Moringa oleifera flocculation. Results showed that pre-treatment with Bdellovibrio bacteriovorus alone did not reduce the concentration of Pseudomonas aeruginosa, but combining it with solar disinfection resulted in significant reductions. The combination treatment effectively reduced the counts of Klebsiella pneumoniae.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Microbiology
Emma J. Banks, Carey Lambert, Samuel S. Mason, Jess Tyson, Paul M. Radford, Cameron McLaughlin, Andrew L. Lovering, R. Elizabeth Sockett
Summary: Antimicrobial resistance poses a serious threat to global health. Bdellovibrio bacteriovorus has the potential to be a novel antibacterial therapeutic and a source of antibacterial enzymes by preying upon Gram-negative bacterial pathogens. This study reveals the role of a secreted lytic transglycosylase from B. bacteriovorus in targeting the septal peptidoglycan of its prey.
JOURNAL OF BACTERIOLOGY
(2023)
Review
Microbiology
Francis M. Cavallo, Lorea Jordana, Alexander W. Friedrich, Corinna Glasner, Jan Maarten van Dijl
Summary: Bdellovibrio bacteriovorus is a predatory bacterium with potential applications as a probiotic and antibiotic agent due to its unique ability to prey on other Gram-negative bacteria. Recent studies have focused on its biology, life cycle, predation resistance, and potential use as a living antibiotic in human therapy. Data suggest that it could be upgraded from academic interest to a tool for combating antibiotic resistant infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Microbiology
Monique Waso-Reyneke, Sehaam Khan, Wesaal Khan
Summary: The interaction between Bdellovibrio bacteriovorus PF13 and mixed bacterial communities was studied. The results showed that PF13 preferentially preys on K. pneumoniae and the presence of Gram-positive bacteria does not affect its predation efficiency.
Review
Microbiology
Benjamin Havenga, Brandon Reyneke, Monique Waso-Reyneke, Thando Ndlovu, Sehaam Khan, Wesaal Khan
Summary: This article reviews the antibiotic resistance and virulence mechanisms of A. baumannii, and discusses the potential of biological control agents to target and combat this pathogen. Limitations and mitigation strategies are also outlined.
Article
Infectious Diseases
Eric G. Romanowski, Shilpi Gupta, Androulla Pericleous, Daniel E. Kadouri, Robert M. Q. Shanks
Summary: Predatory bacteria can eliminate Gram-negative pathogens on the ocular surface, but do not significantly affect the ability of the ocular surface to clear these pathogens.
Article
Fisheries
Xiaoli Chen, Huadong Yi, Shuang Liu, Yong Zhang, Yuqin Su, Xuange Liu, Sheng Bi, Han Lai, Zeyu Zeng, Guifeng Li
Summary: Addition of B. bacteriovorus to aquaculture water can significantly promote the pellet-feed feeding of mandarin fish, improve their survival rates and growth performance, as well as regulate intestinal flora and enhance innate immunity.
Article
Chemistry, Multidisciplinary
Gizem Erturk Bergdahl, Tilde Andersson, Maria Allhorn, Sofie Yngman, Rainer Timm, Rolf Lood
Review
Microbiology
Eleni Bratanis, Tilde Andersson, Rolf Lood, Ewa Bukowska-Faniband
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Tilde Andersson, Anna Blackberg, Rolf Lood, Gizem Erturk Bergdahl
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Microbiology
Tilde Andersson, Aiko D. Adell, Andrea I. Moreno-Switt, Peter Spegel, Charlotta Turner, Soren Overballe-Petersen, Kurt Fuursted, Rolf Lood
Summary: Antibiotic resistance is a major medical challenge globally, and wastewater treatment plants have been identified as a source of resistance genes. Bacterial viruses, known as bacteriophages, play an important role in spreading resistance genes in the environment. This study used amplicon deep sequencing and absolute quantification of resistance genes to investigate the impact of river-borne bacteriophages on resistance spread. The results showed that the microbial biodiversity of rivers is influenced by location, surrounding environment, and sampling time, and agricultural areas have a greater ability to induce bacteriophages carrying resistance genes.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Tilde Andersson, Geofrey Makenga, Filbert Francis, Daniel T. R. Minja, Soren Overballe-Petersen, Man-Hung Eric Tang, Kurt Fuursted, Vito Baraka, Rolf Lood
Summary: The spread of antibiotic resistance is a significant challenge, with faulty usage of antibiotics and horizontal gene transfer through bacteriophages playing important roles. In a study of Tanzanian patients with bacterial infections, significant differences were found in oral microbial diversity between infected and non-infected individuals, as well as before and after oral antibiotic treatment. The resistome carried by both bacteria and bacteriophages also varied significantly.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tilde Andersson, Gizem Erturk Bergdahl, Karim Saleh, Helga Magnusdottir, Kristian Stodkilde, Christian Brix Folsted Andersen, Katarina Lundqvist, Anders Jensen, Holger Bruggemann, Rolf Lood
SCIENTIFIC REPORTS
(2019)