Journal
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Volume 23, Issue 10, Pages 1288-1296Publisher
WILEY
DOI: 10.1111/1756-185X.13879
Keywords
IL23/TH17 signaling pathway; NF-kappa B signaling pathway; psoriatic arthritis; signaling pathways; susceptibility non-HLA genes
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Psoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non-human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases National Center for Biotechnology Information, Google and PubMed, 37 articles are included and 50 susceptibility non-HLA genes for PsA are presented, such asIL23A,TNIP1,TYK2,STAT4,IL12B,RUNX3andTRAF3IP2. In these non-HLA genes, some are common genes shared with other diseases, whereas most of these susceptibility genes are related to the pathogenesis of PsA by activation or inhibition of the signaling pathways. Several signaling pathways possibly implicated in the pathogenesis of PsA are introduced in this paper, including the 2 mainly signaling pathways, IL23/Th17 signaling pathway and NF-kappa B signaling pathway, and the other involved signaling pathways, such as JAK-STAT signaling pathway and MAPK signaling pathway.
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