Article
Nutrition & Dietetics
Yang Yang, Jihong Li, Qing Hong, Xuehong Zhang, Zhenmin Liu, Tiehua Zhang
Summary: Five fractions of polysaccharides from Hericium erinaceus were obtained through column chromatography, with HEP-1 showing significant immunostimulatory effects by promoting the production of various immune-related molecules via multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Xiaopan Liu, Zhe Ren, Ruihong Yu, Shixiong Chen, Junwen Zhang, Yongde Xu, Zhen Meng, Yang Luo, Weini Zhang, Yifan Huang, Tao Qin
Summary: The study demonstrated that enzymatic modification is an effective method to enhance the activity of Hericium erinaceus polysaccharide (HEP). The enzymatic hydrolysis product can enhance the activation of peritoneal macrophages and improve the immunomodulatory function of HEP, showing potential applications in the pharmaceutical and cosmeceutical industry.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Wenji Hu, Minkai Song, Chunyue Wang, Ziang Guo, Yu Li, Di Wang
Summary: Purified polysaccharides from Hericium erinaceus fermented mycelium, known as PHEB, showed significant improvement in cognitive behavior of AD mice by alleviating oxidative stress through Nrf2 regulation. Furthermore, PHEB regulated calcium homeostasis in the brain by modulating CaMK II/IV, ultimately exhibiting anti-AD properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Weijun Cui, Xinling Song, Xueping Li, Le Jia, Chen Zhang
Summary: A low molecular weight polysaccharides, HEP-1, was isolated and characterized from the fruiting body of Hericium erinaceus. HEP-1 showed potential effects against T2DM-induced imbalance of glucose and lipid metabolism by activating the IRS/PI3K/AKT signaling pathway and inhibiting fatty acid synthesis via the AMPK/SREBP-1c signaling pathways. Moreover, HEP-1 promoted the production of beneficial bacteria in the gut and increased beneficial metabolites in the liver, thus resisting the occurrence of T2DM through the gut-liver axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Shang-Yu Yang, Chi-Jung Fang, Yu-Wen Chen, Wan-Ping Chen, Li-Ya Lee, Chin-Chu Chen, Yen-You Lin, Shan-Chi Liu, Chun-Hao Tsai, Wei-Chien Huang, Yang-Chang Wu, Chih-Hsin Tang
Summary: Hericium erinaceus mycelium has therapeutic effects on knee osteoarthritis, including relieving pain, reducing articular cartilage degradation and bone erosion, and inhibiting the synthesis of proinflammatory cytokines. Therefore, it shows promise as a functional food for the treatment of osteoarthritis.
Article
Biochemistry & Molecular Biology
Jian-Qiu Tu, Hui-Ping Liu, Ya-Hui Wen, Pei Chen, Zi-Tian Liu
Summary: A novel polysaccharide fraction (HEP) from Hericium erinaceus was isolated, characterized, and found to possess antioxidant activities. Its composition and properties suggest its potential as a natural antioxidant component, showing similar efficacy to Vitamin C.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Applied
Yang Yang, Haiqing Ye, Changhui Zhao, Li Ren, Cuina Wang, Milen Georgiev, Jianbo Xiao, Tiehua Zhang
Summary: Hericium erinaceus polysaccharides (HEPs) were found to significantly alter the diversity and abundance of gut microbiota by increasing the relative abundance of beneficial bacteria and decreasing harmful bacteria. HEPs also exhibited immunomodulatory activity by promoting the production of various immune factors and activating specific signaling pathways, suggesting their potential as functional ingredients or foods for promoting health.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Guangbo Xie, Lan Tang, Yu Xie, Liyuan Xie
Summary: This study discovered new secondary metabolites of Hericium erinaceus, including a new compound erinarol K and eleven known compounds. The anti-inflammatory effects of these compounds were evaluated, and two compounds showed moderate activity.
Article
Biochemistry & Molecular Biology
Guangming Chen, Nan Jiang, Junping Zheng, Haiming Hu, Huabing Yang, Aizhen Lin, Baifei Hu, Hongtao Liu
Summary: In this study, two homogeneous polysaccharides (APS-A1 and APS-B1) were isolated from Astragalus membranaceus and their chemical structures were characterized. APS-A1 had a 1,4-alpha-D-Glcp backbone with a 1,4,6-alpha-D-Glcp branch every ten residues, while APS-B1 was a heteropolysaccharide composed of glucose, galactose, and arabinose. Bioactivity assays showed that both APS-A1 and APS-B1 exhibited potential anti-inflammatory activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Farida Tripodi, Ermelinda Falletta, Manuela Leri, Cristina Angeloni, Daniela Beghelli, Laura Giusti, Riccardo Milanesi, Belem Sampaio-Marques, Paula Ludovico, Lorenzo Goppa, Paola Rossi, Elena Savino, Monica Bucciantini, Paola Coccetti
Summary: The aqueous extracts of medicinal mushrooms G. frondosa and H. erinaceus have anti-aging and neuroprotective effects, making them potential functional foods for preventing aging and age-related disorders.
Article
Biochemistry & Molecular Biology
UnHak Pak, Hao Cheng, Xianbin Liu, Yuwen Wang, ChungHyok Ho, HyonIl Ri, Jing Xu, Xiaodan Qi, Haitao Yu
Summary: In this study, we isolated and characterized a pectic polysaccharide, WSMP-A2b, from Swertia mileensis. WSMP-A2b is mainly composed of RG-I, RG-II, and HG domains, with a mass ratio of 2.1:1.0:2.2. WSMP-A2b exhibited strong antioxidant activity, potentially attributed to its high galacturonic acid content. Moreover, WSMP-A2b showed protective effects against oxidative stress in INS-1 cells by reducing ROS production and increasing the GSH/GSSG ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Chuanli Hou, Liangyun Liu, Jiaoyan Ren, Min Huang, Erdong Yuan
Summary: Research found that the mycelium polysaccharide (HMP) from Hericium erinaceus had a more uniform distribution compared to the fruiting body polysaccharide (HFP), with HMP also showing greater conformational stability. Both HMP and HFP exhibited protective effects against ethanol-induced gastric mucosal injury, but HMP had better activity than HFP.
Review
Biochemistry & Molecular Biology
Izabela Szucko-Kociuba, Alicja Trzeciak-Ryczek, Patrycja Kupnicka, Dariusz Chlubek
Summary: Hericium erinaceus, a valuable mushroom, has strong bioactive properties and potential as a neuroprotective agent. Its active compounds have protective effects on the nervous system, and further research and standardization processes are crucial for ensuring the effectiveness and safety of dietary supplements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Wenbing Gong, Xiaoya Song, Chunliang Xie, Yingjun Zhou, Zuohua Zhu, Chao Xu, Yuande Peng
Summary: This study investigated the crossover distribution and genetic factors in Hericium erinaceus, revealing that crossover events are more likely to occur in genic regions and are associated with increased gene density and GC content. QTL mapping identified that crossover variations are shaped by multiple small-effect loci, with individual QTL contributing 6.9%-11.7% of the variation.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Food Science & Technology
Pin Gong, Mengrao Wang, Yuxi Guo, Hui Long, Zhineng Wang, Dandan Cui, Wenbo Yao, Wenjuan Yang, Fuxin Chen, Jianwu Xie
Summary: A natural polysaccharide named SGP-1 was discovered from Siraitia grosvenorii, with a purity of 96.83%. The sulfated derivative S-SGP of SGP-1 was prepared and analyzed, showing spherical structures and strong intermolecular forces. The sulfated derivative exhibited antioxidant activity and inhibited the growth of several cancer cell lines in vitro, while also inducing apoptosis and altering the expression of apoptosis-related molecules in lung cancer cells.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)