Journal
CLINICA CHIMICA ACTA
Volume 459, Issue -, Pages 137-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2016.06.004
Keywords
SRA; Long noncoding RNAs; Nuclear receptor; Transcriptional coactivator
Categories
Funding
- National Natural Sciences Foundation of China [81000946, 81270359, 81173047]
- key projects of Hunan Provincial Education Department [15A138]
- Natural Science Foundation of Guangxi Province [2015GXNSFEA139003]
Ask authors/readers for more resources
Steroid receptor RNA activator (SRA) is a type of long noncoding RNA (lncRNA) which coordinates the functions of various transcription factors, enhances steroid receptor-dependent gene expression, and also serves as a distinct scaffold. The novel, profound and expanded roles of SRA are emerging in critical aspects of coactivation of nuclear receptors (NRs). As a nuclear receptor coactivator, SRA can coactivate androgen receptor (AR), estrogen receptor alpha (ER alpha), ER beta, progesterone receptor (PR), glucocorticoid receptor (GR), thyroid hormone receptor and retinoic acid receptor (RAR). Although SRA is one of the least well-understood molecules, increasing studies have revealed that SRA plays a key role in both biological processes, such as myogenesis and steroidogenesis, and pathological changes, including obesity, cardiomyopathy, and tumorigenesis. Furthermore, the SRA-related signaling pathways, such as the mitogen-activated protein kinase (p38 MAPK), Notch and tumor necrosis factor alpha (TNF alpha) pathways, play critical roles in the pathogenesis of estrogen-dependent breast cancers. In addition, the most recent data demonstrates that SRA expression may serve as a new prognostic marker in patients with ER-positive breast cancer. Thus, elucidating the molecular mechanisms underlying SRA-mediated functions is important to develop proper novel strategies to target SRA in the diagnosis and treatment of human diseases. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available