Review
Endocrinology & Metabolism
Huizhen Chen, Chunguang Xie, Qiu Chen, Shougang Zhuang
Summary: Recent studies have shown that HDAC11 plays an important role in metabolic disorders, including adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses, and energy consumption.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu Ji, Hangil Lee, Shawn Kaura, James Yip, Hao Sun, Longfei Guan, Wei Han, Yuchuan Ding
Summary: Obesity is a widespread public health issue with various comorbidities, and bariatric surgery is considered an effective treatment method. Different types of bariatric surgery alter food metabolism pathways and reduce stomach capacity to lower food tolerance, leading to a significant decrease in body mass index.
Review
Endocrinology & Metabolism
Weiyue Zhang, Xin Guo, Lulu Chen, Ting Chen, Jiayu Yu, Chaodong Wu, Juan Zheng
Summary: The ketogenic diet (KD) has shown promising effects in managing various cardio-metabolic diseases (CMDs) like obesity, heart failure, and hypertension, but remains controversial in diabetes and dyslipidemia. Current evidence suggests that KD is generally protective against obesity-related cardiovascular diseases (CVDs) but contradictory in diabetes and other metabolic disorder-related CVDs. More rigorous research focusing on clinical safety, treatment duration, and plan of KDs is needed to address the existing controversies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Rupinder Kaur Sodhi, Raghunath Singh, Yashika Bansal, Mahendra Bishnoi, Ishwar Parhar, Anurag Kuhad, Tomoko Soga
Summary: Neuropsychiatric disorders pose a significant burden on patients and society, often linked to cardio-metabolic comorbidities. TRPA1 channels have emerged as potential therapeutic targets for modulating appetite, lipid metabolism, glucose and insulin homeostasis, and inflammation associated with NPDs.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Wilfrid Mazier, Katy Le Corf, Ccori Martinez, Heloise Tudela, Deborah Kissi, Camille Kropp, Chrislain Coubard, Marion Soto, Frederic Elustondo, Georges Rawadi, Sandrine P. Claus
Summary: The study showed that Christensenella minuta has strong antiobesity potential and can regulate metabolic markers and inhibit de novo lipogenesis to protect against diet-induced obesity.
Review
Endocrinology & Metabolism
Hayder A. Giha, Osman A. O. Alamin, Mai S. Sater
Summary: This article reviews the pathological features and molecular mechanisms of diabetic myopathy. By discussing the etiology, pathophysiological features, and relevant signaling pathways of diabetic muscle atrophy, the mechanisms underlying diabetic myopathy are elucidated.
ACTA DIABETOLOGICA
(2022)
Article
Cell Biology
Hui Peng, Qi Guo, Tian Su, Ye Xiao, Chang-Jun Li, Yan Huang, Xiang-Hang Luo
Summary: The study identified the potential role of SCARA3 in obesity-related disorders and metabolic diseases, and suggested that SCARA3 may be associated with age-related metabolic dysfunction. The findings provide new insights into the pathogenesis and treatment of obesity and other obesity-associated metabolic complications.
Article
Biochemistry & Molecular Biology
Lengyun Wei, Xianlong Ye, Siyuan Cui, Dashuai Li, Shenglong Zhu
Summary: This study investigates the role of free fatty acid receptor 4 (FFAR4) and fibroblast growth factor 21 (FGF21) in metabolic disorders. The findings reveal that FFAR4 deficiency leads to increased levels of FGF21, and the double knockout of FGF21 and FFAR4 results in severe metabolic abnormalities likely caused by decreased energy expenditure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Surgery
Benjamin M. Vierra, Colston A. Edgerton, Scott A. Shikora
Summary: This retrospective study analyzed predictors of hospital readmission rates following metabolic/bariatric surgery. The study found that the readmission rate was similar to existing literature. Among primary procedures, the readmission rate was higher for Roux-en-Y Gastric Bypass compared to laparoscopic sleeve gastrectomy. The reoperation rate was higher for patients undergoing secondary procedures. Most hospital readmissions were due to non-technical causes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Clinical Neurology
Farsad Afshinnia, Evan L. Reynolds, Thekkelnaycke M. Rajendiran, Tanu Soni, Jaeman Byun, Masha G. Savelieff, Helen C. Looker, Robert G. Nelson, George Michailidis, Brian C. Callaghan, Subramaniam Pennathur, Eva L. Feldman
Summary: This study found that differences in serum lipidomic profiles were associated with neuropathy in type 2 diabetes. Changes in abundance of medium-chain acylcarnitines and total free fatty acids, as well as phosphatidylcholines and lysophosphatidylcholines, were observed 10 years prior to the development of neuropathy. These findings suggest that lipid profiles early in the disease course may be useful in identifying individuals at risk for neuropathy in type 2 diabetes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Simon Toupance, Sofia I. Karampatsou, Carlos Labat, Sofia-Maria Genitsaridi, Athanasia Tragomalou, Penio Kassari, George Soulis, Allyson Hollander, Evangelia Charmandari, Athanase Benetos
Summary: In adults, short leukocyte telomere length (LTL) is associated with metabolic disorders, and this association may be influenced by early life interactions between LTL and metabolic disorders. In children, obesity and metabolic disturbances are associated with shorter telomeres, but not with more pronounced LTL attrition.
Article
Neurosciences
Jennifer M. Erichsen, Jim R. Fadel, Lawrence P. Reagan
Summary: Insulin and leptin are important in metabolism and have multiple functions in both the periphery and central nervous system. Resistance to insulin and leptin can impact cognition and neuropsychiatric diseases, with deficits in neuroplasticity potentially reversible by restoring sensitivity to these hormones.
Review
Biochemistry & Molecular Biology
Marakiya T. Moetlediwa, Rudzani Ramashia, Carmen Pheiffer, Salam J. J. Titinchi, Sithandiwe E. Mazibuko-Mbeje, Babalwa U. Jack
Summary: Obesity is a significant risk factor for chronic diseases, leading to an increased interest in finding effective anti-obesity agents. Curcumin, a bioactive compound found abundantly in turmeric, has potential anti-obesity effects. However, its poor bioavailability limits its clinical use. Synthetic curcumin derivatives, which are structurally modified versions, have been studied to improve bioavailability while maintaining therapeutic effects. This review summarizes studies that investigate the effects of curcumin derivatives on obesity and its associated metabolic complications. The findings reveal that these derivatives show more promising results in attenuating obesity and its related complications compared to curcumin alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sandor Somodi, Balazs Ratku, Mariann Harangi, Gyoergy Paragh
Summary: Obesity is characterized by excessive accumulation of fat, causing various medical complications. The understanding of the role of organokines in regulating glucose and lipid metabolism may explain the differences in obesity phenotypes and therapeutic responses.
Review
Medicine, Research & Experimental
Fatemeh Mahboobifard, Mohammad H. Pourgholami, Masoumeh Jorjani, Leila Dargahi, Mina Amiri, Somaye Sadeghi, Fahimeh Ramezani Tehrani
Summary: This article reviews the current understanding of estrogen's role in regulating energy balance at central and peripheral levels. It discusses the importance of estrogen signaling through nuclear and extranuclear pathways, the influence of sex differences on metabolic disorders, and the clinical significance of estrogen signaling in abnormal metabolic conditions such as obesity or high-fat diets. The review highlights research gaps in our understanding of metabolic diseases and their potential impact on developing more effective treatment options.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
