Review
Clinical Neurology
Todd A. Verdoorn, Tom J. Parry, Graziano Pinna, Jonathan Lifshitz
Summary: Traumatic brain injury (TBI) leads to various pathological effects on multiple biochemical and physiological systems in and outside the brain. The recovery of patients is hindered by early brain edema, inflammation, cell death, and neurovascular disruption. Drug treatments targeting these deficits are being developed, and it is likely that effective therapy would require interruption of the TBI-induced pathological processes by either a combination of drugs or a single pleiotropic drug. The complex neurosteroid system offers potential options for the research and development of pleiotropic drug treatments for TBI.
Article
Pharmacology & Pharmacy
Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gomez-A, Todd K. O'Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Summary: Research has shown that allopregnanolone can reduce dopamine release in both male and female rats, with its effects modulated by sex and estrous cycle stages.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Jin Wang, Yushu Hou, Lixia Zhang, Min Liu, Jianshuai Zhao, Zhen Zhang, Yulong Ma, Wugang Hou
Summary: The study demonstrated that E2 treatment significantly alleviated TBI-induced neuroinflammatory injury by inhibiting microglia and astrocyte activation, reducing neurotoxic astrocyte activation, and inhibiting the TLR4/NF-kappa B pathway. E2 treatment may be a potential therapy strategy for TBI-induced neuroinflammation injury.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ting Cao, MiMi Tang, Pei Jiang, BiKui Zhang, XiangXin Wu, Qian Chen, CuiRong Zeng, NaNa Li, ShuangYang Zhang, HuaLin Cai
Summary: The study showed that PROG and ALLO could reverse cognitive deficits induced by ketamine through the PGRMC1 pathway in rat brains. This suggests that they have neuroprotective effects and can restore impaired spatial learning and memory abilities.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Taysa Bervian Bassani, Cynthia Silva Bartolomeo, Rafaela Brito Oliveira, Rodrigo Portes Ureshino
Summary: Neuroactive steroids can have various effects on the nervous system and play a role in the treatment of neurodegenerative disorders. This review aims to summarize the findings related to the actions of neuroactive steroids, particularly progesterone and its derivatives, in experimental models and clinical trials of Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.
NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Clinical Neurology
Brian Fiani, Claudia Covarrubias, Amelia Wong, Thao Doan, Taylor Reardon, Daniel Nikolaidis, Erika Sarno
Summary: Cerebrolysin therapy shows potential in aiding the treatment of various neurological diseases, but further robust clinical data is needed to determine its efficacy in specific conditions.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Shyam Kumar Sudhakar
Summary: Traumatic brain injuries caused by physical impact can have negative effects on the well-being of individuals. This paper reviews the neuroprotective effects of drugs that increase GABAergic currents based on preclinical literature, and finds no evidence of neuroprotection from these drugs after a primary brain injury. In fact, they may even worsen outcomes. Therefore, caution should be exercised when using anesthetic agents that enhance GABAergic neurotransmission in TBI patients until their neuroprotective efficacy is confirmed in clinical literature.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Summary: This literature review investigated whether a single moderate to severe head injury leads to long-term development of tauopathy. The results of most human and animal studies suggest that a single moderate to severe head injury is associated with greater chronic development of tauopathy, but caution is needed due to limitations in the studies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Alice Jacquens, Edward J. Needham, Elisa R. Zanier, Vincent Degos, Pierre Gressens, David Menon
Summary: Head trauma is a common cause of disability in young adults, and cranial trauma in children has particularities in terms of epidemiology, mechanism, and physiopathology. The long-term repercussions of head trauma can be attributed to chronic neuroinflammation, a complex process involving various actors. Numerous studies have explored different anti-inflammatory therapies for traumatic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hao Cheng, Pengfei Wang, Ning Wang, Wenwen Dong, Ziyuan Chen, Mingzhe Wu, Ziwei Wang, Ziqi Yu, Dawei Guan, Linlin Wang, Rui Zhao
Summary: Ferroptosis and iron-related redox imbalance worsen outcomes of traumatic brain injury (TBI). NRF2, the main transcription factor regulating oxidative stress and neuroinflammation in TBI, has an unclear role in iron-induced post-TBI damage. This study investigated ferroptotic neuronal damage in the injured cortex and observed amelioration with the iron chelator deferoxamine (DFO) in wild-type mice. In Nrf2-knockout (Nrf2(-/-)) mice, more severe ferroptosis and neurological deficits were found. Activation of NRF2 with dimethyl fumarate (DMF) alleviated neural dysfunction in TBI mice, partly due to ferroptosis mitigation induced by TBI. Protein levels of FTH-FTL and FSP1, related to iron metabolism and ferroptotic redox balance, were highly dependent on NRF2 after TBI. Therefore, NRF2 has a neuroprotective effect against TBI-induced ferroptosis through regulation of iron levels and redox status, suggesting its potential use in TBI treatment.
Review
Biochemistry & Molecular Biology
Zaynab Shakkour, Hawraa Issa, Helene Ismail, Ohanes Ashekyan, Karl John Habashy, Leila Nasrallah, Hussam Jourdi, Eva Hamade, Stefania Mondello, Mirna Sabra, Kazem Zibara, Firas Kobeissy
Summary: Edaravone, a potent free-radical scavenger, has been used for over 30 years to treat strokes and ALS, and shows promise for repurposing in TBI treatment. Its anti-oxidative effects, neuroprotective properties, and beneficial impacts on inflammatory responses make it a drug of interest for neurological disorders.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Biochemistry & Molecular Biology
Samuel S. Shin, Vanessa M. Mazandi, Andrea L. C. Schneider, Sarah Morton, Jonathan P. Starr, M. Katie Weeks, Nicholas J. Widmann, David H. Jang, Shih-Han Kao, Michael K. Ahlijanian, Todd J. Kilbaugh
Summary: Traumatic brain injury (TBI) leads to the production of tau protein. Targeting hyperphosphorylated tau (p-tau) could potentially provide new therapy for TBI. In a study involving pigs, treatment with PNT001, a monoclonal antibody for p-tau, showed significant improvement in white matter injury and neural injury biomarkers compared to placebo treatment.
Article
Neurosciences
Yuanda Zhang, Jin Lan, Dongxu Zhao, Cijie Ruan, Jue Zhou, Haoyuan Tan, Yinghui Bao
Summary: The study found that NTN1 levels increased after TBI, and it had a neuroprotective effect by inhibiting ferroptosis through activation of the UNC5B/Nrf2 pathway. These findings may provide new strategies for the treatment of TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Pauline Gaignard, Magalie Frechou, Michael Schumacher, Patrice Therond, Claudia Mattern, Abdelhamid Slama, Rachida Guennoun
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Neurosciences
Xiaoyan Zhu, Magalie Frechou, Philippe Liere, Shaodong Zhang, Antoine Pianos, Neike Fernandez, Christian Denier, Claudia Mattern, Michael Schumacher, Rachida Guennoun
JOURNAL OF NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Maria Meyer, Laura I. Garay, Maria Sol Kruse, Agustina Lara, Gisella Gargiulo-Monachelli, Michael Schumacher, Rachida Guennoun, Hector Coirini, Alejandro F. De Nicola, Maria Claudia Gonzalez Deniselle
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Laura Garay, Paula Gonzalez Giqueaux, Rachida Guennoun, Michael Schumacher, Maria Claudia Gonzalez Deniselle, Alejandro F. De Nicola
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Review
Geriatrics & Gerontology
Pauline Gaignard, Philippe Liere, Patrice Therond, Michael Schumacher, Abdelhamid Slama, Rachida Guennoun
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Endocrinology & Metabolism
P. Gaignard, M. Frechou, P. Liere, P. Therond, M. Schumacher, A. Slama, R. Guennoun
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
A. F. De Nicola, L. I. Garay, M. Meyer, R. Guennoun, R. Sitruk-Ware, M. Schumacher, M. C. Gonzalez Deniselle
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xiaoyan Zhu, Magalie Frechou, Michael Schumacher, Rachida Guennoun
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Review
Neurosciences
Rachida Guennoun, Magalie Frechou, Pauline Gaignard, Philippe Liere, Abdelhamid Slama, Michael Schumacher, Christian Denier, Claudia Mattern
Review
Cell Biology
Rachida Guennoun, Xiaoyan Zhu, Magalie Frechou, Pauline Gaignard, Abdelhamid Slama, Philippe Liere, Michael Schumacher
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Agustina Lara, Ivan Esperante, Maria Meyer, Philippe Liere, Noelia Di Giorgio, Michael Schumacher, Rachida Guennoun, Gisella Gargiulo-Monachelli, Alejandro Federico De Nicola, Maria Claudia Gonzalez Deniselle
Summary: The study on the efficacy of testosterone in the ALS animal model Wobblers mice found that testosterone treatment can alleviate inflammatory responses in the degenerating spinal cord, protect neurons, slow down disease progression, and improve motor performance.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Alejandro F. De Nicola, Maria Meyer, Laura Garay, Maria Sol Kruse, Michael Schumacher, Rachida Guennoun, Maria Claudia Gonzalez Deniselle
Summary: Progesterone plays a crucial role in neuroprotection by improving neuropathology in the Wobbler mouse model, including reducing motoneuron vacuolization, enhancing mitochondrial respiratory complex activity, and decreasing nitric oxide synthase activity. Additionally, progesterone has differential effects on glial cells, such as increasing oligodendrocyte density and decreasing astrogliosis. These changes are associated with reduced expression of anti-inflammatory markers.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Magalie Frechou, Xiaoyan Zhu, Narender Kumar, Regine Sitruk-Ware, Michael Schumacher, Claudia Mattern, Rachida Guennoun
Summary: The study demonstrates that intranasal administration of Nestorone can effectively promote recovery after stroke and is effective in male mice. Furthermore, the research findings also indicate that neural PR plays a key role in the cerebroprotective effects of Nestorone.
Article
Endocrinology & Metabolism
Neike Fernandez, Anthony Petit, Antoine Pianos, Lena Haddad, Michael Schumacher, Philippe Liere, Rachida Guennoun
Summary: Ischemic stroke is a leading cause of disability and death, and aging is the main nonmodifiable risk factor. Neuroactive steroids play a key role in cerebroprotection. Older mice have decreased capacity to metabolize steroids toward the 5 alpha-reduction pathway compared to younger mice, which may contribute to worsened stroke outcomes.