Article
Medicine, General & Internal
Silvia Crosignani, Jacopo Fantinati, Matteo Cesari
Summary: The COVID-19 pandemic has highlighted the fragility of global health and social care systems, especially in regards to the response towards older individuals. There is a need for substantial reshaping of healthcare systems, shifting the focus towards community/primary care, improving the identification and management of geriatric conditions, and enhancing training for healthcare professionals.
FRONTIERS IN MEDICINE
(2021)
Article
Psychiatry
Mohammad Ridwan Chattun, Nousayhah Amdanee, Xiangrong Zhang, Zhijian Yao
Summary: Suicide in older adults is a major global concern, and with the increasing aging population, there is a predicted surge in suicidal deaths. This paper reviews the risk factors, protective factors, assessment rating scales, and current prevention strategies in the geriatric population. It emphasizes the need for personalized interventions based on identifying modifiable risk factors and strengthening protective factors. The study found that factors such as psychiatric illness, physical illnesses, loneliness, and low social support commonly increase suicidal susceptibility in older adults, while good physical health, cognitive function, religiousness, and social connectedness increase resilience. Current preventive strategies have not effectively reduced suicidal risk, highlighting the need for a multilevel prevention program to mitigate risk. Further research and improved preventive measures are necessary to address the issue.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Geriatrics & Gerontology
Yang Chen, Shuai Liang, Huiwen Wu, Shihao Deng, Fangyuan Wang, Ciren Lunzhu, Jun Li
Summary: Postoperative delirium (POD) is a common complication in geriatric patients with hip fractures, associated with poorer functional recovery, longer hospital stays, and higher mortality rates. Various factors such as advanced age, preoperative cognitive impairment, comorbidities, perioperative polypharmacy, and delayed surgery increase the risk of developing POD. Effective interventions such as perioperative risk prediction, avoidance of certain medications, and orthogeriatric comprehensive care can help prevent POD. Anesthesia technique choice does not seem to significantly impact the incidence of postoperative delirium in geriatric patients with hip fractures. There are limited pharmaceutical measures available for POD treatment, with dexmedetomidine and multimodal analgesia showing potential effectiveness but also considering adverse complications when using antipsychotics. In conclusion, perioperative risk intervention based on orthogeriatric comprehensive care is the most effective strategy for preventing postoperative delirium in geriatric patients with hip fractures.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
David O. Alao, Arif Alper Cevik, Michal Grivna, Hani O. Eid, Fikri M. Abu-Zidan
Summary: The study revealed a decrease in mortality rate among geriatric trauma patients in Al-Ain City, United Arab Emirates, over the past decade. There was a significant increase in falls on the same level and injuries occurring at home. Targeting home environments in injury prevention programs may help reduce geriatric injuries.
Review
Food Science & Technology
Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon, Oluwafemi Ayodeji Adebo
Summary: Brain aging is an inevitable aspect of old age, leading to changes in the brain such as shrinking of certain parts and decreased communication between neurons. Previous drug treatments for related ailments have had undesirable side effects, but recent research suggests the potential use of natural compounds. This review explores the potential of black pepper as a substance for managing brain aging.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Geriatrics & Gerontology
Stephanie K. Nothelle, Maura McGuire, Cynthia M. Boyd, Jessica L. Colburn
Summary: The study found that screening for geriatric conditions during the Medicare Annual Wellness Visit may have positive effects, highlighting opportunities to improve geriatric care related to prescribing and advance care planning (ACP).
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Review
Orthopedics
Emily K. Bliven, Anita Fung, Peter A. Cripton, Benedikt Helgason, Pierre Guy
Summary: Over the past decade, various designs for femoral augmentation have been investigated to prevent geriatric hip fracture. However, the experimental methods used to evaluate these augmentations have not been critically evaluated or compared. In this study, the authors conducted a scoping review of experimental studies on femoral augmentation approaches and identified areas for concordance with the clinical situation. They found limitations in the clinical relevance of modeled fall scenarios and large variance in the concordance of the identified studies. The authors make recommendations for improving the fidelity of experimental methods to better model clinical sideways falls.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Medicine, General & Internal
Jeannette M. Beasley, Emily A. Johnston, Mary Ann Sevick, Melanie Jay, Erin S. Rogers, Hua Zhong, Sondra Zabar, Eric Goldberg, Joshua Chodosh
Summary: In the DPP trial, older adults who received intensive lifestyle intervention had a 71% reduction in incident diabetes. However, a small number of older adults with prediabetes are participating in the National DPP. The BRIDGE trial aims to compare the effectiveness of in-person and virtual DPP programs in older adults and provide insights into the delivery of evidence-based interventions.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Yusuf Aslan, Gulten Arslan, Kemal Tolga Saracoglu, Banu Eler Cevik
Summary: The study aimed to investigate the predictive value of end-expiratory inferior vena cava diameter and collapsibility index for post-spinal hypotension in older adults undergoing spinal anesthesia. Results showed that expVCI diameter, lactate, and pH values were effective predictors for post-spinal hypotension, indicating the potential utility of noninvasive ultrasound methods in assessing hypotension risk.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Pharmacology & Pharmacy
Marilyn N. Bulloch
Summary: Older adults are more vulnerable to influenza and have different responses to infection and therapeutics compared to younger patients. Influenza vaccination and antiviral therapy are essential for preventing and treating influenza in the elderly. Oseltamivir is the most effective in reducing mortality and complications, while peramivir offers the shortest time for symptom alleviation and baloxavir is well tolerated.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Article
Geriatrics & Gerontology
Joanne Dollard, Keith D. Hill, Anne Wilson, Damith C. Ranasinghe, Kylie Lange, Katherine Jones, Eileen Mary Boyle, Mengqi Zhou, Nicholas Ng, Renuka Visvanathan
Summary: The study introduced the Ambient Intelligent Geriatric Management system, which detected patient movements using wearable sensors. Although it did not reduce the falls rate, participants found the system acceptable and comfortable, and felt reassured with extra monitoring. This feedback will be valuable for refining similar technology developments.
Article
Geriatrics & Gerontology
Patrizia Altorfer, Manuela Adcock, Eling D. de Bruin, Florian Graf, Eleftheria Giannouli
Summary: The study demonstrates that incorporating exergaming into inpatient rehabilitation of geriatric patients is a feasible, safe, and effective cognitive-motor training approach.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
A. Kojaie-Bidgoli, F. Sharifi, F. Maghsoud, M. Alizadeh-Khoei, F. Jafari, F. Sadeghi
Summary: Through interventions on 195 geriatric hospitalized patients, the study found that the modified HELP program in Iran effectively reduced delirium incidence, with a significant impact on improving patients' cognitive and functional abilities.
Article
Environmental Sciences
Lukasz Magnuszewski, Aleksandra Wojszel, Agnieszka Kasiukiewicz, Zyta Beata Wojszel
Summary: By assessing the frequency and circumstances of falls in a hospital geriatrics ward, this study identified that falls most often occur in the patient's room while changing position. Factors associated with falls include higher disability level, presence of multiple diseases (specifically Parkinson's disease and diabetes), history of falls in the past year, and diagnosis of orthostatic hypotension. The study also found significant independent associations between in-hospital falls and a history of falls, orthostatic hypotension, Parkinson's disease, and medication use (statins, benzodiazepines, and insulin).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Orthopedics
Miao-Tian Tang, Shang Li, Xiao Liu, Xiang Huang, Dian-Ying Zhang, Ming-Xing Lei
Summary: By retrospectively analyzing data of hip fracture patients, this study found an association between dementia and postoperative pneumonia and successfully developed an algorithm to predict the risk of developing postoperative pneumonia. The algorithm includes nine predictors and shows good predictive ability in internal and external validation.
ORTHOPAEDIC SURGERY
(2022)
Review
Allergy
Cristoforo Incorvaia, Mona Al-Ahmad, Ignacio J. Ansotegui, Stefania Arasi, Claus Bachert, Catherine Bos, Jean Bousquet, Andrzej Bozek, Davide Caimmi, Moises A. Calderon, Thomas Casale, Adnan Custovic, Frederic De Blay, Pascal Demoly, Philippe Devillier, Alain Didier, Alessandro Fiocchi, Adam T. Fox, Philippe Gevaert, Maximiliano Gomez, Enrico Heffler, Natalia Ilina, Carla Irani, Marek Jutel, Efstrathios Karagiannis, Ludger Klimek, Piotr Kuna, Robin O'Hehir, Oxana Kurbacheva, Paolo M. Matricardi, Mario Morais-Almeida, Ralph Mosges, Natalija Novak, Yoshitaka Okamoto, Petr Panzner, Nikolaos G. Papadopoulos, Hae-Sim Park, Giovanni Passalacqua, Ruby Pawankar, Oliver Pfaar, Peter Schmid-Grendelmeier, Silvia Scurati, Miguel Tortajada-Girbes, Carmen Vidal, J. Christian Virchow, Ulrich Wahn, Margitta Worm, Petra Zieglmayer, Giorgio W. Canonica
Summary: The introduction of personalized medicine has revolutionized the approach to treating diseases by focusing on treating the individual patient. Personalized medicine has shown significant improvements in allergy diagnosis by identifying specific allergens and predicting patient responsiveness to therapies, thereby enhancing the effectiveness of allergen immunotherapy.
Article
Allergy
Gunter Johannes Sturm, Sereina Annik Herzog, Werner Aberer, Teresa Alfaya Arias, Dario Antolin-Amerigo, Patrizia Bonadonna, Elisa Boni, Andrzej Bozek, Marta Chelminska, Barbara Ernst, Nina Frelih, Radoslaw Gawlik, Asli Gelincik, Thomas Hawranek, Wolfram Hoetzenecker, Aranzazu Jimenez Blanco, Karolina Kita, Resat Kendirlinan, Mitja Kosnik, Karin Laipold, Roland Lang, Francesco Marchi, Marina Mauro, Marita Nittner-Marszalska, Iwona Poziomkowska-Gesicka, Valerio Pravettoni, Donatella Preziosi, Oliviero Quercia, Norbert Reider, Marta Rosiek-Biegus, Berta Ruiz-Leon, Christoph Schrautzer, Pilar Serrano, Aytul Sin, Betul Ayse Sin, Johanna Stoevesandt, Axel Trautmann, Martina Vachova, Lisa Arzt-Gradwohl
Summary: The study found that taking beta-blockers or ACE inhibitors does not increase the frequency of systemic adverse events during venom immunotherapy, nor aggravate systemic insect sting reactions. Additionally, these drugs do not impair the effectiveness of venom immunotherapy.
Article
Biotechnology & Applied Microbiology
Andrzej Bozek, Renata Kozlowska, Beata Galuszka, Alicja Grzanka
Summary: The observational study found that after influenza vaccination, middle-aged individuals had a significantly lower risk of SARS-CoV-2 infection, indicating that the vaccine may partially reduce the risk of infection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Infectious Diseases
Magdalena Krupka, Andrzej Bozek, Dorota Bartusik-Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: The study demonstrated the efficacy of photodynamic therapy for infected chronic leg ulcers, with 40% of patients achieving complete remission, 40% experiencing partial response, and 20% showing no response. It also suggested that PDT can be used as a minimally invasive and effective method for treating leg ulcers.
Article
Allergy
Andrzej Bozek, Beata Galuszka, Radoslaw Gawlik, Maciej Misiolek, Wojciech Scierski, Alicja Grzanka, Giorgio Walter Canonica
Summary: For adult patients with local allergic rhinitis and asthma, a 12-month course of sublingual immunotherapy for house dust mite allergies can improve nasal and bronchial symptoms and reduce symptomatic treatment.
Article
Allergy
Andrzej Bozek, Jolanta Zalejska Fiolka, Zenon Czuba, Martyna Miodonska, Renata Kozlowska
Summary: This study compared the cytokine profile in patients with allergic asthma and analyzed the impact of Der p 23 allergy. The results showed that patients with Der p 23 allergy had higher levels of Il-1 and Il-5 activity, which could contribute to more effective allergic inflammation.
Article
Allergy
Magdalena Krupka-Olek, Andrzej Bozek, Milena Drewienkowska, Krzysztof Dryjka, Agata Medrala
Summary: This study analyzed a group of adult patients with concomitant psoriasis and atopic dermatitis, and compared their cytokine profiles with those of homogeneous psoriasis or atopic dermatitis patients and healthy controls. The results suggest that the role of T helper 17 cells may be more essential than previously thought.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Biotechnology & Applied Microbiology
Andrzej Bozek, Renata Kozlowska, Maciej Misiolek, Wojciech Scierski, Radoslaw Gawlik
Summary: This study investigated the combined therapy of omalizumab and sublingual immunotherapy in patients with house dust mite allergy and local allergic rhinitis (LAR). The results showed significant improvements in symptom scores and medication usage compared to therapy with omalizumab alone or sublingual immunotherapy alone.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Marita Nittner-Marszalska, Agnieszka Kopec, Aleksandra Foks-Ciekalska, Aleksandra Lata, Agnieszka Bogacz- Piaseczynska, Marta Rosiek-Biegus, Magdalena Zajac, Andrzej Bozek
Summary: This study aimed to investigate whether immunotherapy with HDM extracts leads to new sensitizations and found that no new sensitizations were observed in patients receiving immunotherapy, while new sensitizations to one HDM molecule were observed in patients who did not receive immunotherapy. Additionally, the study found that sIgE levels against HDM extracts decreased in some patients after 12 months of immunotherapy.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Review
Allergy
Andrzej Bozek
Summary: This review presents current knowledge on the effectiveness and safety of allergen immunotherapy (AIT) in patients over 60 years old with inhalant allergies. Studies have shown the effectiveness of AIT in treating allergic rhinitis in seniors, with evidence from trials using sublingual and injection immunotherapy. Data confirm the high safety of AIT in this age group. Seniors with allergic rhinitis or asthma may benefit from AIT if there are no contraindications, and sustained clinical benefit can be experienced even after completing treatment.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Aleksandra Foks-Ciekalska, Jerzy Jarzab, Ewa Hadas, Elzbieta Swietochowska, Kamila Gumieniak, Wiktor Ciekalski, Andrzej Bozek
Summary: This study aimed to assess the usefulness of potential stress biomarkers in saliva for monitoring the treatment of psoriasis. The results showed that saliva concentrations of sIgA, sAA, and CgA can serve as potential markers for measuring the severity of psoriasis and the associated stress reaction.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Magdalena Zajac, Andrzej Bozek, Renata Kozlowska, Alicja Grzanka
Summary: This study aimed to assess the incidence of a subtype of angioedema-C1-INH-AAE (acquired angioedema with C1 inhibitor deficiency). The study found that C1-INH-AAE occurred more often in patients with cancer, especially in the early stages of breast cancer.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Agnieszka Bogacz-Piaseczynska, Andrzej Bozek
Summary: This study investigated the efficacy and safety of allergen immunotherapy (AIT) in adult patients with atopic dermatitis (AD) and monosensitisation to house dust mites (HDMs). The results showed significant improvement in skin symptoms of AD patients after 12 months of AIT treatment, with decreased EASI scores, % BSA, and IsGA index compared to the placebo group. Therefore, HDM-AIT is effective in improving atopic dermatitis in patients with confirmed monovalent mite allergy.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Magdalena Krupka-Olek, Andrzej Bozek, Aleksandra Kawczyk-Krupka
Summary: Inhalation-dependent IgE sensitizations were common in patients with atopic dermatitis (AD) and possible in patients with psoriasis (PS), often without clinical manifestations in the latter. The investigated cytokine profiles showed high convergence in both AD and PS patients, confirming the active inflammatory nature of these diseases.
MEDICINA-LITHUANIA
(2022)
