Article
Geriatrics & Gerontology
Aaron Choi, Anthony Martyr, Linda Clare, Jane Fossey, Zunera Khan, Joanne McDermid, Clive Ballard
Summary: Delusions and hallucinations in people with dementia living in nursing homes are associated with poorer quality of life. The effects remain significant even after controlling for other factors. Agitation, anxiety, and depression partially mediate the relationship between each psychotic symptom and quality of life.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Clinical Neurology
Grace J. Goodwin, Stacey Moeller, Amy Nguyen, Jeffrey L. Cummings, Samantha E. John
Summary: This study examined the network structure of neuropsychiatric symptoms in older adults with cognitive impairment. The results showed significant connectivity among these symptoms, and disinhibition and agitation/aggression were found to be the most central symptoms in the network. Targeting these symptoms may lead to overall improvement in neuropsychiatric symptoms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Editorial Material
Clinical Neurology
Richard M. Camicioli, Carlo Colosimo
Summary: This study examined the association between different NPS profiles and the risk of cognitive decline in PD-MCI patients, which is of great importance for the diagnosis and management of PD-MCI patients.
Review
Cell Biology
Tien-Wei Hsu, Brendon Stubbs, Chih-Sung Liang, Tien-Yu Chen, Ta-Chuan Yeh, Chih-Chuan Pan, Che-Sheng Chu
Summary: This meta-analysis demonstrates that serotonergic antidepressants effectively alleviate overall neuropsychiatric symptoms, agitation, depressive symptoms, and care burden in patients with dementia, as well as improving cognitive function.
AGEING RESEARCH REVIEWS
(2021)
Review
Neurosciences
Milap A. Nowrangi, John D. Outen, John Kim, Dimitrios Avramopoulos, Constantine G. Lyketsos, Paul B. Rosenberg
Summary: This article reviews the neurobiological mechanisms of neuropsychiatric symptoms of Alzheimer's disease (NPS-AD), including depression, psychosis, and agitation. The authors found that mechanisms involving monoaminergic biosynthesis and function are likely key elements of NPS-AD, but the lack of effectiveness of current treatments may be due to contributions from additional mechanisms.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Annelies E. Veldwijk-Rouwenhorst, Martin Smalbrugge, Sytse U. Zuidema, Suzan A. J. Hanssen, Raymond T. C. M. Koopmans, Debby L. Gerritsen
Summary: The study explored the trajectory leading to continuous palliative sedation in NH residents with dementia and refractory neuropsychiatric symptoms, revealing a complex and burdensome journey that ultimately brought relief and contentment to those involved. Continuous palliative sedation was identified as a valuable treatment option for these residents. External consultation and administering intermittent sedation as a preceding step were recommended in the decision-making process.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Psychiatry
Kathrin Schmuedderich, Daniela Holle, Armin Strobel, Bernhard Holle, Rebecca Palm
Summary: The study revealed a negative correlation between the severity of agitation and dimensions of quality of life such as social isolation, restless tense behavior, positive affect, and social relations among dementia patients in nursing homes.
Review
Geriatrics & Gerontology
Jeffrey Cummings
Summary: Neuropsychiatric syndromes and symptoms are playing increasingly important roles in research diagnostic criteria for neurodegenerative disorders. They are often core diagnostic criteria, and the relationships between neuropsychiatric symptoms and cognitive, motor, and autonomic symptoms are being studied and better understood.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Psychology, Clinical
Elizabeth L. Sampson, Julie Barber, Juliet Gillam, Francesca La Frenais, Katie Lambe, Anne Laybourne, Monica Manela, Louise Marston, Kirsten Moore, Monica Panca, Aisling Stringer, Lucy Webster, Gill Livingston
Summary: The staff training intervention for agitation in people with severe dementia in nursing homes was found to be feasible and acceptable in a study, indicating the potential for a larger trial to evaluate its effectiveness.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Geriatrics & Gerontology
Rachel E. Brimelow, Karthick Thangavelu, Romana Beattie, Nadeeka N. Dissanayaka
Summary: Using fully immersive virtual reality (VR) in multiple sessions can reduce behavioral and psychological symptoms (BPS) in aged care residents, including depression, anxiety, and agitated behaviors, leading to reduced depressive symptoms and apathy, and inducing a positive emotional response.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Psychiatry
Giorgio Bergamini, Helene Massinet, Aaron Hart, Sean Durkin, Gabin Pierlot, Michel Alexander Steiner
Summary: The SAMP8 mouse model of Alzheimer's disease exhibits an accelerated aging phenotype and increased aggressive behavior. Our study found that SAMP8 mice showed increased aggression starting at 5 months of age, which persisted until 7 months of age. Treatment with risperidone, an antipsychotic medication, reduced aggression in both SAMP8 and control mice. These findings suggest that SAMP8 mice could be a valuable preclinical tool for identifying novel treatment options for neurodegenerative disorders associated with reactive aggression, such as Alzheimer's disease.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Ioannis Liampas, Vasileios Siokas, Constantine G. Lyketsos, Efthimios Dardiotis
Summary: This study aimed to investigate whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer's dementia (AD) differed between men and women. Data from cognitively unimpaired individuals and participants with mild cognitive impairment (MCI) were analyzed. The results showed that in cognitively unimpaired individuals, female sex moderated the risk conferred by moderate/severe apathy and depression, while augmenting the risks conferred by mild depression and agitation. However, no significant differences in the risks of future AD between men and women with MCI were found.
JOURNAL OF NEUROLOGY
(2023)
Review
Behavioral Sciences
Simona Karamazovova, Veronika Matuskova, Zahinoor Ismail, Martin Vyhnalek
Summary: In addition to motor coordination, the cerebellum also plays an important role in cognitive and affective processes. Spinocerebellar ataxias (SCA) and Friedreich ataxia (FRDA) are rare neurodegenerative diseases of the cerebellum that not only affect motor functions but also have cognitive and neuropsychiatric symptoms. This review discusses the prevalence, clinical features, and treatment approaches of neuropsychiatric impairments such as depression, anxiety, apathy, agitation, impulse dyscontrol, and psychosis in SCA and FRDA patients. Further research is needed to improve the detection and treatment options for these co-morbidities in ataxia patients due to their significant impact on quality of life.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Byron Creese, Katie Lannon
Summary: New research based on genome-wide association studies in Alzheimer's disease has identified molecular mechanisms that are also seen in some psychiatric disorders. The study used omics data and has the potential to reveal unknown disease mechanisms. However, insufficient information about neuropsychiatric symptoms in Alzheimer's disease patients limits the conclusions.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Psychology, Developmental
Charlotte L. Hall, Louise Marston, Kareem Khan, Beverley J. Brown, Charlotte Sanderson, Per Andren, Sophie Bennett, Isobel Heyman, David Mataix-Cols, Eva Serlachius, Chris Hollis, Tara Murphy
Summary: A study on children and young people with tic disorders found that the COVID-19 pandemic did not significantly impact existing tic symptoms, regardless of age, gender, symptoms of anxiety, or autism spectrum disorder.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Clinical Neurology
Naaheed Mukadam, Louise Marston, Gemma Lewis, Rohini Mathur, Greta Rait, Gill Livingston
Summary: This study investigated the incidence of diagnosed dementia and its association with age at diagnosis and survival afterward among the three largest ethnic groups in the UK. The findings showed that Black people had a higher incidence of dementia, while South Asian and Black people were diagnosed and died at a younger age compared to White individuals. Therefore, targeted prevention and care strategies should be prioritized and tailored to these ethnic groups.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Naomi Launders, Joseph F. Hayes, Gabriele Price, Louise Marston, David P. J. Osborn
Summary: Patients with severe mental illness (SMI) have higher rates of emergency and avoidable physical health hospitalisations compared to the general population. Among SMI diagnoses, planned physical health admissions are underutilised in patients with schizophrenia, while patients with bipolar disorder have higher rates. Emergency admissions for accidents, injuries, and substance misuse are particularly high in the year following SMI diagnosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Kirsten J. Moore, Sophie Crawley, Emily Fisher, Claudia Cooper, Victoria Vickerstaff, Elizabeth L. Sampson
Summary: This study aimed to identify strategies to help carers manage pre-death grief. The results showed that emotion and problem-focused coping styles were associated with lower grief intensity, while dysfunctional coping was associated with higher grief intensity.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Celine El Baou, Roopal Desai, Claudia Cooper, Natalie L. Marchant, Steve Pilling, Marcus Richards, Rob Saunders, Joshua E. J. Buckman, Elisa Aguirre, Amber John, Joshua Stott
Summary: This study aims to examine the association between psychotherapy outcomes for depression and incident cardiovascular disease (CVD). Through the analysis of national healthcare data in England, the study found that reliable improvement from depression symptoms through psychotherapy was associated with a lower risk of new onset of CVD.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Abhinav Kumar, Amrit Sanghera, Balpreet Sanghera, Tahira Mohamed, Ariella Midgen, Sophie Pattison, Louise Marston, Melvyn M. Jones
Summary: Patients with diabetes mellitus are at increased risk of myocardial infarction but may experience less chest pain, leading to delayed treatment and worse outcomes. A meta-analysis of 22 studies showed that patients with diabetes mellitus are less likely to have chest pain during myocardial infarction compared to those without.
Article
Psychology, Clinical
Tiffeny James, Naaheed Mukadam, Andrew Sommerlad, Samara Barrera-Caballero, Gill Livingston
Summary: The study aimed to investigate the care and support received and desired by South Asian and White British individuals affected by dementia in the UK, as well as the equity of access to such services. The findings revealed that South Asian individuals expressed a greater need for care from someone who spoke their language, while language differences could also be a challenge for White British individuals. Personal resources, including financial means and English language proficiency, influenced individuals' choices and access to care. Consequently, individuals from South Asian backgrounds may face a double disadvantage of limited options for suitable care and fewer resources to seek alternative care.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Multidisciplinary Sciences
Larisa Duffy, Louise Marston, Gemma Lewis, Glyn Lewis
Summary: We developed a retrospective Clinical Interview Schedule Revised (rCIS-R) to assess depression relapse in the previous 12 weeks, and found that it has excellent test-retest reliability and construct validity. The rCIS-R can be used in randomized controlled trials due to its simplicity and self-report format.
Article
Medicine, Research & Experimental
Louise Marston, Marie Le Novere, Federico Ricciardi, Irwin Nazareth, Alan Carson, Mark Edwards, Laura H. Goldstein, Jonathan Marsden, Hayley Noble, Markus Reuber, Jon Stone, Rachael M. Hunter, Glenn Nielsen
Summary: Functional motor disorder (FMD) is a common neurological condition that causes symptoms such as weakness and tremor. The Physio4FMD trial aims to evaluate the effectiveness and cost effectiveness of specialist physiotherapy for FMD. The trial was impacted by the COVID-19 pandemic, leading to disruptions in the treatment of participants. The analysis plans have been adjusted to account for these disruptions and maintain the integrity of the trial while providing meaningful results.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Elizabeth ONions, Irene Petersen, Joshua E. J. Buckman, Rebecca Charlton, Claudia Cooper, Anne Corbett, Francesca Happe, Jill Manthorpe, Marcus Richards, Rob Saunders, Cathy Zanker, Will Mandy, Joshua Stott
Summary: This study estimated the numbers of diagnosed and undiagnosed autistic individuals in England and examined the differences in diagnostic rates based on socio-demographic factors. The results showed a higher prevalence of diagnosed autism in children/young people compared to adults/older adults. Age-related inequalities were also evident in new diagnoses, indicating the urgent need to improve access to adult autism diagnostic services.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Health Care Sciences & Services
Chris Hollis, Charlotte L. Hall, Kareem Khan, Marie Le Novere, Louise Marston, Rebecca Jones, Rachael Hunter, Beverley J. Brown, Charlotte Sanderson, Per Andren, Sophie Bennett, Liam R. Chamberlain, Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin Mckenzie, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy
Summary: This study aimed to investigate the clinical and cost-effectiveness of an online-delivered, therapist- and parent-supported therapy for young people with tic disorders. The results showed that this therapy was clinically and cost-effective in reducing tics, with durable benefits extending up to 18 months.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Psychology, Clinical
Larisa Duffy, Gemma Lewis, Louise Marston, Tony Kendrick, David Kessler, Michael Moore, Nicola Wiles, Glyn Lewis
Summary: The number of previous episodes and residual symptoms of depression were associated with an increased likelihood of relapse, while older age of onset was associated with a reduced rate of relapse.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Cell Biology
Andrew Sommerlad, Mika Kivimaki, Eric B. Larson, Susanne Roehr, Kokoro Shirai, Archana Singh-Manoux, Gill Livingston
Summary: The increasing number of people with dementia globally highlights the urgent need to reduce its scale and impact. Lifetime social participation may play a crucial role in reducing dementia risk and could have implications for individual behavior and public health policy. However, more research is needed to fully understand the causal relationship.
Article
Clinical Neurology
Natasha E. Schoeler, Louise Marston, Laura Lyons, Sally Halsall, Ruchika Jain, Siobhan Titre-Johnson, Maryam Balogun, Simon J. R. Heales, Simon Eaton, Michael Orford, Elizabeth Neal, Colin Reilly, Christin Eltze, Elma Stephen, Andrew A. Mallick, Finbar O'Callaghan, Shakti Agrawal, Alasdair Parker, Martin Kirkpatrick, Andreas Brunklaus, Ailsa McLellan, Helen McCullagh, Rajib Samanta, Rachel Kneen, Hui Jeen Tan, Anita Devlin, Manish Prasad, Rohini Rattihalli, Helen Basu, Archana Desurkar, Ruth Williams, Penny Fallon, Irwin Nazareth, Nick Freemantle, J. Helen Cross
Summary: This clinical trial compared the efficacy and safety of a classic ketogenic diet with that of further antiseizure medication in infants with drug-resistant epilepsy. The results showed no significant difference in seizure frequency between the ketogenic diet group and the antiseizure medication group during weeks 6-8, and a similar number of infants experienced serious adverse events in both groups.
