Article
Endocrinology & Metabolism
R. Aird, J. Wills, K. F. Roby, C. Benezech, R. H. Stimson, M. Wabitsch, J. W. Pollard, A. Finch, Z. Michailidou
Summary: This study found that hypoxia in the adipose-tumour microenvironment promotes lipid uptake in cancer cells, leading to increased proliferation. Additionally, hypoxia alters the metabolome of adipocytes and drives proliferation of non-malignant cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Vera L. Silva, Amalia Ruiz, Ahlam Ali, Sara Pereira, Jani Seitsonen, Janne Ruokolainen, Fiona Furlong, Jonathan Coulter, Wafa' T. Al-Jamal
Summary: Novel cupric-tirapazamine [Cu(TPZ)2]-liposomes were developed as an effective hypoxia-targeted therapeutic, which potentiated radiotherapy in a three dimensional (3D) prostate cancer (PCa) model. The highest loading efficiency was obtained at neutral pH, and enhanced drug loading was achieved upon decreasing the lipid:complex molar ratio.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Oncology
Motuma Yigezu Daba, Zhijie Fan, Qinyu Li, Xianglin Yuan, Bo Liu
Summary: Prostate cancer is the most commonly diagnosed cancer in men, and finding new prognostic biomarkers and potential therapeutic targets is crucial. Calcium signaling is involved in the progression of prostate cancer and the development of treatment resistance, with calcium channels playing a significant role in these processes. Modulating these calcium channels through pharmacological means has been suggested as a practical approach.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Medical Laboratory Technology
Manuel M. Garrido, Jose C. Marta, Ruy M. Ribeiro, Luis C. Pinheiro, Joao T. Guimaraes
Summary: Conflicting results have been found in the literature regarding the association between serum lipid levels and prostate cancer. This study found lower LDL and total cholesterol levels in patients with prostate cancer at diagnosis, with no significant differences between risk groups. Low LDL cholesterol and low total cholesterol serum levels seem to be associated with prostate cancer at diagnosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Leslimar Rios-Colon, Pawan Kumar, Susy Kim, Mitu Sharma, Yixin Su, Ashish Kumar, Sangeeta Singh, Nalexus Stocks, Liang Liu, Molishree Joshi, Isabel R. Schlaepfer, Deepak Kumar, Gagan Deep
Summary: The survival and proliferation of prostate cancer cells in hypoxic conditions are regulated by the mitochondrial protein CPT1A. Knockdown of CPT1A reduces cell viability, clonogenicity, and sphere formation, while overexpression increases proliferation. CPT1A may contribute to PCa aggressiveness by regulating cell survival in hypoxic conditions.
Article
Oncology
Yan Jin, Zhengming Zhang, Qiao Yu, Zhu Zeng, Hong Song, Xiaoxu Huang, Qi Kong, Hao Hu, Yabin Xia
Summary: The research revealed that ZEB1-AS1 was significantly upregulated in pancreatic cancer cells under hypoxia conditions, correlating with poor prognosis in patients. ZEB1-AS1 facilitates the transcription of ZEB1 and stabilization of HIF-1α, promoting metastasis in pancreatic cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
S. Pushpa Ragini, Jacinta White, Nigel Kirby, Rajkumar Banerjee, Surendar Reddy Bathula, Calum J. Drummond, Charlotte E. Conn
Summary: The study aimed to create a bifunctional lipid with a cationic charge by combining a cationic lipid with a known pharmacophore, in order to enhance fusion with the cancer cell surface and biological activity through the pharmacophoric head group.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Oncology
Tahlia Scheinberg, Blossom Mak, Lisa Butler, Luke Selth, Lisa G. Horvath
Summary: This article summarizes the epidemiological links between obesity and metabolic syndrome and prostate cancer, the evidence for altered circulating lipids in prostate cancer and their potential role as biomarkers, as well as novel therapeutic strategies for targeting lipids in men with prostate cancer.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matteo Di Maso, Livia S. A. Augustin, David J. A. Jenkins, Greta Carioli, Federica Turati, Benedetta Grisoni, Anna Crispo, Carlo La Vecchia, Diego Serraino, Jerry Polesel
Summary: Evidence suggests that adhering to a cholesterol-lowering diet can reduce the risk of prostate cancer (PCa). Men who fulfill 5 to 7 dietary indicators associated with cholesterol reduction have a 43% lower risk of PCa compared to those who fulfill 0 to 2 indicators.
Article
Biochemistry & Molecular Biology
Qing-Xiang Meng, Ke-Nie Wang, Jun-Hui Li, Hui Zhang, Zhao-Hui Chen, Xue-Jie Zhou, Xu-Chen Cao, Ping Wang, Yue Yu
Summary: The study found that ZNF384 is significantly overexpressed in breast cancer and promotes breast cancer metastasis by regulating ZEB1 expression and inducing an epithelial and mesenchymal-like phenotype. Additionally, ZNF384 may be a target of miR-485-5p, and ZEB1 can up-regulate ZNF384 expression by repressing miR-485-5p expression. These findings provide evidence for the prognostic and therapeutic potential of ZNF384 in breast cancer patients.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Chung Lyul Lee, Minji Lee, Ji Yong Lee, Sin-Hyoung Hong, Seung Woo Yang, Ji-Hyeon Min, Dong-Eon Lee, Joonyoung Baek, Chanseul Kim, Jae Sung Lim, Ki Hak Song, Ju Hyun Shin, Gun-Hwa Kim
Summary: This study evaluated the impact of chronic intermittent hypoxia on prostate cancer progression using RNA sequencing analysis. The results suggest that COL13A1 gene is closely related to metastatic prostate cancer, providing a new strategy for the clinical management of metastatic hormone-resistant prostate cancer.
Article
Oncology
Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park, Hwan Mook Kim
Summary: This study demonstrated the changes in cancer-specific metabolism induced by lactate calcium salt in colorectal cancer cells, leading to anti-cancer effects. The results suggest that lactate calcium salt can alter anaerobic glycolysis, reduce HIF-1 alpha and VEGF expression, and inhibit tumor growth and metastasis.
Article
Chemistry, Medicinal
Alireza Basiri, Wenting Zhang, Jered Garrison
Summary: In this study, a series of dinitrobenzamide mustards (DNBM) based on the PR-104A hypoxia-selective prodrug were designed and synthesized. Various leaving groups and the introduction of a carboxylic acid group were explored to investigate the biological performance of the DNBM constructs. The results showed that the DNBM constructs were tolerant to modifications without substantially degrading their cytotoxic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo
Summary: Prostate cancer (PCa) is a common male malignancy with unclear progression mechanisms. This study found that NRP1, highly expressed in PCa, was associated with poor prognosis in PCa patients. Functionally, NRP1 depletion inhibited PCa cell proliferation and migration, while NRP1 overexpression promoted these processes. Mechanistically, NRP1 was regulated by HIF1 alpha and interacted with EGFR, leading to EGFR phosphorylation and activation of the AKT signaling pathway, promoting PCa progression. Additionally, the NRP1 inhibitor EG01377 inactivated the EGFR/AKT signaling axis and suppressed PCa progression.
CELL DEATH & DISEASE
(2023)
Article
Cell & Tissue Engineering
Shaojun Nong, Zhongqing Wei, Zhiwei Wang, Limin Ma, Yangbo Guan, Jian Ni
Summary: The study showed that reduced expression of DAPK1 in PCa patients promoted stem cell-like characteristics of PCa cells by activating ZEB1, through the Hippo/YAP signaling pathway. Overexpression of DAPK1 inhibited tumor growth of PCa and repressed the expression of ZEB1, YAP, and TAZ in the tumor tissues of PCa mice.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Wassim Moslah, Dorra Aissaoui-Zid, Soioulata Aboudou, Zaineb Abdelkafi-Koubaa, Marie Potier-Cartereau, Aude Lemettre, Ines ELBini-Dhouib, Naziha Marrakchi, Didier Gigmes, Christophe Vandier, Jose Luis, Kamel Mabrouk, Najet Srairi-Abid
Summary: In this study, new dendrimers multi-branched molecules based on the sequence of AaTs-1 were designed and synthesized, and they showed higher inhibitory effects on the proliferation of U87 cells compared to AaTs-1. The newly designed molecules exerted their effects by enhancing the phosphorylation of ERK1/2 and AKT, as well as increasing p53 expression. In particular, AaTs-1-4B also affected the migration of U87 cells.
Article
Cell Biology
Debbie O'Reilly, Tim Downing, Sana Kouba, Marie Potier-Cartereau, Declan J. McKenna, Christophe Vandier, Paul J. Buchanan
Summary: Research has found that the voltage gated calcium channel CaV1.3 is increased in prostate cancer patients undergoing androgen deprivation therapy (ADT). Increased CaV1.3 isoforms promote resistance to ADT by upregulating store operated calcium entry (SOCE) and enhancing the proliferation and survival of castrate resistant prostate cancer cells.
Article
Biochemistry & Molecular Biology
Maxime Gueguinou, Sajida Ibrahim, Jerome Bourgeais, Alison Robert, Trayambak Pathak, Xuexin Zhang, David Crottes, Jacques Dupuy, David Ternant, Valerie Monbet, Roseline Guibon, Hector Flores-Romero, Antoine Lefevre, Stephanie Lerondel, Alain Le Pape, Jean-Francois Dumas, Philippe G. Frank, Alban Girault, Romain Chautard, Francoise Gueraud, Ana J. Garcia-Saez, Mehdi Ouaissi, Patrick Emond, Olivier Sire, Olivier Herault, Gaelle Fromont-Hankard, Christophe Vandier, David Tougeron, Mohamed Trebak, William Raoul, Thierry Lecomte
Summary: This study reveals a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondrial calcium overload. NCLX inhibitors show potential in reducing colorectal cancer tumor growth. Higher NCLX expression is associated with MSI status and significantly correlated with recurrence-free survival.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Alexandre Androuin, Manon Thierry, Susana Boluda, Asha Baskaran, Dominique Langui, Charles Duyckaerts, Marie-Claude Potier, Khalid Hamid El Hachimi, Benoit Delatour, Serge Marty
Summary: This study investigates the subcellular localization of Aβ fibrils in transgenic mouse models and human brain tissue of Alzheimer's disease (AD). Results show the accumulation of Aβ fibrils in intralysosomal lipofuscin granules in mice and undigested material in enlarged lipofuscin granules in human cortical biopsies. However, no intraneuronal accumulations of Aβ fibrils were detected in the examined samples.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Medicinal
Marion Papin, Cyrille Guimaraes, Benoit Pierre-Aue, Delphine Fontaine, Jeoffrey Pardessus, Helene Couthon, Gaelle Fromont, Karine Maheo, Aurelie Chantome, Christophe Vandier, Michelle Pinault
Summary: In this study, we developed a high-performance thin-layer chromatography method for the quantification of total alkyl and alkenyl glycerolipids. This method enables the separation and quantification of these lipids in biological samples, providing a valuable tool for studying the biological role of ether glycerolipids.
Review
Oncology
Xavier Cansouline, Beatrice Lipan, Damien Sizaret, Anne Tallet, Christophe Vandier, Delphine Carmier, Antoine Legras
Summary: This article reviews the latest data on the adjuvant and neoadjuvant use of tyrosine kinase inhibitors, with a focus on their benefits, potential challenges, and the impact of mutation variability and financial evaluations. The review finds that tyrosine kinase inhibitors often show disease-free survival benefits, but overall survival improvement remains difficult, potentially due to variability in stages and mutations. Additionally, the safety profiles of the inhibitors are acceptable, but high costs and limited accessibility pose challenges. Overall, tyrosine kinase inhibitors offer promising opportunities for tailored treatment designs.
Article
Multidisciplinary Sciences
Debbie O'Reilly, Tim Downing, Sana Kouba, Marie Potier-Cartereau, Declan J. McKenna, Christophe Vandier, Paul Buchanan
Summary: The study investigates the role of calcium channel CaV1.3 in androgen-resistant prostate cancer. The results show that the gene expression of CaV1.3 increases during androgen deprivation, along with the expression of androgen receptor and neuron-specific enolase. However, in the prostate cancer model used, CaV1.3 has no significant impact on store release and calcium entry. These findings are important for understanding altered calcium handling in androgen-resistant prostate cancer and developing therapeutic drugs targeting CaV1.3.
Article
Immunology
Laurent Jacob, Jose de Brito Neto, Stephanie Lenck, Celine Corcy, Farhat Benbelkacem, Luiz Henrique Geraldo, Yunling Xu, Jean-Mickael Thomas, Marie-Renee El Kamouh, Myriam Spajer, Marie-Claude Potier, Stephane Haik, Michel Kalamarides, Bruno Stankoff, Stephane Lehericy, Anne Eichmann, Jean-Leon Thomas
Summary: This study characterizes the 3D anatomical structure of meningeal lymphatic vessels and their connection with dural venous sinuses. It also reveals an extended anterior lymphatic network and provides potential diagnostic tools for patients with CSF drainage defects and neurological diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Chemistry, Physical
Simon Garnier, Kevin Brugemann, Agnieszka Zak, Johnny Vercouillie, Marie Potier-Cartereau, Mathieu Marchivie, Sylvain Routier, Frederic Buron
Summary: The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported, and aryl groups were introduced at the C-5 and C-6 positions through regioselective electrophilic brominations followed by Suzuki-Miyaura cross coupling reactions.
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Olivier Romito, Maxime Gueguinou, William Raoul, Ophelie Champion, Alison Robert, Mohamed Trebak, Caroline Goupille, Marie Potier-Cartereau
Summary: Innate and acquired resistance play a significant role in the failure of cancer treatments. Calcium signaling, which regulates various cellular functions, has been implicated in cancer development. However, there is limited information on the role of calcium signaling in cancer drug resistance. This review discusses the potential value of targeting calcium signaling to overcome cancer resistance to therapeutic drugs.
Article
Environmental Sciences
Jean-Philippe Antignac, Sandy Figiel, Michele Pinault, Pascal Blanchet, Franck Bruyere, Romain Mathieu, Souhil Lebdai, Georges Fournier, Jerome Rigaud, Karine Maheo, Philippe Marchand, Ingrid Guiffard, Emmanuelle Bichon, Bruno le Bizec, Luc Multigner, Gaelle Fromont
Summary: This study investigated the association between OCPs concentrations in PPAT and prostate cancer aggressiveness, and found significant ethno-geographic variation in exposure. Most OCPs were positively correlated with age and BMI, while mirex showed an inverse association with aggressive features of PCa.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Michael Constantinides, Alexis Fayd'herbe De Maudave, Marie Potier-Cartereau, Mauricio Campos-Mora, Guillaume Cartron, Martin Villalba
Summary: CD20 monoclonal antibodies have a strong ability to quickly kill B cells using different mechanisms. However, the assessment of killing is difficult. This study shows that common cytometry protocols involving centrifugation can miss important parts of the killing effect of drugs. Alternative methods are proposed to assess fast target cell killing in vitro, avoiding centrifugation or based on survival comparison or counting beads, which are applicable to B cell lines and primary tumor cells.
Article
Medicine, Research & Experimental
Sarah Proteau, Imene Krossa, Chrystel Husser, Maxime Gueguinou, Federica Sella, Karine Bille, Marie Irondelle, Melanie Dalmasso, Thibault Barouillet, Yann Cheli, Celine Pisibon, Nicole Arrighi, Sacha Nahon-Esteve, Arnaud Martel, Lauris Gastaud, Sandra Lassalle, Olivier Mignen, Patrick Brest, Nathalie M. Mazure, Frederic Bost, Stephanie Baillif, Solange Landreville, Simon Turcotte, Dan Hasson, Saul Carcamo, Christophe Vandier, Emily Bernstein, Laurent Yvan-Charvet, Mitchell P. Levesque, Robert Ballotti, Corine Bertolotto, Thomas Strub
Summary: Metastatic uveal melanomas show high resistance to existing treatments. By conducting a kinome-wide CRISPR-Cas9 knockout screen, we identified the LKB1-SIK2 module as a factor restraining tumorigenesis. Loss of LKB1 enhances cell proliferation and survival by inhibiting SIK2 and upregulating SLC8A1, leading to increased levels of intracellular calcium and mitochondrial reactive oxygen species. Furthermore, a combination of an SLC8A1 inhibitor and a mitochondria-targeted antioxidant demonstrates enhanced cell death efficacy in LKB1- and SIK2-negative uveal melanoma cells.
EMBO MOLECULAR MEDICINE
(2023)
