Article
Nutrition & Dietetics
Sietske A. Berghuis, Arend F. Bos, Pieter J. J. Sauer, Gianni Bocca
Summary: This study found that prenatal exposure to persistent organic pollutants (POPs) may have effects on metabolic markers and hormone levels in adolescents, and is associated with overweight and cardiovascular risk.
Review
Biochemistry & Molecular Biology
Charlotte Hinault, Philippe Caroli-Bosc, Frederic Bost, Nicolas Chevalier
Summary: Diabetes mellitus is a significant global health problem, impacting individuals and economies. The chronic hyperglycemia associated with diabetes leads to severe complications, including retinopathy, kidney failure, and cardiovascular diseases. While genetic factors and environmental factors like sedentary lifestyles, overweight, and obesity contribute to the development of diabetes, there is growing evidence suggesting the role of endocrine-disrupting chemicals (EDCs) in the pathophysiology of diabetes and metabolic disorders. This narrative review critically examines the impact of EDCs on our endocrine system and their link to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Eujung Kim, Minjung Song, Adam Gopal Ramu, Dongjin Choi
Summary: Bisphenol A (BPA), a common chemical used in plastic production, has emerged as a serious environmental concern due to its potential toxicity to plants. This study aimed to investigate the mechanism of BPA-induced root cells by examining the effects of BPA on the ultrastructure and function of soybean plant root tip cells. Changes in plant root cell tissues after BPA exposure were observed, and the accumulation of BPA in different plant parts was analyzed. The findings provide insight into how BPA can alter plant root growth.
Article
Obstetrics & Gynecology
A. Crestani, C. Abdel Wahab, A. Arfi, S. Ploteau, K. Kolanska, M. Breban, S. Bendifallah, C. Ferrier, E. Darai
Summary: The study found that MRI-assessed anogenital distance is a strong diagnostic marker of endometriosis, outperforming clinically assessed AGD. Age and BMI were positively associated with MRI-AGD-AC measurements, while the diagnosis of endometriosis was negatively associated with both MRI-AGD-AF and MRI-AGD-AC. MRI-AGD-AF had high sensitivity and specificity in the diagnosis of endometriosis, showing potential for use in MRI examinations of patients with suspected endometriosis.
HUMAN REPRODUCTION OPEN
(2021)
Review
Biochemistry & Molecular Biology
Juliana F. Silva, Bruno P. Moreira, Luis Rato, Maria de Lourdes Pereira, Pedro F. Oliveira, Marco G. Alves
Summary: The increase in obesity prevalence is directly linked to obesogens, which are exogenous chemical compounds that alter metabolic processes and appetite, predisposing to weight gain. Despite being a relatively new theory, the expanding number of compounds suspected to have obesogenic activity highlights the importance of environmental factors in the obesity epidemic.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Emmanuel Sunday Okeke, Weiwei Feng, Guanghua Mao, Yao Chen, Xian Qian, Mengna Luo, Hai Xu, Xuchun Qiu, Xiangyang Wu, Liuqing Yang
Summary: TBBPA-DHEE poses a significant threat to humans and aquatic organisms due to its neurotoxicity and endocrine-disrupting effect. It alters locomotor behavior, hormone levels, and gene expression in zebrafish, suggesting a disruption of the neuroendocrine axis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Sietske A. Berghuis, Arend F. Bos, Henk Groen, Wilhelmina H. A. de Jong, Anneke C. Muller Kobold, Lucie Wagenmakers-Huizinga, Pieter J. J. Sauer, Gianni Bocca
Summary: This study found that prenatal exposure to PCBs may impact pubertal development in 13-15 year old children, with boys showing higher hormone levels, earlier pubic hair development, and larger testicular volume, while girls showed advanced breast development.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Begum Yurdakok-Dikmen, Ozgur Kuzukiran, Recep Uyar, Ummu Gulsum Boztepe, Hasan Tolga Celik, Ozgur Ozyuncu, Yagmur Turgut, Halit Kanca, Kubra Karakas-Alkan, Ayhan Filazi
Summary: Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs) are endocrine-disrupting chemicals (EDCs) that are concerning for fetal exposure. Placenta can serve as a good indicator for potential fetal exposure. This study compared the presence of these chemicals in human and dog placentas, and found differences in the types and concentrations of pollutants, indicating species-specific effects.
Article
Biochemistry & Molecular Biology
Liselott Kallsten, Radwa Almamoun, Paula Pierozan, Erik Nylander, Kalliroi Sdougkou, Jonathan W. Martin, Oskar Karlsson
Summary: This study found that di-n-butyl phthalate (DBP) exposure can lead to persistent effects on testosterone synthesis and spermatogenesis in adult male mice, resulting in decreased testosterone levels. The study also revealed increased levels of key cells and proteins, including steroidogenic enzymes, oxidative stress markers, and germ cell markers, in response to DBP exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jake M. Martin, Jack T. Orford, Gabriela C. Melo, Hung Tan, Rachel T. Mason, Shiho Ozeki, Michael G. Bertram, Bob B. M. Wong, Lesley A. Alton
Summary: Globally, amphibian species are facing dramatic population declines, and endocrine-disrupting chemicals (EDCs) are recognized as a contributing factor. However, the effects of the potent anabolic steroid 178-trenbolone on anuran species, particularly during early life stages, remain poorly understood. This study investigated the effects of 178-trenbolone on tadpoles and found no significant impact on body size, metabolic rate, or behavior, except for a slight decrease in body condition at the highest concentration. Further research is needed to understand the potential taxon-specific effects of 178-trenbolone.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Sophie Guillotin, Nicolas Delcourt
Summary: This review provides a synthesis of knowledge of persistent organic pollutants (POPs) based on proteomics research and explores new features relevant to human health. However, much is still unknown about the mechanisms and molecular cellular responses involved in the adverse effects of these pollutants on human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Corina Lesseur, Patrick Pirrotte, Khyatiben V. Pathak, Fabiana Manservisi, Daniele Mandrioli, Fiorella Belpoggi, Simona Panzacchi, Qian Li, Emily S. Barrett, Ruby H. N. Nguyen, Sheela Sathyanarayana, Shanna H. Swan, Jia Chen
Summary: High maternal urinary levels of Glyphosate were associated with longer anoclitoral distance (AGD-AC) in female infants, while increased levels of AMPA were associated with longer anofourchette distance (AGD-AF). No significant associations were found in male infants.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Analytical
Michael Douglas S. Monteiro, Mercia V. S. Sant'Anna, Jose C. Santos, Jose F. Macedo, Anderson A. C. Alves, Jonatas de Oliveira S. Silva, Iara F. Gimenez, Eliana Midori Sussuchi
Summary: This study reports the development of a modified electrode with reduced graphene oxide for the determination of 17 alpha-ethinylestradiol. The electrode was characterized using various techniques and showed good analytical performance. The method can be used for the identification and quantification of 17 alpha-ethinylestradiol in different matrices.
Review
Endocrinology & Metabolism
Emma Bokobza, Charlotte Hinault, Victor Tiroille, Stephan Clavel, Frederic Bost, Nicolas Chevalier
Summary: Obesity is a significant public health concern associated with increased risk of various cancers, including gastrointestinal tract cancers and hormone-dependent cancers. Adipose tissue plays a crucial role in this process, as it is considered a major internal source of endocrine disrupting chemicals that can impact hormonal balance and cell proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Analytical
Anna Raysyan, Rudolf J. Schneider
Summary: Bisphenol A is a crucial chemical in polymer plastics and coatings production. To address concerns about BPA toxicity, a latex microparticle-based lateral flow immunoassay method was developed for rapid on-site screening. The method showed high sensitivity and efficiency in detecting BPA.
Article
Pediatrics
Julia Sanguesa, Jordi Sunyer, Raquel Garcia-Esteban, Alicia Abellan, Ana Esplugues, Judith Garcia-Aymerich, Monica Guxens, Amaia Irizar, Jordi Julvez, Leire Luque-Garcia, Ana Cristina Rodriguez-Dehli, Adonina Tardon, Maties Torrent, Jesus Vioque, Martine Vrijheid, Maribel Casas
Summary: The study suggests that vitamin D levels in pregnant women and children are associated with allergic and asthma-related symptoms in childhood. Higher vitamin D levels at 4 years old are linked to a lower risk of atopic eczema in later years.
PEDIATRIC RESEARCH
(2023)
Article
Environmental Sciences
Francesca Castiello, Beatriz Suarez, Andrea Beneito, Maria-Jose Lopez-Espinosa, Loreto Santa-Marina, Aitana Lertxundi, Adonina Tardon, Isolina Riano-Galan, Maribel Casas, Martine Vrijheid, Nicolas Olea, Mariana F. Fernandez, Carmen Freire
Summary: This study examined the associations between urinary metabolites of non-persistent pesticides and pubertal development in children from urban and rural areas in Spain. The results showed that higher concentrations of certain pesticide metabolites were associated with increased odds of pubertal development, especially in girls, and BMI may modify these associations.
ENVIRONMENTAL POLLUTION
(2023)
Editorial Material
Engineering, Environmental
Marlene Agerstrand, Kenneth Arinaitwe, Thomas Backhaus, Ricardo O. Barra, Miriam L. Diamond, Joan O. Grimalt, Ksenia Groh, Faith Kandie, Perihan Binnur Kurt-Karakus, Robert J. Letcher, Rainer Lohmann, Rodrigo O. Meire, Temilola Oluseyi, Andreas Schaeffer, Mochamad Septiono, Gabriel Sigmund, Anna Soehl, Temitope O. Sogbanmu, Noriyuki Suzuki, Marta Venier, Penny Vlahos, Martin Scheringer
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Pediatrics
Ana de Lucio Delgado, Jose Antonio Villegas Rubio, Isolina Riano-Galan, Juan Perez Gordon
Summary: Low-grade gliomas are common brain tumors in children, with diverse clinical, histological, and biological behaviors. Recent research has suggested a link between estrogens and progesterone and tumor development. This case study describes a 2-year-old girl with a low-grade brain tumor who showed tumor reduction after starting treatment with Decapeptyl (R) for precocious puberty. While the influence of hormones on glioma development has been studied, their role in brain tumor treatment remains unclear.
Article
Environmental Sciences
Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, Eric Gaudreau, Joan O. Grimalt, Jesus Ibarluzea, Fabrice Laine, Sabrina Llop, Maria-Jose Lopez-Espinosa, Florence Rouget, Loreto Santa -Marina, Martine Vrijheid, Cecile Chevrier, Maribel Casas, Charline Warembourg
Summary: Several studies have shown that prenatal exposure to certain persistent organic pollutants (POPs) is associated with higher adiposity in childhood. This study aimed to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. The findings suggest that prenatal exposure to POPs, especially organochlorine pesticides, is linked to unfavorable cardiometabolic health up to the age of 12.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Rocio Fernandez-Iglesias, Ana Fernandez-Somoano, Cristina Rodriguez-Dehli, Rafael Venta-Obaya, Isolina Riano-Galan, Adonina Tardon
Summary: This study aimed to investigate subgroups of children with different clusters of cardiovascular disease (CVD) risk factors at 4 and 8 years of age, and their patterns of change between these two time points. At 4 years, three subgroups were identified: no disorders (55.9%); some disorders (21.2%), and central obesity (22.9%). At 8 years, three subgroups were identified: no disorders (59.8%); hypertension (17.9%), and central obesity (22.3%). Children who did not present any disorder at 4 years tend to remain in that state at 8 years. Central obesity may play a major role in the development of other disorders.
Article
Multidisciplinary Sciences
Paula Morales-Sanchez, Carmen Lambert, Jessica Ares-Blanco, Lorena Suarez-Gutierrez, Elsa Villa-Fernandez, Ana Victoria Garcia, Miguel Garcia-Villarino, Juan Ramon Tejedor, Mario F. Fraga, Edelmiro Menendez Torre, Pedro Pujante, Elias Delgado
Summary: This study aimed to analyze the circulating miRNA expression profile of patients with type 1 diabetes and no other associated pathology. The expression of hsa-miR-1-3p was found to be significantly increased in patients with type 1 diabetes and positively correlated with glycated haemoglobin levels. Changes in hsa-miR-1-3p were also found to directly affect genes involved in vascular development and cardiovascular pathologies. Circulating hsa-miR-1-3p, along with glycemic control, could be used as prognostic biomarkers in type 1 diabetes to prevent the development of vascular complications in these patients.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
L. Notario-Barandiaran, A. Irizar, M. Begona-Zubero, R. Soler-Blasco, G. Riutort-Mayol, A. Fernandez-Somoano, A. Tardon, M. Casas, M. Vrijheid, A. Meharg, M. Carey, C. Meharg, K. Ralphs, C. McCreanor, J. O. Grimalt, J. Vioque, A. J. Signes-Pastor
Summary: In this study, the association between adherence to the Mediterranean diet (MD) and urinary metal concentrations in children was evaluated. It was found that high adherence to MD was associated with increased urinary levels of arsenic and copper, but also an increase in non-toxic arsenobetaine concentrations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Vasiliki Margari, David A. Hodell, Simon A. Parfitt, Nick M. Ashton, Joan O. Grimalt, Hyuna Kim, Kyung-Sook Yun, Philip L. Gibbard, Chris B. Stringer, Axel Timmermann, Polychronis C. Tzedakis
Summary: Through analyzing deep-sea sediment samples from the Portuguese margin, researchers found pronounced millennial-scale climate variability during the glacial period around 1.154 to 1.123 million years ago, including a terminal stadial cooling comparable to the most extreme events of the last 400,000 years. Climate simulations indicate a drastic decrease in suitability of early human habitats around the Mediterranean during the terminal stadial. These extreme conditions led to the depopulation of Europe, potentially lasting for several successive glacial-interglacial cycles.
Editorial Material
Nutrition & Dietetics
Julian Rodriguez-Suarez, Gonzalo Solis-Sanchez, Isolina Riano-Galan
Article
Nutrition & Dietetics
Fanny Petermann-Rocha, Desiree Valera-Gran, Daniel Prieto-Botella, Dries S. Martens, Sandra Gonzalez-Palacios, Isolina Riano-Galan, Mario Murcia, Amaia Irizar, Jordi Julvez, Loreto Santa-Marina, Adonina Tardon, Jordi Sunyer, Jesus Vioque, Tim Nawrot, Eva-Maria Navarrete-Munoz
Summary: This study found that the use of high-dose folic acid supplements during pregnancy may be associated with shorter telomere length in children at age four, particularly in boys.
Article
Mathematics
Rocio Fernandez-Iglesias, Pablo Martinez-Camblor, Adonina Tardon, Ana Fernandez-Somoano
Summary: This study presents an analysis of cardiovascular measures in children, discussing the challenges in dealing with missing data and selecting the appropriate regression model. It also explores the impact of different decisions on the results.
Article
Engineering, Environmental
Andreas Schaeffer, Ksenia J. Groh, Gabriel Sigmund, David Azoulay, Thomas Backhaus, Michael G. Bertram, Bethanie Carney Almroth, Ian T. Cousins, Alex T. Ford, Joan O. Grimalt, Yago Guida, Maria C. Hansson, Yunsun Jeong, Rainer Lohmann, David Michaels, Leonie Mueller, Jane Muncke, Gunilla Oberg, Marcos A. Orellana, Edmond Sanganyado, Ralf Bernhard Schaefer, Ishmail Sheriff, Ryan C. Sullivan, Noriyuki Suzuki, Laura N. Vandenberg, Marta Venier, Penny Vlahos, Martin Wagner, Fang Wang, Mengjiao Wang, Anna Soehl, Marlene Agerstrand, Miriam L. Diamond, Martin Scheringer
Summary: Pollution caused by chemicals and waste, along with climate change and biodiversity loss, poses a triple planetary crisis. In response, countries have established an intergovernmental science-policy panel to address chemicals, waste, and pollution prevention. Protecting this panel from conflicts of interest is crucial for its success.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Dewan Muhammad Shoaib, Tanvir Ahmed, Kazy Farhat Tabassum, Mehedi Hasan, Fazle Sharior, Mahbubur Rahman, Makfie Farah, Md Azizur Rahman, Alauddin Ahmed, James B. Tidwell, Mahbub-Ul Alam
Summary: An intervention was implemented in Bangladesh during COVID-19 to reduce occupational health risks for waste and sanitation workers. The intervention involved training and distribution of personal protective equipment (PPE). The study found that the intervention improved workers' knowledge, attitude, and practice regarding PPE usage.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Andreas Kortenkamp, Olwenn Martin, Eleni Iacovidou, Martin Scholze
Summary: The European Food Safety Authority's downward revision of the Health-based Guidance Value for bisphenol A (BPA) has led to disagreements with other regulatory agencies, particularly the German Federal Institute for Risk Assessment. The differing views between EFSA and BfR are driven by their respective selection of endpoints and study evaluation systems, as well as their acceptance or refusal of immunotoxic effects as a basis for establishing a Health-based Guidance Value.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Shizhen He, Bjorn Lundberg, Jenny Hallberg, Susanna Klevebro, Goran Pershagen, Kristina Eneroth, Erik Melen, Matteo Bottai, Olena Gruzieva
Summary: Early life air pollution exposure and abnormal inflammation-related protein profiles may interact synergistically towards lower lung function in infants.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Paulien Cleys, Emilie Hardy, Yu Ait Bamai, Giulia Poma, Adam Cseresznye, Govindan Malarvannan, Paul T. J. Scheepers, Susana Viegas, Simo P. Porras, Tiina Santonen, Lode Godderis, Jelle Verdonck, Katrien Poels, Carla Martins, Maria Joao Silva, Henriqueta Louro, Inese Martinsone, Lasma Akulova, An van Nieuwenhuyse, Martien Graumans, Selma Mahiout, Radu Corneliu Duca, Adrian Covaci
Summary: The aim of this study was to assess the exposure of e-waste workers to phthalates and alternative plasticizers. The results showed that e-waste workers had higher urinary concentrations of phthalates and metabolites compared to non-occupationally exposed controls. However, no significant differences were found between pre-and post-shift concentrations in the e-waste workers.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)
Article
Public, Environmental & Occupational Health
Karolina Bralewska
Summary: This review study examines the concentrations of various air pollutants in fire stations, identifies the limitations and strengths of existing research, identifies research gaps and challenges, and suggests potential solutions for reducing firefighter exposure to air pollution at fire stations.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2024)