Article
Orthopedics
Enrico M. Forlenza, Joseph Serino III, Matthew T. Weintraub, Robert A. Burnett III, Vasili Karas, Craig J. Della Valle
Summary: This study compared the outcomes and complications of total joint arthroplasty (TJA) in patients with and without a recent COVID-19 infection. It found that patients with a COVID-19 infection within 1 month prior to TJA had a higher risk of postoperative deep vein thrombosis and venous thromboembolic events. However, complication rates returned to baseline after this time point.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Hematology
Jana J. Anderson, Frederick K. Ho, Claire L. Niedzwiedz, Srinivasa Vittal Katikireddi, Carlos Celis-Morales, Stamatina Iliodromiti, Paul Welsh, Pierpaolo Pellicori, Evangelia Demou, Claire E. Hastie, Donald M. Lyall, Stuart R. Gray, John F. Forbes, Jason M. R. Gill, Daniel F. Mackay, Colin Berry, John G. F. Cleland, Naveed Sattar, Jill P. Pell
Summary: The study explored the association between remote history of VTE and COVID-19 severity, finding that a remote history of VTE is associated with an increased risk of nonfatal community, nonfatal hospitalized, and severe COVID-19. The association was stronger among men, suggesting the importance of considering sex-specific risk factors in COVID-19 risk prediction models.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Surgery
Danielle C. Sutzko, Andrea T. Obi, Neil Kamdar, Monita Karamkar, Thomas W. Wakefield, Nicholas H. Osborne, Peter K. Henke
Summary: This retrospective cohort study examined the incidence, morbidity, and mortality of VTE in postoperative patients within a quality collaborative, revealing that despite widespread use of postoperative thromboprophylaxis, no decrease in VTE incidence was observed.
Review
Critical Care Medicine
Shannon M. Fernando, Alexandre Tran, Wei Cheng, Behnam Sadeghirad, Yaseen M. Arabi, Deborah J. Cook, Morten Hylander Moller, Sangeeta Mehta, Robert A. Fowler, Karen E. A. Burns, Philip S. Wells, Marc Carrier, Mark A. Crowther, Damon C. Scales, Shane W. English, Kwadwo Kyeremanteng, Salmaan Kanji, Michelle E. Kho, Bram Rochwerg
Summary: In critically ill adults, low-molecular-weight heparin (LMWH) reduces the incidence of deep vein thrombosis (DVT) compared to control treatment, and unfractionated heparin (UFH) may also reduce the risk of DVT. LMWH is likely more effective in reducing DVT compared to UFH. Mechanical compressive devices may decrease the risk of DVT, but the evidence is limited. The efficacy and safety of combination pharmacologic therapy and mechanical compressive devices are still unclear.
Article
Critical Care Medicine
Scott M. Stevens, Scott C. Woller, Lisa Baumann Kreuziger, Henri Bounameaux, Kevin Doerschug, Geert-Jan Geersing, Menno Huisman, Clive Kearon, Christopher S. King, Andrew J. Knighton, Erica Lake, Susan Murin, Janine R. E. Vintch, Philip S. Wells, Lisa K. Moores
Summary: This is the 2nd update to the 9th edition of guidelines, providing recommendations on 17 PICO questions, with four new questions addressed. Strong and weak recommendations were generated based on high-, moderate-, and low-certainty evidence, resulting in 29 guidance statements, 13 of which are strong recommendations. New evidence has emerged since 2016, improving the standard of care for VTE patients, but substantial uncertainty remains regarding certain important management questions.
Article
Critical Care Medicine
Scott M. Stevens, Scott C. Woller, Lisa Baumann Kreuziger, Henri Bounameaux, Kevin Doerschug, Geert-Jan Geersing, Menno Huisman, Clive Kearon, Christopher S. King, Andrew J. Knighton, Erica Lake, Susan Murin, Janine R. E. Vintch, Philip S. Wells, Lisa K. Moores
Summary: This is the 2nd update to the 9th edition of the guidelines, with 29 guidance statements generated using GRADE methodology. These statements cover various aspects of antithrombotic management of VTE, from initial management through secondary prevention and risk reduction of postthrombotic syndrome.
Article
Medicine, General & Internal
Raghu Tiperneni, Adhithya Rajamohan, Rana Prathap P. Padappayil, Vishakha Sirpal, Harshil Fichadiya
Summary: Venous thromboembolism (VTE) is a condition where blood clots form in the venous system, commonly in the deep veins of the lower extremities and pulmonary arteries. Prevention and treatment options include anticoagulation and mechanical thrombectomy. This article discusses a rare case of a 40-year-old male with recurrent VTE that was resistant to various treatment options, presenting with a completely occlusive thrombus in the right-sided deep venous structures.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Emergency Medicine
Liam Barrett, Tom Jones, Daniel Horner
Summary: The study found that applying an age adjusted D-dimer strategy to patients with suspected VTE in the emergency department can increase the proportion of patients in which VTE can be excluded without the need for reference standard imaging, potentially leading to cost savings.
BMC EMERGENCY MEDICINE
(2022)
Review
Critical Care Medicine
David Jimenez, Aldara Garcia-Sanchez, Parth Rali, Alfonso Muriel, Behnood Bikdeli, Pedro Ruiz-Artacho, Raphael Le Mao, Carmen Rodriguez, Beverley J. Hunt, Manuel Monreal
Summary: The pooled incidence of VTE and bleeding among hospitalized patients with COVID-19 was 17.0% and 7.8% respectively. Factors such as routine screening, critical illness, inclusion of distal DVT and subsegmental PE, and prospective studies were associated with higher rates of VTE. The incidence of bleeding events was sensitive to escalated doses of anticoagulants and the nature of data collection.
Review
Pharmacology & Pharmacy
Christina A. Theochari, Nikoletta A. Theochari, Konstantinos S. Mylonas, Dimitrios Papaconstantinou, Ilias Giannakodimos, Eleftherios Spartalis, Nikolaos Patelis, Dimitrios Schizas
Summary: This study investigated the incidence of post-operative VTE in patients undergoing major abdominal surgery for cancer and identified several risk factors associated with VTE. The results suggest that VTE remains an important complication after major abdominal surgery, which might increase mortality rates.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Review
Pharmacology & Pharmacy
Sharanyah Srinivasan, Muhammad Ajmal, Cristina Pecci, Tom Lassar
Summary: Edoxaban, the most recently approved DOAC, has applications beyond stroke prevention in various conditions. This review provides a comprehensive outline of the growing indications, evidence for use in special populations, pharmacogenetics, and side-effects profile of edoxaban.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Zhen-Yi Jin, Chun-Min Li, Kai Zheng, Hong Qu, Wen-Tao Yang, Jia-Hao Wen, Wang-De Zhang, Hua-Liang Ren
Summary: This study found a high incidence of isolated distal deep venous thrombosis (IDDVT) concurrent with pulmonary embolism (PE) in gynecologic inpatients. Glucocorticoid therapy, hypertension, diabetes, and body mass index (BMI) were identified as independent risk factors for IDDVT patients with PE. A nomogram risk prediction model based on these factors was developed to facilitate early detection of concurrent PE.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammed A. Alsheef, Alhanouf M. Alabbad, Rowida A. Albassam, Rawan M. Alarfaj, Abdul Rehman Zia Zaidi, Ouhod A. Alarfaj, Mohsen Ayyash, Amani Abu-Shaheen
Summary: The study identified family history, thrombophilia, and presence of gross varicose veins as predictors of pregnancy-associated VTE (DVT and PE), highlighting the importance of prophylaxis for women with these risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Alexander G. G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lopes, Chern-En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar
Summary: GARFIELD-VTE is an observational study that aims to collect clinical data of patients with deep vein thrombosis and pulmonary embolism worldwide. The study found that the highest accumulation of events occurred within the first 12 months after diagnosis, which may help identify treatment gaps and improve patient outcomes.
THROMBOSIS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mohammed AlSheef, Fouad Taiwilaa Alshammari, Mashel khalid Alhawish, Abduljabar Ghazi Alghamdi, Abdullah Fahad Alqudhybi, Amani Abu-Shaheen
Summary: This study aimed to assess the clinical characteristics, risk factors, diagnostic methods, management, and clinical outcomes of patients with venous thromboembolism (VTE) in Saudi Arabia. The results showed that unprovoked VTE was more common in the Saudi Arabian cohort, suggesting a hereditary predisposition. Furthermore, male sex, family history of VTE, prior history of VTE, type of VTE, underlying obesity, history of trauma, surgery, hospitalization, pregnancy, and 3-6 months of anticoagulation therapy were identified as the most critical risk factors for VTE recurrence. The treatment patterns and clinical results were comparable to those reported in the literature.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)