Journal
CLINICAL AND EXPERIMENTAL NEPHROLOGY
Volume 21, Issue 1, Pages 1-6Publisher
SPRINGER
DOI: 10.1007/s10157-016-1247-y
Keywords
Notch; Podocyte; Proteinuria; Glomerulosclerosis; Apopotosis
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [26670431]
- Grants-in-Aid for Scientific Research [26670431] Funding Source: KAKEN
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The Notch signaling pathway is a basic cell-to-cell communication mechanism. This pathway is activated by the interaction between Notch receptors and the ligands of adjacent cells. Once activated, Notch receptors are cleaved and the intracellular domains translocate into the nucleus, where the transcription of target genes starts. In the mammalian kidney, Notch receptors are activated during nephrogenesis. Afterwards, in the mature glomeruli, the Notch pathway becomes silent. However, many researchers have reported the activation of Notch receptors in mature podocytes under pathological conditions. In this review, we discuss the role of Notch signaling in podocytes.
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