Article
Nanoscience & Nanotechnology
Yuanhui Long, Yue Feng, Yunqing He, Binghong Luo, Mingxian Liu
Summary: This study developed a multifunctional nanoplatform using halloysite nanotubes for chemo/photothermal therapy in breast cancer. The nanoplatform showed high drug encapsulation efficiency and superior photothermal capability, effectively inhibiting cancer cell growth.
ACS APPLIED NANO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jie Zheng, Bingzhi Li, Yuan Ji, Yin Chen, Xun Lv, Xing Zhang, Robert J. Linhardt
Summary: Natural active polysaccharides are gaining attention in pharmaceutical industries for their biological activities, while metal-organic frameworks (MOFs) help deliver cargo to specific locations, protecting drugs and improving therapeutic effectiveness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Lichuan Tan, Guangsong Yuan, Peng Wang, Siwen Feng, Yan Tong, Cuijuan Wang
Summary: In this study, we report a novel biocomposite material (Ag-Phy@ZIF-8) that encapsulates silver nanoparticles and physcion in Zeolitic imidazolate framework-8. This material exhibits controlled release properties in a micro-acidic environment and, after modification with hyaluronate, shows strong inhibitory effects on bacterial growth without impacting cell growth, demonstrating good biocompatibility. These pH-responsive biocomposites have the potential to be used as smart wound dressings for the treatment of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biophysics
Shaoxuan Yu, Shanyu Wang, Zhike Xie, Shuyan Yu, Ling Li, Haifang Xiao, Yuanda Song
Summary: The study successfully synthesized Cur-loaded and HA-coated ZIF-8 nanoparticles, which showed better stability and anticancer activities in breast cancer therapy, with a greater inhibitory effect on breast cancer and potential as an effective agent.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Multidisciplinary Sciences
Weenawan Somphon, Arthorn Loisruangsin
Summary: The successful encapsulation of two model drugs in ZIF-8 using the one-pot method is reported in this study. The addition of chitosan or beta-cyclodextrin into the drug encapsulation process was also investigated. Experimental characterization and computational analysis were conducted to understand the drug loading and release mechanisms. The properties of the coating materials and the interaction between the drugs and other components play a crucial role in drug loading and release.
Article
Chemistry, Analytical
Tao Yao, Jiejie Feng, Changshun Chu, Zhanfang Ma, Hongliang Han
Summary: A novel cascade controlled release system was proposed for the electrochemical detection of tumor marker, utilizing pH-responsive ZIF-8 capsule and enzyme-responsive hyaluronic acid hydrogel. This system showed excellent analytical performance with a wide range and ultralow detection limit, opening up new perspectives for controlled release systems in electrochemical sensing applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biotechnology & Applied Microbiology
Guanqun Ju, Bing Liu, Mingfei Ji, Rui Jin, Xiaojian Xu, Yongshuang Xiao, Jie Li, Dongliang Xu, Yuhua Huang, Jianquan Hou
Summary: miR-491-5p regulates the development of CRPC by targeting EPHX1, and the synthesized nanodrug carrier effectively inhibits the proliferation and migration of CRPC cells, providing a promising treatment strategy for CRPC.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
Kai Wang, Yali Xue, Jianjian Lin, Jun Yu, Qimeng Wang, Zhiying Xie, Haizhou Yu, Xiaoyan Qiu
Summary: A biocompatible porous material, ZMDPCs, based on ZIF-8 is designed with ordered topology and dual responsive surfaces to address the challenges of dosage limitation, toxicity, and intelligent responsiveness. The high loading capacity is achieved through the large specific surface area and hierarchical pores. Polydopamine decoration enhances biocompatibility, and it can trigger the phase transition of PCM (a thermal response valve) through NIR irradiation. Drug release can be controlled by NIR or pH stimulation. With its biocompatibility, degradability, and responsive surfaces, ZMDPCs show promising potential as a drug delivery vehicle.
SURFACES AND INTERFACES
(2023)
Article
Materials Science, Coatings & Films
Runjia Liu, Yan Liu, Qiwen Yong, Zhi-Hui Xie, Liang Wu, Chuan-Jian Zhong
Summary: The long-term corrosion resistance of conventional micro-arc oxidation (MAO) coatings on magnesium alloy is limited by the inherent micro-scale pores. Zeolitic imidazolate framework-8 (ZIF-8) and zinc gluconate (ZnG) loaded ZIF-8 (ZnG@ZIF-8) were synthesized and incorporated into the MAO coating to enhance the corrosion resistance. The (ZIF-8 + ZnG@ZIF-8)/MAO composite coating showed significant improvement in corrosion protection compared to the blank MAO coating.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yongchao Jiang, Yingying Guo, Haonan Wang, Xiaofeng Wang, Qian Li
Summary: A double-layered hydrogel coating with spatiotemporal drug release capacity was applied on a poly-caprolactone (PCL) fibrous scaffold to promote quick endothelialization on vascular grafts. The composite coating consisted of dopamine-modified hyaluronic acid (HA) hydrogel and gelatin hydrogel, with heparin and chondroitin sulfate introduced for drug release behavior. The coating improved the surface properties of the PCL scaffold and enhanced endothelial cell proliferation and angiogenesis behaviors. In vitro tests confirmed the long-term anticoagulation property of the modified scaffold. This research provides a universal strategy for promoting endothelialization and anticoagulation in vascular grafts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaodong Sun, Maryam Keywanlu, Reza Tayebee
Summary: In the treatment of epilepsy, ZIF nanoparticles show potential in improving drug efficacy and reducing side effects. By loading common antiepileptic drugs into ZIF-8 and conducting release experiments, ZIF-8 was found to be an effective drug carrier. Additionally, through MTT experiments, the cytotoxicity of Gabapentin-ZIF-8 on cancer cells was confirmed.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ruiying Zou, Yuanfeng Wei, Weijian Yang, Yuxin Li, Hongyu Lv, Jing Zhao, Chengbin Liu
Summary: A new sustainable biocomposite nanofiber mat, called ZIF-8@PLA/NFM, was developed for the removal of As(III) contamination. The mat demonstrated fast kinetics and high utilization of ZIF-8 nanoparticles for effective As(III) removal, especially in combination with H2O2. The study provides a novel and efficient approach for As(III) decontamination using MOFs-based biocomposites.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Engineering, Environmental
Xiaolin Zhang, Xiangang Hu, Hao Wu, Li Mu
Summary: This study reveals the significant impacts of ZIFs on algae, showing that the effects are reversible. Different types of ZIFs (such as ZIF-8 and ZIF-67) induce toxicity effects and are internalized differently, while factors related to oxidative phosphorylation are crucial for the persistence of plant toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunbo Zhao, Hongshui Wang, Xianrui Zou, Donghui Wang, Ying Fan, Xiaoyan Zhao, Mingjun Li, Lei Yang, Chunyong Liang
Summary: By loading the antibacterial drug vancomycin into zeolitic imidazolate framework-8 (ZIF-8) and preparing it into polyvinyl alcohol (PVA) fiber membrane through electrospinning, a composite bone filler with antibacterial and bone cell-promoting effects can be obtained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Juan-Ding Xiao, Qing-Nan Wang, Zhen-Dong Feng, Shan Tang, Yan Liu, Can Li
Summary: This study demonstrates the tuning of the acid-base property of MOF materials by changing the calcination temperature. The catalysts exhibited superior catalytic activity when calcined at 610 degrees C, showing synergistic effects between acid and base sites.
JOURNAL OF CATALYSIS
(2022)
Article
Engineering, Environmental
Zehao Li, Yinyin Liu, Shuiyang Zou, Chunbo Lu, Hu Bai, Haibo Mu, Jinyou Duan
CHEMICAL ENGINEERING JOURNAL
(2020)
Article
Chemistry, Applied
Chunbo Lu, Yao Xiao, Yinyin Liu, Feifei Sun, Yuanhao Qiu, Haibo Mu, Jinyou Duan
CARBOHYDRATE POLYMERS
(2020)
Article
Nanoscience & Nanotechnology
Yao Xiao, Chunbo Lu, Yinyin Liu, Lili Kong, Hu Bai, Haibo Mu, Zehao Li, Huiling Geng, Jinyou Duan
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Biochemistry & Molecular Biology
Yuanhao Qiu, Dan Xu, Guoqing Sui, Dongdong Wang, Ming Wu, Lipeng Han, Haibo Mu, Jinyou Duan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Yifan Chang, Yu Yang, Ningning Xu, Haibo Mu, Hongli Zhang, Jinyou Duan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Nanoscience & Nanotechnology
Xinling Wang, Zehao Li, Yi Wu, Hongran Guo, Xiaoli Zhang, Yuxin Yang, Haibo Mu, Jinyou Duan
Summary: The study presents a chitosan/gelatin-based IPN sponge incorporated with melanin-coated titania hollow nanospheres as a solar thermal converter, enhancing steam generation performance and inhibiting bacteria growth. This advanced sponge demonstrates excellent photothermal conversion efficiency and provides a novel approach for solar-driven wastewater treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
Qianqian Chu, Bin Zhang, Zhipeng Yang, Huifang Zhou, Haibo Mu, Wenyan Zhang, Bo Liu, Yao-Yu Wang
Summary: A novel indium pyridylcarboxylate framework with large void space was synthesized, showing high adsorption selectivity and capacity for cationic dyes in aqueous solution, as well as selectivity and sensitivity to nitenpyram with good recyclability in terms of luminescence performance.
INORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Xinling Wang, Zehao Li, Yu Zhang, Qiulei Li, Huan Du, Fang Liu, Xiaoli Zhang, Haibo Mu, Jinyou Duan
Summary: Efficient and recyclable CoFe2O4/CoFe2S4/MgBi2O6 (CFO/CFS/MBO) magnetic fibers (MNFs) photocatalyst with p-n-p type heterojunction were prepared by a simple hydrothermal method. The photocatalyst showed high antibacterial activity against MRSA and degradation efficiency towards CTX under visible light irradiation, displaying promising applications in wastewater treatment.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Peng Jiang, Lijie Huang, Junjie Wang, Qiulei Li, Haibo Mu
Summary: This study develops a biocompatible wound dressing by incorporating SBO, which has excellent photothermal performance, into an antibacterial hydrogel. The prepared gel exhibits potent broad-spectrum bactericidal activities and accelerates wound healing in mice infected with drug-resistant bacteria. This is the first report of SBO as a photothermal agent applied in anti-infection treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Mathematical & Computational Biology
Fang Liu, Xing Wang, Lijie Huang, Xinling Wang, Lili Kong, Jinyou Duan, Xiaoli Zhang, Haibo Mu, Jianguo He
Summary: In vitro experiments demonstrated that lysozyme has both antibacterial and antibiofilm activities against Gram-positive bacteria, especially methicillin-resistant Staphylococcus aureus (MRSA).
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Junjie Wang, Yu Yang, Lijie Huang, Lili Kong, Xing Wang, Jingru Shi, Yinghua Lu, Haibo Mu, Jinyou Duan
Summary: A responsive chitosan-based hydrogel was developed to improve the antimicrobial effect and accelerate wound healing by sustainably releasing vancomycin locally.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lijie Huang, Junjie Wang, Lili Kong, Xing Wang, Qiulei Li, Lingjiao Zhang, Jingru Shi, Jinyou Duan, Haibo Mu
Summary: Probiotics are commonly used in inflammatory bowel disease, but their effectiveness is limited by low survival rate and short retention time. To address this issue, researchers developed a ROS-responsive hydrogel based on hyaluronic acid for encapsulation and targeted delivery of probiotics. The hydrogel improved the survival rate of encapsulated probiotics in simulated digestive conditions and selectively released them at inflammation sites. Animal experiments showed that hydrogel-encapsulated probiotics significantly alleviated symptoms and improved survival rate in mice with colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yuanhao Qiu, Kun Shang, Ningning Xu, Peng Chen, Huashan Gao, Haibo Mu, Wenpo Feng, Jinyou Duan
Summary: A novel amphipathic micelle (HATAD-TCS) consisting of hyaluronic acid-derivative and antibacterial agent triclosan was developed, which can kill bacteria and maintain intracellular ROS levels. In a mouse pneumonia model, the HATAD-TCS micelles showed promising therapeutic effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Peng Chen, Maofang Hei, Lili Kong, Yinyin Liu, Yu Yang, Haibo Mu, Xiuyun Zhang, Shanting Zhao, Jinyou Duan
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
