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Immunology
Lindsay G. A. McKay, Jordan Thomas, Wejdan Albalawi, Antoine Fattaccioli, Marc Dieu, Alessandra Ruggiero, Jane A. McKeating, Jonathan K. Ball, Alexander W. Tarr, Patricia Renard, Georgios Pollakis, William A. Paxton
Summary: HCV glycoprotein inhibits HIV-1 LTR activation by suppressing NF-kappa B activity, potentially affecting the clearance of infection. This process may be influenced by host and viral genetic factors, as well as HCV encoded immunomodulatory proteins. Additionally, HCV glycoprotein can activate endoplasmic reticulum stress pathway and upregulate related gene expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Biochemistry & Molecular Biology
Daphne E. Lodes, Jiuhe Zhu, Nien-Pei Tsai
Summary: E3 ubiquitin ligase Nedd4-2 exerts neuroprotective effects during endoplasmic reticulum stress.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
John C. Christianson, Pedro Carvalho
Summary: This article discusses recent advances in understanding the mechanisms of ERAD and its impact on the regulation of ER functions.
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Immunology
Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun
Summary: Limonin mitigates DSS-induced chronic colitis by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-kappa B signaling, showing potential as an effective drug for IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
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Microbiology
Xingang Xu, Jingjing Wang, Yuting Zhang, Yuchao Yan, Yi Liu, Xiaojie Shi, Qi Zhang
Summary: This study reveals the potential role of DDX6 in regulating autophagy during PEDV infection. DDX6 protein expression is down-regulated while mRNA expression is up-regulated in PEDV-infected cells. Overexpression of DDX6 inhibits PEDV replication, while knockdown of DDX6 promotes viral replication. PEDV-induced ER stress down-regulates DDX6 protein level, and silencing of DDX6 alleviates ER stress and cell apoptosis.
VETERINARY MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
David Millrine, Joshua J. Peter, Yogesh Kulathu
Summary: Ubiquitin Fold Modifier-1 (UFM1) is a ubiquitin-like modifier that attaches to substrates via a unique system of enzymes. UFMylation pathway mutations have been linked to human musculoskeletal and neurodevelopmental diseases, possibly due to increased ER stress and disrupted translational homeostasis. UFM1 is also involved in DNA damage response, telomere maintenance, and ribosomal function at the ER, providing potential therapeutic opportunities for human health.
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Plant Sciences
Fengyan Fang, Wenlong Zhou, Yanfeng Liu, Zhizhong Song, Songfeng Zheng, Fei Wang, Zeyu Lu, Dazhuang Qi, Bei Li, Nan Sun, Xiaoli Tang, Juan Zhang, Renhui Zhan, Limin Wang, Hongxia Zhang
Summary: A total of 23 BnaSINAs were identified in rapeseed, which play a crucial role in plant growth and development. These genes have potential functions in response to salt and osmotic stresses, and provide a genetic foundation for breeding new oil crop cultivars with improved stress resistance.
PLANT CELL REPORTS
(2023)
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Oncology
Elisa Principi, Elvira Sondo, Giovanna Bianchi, Silvia Ravera, Martina Morini, Valeria Tomati, Cristina Pastorino, Federico Zara, Claudio Bruno, Alessandra Eva, Nicoletta Pedemonte, Lizzia Raffaghello
Summary: This study validates RNF5 as an innovative drug target in neuroblastoma and melanoma. RNF5 expression is positively correlated with better prognosis in both types of tumors. Activating RNF5 with Analog-1 leads to cytotoxic effects on tumor cells by modulating metabolism and inducing cell death.
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Pharmacology & Pharmacy
Yi-nan Cao, Yong Wang, Longsheng Zhang, Yujia Hou, Jinhua Shan, Mengjie Li, Cairui Chen, Yufeng Zhou, Enfang Shan, Jie Wang
Summary: This study revealed that 5-FU could induce severe endoplasmic reticulum stress (ERS), leading to cell apoptosis and oral mucosal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
A. M. Shamseldeen, M. Hamzawy, N. A. Mahmoud, L. Rashed, S. S. Kamar, L. A. Harb, N. Sharawy
Summary: The study revealed that endoplasmic reticulum stress and autophagy play important roles in mediating renal injury and aggravating inflammation in response to a western diet. Vitamin E was found to alleviate endoplasmic reticulum stress and promote autophagy to protect intestinal and renal tissues.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
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Cell Biology
Yihui Shen, Hui Zhang, Yangyue Ni, Xuejun Wang, Yifan Chen, Jiahui Chen, Yan Wang, Jinyi Lin, Yuchen Xu, Jian-Yuan Zhao, Leilei Cheng
Summary: The study revealed that TRIM25 plays a protective role in DOX-induced cardiotoxicity by mitigating endoplasmic reticulum stress and apoptosis. TRIM25 affects the stability and ubiquitination of p85 alpha, leading to increased nuclear translocation of XBP-1s and alleviation of ER stress. These findings suggest that TRIM25 may have therapeutic potential for DOX-induced cardiotoxicity.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Zhibin Lin, Peijun Yang, Yufeng Hu, Hao Xu, Juanli Duan, Fei He, Kefeng Dou, Lin Wang
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NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Boxin Li, Hui Yang, Haipeng Wu, Huanhuan Wang, Zhongming Ye, Yao Wu, Yuting Chen, Huanwen Tang
Summary: This study shows that hydroquinone induces autophagy and apoptosis in human lymphoblastoid cells via endoplasmic reticulum stress (ERS), and the involvement of activating transcription factor 6 (ATF-6) is identified. It is also found that ROS-mediated ERS may promote autophagy and apoptosis by inhibiting the ATF6-mTOR pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
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Biotechnology & Applied Microbiology
Wei Li, Xiangping Zhou, Jialun Cai, Feijun Zhao, Ting Cao, Lichang Ning, Chunyi Luo, Xinhua Xiao, Shuangquan Liu
Summary: Tp0768 stimulation of macrophages increases IL-1 beta, IL-6, and IL-8 expression levels in a dose- and time-dependent manner. This process is mediated through ER stress and the ROS/NF-kappa B pathway, leading to the secretion of proinflammatory cytokines.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Fisheries
Yuedong Shen, Wenli Zhao, Oscar Monroig, Yangguang Bao, Tingting Zhu, Lefei Jiao, Peng Sun, Douglas R. Tocher, Qicun Zhou, Min Jin
Summary: This study revealed the role of Ire1 alpha in mediating inflammation and apoptosis in black seabream under high-fat-diet conditions. High-fat-diet led to lipid deposition in the liver and triggered endoplasmic reticulum stress, inflammation, and apoptosis. Inhibiting Ire1 alpha alleviated these effects.
FISH & SHELLFISH IMMUNOLOGY
(2023)
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Biochemistry & Molecular Biology
Soshi Kanemoto, Ryota Nitani, Tatsuhiko Murakami, Masayuki Kaneko, Rie Asada, Koji Matsuhisa, Atsushi Saito, Kazunori Imaizumi
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Pharmacology & Pharmacy
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YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2016)
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Biochemistry & Molecular Biology
Atsushi Saito, Longjie Cai, Koji Matsuhisa, Yosuke Ohtake, Masayuki Kaneko, Soshi Kanemoto, Rie Asada, Kazunori Imaizumi
JOURNAL OF NEUROCHEMISTRY
(2018)
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Neurosciences
Yosuke Ohtake, Koji Matsuhisa, Masayuki Kaneko, Soshi Kanemoto, Rie Asada, Kazunori Imaizumi, Atsushi Saito
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Multidisciplinary Sciences
Yan Wu, Xiao Peng Guo, Soshi Kanemoto, Yujiro Maeoka, Atsushi Saito, Rie Asada, Koji Matsuhisa, Yosuke Ohtake, Kazunori Imaizumi, Masayuki Kaneko
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CELL DEATH & DISEASE
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Yujiro Maeoka, Yan Wu, Takumi Okamoto, Soshi Kanemoto, Xiao Peng Guo, Atsushi Saito, Rie Asada, Koji Matsuhisa, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
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Biochemistry & Molecular Biology
Yosuke Osaki, Koji Matsuhisa, Wang Che, Masayuki Kaneko, Rie Asada, Takao Masaki, Kazunori Imaizumi, Atsushi Saito
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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Yujiro Maeoka, Takumi Okamoto, Yan Wu, Atsushi Saito, Rie Asada, Koji Matsuhisa, Miho Terao, Shuji Takada, Takao Masaki, Kazunori Imaizumi, Masayuki Kaneko
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
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Shin-ichiro Sekine, Masayuki Kaneko, Masaki Tanaka, Yuhei Ninomiya, Hisaka Kurita, Masatoshi Inden, Megumi Yamada, Yuichi Hayashi, Takashi Inuzuka, Jun Mitsui, Hiroyuki Ishiura, Atsushi Iwata, Hiroto Fujigasaki, Hisamitsu Tamaki, Ryusei Tamak, Shinsuke Kito, Yoshiharu Taguchi, Kortaro Tanaka, Naokia Tsuta, Gen Sobue, Takayuki Kondo, Haruhisa Inoue, Shoji Tsuji, Isao Hozumi
SCIENTIFIC REPORTS
(2019)
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Takumi Okamoto, Yan Wu, Koji Matsuhisa, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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Koji Matsuhisa, Atsushi Saito, Longjie Cai, Masayuki Kaneko, Takumi Okamoto, Fumika Sakaue, Rie Asada, Fumihiko Urano, Kanta Yanagida, Masayasu Okochi, Yukitsuka Kudo, Masaki Matsumoto, Keiichi I. Nakayama, Kazunori Imaizumi
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Multidisciplinary Sciences
Yan Wu, Yuka Kimura, Takumi Okamoto, Koji Matsuhisa, Rie Asada, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko
SCIENTIFIC REPORTS
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Pharmacology & Pharmacy
Masayuki Kaneko, Kazunori Imaizumi, Atsushi Saito, Soshi Kanemoto, Rie Asada, Koji Matsuhisa, Yosuke Ohtake
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2017)