Article
Chemistry, Multidisciplinary
Felix Steinmeyer, Dorothee Hueser, Rudolf Meess, Martin Stein
Summary: The novel physical measurement standard (PMS) for roughness measurements on involute gears bridges the gap between roughness measurements on planar surfaces and gear measurements, providing calibrated roughness values for various parameters and allowing measurements with both classic profilometers and gear measurement systems.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Multidisciplinary
Camilla Nicol Bonacina, Paolo Tafani Alunno, Massimo Mastromatteo, Gianluca Valenti, Gilberto Serafini, Claudio Imboccioli, Matteo Russo, Caterina Soranno, Lorenzo Mori, Filippo Maria Lombardi
Summary: There is a lack of international standards for hydrogen measurement in legal frameworks. This study proposes a new approach for legally measuring pure hydrogen volume and volumetric flow rate based on international metrology standards. A wet drum meter filled with water is used as the reference meter. The selected reference instrumentation and procedures can be replicated in other laboratories. Simulations show that hydrogen diffusivity in water does not affect error estimations, but water evaporation does affect volumetric flow rate measurement. The expanded uncertainty of the total metrological chain is less than 0.25%. This reference procedure allows for testing the error of indication of new meters using hydrogen and other flowing gases with the same principles, instrumentation, and procedures, which is beneficial for the development and certification of new products for the upcoming energy transition.
Article
Medical Laboratory Technology
Corey Markus, Rui Zhen Tan, Chun Yee Lim, Wayne Rankin, Susan J. Matthews, Tze Ping Loh, William M. Hague
Summary: This study investigates the use of different regression frameworks to assess the commutability between reference materials and clinical samples. The results show that selecting the appropriate regression model is crucial depending on the variance profiles.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Quantum Science & Technology
Anish M. Bhargav, Rajib K. Rakshit, Samaresh Das, Manju Singh
Summary: The evolution of quantum standards for SI units and funding support from national governments have led to rapid technological developments in quantum sciences, specifically in the calibration of single-photon detectors (SPDs). Different methods and techniques have been developed globally for SPD calibration, achieving certain uncertainty values with room for improvement in the future.
ADVANCED QUANTUM TECHNOLOGIES
(2021)
Article
Chemistry, Analytical
Kruno Milicevic, Ivan Tolic, Davor Vinko, Goran Horvat
Summary: This paper presents a blockchain-based concept for the digital transformation of the traceability pyramid for electrical energy measurement in metrology. The concept comprehensively covers all aspects of the pyramid and describes the responsibilities and processes of all stakeholders. Possible legal and technical issues are identified and corresponding solutions are presented.
Article
Optics
Shihua Zhang, Dandna Shan, Hao Jin, Yingtian Lou, Liping Yan, Benyong Chen
Summary: This paper proposes a frequency sweeping interferometry method based on sinusoidal phase modulation and reference interferometer for absolute distance measurement. By monitoring and compensating the drifts of the target and reference length in real time, the influences caused by drifts during the measurement can be reduced. Experimental results show that the measurement uncertainty can be considerably reduced by compensating the influences of drifts and applying linear regression.
Article
Engineering, Industrial
Wim Dewulf, Harald Bosse, Simone Carmignato, Richard Leach
Summary: This paper reviews the metrological performance and traceability of X-ray computed tomography (XCT) and discusses the error sources, qualification, calibration, and optimization procedures influencing the measurement results. It also summarizes the results of interlaboratory comparisons and illustrates the performance in various dimensional measurement fields, while providing conclusions and an outlook for future research activities.
CIRP ANNALS-MANUFACTURING TECHNOLOGY
(2022)
Review
Engineering, Multidisciplinary
Massimiliano Ferrucci, Evelina Ametova
Summary: X-ray CT is now being recognized for its value in industrial applications such as material characterization, defect analysis, and dimensional inspection. Achieving metrological traceability involves ensuring traceability of the measurement scale and assessing uncertainty in the resulting quantity, providing a quantitative indication of measurement quality.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Javier de Lucas
Summary: An experimental procedure for characterizing the size-of-source effect is proposed in this paper, which is an important factor causing uncertainty in the measurement of direct reading radiation thermometers. The procedure and uncertainty calculation described in the paper are aligned with the requirements of metrological traceability in industry and science. The results of applying and validating this procedure in the calibration laboratories of radiation thermometry in the industrial field are presented.
Article
Instruments & Instrumentation
A. J. Lancaster, D. O'Connor
Summary: This paper proposes a method for traceable distance measurement using a spectral lamp and imaging spectrometer, and demonstrates its experimental feasibility. Initial experiments show distance measurements within a working range of 200 μm with a standard uncertainty of 0.6 nm and an expanded uncertainty of 1.2 nm at k = 2.
Review
Chemistry, Analytical
Shanshan Zhao, Yan Zhao
Summary: Stable isotope ratio analysis is a relatively new technology in the field of food traceability, and selecting appropriate isotope reference materials is crucial for improving analysis effectiveness. By cooperating with different laboratories, high-quality isotope reference materials can be prepared to provide more choices for users.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Elena Cubero-Leon, Hendrik Emons, Gavin O'Connor, Jorgen Norgaard, Piotr Robouch
Summary: Inconsistent quantification results from different analytical methods for food allergen testing hinder accurate quantitative risk assessment and regulatory implementation. To address this issue, a concept called reference measurement system for food allergens is proposed to ensure comparability of quantitative results. It is based on a commonly agreed reference, the 'mass fraction of total protein of the allergenic ingredient in food'. The necessary components of this metrology-based concept include a primary reference measurement method, a certified reference material, and a reference laboratory. The approach can be applied to quantify various food allergens determined with different analytical procedures, as demonstrated by the example of 'milk in cookies'.
Article
Physics, Multidisciplinary
Stanislaw Kurdzialek, Rafal Demkowicz-Dobrzanski
Summary: Fisher information is used to quantify the maximum precision of estimating parameters encoded in quantum states using general quantum measurements. However, it does not account for the robustness of quantum estimation schemes against measurement imperfections. This study introduces a new concept of Fisher information measurement noise susceptibility, which quantifies the potential loss of Fisher information due to small measurement disturbances. An explicit formula for this quantity is derived and its usefulness is demonstrated in analyzing quantum estimation schemes such as interferometry and superresolution optical imaging.
PHYSICAL REVIEW LETTERS
(2023)
Article
Medical Laboratory Technology
Chiara Giangrande, Helene Vaneeckhoutte, Amandine Boeuf, Beatrice Lalere, Christophe Hirtz, Sylvain Lehmann, Milena Quaglia, Vincent Delatour
Summary: The objective of this work is to develop a higher order candidate reference measurement procedure (RMP) for the absolute quantification of t-tau in cerebrospinal fluid. A primary calibrator consisting of a highly purified recombinant protein was sourced to establish metrological traceability. An isotopically-labelled homologue was obtained to develop a candidate RMP by isotope dilution mass spectrometry (IDMS) for t-tau absolute quantification. The candidate RMP has been validated and can be used for global standardization of CSF t-tau measurements.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Chemistry, Physical
Alberto Minguez Martinez, Cecilia Gomez Perez, David Canteli Perez-Caballero, Laura Carcedo Cerezo, Jesus de Vicente y Oliva
Summary: This paper discusses the importance of surface characterization and proposes the use of material standards to calibrate optical measuring instruments for more precise surface feature measurements. The authors aim to establish a foundation for the development of custom standards with specialized features in order to achieve better metrological control when measuring specific geometric surface properties.
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)