Journal
HUMAN MOLECULAR GENETICS
Volume 29, Issue 18, Pages 3154-3164Publisher
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddaa155
Keywords
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Funding
- Wellcome Trust [206619/Z/17/Z, 105022/Z/14/Z]
- National Institute for Health Research (NIHR)
- King's College London
- Medical Research Council [MR/N003284/1, MC-UU_12015/1, MC_PC_13048]
- Cancer Research UK [C864/A14136]
- Moorfields Eye Charity Career Development Fellowship
- MRC [G0500300, MR/N003284/1] Funding Source: UKRI
- Wellcome Trust [105022/Z/14/Z] Funding Source: Wellcome Trust
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Corneal hysteresis and corneal resistance factor are parameters that reflect the dynamic biomechanical properties of the cornea and have been shown to be biomarkers of corneal disease. In this genome-wide association study of over 100 000 participants, we identified over 200 genetic loci, all but eight novel, significantly associated with either one or both of these traits. In addition to providing key insights into the genetic architecture underlying normal corneal function, these results identify many candidate loci in the study of corneal diseases that lead to severe visual impairment. Additionally, using Mendelian randomization, we were able to identify causal relationships between corneal biomechanics and intraocular pressure measurements, which help elucidate the relationship between corneal properties and glaucoma.
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