Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 70, Issue 15, Pages 1077-1089Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1785451
Keywords
Gallium-68; iron oxide nanoparticles; PET; MR imaging agent; poly(amidoamide) dendrimer; radiolabeling
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Funding
- Iran National Science Foundation (INSF) [96006767]
- Tehran University of Medical Sciences and Health Services [96-03-58-35638]
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Developed Gallium-68 radiolabeled DOTA-acetyl-PAMAM coated iron oxide nanoparticles are dual-modality agents for PET-MR imaging, with distinctive physical, biological, and radiochemical properties, high r2 relaxivity coefficient, and significant uptake in liver, spleen, and tumor site.
Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM(-1)s(-1). High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging.
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