Article
Nutrition & Dietetics
Cristina Tejera, Cristina Porca, Gemma Rodriguez-Carnero, Paula Andujar, Felipe F. Casanueva, Diego Bellido, Ana B. Crujeiras
Summary: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, type 2 diabetes mellitus, and cancer. This study aimed to investigate the effectiveness of an intensive lifestyle program in reducing the prevalence of MetS in adults with obesity. The results showed that implementation of the IGOBE program resulted in a significant reduction in MetS prevalence and better control of MetS features compared with the standard of care.
Article
Nutrition & Dietetics
Federica Vinciguerra, Luigi Piazza, Carla Di Stefano, Claudia Degano, Alfredo Pulvirenti, Roberto Baratta, Lucia Frittitta
Summary: This study evaluated the efficacy of liraglutide treatment in patients who experienced poor response after bariatric surgery. The results showed that liraglutide was effective in promoting significant weight loss, improving body composition, and reducing the prevalence of metabolic syndrome in these patients.
FRONTIERS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Samaneh Zolghadri, Armand Cholewka, Wojciech Myslinski
Summary: Obesity is a disease caused by the accumulation of fat, and dietary intervention is the primary treatment. Intermittent energy restriction diets have been proven effective for weight loss and have beneficial effects on metabolic parameters. This provides an alternative option for individuals who cannot adhere to continuous dietary restrictions.
Review
Nutrition & Dietetics
Simone Perna, Zahra Ilyas, Attilio Giacosa, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Chiara Rigon, Maurizio Naso, Antonella Riva, Giovanna Petrangolini, Ali A. Redha, Mariangela Rondanelli
Summary: This meta-analysis study found that probiotic supplementation can significantly reduce BMI, waist circumference, and hip circumference in overweight and obese patients, but the effect on body weight is not significant. Although there is a positive trend, further research is needed before recommending probiotics as a therapeutic strategy for these patients.
Article
Medicine, General & Internal
Nathalie Kliemann, Vivian Viallon, Neil Murphy, Rebecca J. Beeken, Joseph A. Rothwell, Sabina Rinaldi, Nada Assi, Eline H. van Roekel, Julie A. Schmidt, Kristin Benjaminsen Borch, Claudia Agnoli, Ann H. Rosendahl, Hanna Sartor, Jose Maria Huerta, Anne Tjonneland, Jytte Halkjaer, Bas Bueno-de-Mesquita, Audrey Gicquiau, David Achaintre, Krasimira Aleksandrova, Matthias B. Schulze, Alicia K. Heath, Konstantinos K. Tsilidis, Giovanna Masala, Salvatore Panico, Rudolf Kaaks, Renee T. Fortner, Bethany Van Guelpen, Laure Dossus, Augustin Scalbert, Hector C. Keun, Ruth C. Travis, Mazda Jenab, Mattias Johansson, Pietro Ferrari, Marc J. Gunter
Summary: Obesity is associated with specific changes in levels of amino acids and lipids, which are positively correlated with the risk of colorectal and endometrial cancer and may be reversible following weight loss.
Review
Medicine, General & Internal
Razvan-Marius Ion, Melania Sibianu, Adina Hutanu, Felicia Gabriela Beresescu, Daniela Tatiana Sala, Mocian Flavius, Ancuta Rosca, Calin Constantin, Alexandra Scurtu, Renata Moriczi, Mircea Gabriel Muresan, Popescu Gabriel, Raluca Niculescu, Radu Mircea Neagoe
Summary: Obesity, as a part of metabolic syndrome, is the leading factor for disability and is associated with higher inflammation status, morbidity, and mortality. Chronic systemic inflammation biomarkers are important predictors of pro-inflammatory disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Qing Wen, Song Fang, Yanjing Liang, Yuting Tian, Yiding Chen, Jun Yuan, Qiu Chen
Summary: This study aimed to observe the effect of beinaglutide combined with metformin versus metformin alone on weight loss and metabolic profiles in obese patients with polycystic ovary syndrome. The results showed that the combined treatment was more effective in reducing weight, body mass index, waist circumference, and waist to height ratio compared to metformin monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Mari Naatanen, Anna Karlund, Santtu Mikkonen, Anton Klavus, Otto Savolainen, Marko Lehtonen, Leila Karhunen, Kati Hanhineva, Marjukka Kolehmainen
Summary: This study investigated the effect of two isocaloric 24-week weight maintenance diets on metabolism and identified metabolite features associated with successful weight loss maintenance. It was found that the dietary fiber, protein, and fat content of the diet influenced amino acid and lipid metabolism, and increased abundance of certain phospholipids and free fatty acids was associated with better weight loss maintenance.
CLINICAL NUTRITION
(2023)
Article
Medicine, Research & Experimental
Jessica D. Schroder, Hugo Falqueto, Aline Manica, Daniela Zanini, Tacio de Oliveira, Clodoaldo A. de Sa, Andreia Machado Cardoso, Leandro Henrique Manfredi
Summary: TRF is an effective dietary approach for weight loss and reduction of cardiovascular risk in obese middle-aged women. It helps in reducing body weight and waist circumference, with no changes in biomarkers associated with Metabolic Syndrome.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lili Liu, Wei Chen, Dan Wu, Fang Hu
Summary: This meta-analysis and systematic review suggests that time-restricted eating may be an effective approach to improving the metabolic state of nonobese individuals, particularly overweight individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ahmad Kamil Nur Zati Iwani, Muhammad Yazid Jalaludin, Abqariyah Yahya, Fazliana Mansor, Fuziah Md Zain, Janet Yeow Hua Hong, Ruziana Mona Wan Mohd Zin, Abdul Halim Mokhtar
Summary: This study found that using TG : HDL-C ratio as an insulin resistance marker can better model the structure of metabolic syndrome in obese children, showing superior performance compared to using fasting blood glucose (FBG) as a marker.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Hammad Qureshi, Naba Saeed, Manol Jovani
Summary: The increasing prevalence of obesity has led to the development of various weight loss strategies. While lifestyle modifications and bariatric surgery have shown some success, endoscopic bariatric and metabolic therapies (EBMTs) provide a less invasive treatment option. This article discusses the effectiveness and outcomes of different endoscopic techniques for weight loss and their impact on metabolic parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sangeetha Shyam, Jesus Francisco Garcia-Gavilan, Indira Paz-Graniel, Jose J. Gaforio, Miguel angel Martinez-Gonzalez, Dolores Corella, J. Alfredo Martinez, angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M. Asensio, Olga Castaner, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gomez-Gracia, M. Angeles Zulet, Nuria Goni Ruiz, Rosa Casas, Naomi Cano-Ibanez, Lucas Tojal-Sierra, A. M. Gomez-Perez, Jose V. Sorli, Sergio Cinza-Sanjurjo, Sandra Martin-Pelaez, Patricia J. Pena-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, Maria Dolores Zomeno, Alice Chaplin, Miguel Delgado-Rodriguez, Nancy Babio, Montserrat Fito, Jordi Salas-Salvado
Summary: Older adults with overweight/obesity are at increased risk of COVID-19, with higher baseline body weight, BMI, waist circumference, and waist-to-height ratio associated with higher risk. Every unit increase in body weight and BMI during follow-up was also linked to increased COVID-19 risk. In this group, significant weight loss may help protect against COVID-19.
Article
Health Care Sciences & Services
Nuha Alamro, Afnan S. Azhri, Asma Almuqati, Firas Azzeh, Wedad Azhar, Alaa Qadhi, Najlaa H. Almohmadi, Wafaa F. Abusudah, Khloud Ghafouri
Summary: Bariatric surgery has been shown to achieve sustained weight loss and improve metabolism, reducing the risk of cardiovascular disease and diabetes. This retrospective study found that bariatric surgery resulted in significant decreases in blood pressure, glycated hemoglobin, thyroid-stimulating hormone, LDL cholesterol, triglycerides, and total cholesterol levels. The surgery also decreased the prevalence of metabolic syndrome and significantly reduced the Framingham risk score.
Article
Nutrition & Dietetics
Teofana Otilia Bizerea-Moga, Laura Pitulice, Cristina Loredana Pantea, Orsolya Olah, Otilia Marginean, Tudor Voicu Moga
Summary: This study aimed to investigate the correlation between extreme birth weights and metabolic syndrome in obese children. The findings showed that birth weight had an independent effect on triglycerides and insulin resistance, while obesity was directly associated with hypertension, impaired glucose metabolism, and hypertriglyceridemia. Larger prospective studies in normal-weight patients are needed to further understand this relationship.
Article
Biochemistry & Molecular Biology
Gilberto Vargas-Alarcon, Jose Manuel Fragoso, Julian Ramirez-Bello, Rosalinda Posadas-Sanchez
Summary: FOXA3 polymorphisms are not associated with subclinical atherosclerosis, but they are related to cardiometabolic parameters in individuals with and without SA.
Article
Cardiac & Cardiovascular Systems
F. D. Martinez-Sanchez, A. X. Medina-Urrutia, E. Jorge-Galarza, M. Del Rocio Martinez-Alvarado, J. Reyes-Barrera, H. Osorio-Alonso, A. S. Arellano-Buendia, M. Del Carmen Gonzalez-Salazar, R. Posadas-Sanchez, G. Vargas-Alarcon, C. Posadas-Romero, J. G. Juarez-Rojas
Summary: This study aimed to analyze the composite control of blood pressure, lipids, and glucose in patients with premature coronary artery disease (CAD). The study found that achieving control targets for blood lipids, blood pressure, and blood glucose significantly reduced the risk of recurrent major adverse cardiovascular events (MACE).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Benny Giovanni Cazarin-Santos, Nonanzit Perez-Hernandez, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Juan Rodriguez-Silverio, Bladimir Roque-Ramirez, Veronica Marusa Borgonio-Cuadra, Jose Manuel Rodriguez-Perez
Summary: This study found an association between genetic variants and the development of subclinical atherosclerosis, with the rs3102735 polymorphism showing a protective effect and the GACC haplotype decreasing risk while the GACT haplotype increasing risk.
Article
Medicine, General & Internal
Gilberto Vargas-Alarcon, Maria del Carmen Gonzalez-Salazar, Adrian Hernandez-Diaz Couder, Fausto Sanchez-Munoz, Julian Ramirez-Bello, Jose Manuel Rodriguez-Perez, Rosalinda Posadas-Sanchez
Summary: This study found that the rs17574 polymorphism is associated with a lower risk of pCAD in diabetic patients. DPP4 concentrations were lower in diabetic pCAD patients, and carriers of the rs17574 GG genotype had the lowest protein levels.
Article
Biochemistry & Molecular Biology
Paola Pena-de-la-Sancha, Adolfo Munoz-Garcia, Nilda Espinola-Zavaleta, Rocio Bautista-Perez, Ana Maria Mejia, Maria Luna-Luna, Victoria Lopez-Olmos, Jose-Manuel Rodriguez-Perez, Jose-Manuel Fragoso, Elizabeth Carreon-Torres, Oscar Perez-Mendez
Summary: This study examined the effects of n-3 EPA and DHA supplementation on vascular function in hypertriglyceridemic patients. The results showed that supplementation improved vascular function, increased HDL-cholesterol and HDL-phospholipids levels, and modified the fatty acid composition of HDLs to a more anti-inflammatory profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Esbeidy Garcia-Flores, Juan Calderon-Colmenero, Veronica Marusa Borgonio-Cuadra, Juan Pablo Sandoval, Jose Antonio Garcia-Montes, Benny Giovanni Cazarin-Santos, Antonio Miranda-Duarte, Armando Gamboa-Dominguez, Jose Manuel Rodriguez-Perez, Nonanzit Perez-Hernandez
Summary: This study analyzed the DNA methylation status of seven CpG sites in the TBX20 gene promoter and found that patients with congenital septal defects had higher average methylation levels. High methylation levels were associated with an increased risk of congenital septal defects. The study also found an association between vitamin intake, maternal infections, and the occurrence of septal defects.
Review
Cardiac & Cardiovascular Systems
Rosa Giannina Castillo-Avila, Thelma Beatriz Gonzalez-Castro, Carlos Alfonso Tovilla-Zarate, Jose Jaime Martinez-Magana, Maria Lilia Lopez-Narvaez, Isela Esther Juarez-Rojop, Pedro Ivan Arias-Vazquez, Veronica Marusa Borgonio-Cuadra, Nonanzit Perez-Hernandez, Jose Manuel Rodriguez-Perez
Summary: This study aimed to investigate the association of three polymorphisms (rs646776, rs599839, and rs464218) in the cluster of CELSR2, PSRC1, and SORT1 with cardiovascular diseases. The meta-analysis showed that rs599839 and rs646776 polymorphisms were associated with an increased risk of cardiovascular diseases, particularly coronary artery disease. PheWAS analysis revealed associations with coronary artery disease and total cholesterol. These findings suggest the involvement of CELSR2-PSRC1-SORT1 cluster variants in the risk association of cardiovascular diseases.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ana L. Vega-Jasso, Luis M. Amezcua-Guerra, Hector Gonzalez-Pacheco, Julio Sandoval-Zarate, Cesar A. Gonzalez-Diaz, Jennifer Escobar-Alvarado, Jennifer D. Manzano-Luna, Malinalli Brianza-Padilla
Summary: This study investigated the involvement of adipokines in AMI patients, and found that both AMI patients and AMI patients with OSA exhibited elevated levels of adipokines. AMI patients with concomitant OSA also showed greater cardiac damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jorge A. Ortega-Hernandez, Hector Gonzalez-Pacheco, Jardiel Arguello-Bolanos, Jose Omar Arenas-Diaz, Roberto Perez-Lopez, Mario Ramon Garcia-Arias, Rodrigo Gopar-Nieto, Daniel Sierra-Lara-Martinez, Diego Araiza-Garaygordobil, Daniel Manzur-Sandoval, Luis Alejandro Soliz-Uriona, Gloria Monserrath Astudillo-Alvarez, Jaime Hernandez-Montfort, Alexandra Arias-Mendoza
Summary: This study aimed to better understand the hemodynamic profiles of different phenotypes in acute myocardial infarction-CS (AMI-CS) and identify different outcomes associated with these phenotypes using pulmonary artery catheter (PAC) data. The results showed that the three different AMI-CS phenotypes had varying mortality rates and hemodynamic parameters, and the phenotypes remained statistically significant even after adjustments. These findings have important implications for patient prognosis assessment and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Angelica Sarai Jimenez-Osorio, Elizabeth Carreon-Torres, Emmanuel Correa-Solis, Julieta Angel-Garcia, Jose Arias-Rico, Octavio Jimenez-Garza, Lizbeth Morales-Castillejos, Hugo Alexander Diaz-Zuleta, Rosa Maria Baltazar-Tellez, Maria Luisa Sanchez-Padilla, Olga Rocio Flores-Chavez, Diego Estrada-Luna
Summary: Inflammation and oxidative stress play crucial roles in the development of metabolic and chronic diseases. Maintaining a balance between necessary and pathological levels of inflammation and oxidative stress is important during pregnancy. High-density lipoproteins (HDL) are essential for a healthy pregnancy, but in certain conditions, they can lose their protective properties. Bioactive compounds from functional foods can increase the concentration of HDL, TRC, and antioxidant activity.
Review
Biochemistry & Molecular Biology
Emanuel Amezcua-Castillo, Hector Gonzalez-Pacheco, Arturo Saenz-San Martin, Pablo Mendez-Ocampo, Ivan Gutierrez-Moctezuma, Felipe Masso, Daniel Sierra-Lara, Rashidi Springall, Emma Rodriguez, Alexandra Arias-Mendoza, Luis M. Amezcua-Guerra
Summary: Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide, and inflammation plays a crucial role in the pathogenesis of coronary artery disease (CAD). C-reactive protein (CRP), as an inflammatory marker, has been widely used in cardiovascular risk assessment and therapeutic decision-making. Pharmacological interventions with anti-inflammatory properties have also shown promising effects in reducing cardiovascular risks and CRP levels.
Article
Biochemistry & Molecular Biology
Brianda Amezcua-Guerra, Luis M. Amezcua-Castillo, Jazmin A. Guerra-Lopez, Kietsee A. Diaz-Dominguez, Jose L. Sanchez-Gloria, Andres Cruz-Melendez, Adrian Hernandez-Diazcouder, Yaneli Juarez-Vicuna, Fausto Sanchez-Munoz, Fengyang Huang, Claudia Tavera-Alonso, Malinalli Brianza-Padilla, Elvira Varela-Lopez, Daniel Sierra-Lara, Alexandra Arias-Mendoza, Gabriela Fonseca-Camarillo, Ricardo Marquez-Velasco, Hector Gonzalez-Pacheco, Rashidi Springall, Luis M. Amezcua-Guerra
Summary: This study suggests that miR-133b and miR-126 may serve as potential diagnostic biomarkers for distinguishing patients with ST-segment elevation myocardial infarction (STEMI) from those presenting with nonischemic chest discomfort. However, microRNAs have no associations with inflammatory markers or cardiovascular risk scores, nor do they have associations with the occurrence of major adverse cardiovascular events.
Article
Medicine, Research & Experimental
Gilberto Vargas-Alarcon, Oscar Perez-Mendez, Rosalinda Posadas-Sanchez, Hector Gonzalez-Pacheco, Alexandra Arias -Mendoza, Galileo Escobedo, Teresa Juarez-Cedillo, Marva Arellano-Gonzalez, Jose Manuel Fragoso
Summary: This study found that ABO gene polymorphisms are associated with a lower risk of ACS, lower systolic blood pressure, and plasma lipid levels.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Maria Elena Soto, Giovanny Fuentevilla-Alvarez, Solange Gabriela Koretzky, Gilberto Vargas-Alarcon, Yazmin Estela Torres-Paz, Sergio Enrique Meza-Toledo, Israel Perez-Torres, Claudia Huesca-Gomez, Ricardo Gamboa
Summary: Marfan syndrome is an inherited connective tissue disorder associated with spinal deformities. A study found that the SNP rs7755109 of the GPR126 gene is associated with scoliosis in patients with MFS.
BIOMOLECULES AND BIOMEDICINE
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)