Review
Food Science & Technology
Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Victoria Jimenez-Trigo, Jianbo Xiao, Francesca Giampieri, Tamara Y. Forbes-Hernandez, Giuseppe Grosso, Maurizio Battino, Cristina Sanchez-Gonzalez, Jose L. Quiles
Summary: The growing number of older people has led to increased research on new approaches to manage or delay aging. Diet is a crucial factor in healthy aging and prevention of age-related diseases. Foods such as berries, curcumin, and virgin olive oil have shown positive effects on certain aspects of aging.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Angela Criscuolo, Palina Nepachalovich, Diego Fernando Garcia-del Rio, Mike Lange, Zhixu Ni, Massimo Baroni, Gabriele Cruciani, Laura Goracci, Matthias Blueher, Maria Fedorova
Summary: This study utilizes bioinformatics and LC-MS/MS technologies to uncover the diversity and specificity of modified lipids in human blood plasma of lean and obese individuals, revealing the significant alteration of endocrine signaling by oxidized lipids in metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Agnieszka Gorska, Diana Manko-Jurkowska, Joanna Brys, Agata Gorska
Summary: The study characterized lipid fractions from self-prepared and commercial cat foods using GC and PDSC techniques. Self-prepared foods had high levels of essential fatty acids but low oxidative stability, while commercial foods had beneficial omega-6 to omega-3 ratios and higher oxidative stability.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Christiana Mantzourani, Charikleia S. Batsika, Maroula G. Kokotou, George Kokotos
Summary: A new method was developed to simultaneously determine multiple fatty acids in yogurt samples, including both common and uncommon ones. The concentrations of various fatty acids in the samples allowed the discrimination between cow and sheep yogurt.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Amanda Gisler, Kapil Dev Singh, Jiafa Zeng, Martin Osswald, Mo Awchi, Fabienne Decrue, Felix Schmidt, Noriane A. Sievi, Xing Chen, Jakob Usemann, Urs Frey, Malcolm Kohler, Xue Li, Pablo Sinues
Summary: Exhaled breath analysis provides valuable molecular-level information and has promising potential for precision medicine. However, the lack of validation in multicenter trials hinders the transition of breath tests into routine clinical practice. In this study, an interoperability framework was developed and applied, revealing a technical variability of approximately 20% and identifying a core signature of the human exhaled metabolome. The results showed high inter-subject variability for certain metabolic classes but relative stability in other regions, such as the TCA cycle. This framework and the overview of metabolic coverage will pave the way for future large-scale multicenter trials.
Article
Food Science & Technology
Guodong Rao, Jianguo Zhang, Xiaoxia Liu, Xue Li, Chenhe Wang
Summary: The study revealed the variation in fatty acids and minor components in olive fruits of different colors, providing insights into the determination of optimal harvest strategies for olive oil production. Additionally, genes related to the biosynthetic pathways of hydroxytyrosol and oleuropein were identified through the combined analysis of gene expression data.
Article
Biochemical Research Methods
Maria Alcoriza-Balaguer, Juan C. Garcia-Canaveras, Marta Benet, Oscar Juan-Vidal, Agustin Lahoz
Summary: FAMetA is an R package and web-based application that uses C-13 mass isotopologue profiles to estimate fatty acid metabolism. It provides comprehensive characterization of FA biosynthesis and easy-to-interpret graphical representations, allowing for insights into how cells reprogram their FA metabolism and identification of new FAs through metabolic reconstruction.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Biochemical Research Methods
Nigina Khamidova, Melissa R. Pergande, Koralege C. Pathmasiri, Rida Khan, Justin T. Mohr, Stephanie M. Cologna
Summary: MALDI-TOF MS is a powerful tool for analyzing biomolecules. A new matrix, DBDA, has been reported to facilitate the ionization of fatty acids and sulfatides. In this study, we successfully mapped the spatial distribution of various fatty acids and demonstrated that DBDA provides superior ionization for sulfatides compared to traditional matrices. These results open new opportunities for studying sulfatides using MALDI-TOF MS.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Chemistry, Medicinal
Tiago A. Conde, Bruna F. Neves, Daniela Couto, Tania Melo, Bruno Neves, Margarida Costa, Joana Silva, Pedro Domingues, M. Rosario Domingues
Summary: The study used gas-chromatography mass-spectrometry to characterize the fatty acid profiles of seven different commercial microalgae, revealing unique compositions among them, especially in terms of omega-3 fatty acids, with species of the same phylum showing similar trends. Additionally, the research found that different lipid extracts exhibited comparable antioxidant activities, further demonstrating the potential of microalgae as sustainable and healthy sources of essential lipids.
Article
Biochemistry & Molecular Biology
Yi Lu, Finnur Freyr Eiriksson, Margret Thorsteinsdottir, Nils Cronberg, Henrik Toft Simonsen
Summary: Bryophytes, such as mosses, liverworts, and hornworts, have attracted researchers due to their diverse chemicals and potential applications in pharmaceutical, food, and cosmetic industries. They accumulate long-chain polyunsaturated fatty acids (l-PUFA) to maintain cell fluidity in cold environments. While Iceland has a rich bryophyte vegetation, the lipid profiles of these plants are largely unknown. In this study, lipidomics analysis was performed on 39 local bryophyte species in Iceland using UPLC-ESI-QTOF-MS, revealing that six moss species had abundant arachidonic acid (AA) and eicosapentaenoic acid (EPA) in their phospholipids and glycerolipids.
Review
Biochemistry & Molecular Biology
Jenny Leopold, Patricia Prabutzki, Kathrin M. Engel, Juergen Schiller
Summary: The occurrence of free fatty acids and reactive oxygen species is characteristic of inflammatory diseases. Unsaturated fatty acids react with reactive oxygen species, producing important products. These modified fatty acids can be released from phospholipids or oxidatively modified, and oligomeric products may be formed. Hydroxy fatty acid esters are considered important products, and there are different opinions on the role of dimeric fatty acids.
Article
Engineering, Chemical
Ana Ballesteros-Gomez, Antonio Serrano-Crespin, Soledad Rubio
Summary: In this study, a simple liquid-liquid extraction method using green supramolecular solvents was developed for the extraction of hydroxytyrosol from brines of table olive processing. The optimized extraction conditions were found to be 4.8% v/v 1,2-hexanediol and 1 M Na2SO4. The final extracts were further analyzed to identify other compounds of interest.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Food Science & Technology
Xufang Wu, Fengen Wang, Meiqing Chen, Jiaqi Wang, Yangdong Zhang
Summary: The aim of this research was to establish a method for quantifying 10 short-chain fatty acids (FSCFAs) in raw cow milk. Acidified raw cow milk samples were processed using gas chromatography-mass spectrometry after pretreatment with hydrochloric acid ethanol (0.5%) solution. Except for iso C5:0 and anteiso C5:0 co-elution, the remaining eight FSCFAs were effectively separated by chromatography. The methodological validation showed satisfactory linear relationships, low limits of quantification, good recoveries, and precision. Our study provides a valuable method for future quality and safety control of raw milk and nutritional studies.
Article
Chemistry, Applied
Nuno Rodrigues, Fatima Peres, Susana Casal, Arantzazu Santamaria-Echart, Filomena Barreiro, Antonio M. Peres, Jose Alberto Pereira
Summary: Olive oils from different regions in Portugal were analyzed to study the effect of geographical origin on their composition. The results showed that the geographical origin significantly influenced the chemical composition and stability of the oils. Principal component analysis and Fourier transform infrared spectroscopy were used to establish markers and a discriminant model for identifying the origin of the oils.
Article
Dentistry, Oral Surgery & Medicine
M. Reich, C. Hannig, M. Hannig, K. Kuemmerer, A. Kensche
Summary: The lipid profiles of both in situ pellicle and saliva were effectively characterized in this study. Variations in phospholipid and fatty acid composition between pellicle and saliva suggest a selective pellicle formation process. This study provides important reference and fundamental data for further exploration of intricate surface interactions in the oral cavity, particularly involving hydrophobic substances.
ARCHIVES OF ORAL BIOLOGY
(2022)
Review
Chemistry, Applied
Francisco J. Salar, Raul Dominguez-Perles, Cristina Garcia-Viguera, Pablo S. Fernandez
Summary: This article critically reviews the main non-thermal processing alternatives for non-alcoholic fruit and vegetable-based beverages, analyzing their advantages and downsides compared to conventional thermal treatments. It provides insights into their practical application and suitability for the industry.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Silvia Montoro-Garcia, Sara Martinez-Sanchez, Miguel Carmena-Bargueno, Horacio Perez-Sanchez, Maria Campillo, Camille Oger, Jean-Marie Galano, Thierry Durand, Angel Gil-Izquierdo, Jose Antonio Gabaldon
Summary: The effects of 9-D1t-PhytoP on platelet activation and vascular cells were tested, along with possible interactions with platelets and the endothelial EP3 receptor. The results showed that 9-D1t-PhytoP has prothrombotic and wound-healing properties, and mimics the migration stimulus of PGE(2) in endothelial cells. Computational analysis revealed its potential as an EP3 agonist by forming a stable complex with the EP3 receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Catarina Andrade, David M. Pereira, Nelson G. M. Gomes, Federico Ferreres, Angel Gil-Izquierdo, Paula B. Andrade, Sutsawat Duangsrisai, Patricia Valenta
Summary: Kitul (Caryota urens L.) inflorescences are widely used for sweet sap production in Asian countries and have potential antidiabetic properties. In this study, the methanol extract of the inflorescences was shown to reduce reactive species in pancreatic cells and inflammatory markers in stimulated macrophages. The extract also inhibited 5-lipoxygenase activity. These findings suggest that Kitul inflorescences may have pleiotropic mechanisms as an antidiabetic agent.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Joana Moutinho, Irene Gouvinhas, Raul Dominguez-Perles, Ana Barros
Summary: This study aimed to extract bioactive compounds from grape pomace using methodologies easily integrated into industrial workflows. The highest yield and antioxidant activity were achieved at 60 degrees C, using 3.5% HCl and 70% ethanol.
Article
Biochemistry & Molecular Biology
Antonio Costa-Perez, Sonia Medina, Paola Sanchez-Bravo, Raul Dominguez-Perles, Cristina Garcia-Viguera
Summary: The by-products of grape winemaking process, such as grape stems, pomace, and wine lees, contain a diverse range of phytochemical compounds, notably polyphenols, which have health benefits. However, these by-products have negative impacts on the sustainability of the agro-food industry and the local environment. This study compares the polyphenolic profiles of these three residues and provides new knowledge on the role of yeast and lactic acid bacteria metabolism in diversifying the phenolic composition. The results show that grape stems have the highest diversity of polyphenols, followed closely by wine lees. Yeasts and LAB may play a key role in transforming phenolic compounds, resulting in new molecules with specific bioactivity features and improving the biological potential of these underexploited residues.
Article
Biochemistry & Molecular Biology
Mari Merce Cascant-Vilaplana, Eduardo Viteritti, Victor Sadras, Sonia Medina, Maria Puerto Sanchez-Iglesias, Camille Oger, Jean-Marie Galano, Thierry Durand, Jose Antonio Gabaldon, Julian Taylor, Federico Ferreres, Manuel Sergi, Angel Gil-Izquierdo
Summary: This study investigates the impact of aphids feeding on wheat plants and their role in triggering a defensive plant reaction to oxidative stress. The experiment involves different nitrogen and CO2 concentrations, as well as two types of aphids. The results show that aphids significantly affect the levels of certain oxylipins in wheat leaves, indicating their ability to manipulate plant defense mechanisms.
Article
Agronomy
Maria Pinciroli, Raul Dominguez-Perles, Sonia Medina, Camille Oger, Alexandre Guy, Thierry Durand, Mari Merce Cascant-Vilaplana, Jose Antonio Gabaldon-Hernandez, Federico Ferreres, Angel Gil-Izquierdo
Summary: This study aimed to investigate the effects of exogenously foliar-applied salicylic acid (SA) on oxidative stress in rice. The concentrations of PhytoPs and PhytoFs in immature and mature grains of three different genotypes of rice were monitored, and their influence on grains per panicle and chalkiness was examined. The results showed that SA reduced oxylipin levels and increased rice yield.
Article
Biochemistry & Molecular Biology
Raul Arcusa, Juan Angel Carillo, Begona Cerda, Thierry Durand, Angel Gil-Izquierdo, Sonia Medina, Jean-Marie Galano, Maria Pilar Zafrilla, Javier Marhuenda
Summary: This study aimed to evaluate the efficacy of long-term consumption of high polyphenolic content from fruits and vegetables (such as berries) as a nutraceutical against central nervous system lipid peroxidation, as assessed through urine biomarkers. The results showed significant reductions in AdA and DHA-derived metabolites after consumption of the nutraceutical, indicating its effectiveness in preventing CNS lipid peroxidation.
Article
Food Science & Technology
Nieves Baenas, Cristina Garcia-Viguera, Raul Dominguez-Perles, Sonia Medina
Summary: This study aimed to identify and quantify tryptophan, serotonin, and melatonin in winery by-products and evaluate their antioxidant capacity. The results showed that grape stems had the highest content of tryptophan and antioxidant capacity, while grape pomace contained higher levels of serotonin and melatonin. These findings suggest that winery by-products can be valuable sources of tryptophan, serotonin, and melatonin, with tryptophan being the most important contributor to the antioxidant capacity.
Article
Biochemistry & Molecular Biology
Tiago Macedo, Fatima Paiva-Martins, Federico Ferreres, Nelson G. M. Gomes, Andreia P. Oliveira, Angel Gil-Izquierdo, Luisa Araujo, Patricia Valentao, David M. Pereira
Summary: The inflammatory response plays a vital role in repairing damage, but persistent activation can contribute to chronic diseases. The NF-kappa B inflammatory pathway is a critical target for therapeutic interventions. This study aimed to determine the phytochemical composition of P. excelsa stem bark and investigate its role in inflammation.
BIOORGANIC CHEMISTRY
(2023)
Article
Agricultural Engineering
Gustavo J. Caceres-Cevallos, Alfonso A. Albacete-Moreno, Federico Ferreres, Angel Gil-Izquierdo, Maria J. Jordan
Summary: In this study, Lavandula latifolia was subjected to drought stress and the antioxidant defense system was analyzed. The researchers found that the physiological parameters of the leaves changed under drought conditions and the response of the antioxidant defense to drought varied depending on the plant type. The concentrations of most polyphenols decreased, but rosmarinic acid showed some drought resistance. These findings provide valuable information for the selection of drought-tolerant cultivars.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Ana Abraao, Carlos Martins-Gomes, Raul Dominguez-Perles, Ana Barros, Amelia M. Silva
Summary: This study aimed to determine the phenolic profile and health-promoting activities of hydroethanolic extracts obtained from Prunus lusitanica fruits harvested from three different locations. The results showed that the extracts contained high levels of phenolic compounds and exhibited high antibacterial activity and neuroprotective potential, as well as moderate anti-aging and anti-diabetic effects. Therefore, the bioactive molecules in Prunus lusitanica fruits deserve further exploration for the development of new drugs in the pharmaceutical and cosmetic industry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Raul Dominguez-Perles, Cristina Garcia-Viguera, Sonia Medina
Summary: Wine-making byproducts have negative impacts on the environment and industrial sustainability, but they can be utilized as sources of bioactive compounds. This study found that wine lees contain a high concentration of alkyl gallates, and the drying process reduces their concentration to some extent. Freeze-dried grape stems and pomace showed strong radical scavenging capacity and α-glucosidase inhibitory activity. These findings suggest potential valorization alternatives for these winery residues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
