☆ 4.6 Letter

The negative impact of comorbidities on the disease course of COVID-19

INTENSIVE CARE MEDICINE (2020)

Journal

INTENSIVE CARE MEDICINE

Volume 46, Issue 9, Pages 1784-1786

Publisher

SPRINGER

DOI: 10.1007/s00134-020-06161-9

Keywords

-

Categories

Critical Care Medicine

Funding

European Union (European Regional Development Fund) [EFOP-3.6.2-16-2017-0006 -LIVE LONGER]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Public, Environmental & Occupational Health

The Negative Impact of COVID-19 on Life Insurers

Xun Zhang, Pu Liao, Xiaohua Chen

Summary: This study proposed a temporary adverse mortality jump model to analyze the impact of COVID-19 on the financial sustainability of life insurers. By comparing the mortality, survival probability, and liability of life insurers considering and not considering COVID-19, it was found that the financial sustainability of life insurers deteriorates due to higher mortality rates than expected after COVID-19 outbreak.

FRONTIERS IN PUBLIC HEALTH (2021)

Add to Collection

Article Immunology

High Number and Specific Comorbidities Could Impact the Immune Response in COVID-19 Patients

Dafeng Liu, Xiaoyan Yuan, Fengjiao Gao, Bennan Zhao, Ling Ding, Mingchang Huan, Chao Liu, Liangshuang Jiang

Summary: This study found that comorbidities have a significant impact on cellular immunity in COVID-19 patients, with specific comorbidities such as cancer and cardiovascular diseases showing specific associations with lymphocyte counts and subsets.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Impact of smoking, COPD and comorbidities on the mortality of COVID-19 patients

Donato Lacedonia, Giulia Scioscia, Carla Santomasi, Paolo Fuso, Giovanna Elisiana Carpagnano, Andrea Portacci, Franco Mastroianni, Giovanni Larizza, Eugenio Sabato, Emanuela Profilo, Emanuela Resta, Maria Pia Foschino Barbaro, Onofrio Resta

Summary: This study found that the prevalence of COPD and current smokers among COVID-19 patients was not high, suggesting they were not at increased risk of infection. However, once infected, COPD patients and former smokers had the highest all-cause mortality, primarily due to the presence of comorbidities.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

The impact of comorbidities and COVID-19 on the evolution of community onset sepsis

Giovanna Colantuono de Araujo, Andrea Pardini, Camila Lima

Summary: Despite advances in diagnostic procedures and therapeutic strategies, sepsis remains a disease with high mortality and morbidity. This retrospective, multicenter study evaluated the profile and outcomes of community-onset sepsis from January 2018 to December 2021. The study included 2630 patients diagnosed with sepsis or septic shock, with 43.76% admitted to the intensive care unit, 12.2% mortality rate, and 4.1% having sepsis and 30% having septic shock. Comorbidities such as chronic kidney disease on dialysis (CKD-d), bone marrow transplantation, and neoplasia were independent predictors of septic shock and mortality. COVID-19 infection as the primary focus was an independent predictor of mortality in patients with sepsis.

SCIENTIFIC REPORTS (2023)

Add to Collection

Review Immunology

COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes

Banafsheh Bigdelou, Mohammad Reza Sepand, Sahar Najafikhoshnoo, Jorge Alfonso Tavares Negrete, Mohammed Sharaf, Jim Q. Ho, Ian Sullivan, Prashant Chauhan, Manina Etter, Tala Shekarian, Olin Liang, Gregor Hutter, Rahim Esfandiarpour, Steven Zanganeh

Summary: The interactions between COVID-19 and co-existing diseases have significant implications for clinical outcomes. Co-existing diseases make patients more vulnerable to severe consequences from COVID-19, highlighting the importance of further research for the optimal management of patients with comorbidities.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Medicine, General & Internal

The Impact of Cardiovascular Risk Factors on the Course of COVID-19

Katarzyna Wilk-Sledziewska, Piotr Jan Sielatycki, Natalia Uscinska, Elzbieta Bujno, Mariusz Rosolowski, Katarzyna Kakareko, Rafal Sledziewski, Alicja Rydzewska-Rosolowska, Tomasz Hryszko, Edyta Zbroch

Summary: This study aims to review the impact of cardiovascular risk factors on the course and mortality of COVID-19 infection. The findings suggest a strong correlation between risk factors such as obesity, diabetes, lipid profile, hypertension, and smoking with severe clinical complications and death in COVID-19 patients. These risk factors are widespread and pose a significant global health problem.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Medicine, General & Internal

Negative Impact of the COVID-19 Pandemic on Kidney Disease Management-A Single-Center Experience in Romania

Adrian Vasile Muresan, Eliza Russu, Emil Marian Arbanasi, Reka Kaller, Ioan Hosu, Eliza Mihaela Arbanasi, Septimiu Toader Voidazan

Summary: The COVID-19 pandemic has negatively impacted the outcomes and treatment of nephrology patients, leading to changes in the workload of the nephrology department. During the pandemic, there was a significant increase in dialysis sessions and hospitalization days, while the number of one-day hospitalizations decreased.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Allergy

Preexisting comorbidities shape the immune response associated with severe COVID-19

Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolas Gonzalo Nunez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Gopel, Peter Rosenberger, Helene A. Haberle, Ikram Ayoub, Sally Al-Hajj, Manfred Claassen, Roland Liblau, Guillaume Martin-Blondel, Michael Bitzer, Antoine Roquilly, Burkhard Becher

Summary: This study investigated the complex interactions between comorbidities, immune response, and patient outcomes in COVID-19. The researchers discovered characteristic immune signatures associated with severe COVID-19 and underlying medical conditions. They found that different factors of the metabolic syndrome affected distinct immune populations, and comorbidities such as lung or heart diseases were clustered together with metabolic syndrome factors. Chronic kidney disease in COVID-19 patients was characterized by the highest number of altered immune signatures. Overall, this study provided mechanistic insights into the immunologic underpinnings of comorbidity-driven patient risk in COVID-19.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Impact of comorbidities on hospitalised Syrian patients with COVID-19: a retrospective study

Michel Najjar, Sara Albuaini, Mohammad Fadel, Ahmad Aljbawi, Yara AlAwad, Fatema Mohsen

Summary: This study compared the clinical manifestations, laboratory findings, outcomes, and overall survival time of COVID-19 patients with and without comorbidities. The results showed that patients with comorbidities were more susceptible to poor outcomes such as severe infection, severe complications, mechanical ventilation usage, and death.

BMJ OPEN (2023)

Add to Collection

Review Physiology

Sequelae and Comorbidities of COVID-19 Manifestations on the Cardiac and the Vascular Systems

Yashvardhan Batta, Cody King, John Johnson, Natasha Haddad, Myriam Boueri, Georges Haddad

Summary: COVID-19 patients with pre-existing cardiovascular conditions face greater risks of severe illness, including hypertension, cardiac arrhythmias, and hypercoagulation. Age is a significant prognostic indicator, with elderly patients, especially those with cardiovascular comorbidities, being at increased risk of critical cases and higher case fatality rates. Further research on the interactions between SARS-CoV-2 and the cardiovascular system is essential for improving clinical outcomes.

FRONTIERS IN PHYSIOLOGY (2022)

Add to Collection

Article Cell Biology

Age cohorts stratified according to age-distributions of COVID-19 lymphocytopenia in COVID-19 patients without comorbidities on admission

Shengwei Jin, Hui An, Tong Zhou, Ting Li, Chengshui Chen, Binyu Ying, Zhangye Xu, Xiaokun Li, Ming Li

Summary: In a retrospective study of 447 patients, age-dependent immune features of COVID-19 were observed, with CD8(+) T cell counts being significantly decreased in an age-dependent manner and plasma C-reactive protein concentrations increasing with age.

AGING-US (2021)

Add to Collection

Article Multidisciplinary Sciences

Estimating the impact of COVID-19 vaccine inequities: a modeling study

Nicolo Gozzi, Matteo Chinazzi, Natalie E. Dean, Ira M. M. Longini Jr, M. Elizabeth Halloran, Nicola Perra, Alessandro Vespignani

Summary: Global COVID-19 vaccine distribution has been inequitable, leading to significant disparities in access. A study using mathematical modelling estimates that over 50% of deaths in selected low and lower-middle-income countries could have been prevented if vaccines had been more widely available early on. Even with similar access to vaccines as high-income countries, a considerable proportion of deaths could still have been averted. Lack of vaccine availability would require additional non-pharmaceutical interventions to reduce transmission.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Psychiatry

Negative Appraisals of the COVID-19 Social Impact Associated With the Improvement of Depression and Anxiety in Patients After COVID-19 Recovery

Wentao Chen, Yumeng Ju, Bangshan Liu, Mei Huang, Aiping Yang, Yun Zhou, Mi Wang, Mei Liao, Kongliang Shu, Jiyang Liu, Yan Zhang

Summary: This study found a significant decrease in anxiety and depression levels in COVID-19 patients after discharge. Changes in the social impact of COVID-19 may play a key role in improving depression and anxiety symptoms in infected patients.

FRONTIERS IN PSYCHIATRY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

International Impact of COVID-19 on the Diagnosis of Heart Disease

Andrew J. Einstein, Leslee J. Shaw, Cole Hirschfeld, Michelle C. Williams, Todd C. Villines, Nathan Better, Joao V. Vitola, Rodrigo Cerci, Sharmila Dorbala, Paolo Raggi, Andrew D. Choi, Bin Lu, Valentin Sinitsyn, Vladimir Sergienko, Takashi Kudo, Bjarne Linde Norgaard, Pal Maurovich-Horvat, Roxana Campisi, Elisa Milan, Lizette Louw, Adel H. Allam, Mona Bhatia, Eli Malkovskiy, Benjamin Goebel, Yosef Cohen, Michael Randazzo, Jagat Narula, Thomas Nb Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez

Summary: The COVID-19 pandemic has significantly reduced cardiovascular diagnostic testing globally, especially affecting economically challenged regions. Further research on cardiovascular outcomes and changes in care delivery due to COVID-19 is needed.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Add to Collection

Article Green & Sustainable Science & Technology

The negative impact of the COVID-19 on renewable energy growth in developing countries: Underestimated

Shuyu Li, Qiang Wang, Xue-ting Jiang, Rongrong Li

Summary: This study redesigned the analytical framework for assessing the impact of the COVID-19 pandemic on renewable energy. The results showed a decline in renewable energy consumption in China and India, while the increase in renewable energy in the US was overestimated.

JOURNAL OF CLEANER PRODUCTION (2022)

Add to Collection

Article Gastroenterology & Hepatology

The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT): Protocol of a multicenter randomized controlled trial

Mark Felix Juhasz, Zsofia Vereczkei, Klementina Ocskay, Lajos Szako, Nelli Farkas, Zsolt Szakacs, Noemi Zadori, Michael Wilschanski, Stephen J. Pandol, Francisca Joly, Gabriele Capurso, Paolo Giorgio Arcidiacono, Ferenc Izbeki, Laszlo Czako, Maria Papp, Laszlo Czopf, Peter Hegyi, Andrea Parniczky

Summary: This study aims to test the effect of reducing dietary fat on the recurrence of idiopathic acute pancreatitis (AP), and collect data on mortality, serum lipids, and weight loss. There are currently no preventive measures for idiopathic acute recurrent pancreatitis (ARP), but a low-fat diet is often recommended.

PANCREATOLOGY (2022)

Add to Collection

Article Virology

Hepatitis C Screening and Treatment Program in Hungarian Prisons in the Era of Direct Acting Antiviral Agents

Klara Werling, Bela Hunyady, Mihaly Makara, Krisztina Nemesi, Gabor Horvath, Ferenc Schneider, Judit Enyedi, Zsofia Mueller, Miklos Lesch, Zoltan Peterfi, Tamas Toth, Judit Gacs, Zsuzsanna Feher, Eszter Ujhelyi, Emese Molnar, Anna Nemes Nagy

Summary: The voluntary hepatitis C virus screening and treatment program in Hungarian prisons achieved a high success rate in treating infected individuals, showing the efficacy and feasibility of the test-and-treat principle in micro-eliminating HCV in prisons with high infection rates and history of intravenous drug use.

VIRUSES-BASEL (2022)

Add to Collection

Review Cardiac & Cardiovascular Systems

Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta-Analysis

Orsolya Anna Simon, Aniko Gorbe, Peter Hegyi, Lajos Szako, Eduard Ostarijas, Fanni Dembrovszky, Szabolcs Kiss, Laszlo Czopf, Balint Eross, Imre Szabo

Summary: This study found an association between H. pylori infection and increased carotid intima-media thickness through a systematic review and meta-analysis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Add to Collection

Review Environmental Sciences

Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis

Krisztina Lantos, Zsuzsa Reka Domotor, Nelli Farkas, Szabolcs Kiss, Zsolt Szakacs, Andras Garami, Gabor Varga, Laszlo Lujber, Reem Kanaan, Peter Hegyi, Gergely Feher, Valeria Gaal

Summary: Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of permanent visual loss in adults. This study analyzed the efficacy of different therapeutic options and found that there is currently no effective treatment available.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Add to Collection

Review Biology

Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials

Aba Lorincz, Alex Varadi, Peter Hegyi, Zoltan Rumbus, Mate Tuba, Anna Gabriella Lamberti, Margit Varju-Solymar, Andrea Parniczky, Balint Eross, Andras Garami, Gergo Jozsa

Summary: This study conducted a meta-analysis to evaluate the effectiveness of different dressings for paediatric second-degree burn injuries. The results showed that biosynthetic, silver foam, and amnion membrane dressings were associated with faster healing times and reduced complication rates. The number of dressing changes also had an impact on pain, narcosis, and treatment duration. However, due to heterogeneity among studies, no significant difference was found in the main outcomes. Further research is needed to determine the most effective treatment for these burns.

LIFE-BASEL (2022)

Add to Collection

Article Oncology

Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors

Orsolya Juhasz, Noemi Jakob, Hajnalka Rajnai, Marcell Imrei, Miklos Garami

Summary: The study found that lower vitamin D receptor (VDR) expression is associated with worse prognosis in different types of childhood cancer. Identifying the VDR status provides clinicians with a valuable biomarker to guide additional therapy.

CANCERS (2022)

Add to Collection

Article Gastroenterology & Hepatology

Inflammatory bowel disease does not alter the clinical features and the management of acute pancreatitis: A prospective, multicentre, exact-matched cohort analysis

Dora Dohos, Nelli Farkas, Alex Varadi, Balint Eross, Andrea Parniczky, Andrea Szentesi, Peter Hegyi, Patricia Sarlos

Summary: No significant differences in prognosis and severity of acute pancreatitis were found between patients with both inflammatory bowel disease and pancreatitis only. Therefore, different acute pancreatitis management is unnecessary in the presence of inflammatory bowel disease, and antibiotic overuse should be avoided.

PANCREATOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

Topical pharmacotherapy for ocular surface squamous neoplasia: systematic review and meta-analysis

Kincso Kozma, Zsuzsa Reka Domotor, Adrienne Csutak, Laszlo Szabo, Peter Hegyi, Balint Eross, Zsuzsanna Helyes, Zsolt Molnar, Fanni Dembrovszky, Eszter Szalai

Summary: Surgical excision and topical pharmacotherapy (5-FU, IFN, or MMC) show comparable clinical outcomes, recurrence rates, and side effects in treating patients with OSSN.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Medicine, General & Internal

Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study

Noemi Zadori, David Nemeth, Levente Frim, Nora Vorhendi, Lajos Szako, Szilard Vancsa, Peter Hegyi, Jozsef Czimmer

Summary: Dyspeptic symptoms are common in the general population, resulting in a high socioeconomic burden. In patients with H. pylori negative chronic gastritis, there is a subset of patients who experience dyspeptic symptoms. Further investigation into the role of autoimmunity may help in developing optimal treatment strategies.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Add to Collection

Article Immunology

Adverse Reactions after Booster SARS-CoV-2 Vaccination Have Less Impact on Antibody Response than after Basic Vaccination Scheme

Andrea Kanizsai, Laszlo Zavori, Tihamer Molnar, Margit Tokes-Fuezesi, Zoltan Szalai, Janos Berecz, Reka Varnai, Zoltan Peterfi, Attila Schwarcz, Peter Csecsei

Summary: This study investigates the correlation between adverse reactions following booster vaccinations and subsequent antibody levels. It found that except for fever, adverse reactions after the booster dose were not positively correlated with antibody levels. Additionally, there were more symptomatic patients in the group receiving heterologous booster vaccine, and fever after the second dose was independently associated with a reduction in the likelihood of COVID-19 positivity after the booster dose.

VACCINES (2023)

Add to Collection

Review Biochemistry & Molecular Biology

No Association between Gastrointestinal Rebleeding and DOAC Therapy Resumption: A Systematic Review and Meta-Analysis

Daniel Palinkas, Brigitta Teutsch, Endre Botond Gagyi, Marie Anne Engh, Patricia Kallo, Daniel S. Veres, Laszlo Foldvari-Nagy, Nora Hosszufalusi, Peter Hegyi, Balint Eross

Summary: This study found that restarting DOACs after GIB did not significantly increase the risk of rebleeding. However, the quality of the studies was limited and higher quality randomized clinical trials are needed.

BIOMEDICINES (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Acute Phase Protein Orosomucoid (Alpha-1-Acid Glycoprotein) Predicts Delayed Cerebral Ischemia and 3-Month Unfavorable Outcome after Aneurysmal Subarachnoid Hemorrhage

Laszlo Zavori, Reka Varnai, Tihamer Molnar, Balazs Szirmay, Nelli Farkas, Attila Schwarcz, Peter Csecsei

Summary: This study found that early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) affects the level of orosomucoid (ORM). Serum ORM levels can serve as a marker for assessing the extent of EBI-induced damage and are associated with delayed cerebral ischemia (DCI) and unfavorable long-term functional outcomes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Nutrition & Dietetics

Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients

Nora Karasz, Orsolya Juhasz, Marcell Imrei, Miklos Garami

Summary: This study found that hypovitaminosis D is associated with an increased risk of relapse and death in pediatric cancer patients. Lower serum Vitamin D concentrations may lead to earlier cancer recurrence or fatal outcomes.

NUTRIENTS (2023)

Add to Collection

Review Microbiology

Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation

Agnes Kappeter, David Sipos, Adorjan Varga, Szabolcs Vigvari, Bernadett Halda-Kiss, Zoltan Peterfi

Summary: Migraine, a neurologic condition causing severe head pain, may be associated with changes in the gut microbiota, influenced by antibiotic use and other factors. Dysbiosis resulting from previous antibiotic therapy can lead to various diseases, including metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Probiotics as a dietary supplement and fecal microbiota transplantation can help restore gut microbial balance and reduce the severity and frequency of migraines.

MICROORGANISMS (2023)

Add to Collection

Article Medicine, General & Internal

Screening and treatment of hepatitis C virus in prisons: 10 years of experience

Klara Werling, Mihaly Makara, Krisztina Nemesi, Gabor Horvath, Ferenc Schneider, Ildiko Bali, Judit Enyedi, Viktor Jancsik, Andras Kafony, Miklos Lesch, Bela Lombay, Zsofia Muller, Zsofia Ozsvar, Arpad Patai, Zoltan Peterfi, Margit Pusztay, Olga Szabo, Janos Szlavik, Tamas Toth, Marta Varga, Judit Gacs, Eszter Ujhelyi, Nemes Anna Nagy

Summary: This article summarizes the results of HCV screening carried out in Hungarian prisons from 2007 to 2017. The study found that HCV screening and treatment programs in prisons were highly effective, with a high proportion of positive cases. However, the number of patients receiving full treatment was relatively low. Patient education and collaboration between hepatologists and prison medical staff played an important role in the successful treatment outcomes.

ORVOSI HETILAP (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.