Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medical Laboratory Technology
Marco Ciotti, Massimo Ciccozzi, Massimo Pieri, Sergio Bernardini
Summary: The article discusses the development of COVID-19 vaccines, the impact of viral variants on transmission and virus antibodies, and methods for measuring vaccine antibody responses. It also emphasizes the importance of using the WHO International Standard to accurately calibrate immunoassays.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Article
Immunology
Yifan Li, Melanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael Iroezindu, Emmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, Morgane Rolland
Summary: Prior immune responses to coronaviruses may impact the human response to SARS-CoV-2. There were differences in antibody responses to SARS-CoV-2 and other coronaviruses between participants from Africa and Thailand. These findings have implications for the distribution of vaccines and monoclonal antibodies globally.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Yuntao Zhang, Xiaotong Zheng, Wang Sheng, Hongyang Liang, Yuxiu Zhao, Xiujuan Zhu, Rong Yang, Yadan Zhang, Xiaofei Dong, Weidong Li, Fei Pei, Ling Ding, Zhen Chang, Li Deng, Guangying Yuan, Zhaona Yang, Di Zhu, Xiaoming Yang, Hui Wang
Summary: Since the beginning of the COVID-19 pandemic, various variants of SARS-CoV-2 have emerged, including five variants of concern. These variants, especially Omicron, have been shown to evade the immune response induced by existing COVID-19 vaccines to varying degrees, posing a significant risk to global health. In this study, a vaccine based on inactivated SARS-CoV-2 and an adjuvant was developed and tested in rats. The candidate vaccine elicited high levels of neutralizing antibodies against not only the original SARS-CoV-2, but also the Beta, Delta, and Omicron variants.
Article
Virology
Diego C. Carneiro, Jessica D. Sousa, Joana P. Monteiro-Cunha
Summary: The COVID-19 pandemic has caused significant social and economic disruptions, prompting a global effort to develop effective vaccines. Designing and developing vaccines involves multiple stages, including selecting appropriate platforms, conducting clinical trials, and scaling up production. The world is facing various challenges in combating the pandemic, requiring collaborative efforts to overcome them.
Editorial Material
Medicine, Research & Experimental
Khan Sharun, Kuldeep Dhama
Summary: Wealthy countries have secured 60% of COVID-19 vaccine supplies, with some preordering enough doses to vaccinate their populations multiple times. India's Vaccine Maitri initiative aims to provide doses to low-income countries, emphasizing equitable access to vaccines is crucial for global vaccination coverage. Manufacturing affordable vaccines and exporting large consignments worldwide will help meet global vaccine needs.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Infectious Diseases
Philippe Buchy, Yves Buisson, Otavio Cintra, Dominic E. Dwyer, Michael Nissen, Raul Ortiz de Lejarazu, Eskild Petersen
Summary: During the COVID-19 pandemic, there is still limited understanding of the virus origin and transmission, but advancements have been made in healthcare services and vaccine development speed. The feasibility of globally coordinated response to large-scale pandemics has been demonstrated.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Shaofeng Deng, Hui Liang, Pin Chen, Yuwan Li, Zhaoyao Li, Shuangqi Fan, Keke Wu, Xiaowen Li, Wenxian Chen, Yuwei Qin, Lin Yi, Jinding Chen
Summary: Viral vector vaccines have played an important role in combating the COVID-19 pandemic and have unique advantages compared to other vaccine platforms. The development of intranasal viral vector vaccines has become more urgent with the emergence of the Omicron variant.
Review
Medicine, General & Internal
Chao Wang, Min Wang, Guanjian Li, Bing Song, Qiong Xing, Yunxia Cao
Summary: This study reviews relevant research from the perspectives of males, females with or without pregnancy, and different vaccine types, and finds that vaccination does not significantly affect the pregnancy probability of partners. For females without pregnancy, vaccination is believed to have no impact on fertility, but further research is needed to explore short-term effects. Vaccination during any trimester is considered safe for pregnant women.
ANNALS OF MEDICINE
(2023)
Editorial Material
Nanoscience & Nanotechnology
Jianshe Yang
Summary: The article introduces a new technique of light vaccine for controlling the COVID-19 pandemic, which has germicidal advantages against SARS-CoV-2 but limitations in widespread use. A perspective is provided on a real nano light vaccine that could play an essential role in the prevention and control of COVID-19.
NANO-MICRO LETTERS
(2021)
Article
Virology
Ninghua Huang, Chao Wang, Bingfeng Han, Tianshuo Zhao, Bei Liu, Linyi Chen, Mingzhu Xie, Hui Zheng, Sihui Zhang, Yu Wang, Du Juan, YaQiong Liu, QingBin Lu, Fuqiang Cui
Summary: This study found that attitudes towards the SARS-CoV-2 vaccine have significantly improved over time, with increasing confidence and decreasing concerns about safety. However, concerns about vaccine effectiveness have increased. Vaccine confidence plays a crucial role in enhancing vaccine uptake willingness.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Immunology
Ariane Laguila Altoe, Anna PaulaMarques Mambriz, Daniela Maira Cardozo, Joana MairaValentini Zacarias, Jeane Eliete Laguila Visentainer, Larissa Danielle Bahls-Pinto
Summary: The COVID-19 pandemic has posed significant challenges to the healthcare of pregnant women. Increasing evidence suggests that pregnant women are at higher risk of severe outcomes from COVID-19, as well as the potential risk to the fetus. Vaccination during pregnancy is crucial in protecting both the mother and the newborn, as maternal antibodies can be transmitted through the placenta and breastfeeding. However, many questions regarding the immunity transfer, duration, and optimal timing of vaccination in pregnancy remain unanswered.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Asaf Zigron, Amiel A. Dror, Nicole G. Morozov, Tali Shani, Tharwat Haj Khalil, Netanel Eisenbach, Doaa Rayan, Amani Daoud, Fares Kablan, Hesham Marei, Eyal Sela, Samer Srouji
Summary: The COVID-19 pandemic led to widespread lockdowns, impacting the economy and employment levels, with dental medicine being one of the hardest hit sectors. A study found a significant correlation between individual unemployment rates and willingness to receive the SARS-CoV-2 vaccine, which can help predict vaccine acceptance or rejection trends based on economic burden during the pandemic.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Amalio Telenti, Ann Arvin, Lawrence Corey, Davide Corti, Michael S. Diamond, Adolfo Garcia-Sastre, Robert F. Garry, Edward C. Holmes, Phillip S. Pang, Herbert W. Virgin
Summary: This article discusses the future patterns of SARS-CoV-2 infection, the development of variants, and the implications for vaccine deployment. It suggests that the virus may become endemic fueled by pockets of susceptible individuals and waning immunity. Effective surveillance and response are crucial to prevent new epidemic or pandemic patterns.
Review
Biochemistry & Molecular Biology
Pravas Kumar Baral, Jiang Yin, Michael N. G. James
Summary: Researchers worldwide are working on developing prophylactic and therapeutic interventions to combat the COVID-19 crisis, with a focus on antibody-based therapies targeting the viral spike protein, particularly monoclonal antibodies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Tatyana P. Makalish, Ilya O. Golovkin, Volodymyr V. Oberemok, Kateryna V. Laikova, Zenure Z. Temirova, Olesya A. Serdyukova, Ilya A. Novikov, Roman A. Rosovskyi, Andrey I. Gordienko, Evgeniya Yu. Zyablitskaya, Elvina A. Gafarova, Kseniya A. Yurchenko, Iryna I. Fomochkina, Anatoly V. Kubyshkin
Summary: The study demonstrates the potential of Cytos-11 antisense oligonucleotide in treating rheumatoid arthritis by effectively suppressing TNF-alpha gene expression, reducing joint inflammation, and inhibiting pannus development, showing comparable results to adalimumab.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
V. V. Oberemok, O. A. Andreeva, K. V. Laikova, I. A. Novikov, A. V. Kubyshkin
Summary: The coronavirus pandemic highlights the need for effective vaccines against viral diseases. New platforms for vaccine creation, such as adenovirus vectors and mRNA vaccines, have shown potential in preventing coronavirus infection. However, these platforms have the disadvantage of limited antigen presentation, allowing the virus to evade immunity. The development of new vaccine platforms that can adapt to virus subtypes is urgently needed.
INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
V. V. Oberemok, O. A. Andreeva, K. V. Laikova, I. A. Novikov, Y. V. Puzanova, A. V. Kubyshkin
Summary: The worldwide vaccination rate has reached enormous proportions, with at least 75% of the world's population likely to be vaccinated. There is controversy surrounding plans to vaccinate young people under 20, despite the significantly higher mortality rate among those aged 65 and older. The question of vaccinating individuals who already have antibodies and memory cells from contracting and surviving the virus is also a thorny issue. The consequences of large-scale vaccination are difficult to predict, especially when some people have limited access to vaccines while others have already received multiple doses.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Maxim A. Kriventsov, Yulianna A. Yermola, Alexandra A. Davydova, Alexey A. Beketov, Tatyana P. Makalish, Evgeniya Yu Zyablitskaya, Alina Geraschenko, Anatoly Kubyshkin, Anna A. Galyshevskaya, Anastasia Zausalina
Summary: This study analyzed myocardial samples from critically ill COVID-19 patients and found minimal or no expression of vitamin D receptors (VDRs) in cardiomyocyte nuclei, while lymphoid cells still showed strong expression. These findings provide interesting insights for further research on the effects of ligand-associated VDR activation on the cardiovascular system.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Iuliana I. Shramko, Elizaveta S. Ageeva, Konstantin D. Maliy, Irina N. Repinskaya, Cyrill O. Tarimov, Iryna I. Fomochkina, Anatolii V. Kubishkin, Olga V. Ostapenko, Anna K. Gurtovaya, Suman Shekhar
Summary: Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). This study analysed the frequency of adiponectin (ADIPOQ) and leptin (LEP) gene polymorphisms in MS patients and their association with MS symptoms. The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype, while the A allele of the LEP (rs7799039) gene was the most frequent. MS patients carrying the GG genotype of the LEP (rs7799039) gene had the highest systolic blood pressure. ADIPOQ (rs2241766) GT genotype carriers were associated with the highest systolic blood pressure and body mass index (BMI), while ADIPOQ (rs2241766) GG genotype carriers were associated with the highest diastolic blood pressure, hyperglycemia, and elevated glycated hemoglobin (HbA1c). This study identified unique gene variants associated with the risk of developing MS in the Crimean population.
JOURNAL OF DIABETES RESEARCH
(2022)
Editorial Material
Cell Biology
A. Kubyshkin, E. Kovalenko
Summary: This article summarizes the 15th World Congress on Inflammation (WCI2022), held in Rome, Italy from June 5 to 8, 2022. It presents the main trends and promising research developments in inflammation, including cellular and molecular mechanisms, new pathogenetic pathways, target molecules, genetic mechanisms, and therapeutic strategies. Additionally, it describes the primary areas of research in inflammatory pathology mechanisms engaged by leading scientific groups and national societies from various countries.
INFLAMMATION RESEARCH
(2023)
Article
Mechanics
A. Kubyshkin, I. N. Belokon, V. V. Karagodin
Summary: The possibility of intercepting ballistic missiles by American sea-based antimissiles is analyzed in this study. The mathematical modeling results show that using liquid propulsion systems on the interceptor can greatly expand the interception zones. Meanwhile, the launch window is divided into two spatially separated regions, allowing for the maximization of both defensive and offensive capabilities.
MECHANICS OF SOLIDS
(2022)
Article
Biochemistry & Molecular Biology
Kseniya A. Yurchenko, Kateryna V. Laikova, Ilya O. Golovkin, Ilya A. Novikov, Alyona A. Yurchenko, Tatyana P. Makalish, Volodymyr V. Oberemok
Summary: Skin cancer tops the list in terms of incidence among all tumors, with melanoma being the most deadly. The search for new therapeutic agents to combat melanoma is highly relevant. Antisense oligonucleotides (ASO) targeting the genes responsible for cancer cell viability show promise in eliminating cancer cells near the tumor site before and after surgery. This article discusses the significant decrease in proliferative activity of murine melanoma cells using Skeen-11 phosphorothioate oligonucleotide and its tumor growth inhibition in mice with melanoma.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Volodymyr V. Oberemok, Kateryna V. Laikova, Kseniya A. Yurchenko, Ilya A. Novikov, Tatyana P. Makalish, Anatolii V. Kubyshkin, Oksana A. Andreeva, Anastasiya I. Bilyk
Summary: The main challenge in developing anti-coronavirus vaccines that target the virus's outer membrane proteins is the rapid variability in the pathogen's RNA genome. Affordable and quickly adaptable vaccine formulas are needed to address the emergence of new SARS-CoV-2 subtypes. This study evaluates the effectiveness of La-S-so-type adjuvant oligonucleotide vaccines on transgenic mice and shows that they increase the survival rate of animals infected with SARS-CoV-2 and reduce the destructive effects on lung tissue.
SCIENTIA PHARMACEUTICA
(2023)
Meeting Abstract
Cell Biology
Kseniya A. Yurchenko, Kateryna V. Laikova, Volodymyr V. Oberemok, Ilya A. Novikov, Alyona A. Yurchenko, Tatyana P. Makalish, Irina I. Fomochkina, Anatoly V. Kubyshkin
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Pathology
Iuliana Shramko, Elizaveta Ageeva, Eugene Krutikov, Konstantin Maliy, Irina Repinskaya, Iryna Fomochkina, Anatolii Kubishkin, Anna Gurtovaya, Cyrill Tarimov, Suman Shekhar
Summary: This study investigated the relationship between adiponectin and polymorphism in its gene receptors with the primary symptoms of pathogenesis in type 2 diabetes mellitus (DM2). The findings showed a strong correlation between rs16928751 polymorphism on the ADIPOR2 gene and increased body mass index (BMI), as well as associations between rs2275737 polymorphism on the ADIPOR1 gene and high levels of glycosylated hemoglobin (HbA1C) and stable hyperglycemia caused by rs2275738 polymorphism. Unique gene variants associated with the risk of developing DM2 were also identified in the Crimean population.