Article
Biochemistry & Molecular Biology
Marine M. Tanashyan, Alla A. Shabalina, Polina I. Kuznetsova, Anton A. Raskurazhev
Summary: Atherosclerosis is a chronic inflammatory disease with complex pathogenesis, and miR-33a is involved in cholesterol efflux and atherosclerosis development. This study aimed to investigate the relationship between miR-33a expression and lipid biomarkers in carotid atherosclerosis patients. The results showed that lower miR-33a levels were associated with lower LDL cholesterol and higher degree of carotid stenosis. miR-33a may play a role in cholesterol metabolism in carotid atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Fang Liu, Zheng Wang, Xia Cao, Yingxia Pan, Erqiang Zhang, Jiahuan Zhou, Lina Zheng
Summary: This study investigated the relationship between small dense low-density lipoprotein cholesterol (sdLDL-C) and carotid artery intima-media thickness (CA-IMT) and carotid plaque (CAP) in the Chinese general population. The results suggest that sdLDL-C is an independent risk factor for the occurrence of CAP in individuals with abnormal IMT, providing alternative methods for predicting early stage cardiovascular disease (CVD).
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Medical Laboratory Technology
Yang Geng, Yan Liu, Yan Chen, Zhenwen Zhang, Liping Wang, Xiaobo Li, Binlan Xia, Bin Song, Hengzhong Zhang
Summary: In the Chinese population with a high risk of stroke, a higher LDLc/HDLc ratio was significantly associated with the presence of carotid plaques.
CLINICAL BIOCHEMISTRY
(2021)
Article
Peripheral Vascular Disease
Tianxiao Liu, Dong Zhao, Miao Wang, Jiayi Sun, Jun Liu, Jiangtao Li, Youling Duan, Zhaoqing Sun, Piaopiao Hu, Jing Liu, Yue Qi
Summary: This community-based study aimed to examine the association between IDL particle concentrations and the 5-year progression of carotid atherosclerosis. The results showed that elevated IDL particle concentrations were independently associated with the progression of carotid atherosclerosis, regardless of baseline concentrations of LDL particles and VLDL particles and their subclasses.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Clinical Neurology
Pierre C. Amarenco, Philippa S. Lavallee, Jong Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Helene Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Eric Vicaut, Eric Bruckert, Treat Stroke Target Invest
Summary: This study investigated the effects of two different strategies for reducing low-density lipoprotein (LDL) cholesterol on reducing cardiovascular risk. The results showed that among patients with a target LDL cholesterol level of <70 mg/dL, a reduction in LDL cholesterol of >50% from baseline significantly reduced the risk of the primary outcome.
Review
Biochemistry & Molecular Biology
Francesco Baratta, Nicholas Cocomello, Mattia Coronati, Domenico Ferro, Daniele Pastori, Francesco Angelico, Maria Del Ben
Summary: Randomized clinical trials have shown that there is a residual cardiovascular risk in patients treated with statins and other lipid-lowering drugs to target LDL-cholesterol. This risk is mainly associated with lipid components other than LDL, particularly remnant cholesterol (RC) and lipoproteins rich in triglycerides. RCs play a major role in the development of atherosclerosis, easily passing through the arterial wall and stimulating the progression of smooth muscle cells and resident macrophages. Further studies and clinical trials are needed to evaluate the effects of drugs on RC levels and the efficacy of reducing RC on cardiovascular events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Xiangming Hu, Jieliang Liu, Wei Li, Chenyang Wang, Guang Li, Yingling Zhou, Haojian Dong
Summary: Uric acid (UA) and high-density lipoprotein cholesterol (HDL-C) are associated with atherosclerosis, but it is unclear whether UA affects the role of HDL-C in atherosclerosis. This study found that patients with hyperuricemia were different from those with normouricemia in terms of age, disease history, and unhealthy behavior. In patients with normouricemia, HDL-C was negatively associated with carotid atherosclerosis indicators, while this correlation was not significant in patients with hyperuricemia. These findings suggest that the pre-inflammatory state marked by elevated UA may impact the association between HDL-C and carotid atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Ying Zhu, Xu Liu, Ruixia Zhu, Jingjing Zhao, Qianwen Wang
Summary: This study found an association between elevated blood levels of total cholesterol (TC) and triglycerides (TG) with increased risk of dementia, especially Alzheimer's disease (AD). The analysis also revealed a linear relationship between TC or TG and the risk of AD, with each 3-mmol/L increment in TC and TG associated with a 9% and 12% increase in risk, respectively.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Peripheral Vascular Disease
Hannelore K. Neuhauser, Julia Bueschges, Angelika Schaffrath Rosario, Anja Schienkiewitz, Giselle Sarganas, Karsten Koenigstein, Dieter Schweizer, Arno Schmidt-Trucksaess
Summary: This study derived carotid intima media thickness (CIMT) percentiles using improved technology and statistical techniques, and found an association between CIMT and hypertensive blood pressure (BP) and obesity in a population-based sample of adolescents and young adults.
Article
Endocrinology & Metabolism
Anne Gedebjerg, Mette Bjerre, Alisa Devedzic Kjaergaard, Jens Steen Nielsen, Jorgen Rungby, Ivan Brandslund, Michael Maeng, Henning Beck-Nielsen, Allan Vaag, Henrik Toft Sorensen, Troels Krarup Hansen, Reimar Wernich Thomsen
Summary: We investigated the relationship between hs-CRP and C-peptide in patients with recently diagnosed T2D and found that high levels of hs-CRP were associated with increased risk of CVEs and all-cause mortality. Patients with high levels of both biomarkers had the highest risk. These findings have important implications for early detection and prevention of deadly diseases beyond CVEs.
Review
Cardiac & Cardiovascular Systems
Xiao Jin, Shengjie Yang, Jing Lu, Min Wu
Summary: This article summarizes the possible mechanisms of sdLDL-C in atherosclerosis (AS). Research has found that sdLDL-C increases the risk of AS by regulating gene networks, monocytes, and enzymes. Furthermore, the article reviews the effects of sdLDL-C on endothelial function, lipid metabolism, and inflammation, as well as discusses intervention methods.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaoxian Gong, Luowei Chen, Bo Song, Xiang Han, Weihai Xu, Bo Wu, Feng Sheng, Min Lou
Summary: The study found that an increase in total cholesterol and triglycerides is associated with an increased risk of ischemic stroke and a reduced risk of hemorrhagic stroke, while an increase in high-density lipoprotein cholesterol is associated with a reduced risk of ischemic stroke. It is recommended to control total cholesterol and low-density lipoprotein cholesterol levels within certain ranges.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Akshyaya Pradhan, Ravninder Kuka, Pravesh Vishwakarma, Wahid Ali, Marco Alfonso Perrone, Ferdinando Iellamo, Gaurav Chaudhary, Sharad Chandra, Rishi Sethi, Sudhanshu Dwivedi, Varun Narain, R. K. Saran
Summary: In ACS patients, age, sex, diabetes, smoking, and the severity of coronary artery disease did not significantly affect sd-LDL levels. However, prior statin usage was associated with lower sd-LDL levels, and diabetic patients had higher sd-LDL/lb-LDL ratios.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Naoki Nanashima, Kayo Horie, Maiko Kitajima, Shizuka Takamagi, Kasumi Mikami, Naoya In, Toshiko Tomisawa
Summary: The daily intake of blackcurrant extract for 29 days can lower total cholesterol levels in healthy women, particularly affecting total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol, showing efficacy in preventing arteriosclerosis.
Article
Biochemistry & Molecular Biology
Yu-Chen Chang, Chien-Ju Lin, Tzu-Lin Yeh, Ming-Chieh Tsai, Le-Yin Hsu, Kuo-Liong Chien, Hsin-Yin Hsu
Summary: This prospective cohort study in Taiwan found a decreased risk of cancer incidence associated with an increase in lower-baseline total cholesterol, LDL-C, and non-HDL-C levels. Participants with stable lower-baseline, decreasing, and increasing higher-baseline LDL-C levels, as well as decreasing and stable higher-baseline non-HDL-C levels, also showed a reduced risk for cancer. The study suggests that a decline in serum lipid levels may be linked to a higher risk of cancer and warrants further investigation.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Chemistry, Medicinal
Haiyu Zhang, Xinmei Xie, Junzhuo Shi, Qian Zhao, Dongmei Luo, Jiaojiao Hao, Yunfeng Zhou, Guang Han, Xiaobin Pang
Summary: The present study confirmed the cognition-enhancing effect of 3, 14, 19-Triacetyl andrographolide (ADA) on learning and memory deficits in 3 x Tg-AD mice. ADA improves synaptic plasticity and cognitive function mainly through inducing autophagy and promoting the degradation process.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Rilei Jiang, Bing Lu, Fanchao Feng, Qian Li, Xiaolei Chen, Shibing Cao, Zhaoxia Pan, Zhengming Deng, Yufei Zhou, Ping Liu, Jiatuo Xu
Summary: The study indicated that a derivative of Houttuynia cordata (SNH) promoted pyroptosis in non-small cell lung cancer (NSCLC) cells by up-regulating a novel lncRNA (TCONS-14036) and activating the TCONS-14036/miR-1228-5p/PRKCDBP pathway. This finding offers a potential therapeutic target for NSCLC.
CELL PROLIFERATION
(2023)
Article
Chemistry, Multidisciplinary
Huixian Miao, Yujie Zhou, Pingping Wang, Zetao Huang, Wenjiang Zhaxi, Luying Liu, Fengnan Duan, Jinmin Wang, Xiao Ma, Shenlong Jiang, Wei Huang, Qun Zhang, Dayu Wu
Summary: In this study, the high-temperature negative thermal quenching (NTQ) effect was observed in copper iodide cluster-based coordination polymers that emit deep-red to near-infrared (NIR) light. The NTQ operating temperature of these unconventional phosphors can reach as high as 500 K, which is the highest temperature achieved by NTQ molecular-based materials.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Chengliang Sun, Mingxiao Yin, Yao Cheng, Zean Kuang, Xiaojia Liu, Gefei Wang, Xiao Wang, Kai Yuan, Wenjian Min, Jingwen Dong, Yi Hou, Lingrong Hu, Guoyu Zhang, Wenli Pei, Liping Wang, Yanze Sun, Xinmiao Yu, Yibei Xiao, Hongbin Deng, Peng Yang
Summary: S4-1 is an innovative small-molecule inhibitor of PD-L1 that effectively alters the PD-L1/PD-1 interaction, enhances cytotoxicity of immune cells towards tumor cells, and shows significant tumor growth inhibition in vivo. It also activates T-cells and reverses the inhibitory tumor microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pathology
Marilyn M. Li, Catherine E. Cottrell, Mrudula Pullambhatla, Somak Roy, Robyn L. Temple-Smolkin, Scott A. Turner, Kai Wang, Yunyun Zhou, Cindy L. Vnencak-Jones
Summary: To evaluate the clinical implementation of the 2017 Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer, a working group conducted variant interpretation challenges and a guideline implementation survey. The study found that while a majority of participants correctly classified clinically significant variants, there was disagreement regarding the consensus intended responses. The 2017 guidelines were being implemented by a significant number of respondents, but areas for improvement were identified.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Article
Chemistry, Physical
Xiaojia Luo, Xiao Liang, Yang Wei, Ligan Hou, Ru Li, Dandan Liu, Mo Li, Shuyu Zhou
Summary: With the shrinking size of electronic devices, it is important to develop new wire materials with higher current carrying capacity. Super-aligned carbon nanotubes (SACNTs) introduced into copper thin films offer a solution for atom chips, exhibiting an ultra-high current carrying capacity beyond traditional wires. The composite structures have potential in high-power electronic devices, high-performance on-chip interconnecting, and other applications with long-term high-current demands.
Article
Agronomy
Yong-Kang Liu, Cai-Di Xu, Xu-Song Zheng, Lei Chao, Yan-Fei Zhou, Guo-Yong Li, Yan Wu, Xue-Lian Bai, Ting Zhou, Bin Tang, Hong-Xing Xu
Summary: Excessive zinc is toxic to plants and its effect on the herbivorous insect Nilaparvata lugens is still unclear. This study assessed the impact of zinc-stressed rice plants on N. lugens. The results showed that zinc treatment altered sugar content in rice, reduced fecundity and trehalose content in N. lugens, and impacted trehalose metabolism. These findings suggest that zinc-stressed plants may have negative effects on herbivorous insects.
Article
Agronomy
Nan Wang, Yuping Zeng, Miao Wang, Linjun Shen, Zhijiang Liu, Long He, Xin Zhao, Hongpeng Guo, Yue Liu, Shuai Wang
Summary: In this study, the priming effects of Maillard reaction precursors on the microbial decomposition of rice straw at different incubation temperatures were investigated. The addition of glucose alone and mixed precursors increased the humic-extracted acid content. Glucose enhanced the quality of humic substance and the condensation degree of humic-like acid molecules. The addition of precursors had different effects on the composition and molecular structure of humic-like acid.
Article
Surgery
Chio-Hou Chong, Jia-Ming Sun, Yu-Xin Liu, Yi-Tung Tsai, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu
Summary: This study demonstrated the antifibrotic effect of Sal-B on hypertrophic scars in both in vitro and in vivo experiments. Sal-B inhibited the proliferation and migration of hypertrophic scar-derived fibroblasts in vitro and reduced scar size and fibrotic marker expression in vivo. These findings suggest that Sal-B can inhibit fibroblast proliferation and migration and attenuate hypertrophic scar formation.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Environmental Sciences
Xin Ma, Yi Li, Lihua Niu, Jiahui Shang, Nan Yang
Summary: Low-head dams are common hydraulic facilities that fragment rivers and contribute to river eutrophication. This study examined the effects of low-head dams on microbial community structure and ecosystem function in an urban river. The findings showed significant differences in microbial communities among cascade impoundments, which may be due to environmental heterogeneity caused by the dams. The study also revealed that the flow velocity is a key factor controlling river eutrophication. Therefore, careful consideration should be given to the location, type, and water storage capacity of low-head dams in river construction projects to optimize hydrodynamic conditions.
ENVIRONMENTAL RESEARCH
(2023)
Article
Genetics & Heredity
Yuzhen Li, Ziming Chen, Feng Zhang, Tianming Chen, Junxia Fan, Xin Deng, Xiaocui Lei, Bin Zeng, Zhe Zhang
Summary: This study reveals the role of the C2H2-type zinc-finger protein AoKap5 in the growth and kojic acid biosynthesis of A. oryzae. AoKap5 regulates kojic acid production through binding to the kojT promoter.
FUNGAL GENETICS AND BIOLOGY
(2023)
Article
Engineering, Civil
Zhangyan Chen, Yun Zhou, Takuya Kinoshita, Matthew J. DeJong
Summary: This study uses the Distinct Element Method (DEM) to predict the response of ordinary and innovative masonry infill walls (MIWs) within RC frames. The DEM simulation methodology is capable of accurately predicting the load-displacement response and damage patterns, indicating its potential for improving the design of DMIWs.
Article
Environmental Sciences
Aiping Cheng, Yafeng Zhou, Guoju Chen, Shibing Huang, Zuyang Ye
Summary: Cemented tailings backfill (CTB) is a cost-effective and environmentally friendly method for recycling tailings in mining. This study investigates the fracture mechanism of CTB through an acoustic emission (AE) test under uniaxial compression. The results reveal the periodic characteristics of CTB in different stages, the significance of ultra-high frequency AE signals as precursor information, and the differentiation of AE signals between shear and tension cracks. The study also classifies the fracture types of AE sources in CTB. These findings provide a basis for stability monitoring and fracture prediction in CTB.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Chunjiang Liu, Liming Tang, Yue Zhou, Xiaoqi Tang, Gang Zhang, Qin Zhu, Yufei Zhou
Summary: This study systematically identified three candidate hub genes (FGR, LCP1, and C5AR1) and established a nomogram to assist in diagnosing unstable carotid plaques (USCP) with uremia using various bioinformatic analyses and machine learning algorithms. The findings provide a foothold for future studies on potential diagnostic candidate genes for USCP in uremic patients. Additionally, immune cell infiltration analysis revealed that dysregulated immune cell proportions were identified, and macrophages could have a critical role in USCP pathogenesis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Construction & Building Technology
Songwei Lin, Zhiming He, Tong Ou, Yun Zhou
Summary: This paper introduces a type of composite damped hinge bearing (CDHB) to resolve the problem of the super-long steel structures producing high-temperature stress on the lower concrete roof column section and improve the structure's seismic performance. The construction and working principle of the CDHB are explained. Mechanical properties of the CDHB, including the monotonic loading test on the whole bearing and the reciprocal loading test on the built-in dampers, are tested and discussed. The study results demonstrate the stable performance of the CDHB in terms of vertical deformation, rotation, and energy consumption under different forces.
