Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 76, Issue 4, Pages 1243-1248Publisher
IOS PRESS
DOI: 10.3233/JAD-200145
Keywords
Amyloid-beta; apolipoprotein E; plasminogen activator; positron emission tomography; type 2 diabetes
Categories
Funding
- European Research Council [804371]
- Academy of Finland (Finland)
- Finnish Social Insurance Institution (Finland)
- Alzheimer's Research and Prevention Foundation (Finland)
- Alzheimer Association (Finland)
- Yrjo Jahnsson Foundation (Finland)
- Juho Vainio Foundation (Finland)
- Swedish Research Council (Sweden)
- Alzheimerfonden (Sweden)
- Region Stockholm ALF and NSV (Sweden)
- Center for Innovative Medicine (CIMED) at Karolinska Institutet (Sweden)
- Knut and Alice Wallenberg Foundation (Sweden)
- Stiftelsen Stockholms sjukhem (Sweden)
- Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse (Sweden)
- Joint Program of Neurodegenerative Disorders - prevention (MIND-AD)
- Sigrid Juselius Foundation
- Finnish State Research Funding
- Academy of Finland [310962]
- European Research Council (ERC) [804371] Funding Source: European Research Council (ERC)
- Academy of Finland (AKA) [310962, 310962] Funding Source: Academy of Finland (AKA)
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We explored the association of type 2 diabetes related blood markers with brain amyloid accumulation on PiB-PET scans in 41 participants from the FINGER PET sub-study. We built logistic regression models for brain amyloid status with12 plasma markers of glucose and lipid metabolism, controlled for diabetes and APOE epsilon 4 carrier status. Lower levels of insulin, insulin resistance index (HOMA-IR), C-peptide, and plasminogen activator (PAI-1) were associated with amyloid positive status, although the results were not significant after adjusting for multiple testing. None of the models found evidence for associations between amyloid status and fasting glucose or HbA1c.
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