Article
Chemistry, Applied
Tanmay Bharadwaj, Shreya Chrungoo, Devendra Verma
Summary: Chitosan-based thermosensitive bioink has great potential for bone tissue engineering due to its excellent biocompatibility and gelation at physiological temperature without the need for crosslinkers. However, it has limitations in terms of low mechanical strength, poor printability, and low post-printing cell viability. This study incorporated self-assembled nanofibrous aggregates and nanohydroxyapatite into chitosan-based bioinks to improve their printability, mechanical properties, and cell viability. The optimized nanocomposite bioink showed good printability, high cell viability, low water uptake, and degradation in the presence of lysozyme. The bioink also exhibited a suitable elastic modulus and enhanced cellular activity in osteogenic media.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Soroush Ahmadi, Ahmad Hivechi, S. Hajir Bahrami, Peiman B. Milan, Seyedeh Sara Ashraf
Summary: This study developed chitosan/gelatin nanofiber membranes with sustained release capacity to prevent infection by delivering cinnamon extract (CE) in the implanted site. The incorporation of CE enhanced the properties of the nanofibers, including degradation behavior, antibacterial activity, and biocompatibility. The extract release profile showed a burst release in the first 6 hours, followed by a controlled release in the next 138 hours.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sakchi Bhushan, Sandhya Singh, Tushar Kanti Maiti, Ankita Das, Ananya Barui, Leena R. Chaudhari, Meghnad G. Joshi, Dharm Dutt
Summary: Cell-free and cell-loaded constructs are used to repair critical-sized bone defects, with interest in enhancing three-dimensional scaffolds with free radical scavenging materials. In this study, CG-CNPs nanocomposite scaffolds with improved physico-chemical, mechanical, and biological properties were fabricated using freeze-drying. These scaffolds showed cyto-friendly behavior, antimicrobial activity, and demonstrated the best characteristics in terms of porosity, weight loss, compressive modulus, and Ca/P ratio. Therefore, the CG-CNP2 scaffolds are highly biocompatible and suitable for bone defect repair.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Materials Science, Multidisciplinary
Sneh Gautam, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chhavi Sharma, Chia -Fu Chou, Narayan Chandra Mishra
Summary: Bone tissue engineering has received attention for the treatment of bone injury. A tri-polymer scaffold (PCL-gelatin-chitosan) was fabricated through electrospinning and treated with nanohydroxyapatite. The modified scaffold showed a uniform distribution of nanohydroxyapatite particles on the surface of fibers.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ryoma Goto, Eisaku Nishida, Shuichiro Kobayashi, Makoto Aino, Tasuku Ohno, Yuki Iwamura, Takeshi Kikuchi, Jun-ichiro Hayashi, Genta Yamamoto, Masaki Asakura, Akio Mitani
Summary: The study found that visible-light-crosslinked GelMA hydrogels, along with encapsulated osteoblasts, exhibited good mechanical and biological properties, making them suitable for use as scaffolds for bone regeneration. Osteoblasts encapsulated in GelMA hydrogels photopolymerized with visible light showed higher cell viability. Additionally, GelMA-RF hydrogels promoted osteoblast differentiation and have the potential to treat bone-destructive diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Tansza Setiana Putri, Devi Rianti, Priyawan Rachmadi, Anita Yuliati
Summary: A composite scaffold was successfully fabricated using beta-tricalcium phosphate (beta TCP) extracted from limestone, mixed with chitosan and gelatin. The study optimized the fabrication process and evaluated the effect of glutaraldehyde on scaffold characteristics. Results showed that lower porosity led to higher compressive strength in the cross-linked scaffolds.
Article
Biotechnology & Applied Microbiology
Azam Bozorgi, Mozafar Khazaei, Maryam Bozorgi, Zahra Jamalpoor
Summary: Fabricating degradable polymer-based membranes for guided bone regeneration has attracted attention. Chitosan/gelatin composites have structural similarity to bone matrix and can support cell attachment and proliferation. Apigenin, a plant-derived phenolic compound, was incorporated into Cs/Gel membranes to improve bioavailability and enhance biological activities.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Qiushuo Sun, Lu Yu, Zhuocheng Zhang, Cheng Qian, Hongzhe Fang, Jintao Wang, Peipei Wu, Xiaojing Zhu, Jian Zhang, Liangjun Zhong, Rui He
Summary: This study presents a new degradable bone scaffold loaded with nano-HA and beta-TCP, with highly connected macropores achieved through freeze drying combined with stir foaming. In vitro tests demonstrate the biodegradation potential and appreciable swelling ratio of the scaffolds. The results of MC3T3-E1 cell culture suggest that the osteoinductivity and osteoconduction of the scaffolds increase with higher HCP content.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ece Guler, Yaren Ezgi Baripoglu, Hussain Alenezi, Ayca Arikan, Ravana Babazade, Semra Unal, Gokhan Duruksu, Fawzan S. Alfares, Yusufhan Yazir, Faik Nuzhet Oktar, Oguzhan Gunduz, Mohan Edirisinghe, Muhammet Emin Cam
Summary: DKMF, loaded with Vitamin D3, Vitamin K2, and Mg, demonstrated osteoinductive effects by activating the Wnt/beta-catenin signaling pathway and promoting the growth and function of osteoblast cells, making it a promising treatment approach in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Shikha Kumari, Pradeep Srivastava, Abha Mishra
Summary: In this study, chitosan and gelatin-based artificial biomimetic 3D structures were developed and loaded with nanobioglass and beta tri-calcium phosphate to create potential artificial acellular bone grafts. The scaffolds exhibited porous structure, low swelling, and high mechanical properties, while promoting cell viability and osteogenesis.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Medicine, Research & Experimental
JiUn Lee, Dongyun Kim, Chul Ho Jang, Geun Hyung Kim
Summary: This study attempted to fabricate a 3D printed scaffold with excellent mechanical properties and recoverable behavior, using human placental extracts as bioactive components. In vitro and in vivo results suggested that the G/H/hPE scaffold is a potential candidate for use in bone tissue engineering.
Article
Biochemistry & Molecular Biology
Zhengyue Li, Xiuqiong Chen, Chaoling Bao, Chang Liu, Chunyang Liu, Dongze Li, Huiqiong Yan, Qiang Lin
Summary: The combination of alginate with bacterial cellulose nanocrystals-chitosan-gelatin composite scaffolds showed regular 3D morphologies and well-developed pore structures, with the addition of BCNs effectively controlling the swelling and biodegradation behavior. This composite scaffold exhibited good cytocompatibility, making it potentially suitable for bone tissue engineering applications.
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
N. Akshaya, N. Srinaath, M. Rohini, R. Ilangovan, N. Selvamurugan
Summary: In this study, the authors investigated the role of PTH-responsive miR-290 in the regulation of Runx2-mediated MMP-13 expression in rat osteoblastic cells. The results suggested that miR-290 may serve as a molecular marker or target for bone and bone-related diseases.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Materials Science, Biomaterials
Soubhagya Attayil Sukumaran, Balagangadharan Kalimuthu, Nagarajan Selvamurugan, Prabaharan Mani
Summary: The microporous films composed of chitosan, gelatin and magnesium oxide nanoparticles demonstrated improved swelling behavior, mechanical strength, antimicrobial activity, biocompatibility, bioactivity, and cell migration ability, making them a potential dermal substitute for wound healing applications.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Review
Biochemistry & Molecular Biology
S. Pranav Adithya, K. Balagangadharan, N. Selvamurugan
Summary: In bone biology, epigenetics and histone modifications play a crucial role in the commitment and differentiation of mesenchymal stem cells towards osteoblasts. Understanding the importance of histone modifications in osteogenesis can lead to the development of epigenetic-based therapies for genetic bone disorders. This review highlights the significance of epigenetic modifications, including post-translational modifications of histones, in regulating gene expression during osteoblast differentiation and discusses future advancements in the field of epigenetics for orthopaedic therapeutics.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
R. Mohanapriya, R. L. Akshaya, N. Selvamurugan
Summary: Osteoblast differentiation is a crucial process in skeletal development and bone remodeling, and its regulation involves various non-coding RNAs. Circular RNAs and microRNAs can directly or indirectly regulate the expression of osteoblast marker genes and interact with mRNAs. Understanding these regulatory mechanisms can provide valuable insights for diagnosing and treating bone and bone-related disorders.
Article
Biochemistry & Molecular Biology
Kanagaraj Gomathi, Muthukumar Rohini, Nicola C. Partridge, Nagarajan Selvamurugan
Summary: This study demonstrated the transcriptional regulation of MMP13 by TGF-beta 1 via Runx2 acetylation in rat osteoblastic cells, contributing to the knowledge of events presiding bone metabolism.
BIOLOGICAL CHEMISTRY
(2022)
Review
Biochemical Research Methods
Dharmaraj Saleth Sidharthan, Ranganathan Abhinandan, Kalimuthu Balagangadharan, Nagarajan Selvamurugan
Summary: The dynamic biology of bone provides abundant biomolecular targets, where delivery of nucleic acids can enhance regeneration. Advances in nanomaterials offer effective transfection tools, while CRISPR and DNA nanostructures show great potential in regenerative medicine.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Engineering, Biomedical
A. S. Soubhagya, K. Balagangadharan, N. Selvamurugan, D. Sathya Seeli, M. Prabaharan
Summary: A novel type of porous three-dimensional film CCMPBG was fabricated using the freeze-drying method, showing improved biocompatibility, antimicrobial activity and wound closure ability, making it an effective dressing material for wound therapy.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2022)
Article
Cell Biology
R. Hari Krishnan, Lakshana Sadu, Udipt Ranjan Das, Sneha Satishkumar, S. Pranav Adithya, I Saranya, R. L. Akshaya, N. Selvamurugan
Summary: This review article introduces the function of p300 in osteoblast differentiation. As a factor with histone acetyltransferase activity, p300 plays an important role in regulating histones and transcription factors. The article also highlights the regulation of p300 at posttranscriptional and non-coding RNA levels, which may have an indirect influence on bone formation.
Review
Cell & Tissue Engineering
Aarkampoondi Elumalai Purushothaman, Ranganathan Abhinandan, Senthilkumar Pranav Adithya, Dharmaraj Saleth Sidharthan, Kalimuthu Balagangadharan, Nagarajan Selvamurugan
Summary: Bone tissue engineering (BTE) involves using different biomaterials, cells, and bioactive molecules to generate biosynthetic grafts for bone regeneration. Electrospinning has been employed to create fibrous scaffolds with nanoscale architecture, mimicking natural tissues and promoting the formation of functional tissues. These electrospun fibers, primarily made from polymers and bioceramics, are loaded with bioactive molecules that influence stem cell differentiation towards osteoblasts, thus aiding in bone tissue regeneration. This review provides an overview of the current development of polymers and bioceramic-based electrospun fibers and their interaction with bioactive molecules for bone tissue regeneration.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Lakshana Sadu, R. Hari Krishnan, R. L. Akshaya, Udipt Ranjan Das, Sneha Satishkumar, N. Selvamurugan
Summary: Exosomes play a crucial role in bone remodeling and breast cancer bone metastasis, and have the potential to serve as biomarkers or delivery vehicles for the diagnosis and treatment of breast cancer bone metastasis.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ganesh Harini, S. Shree Ganesh, Ramprasad Anushikaa, Ramanathan Bharathi, Sankaranarayanan Aravind, Kumari Vatsala, Abinaya Shanmugavadivu, Nagarajan Selvamurugan
Summary: This study evaluated the anticancer effect of veratric acid (VA) on highly invasive triple-negative breast cancer (TNBC), using polydopamine nanoparticles (nPDAs) as a drug carrier for sustained release. The pH-sensitive nano-formulations of VA-loaded nPDAs showed good colloidal stability and sustained release, targeting tumor cells. The VA-nPDAs exhibited higher antiproliferative effects and induced apoptosis in MDA-MB-231 cells compared to free VA, indicating the potential of VA as an anticancer agent.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Materials Science, Multidisciplinary
Ganesh Harini, Ramanathan Bharathi, Aravind Sankaranarayanan, Abinaya Shanmugavadivu, Nagarajan Selvamurugan
Summary: In recent years, the use of nanomaterials in tissue engineering has increased significantly. Nanostructured scaffolds with cells provide a supportive environment similar to natural bone microarchitecture and regulate cell functions for tissue development. Chitosan, a promising biomaterial, has remarkable qualities but lacks mechanical strength. Combinations of chitosan with other biomaterials, such as bioceramics, can overcome this limitation. The review article discusses the use of bioinert, bioresorbable, and bioactive nanoceramics-reinforced chitosan scaffolds in bone tissue engineering and highlights their advantages and challenges in bone defect regeneration.
MATERIALS ADVANCES
(2023)
Review
Chemistry, Multidisciplinary
Aravind Sankaranarayanan, Anushikaa Ramprasad, S. Shree Ganesh, Harini Ganesh, Bharathi Ramanathan, Abinaya Shanmugavadivu, Nagarajan Selvamurugan
Summary: Nanogels are hydrogel nanoparticles with porous structure, combining the advantages of hydrogels and nanoparticles. They have attracted attention in bone tissue engineering for growth factor transport and cell adhesion. Nanogels can encapsulate various drugs, enhance their stability, and hinder enzymatic breakdown. They act as carriers for controlled release, mechanical support, and osteogenesis in bone tissue regeneration. This review highlights the potential of nanogel-based scaffolds in bone tissue engineering.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)