Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 70, Issue 17, Pages 1224-1235Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1785460
Keywords
Drug release; macro-cross-linker; microgel; PVA hydrogel; self-healing
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A novel microgel-reinforced PVA hydrogel was developed to enhance its mechanical strength, self-healing abilities, and drug-release capabilities. The study demonstrated that the microgel reinforcement of PVA networks holds great potential for the design of self-healing and drug-releasing hydrogels.
A beneficial mircogel-reinforced polyvinyl alcohol (PVA) hydrogel is presented, aiming at improving its mechanical strength, self-healing, and drug-releasing features. The guar gum based microgel was prepared by inverse emulsion polymerization and cross-reacted with PVA and borax to form a network structure. The macro cross-linker and the PVA polymer chain were strongly bonded to generate a self-healable microgel-reinforced PVA hydrogel. The hydrogel was incorporated with hyaluronic acid and simulated its drug-releasing behavior. This work suggests that the microgel reinforced of macro-crosslinking PVA networks gives them a great potential in the design of self-healing and drug-releasing hydrogels.
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