Review
Biochemistry & Molecular Biology
Jacek Rysz, Beata Franczyk, Janusz Lawinski, Anna Gluba-Brzozka
Summary: Renal cell carcinoma is a group of malignant tumors of the renal cortex. Clear cell papillary renal cell carcinoma, a specific subtype, shares morphologic and genetic features with other subtypes but also has distinct clinical behavior. Differentiating clear cell papillary renal cell carcinoma from other subtypes is crucial for appropriate management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Huimin Sun, Xing Wei, Changchun Zeng
Summary: Xp11 translocation renal cell carcinoma (tRCC) is a newly identified subtype of RCC that urgently requires effective prevention and treatment strategies. Autophagy plays a crucial role in tRCC and could potentially serve as a therapeutic target.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Xiang Dong, Yuxin Chen, Jun Pan, Wenliang Ma, Peng Zhou, Ming Chen, Hongqian Guo, Weidong Gan
Summary: This study found that TFE3 expression in RCC is associated with tumor progression and poor prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Brannan B. Griffin, Xiaoqi Lin
Summary: The study compared the cytomorphology, immunoprofile, and clinical management of clear cell papillary renal cell carcinoma (CCPRCC), clear cell RCC (CCRCC), and papillary RCC (PRCC). Certain morphologic features and immunostaining patterns were found to help distinguish CCPRCC from CCRCC and PRCC, aiding in the diagnostic confirmation and clinical management of patients with CCPRCC's low-grade, indolent behavior.
CANCER CYTOPATHOLOGY
(2021)
Article
Pediatrics
Kaihang Yang, Yuhao Ma, Shuyang Dai, Rui Dong
Summary: Xp11.2 tRCC is a rare subtype of renal cell carcinoma in children and adults, characterized by TFE3 gene rearrangements. We reported a rare case of a 6-year-old male patient with Xp11.2 tRCC and retroperitoneal metastasis. The patient achieved a good therapeutic outcome after undergoing several surgeries. This case can provide reference and guidance for pediatric urologists and oncologists in recognizing and diagnosing rare renal cell carcinoma in children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Acoustics
Wenliang Ma, Fan Zhang, Haifeng Huang, Wei Wang, Yiqi Zhu, Yanwen Lu, Hongqian Guo, Weidong Gan
Summary: Conventional ultrasound (US) and contrast-enhanced US (CEUS) can be used to differentiate Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC) from other common renal cell carcinoma (RCC) subtypes. Xp11.2 tRCC is more common in young women and has hypo- and isoechoic lesions with a higher frequency of calcification. CEUS features include synchronous wash-in, iso-enhancement at peak, and fast wash-out.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Pathology
Sean R. Williamson
Summary: Clear cell papillary renal cell carcinoma is a distinct entity with recognizable morphological features, often small in size and showing consistent immunohistochemical markers. It shares similarities with extrarenal benign neoplasms and may be reclassified as a benign or low malignant potential neoplasm based on its clinical behavior and molecular characteristics.
Article
Pathology
Yunxia Li, Xiaofeng Wu, Jing Yang, Yanxia Jiang, Yujun Li, Wei Zhang, Wenjuan Yu
Summary: BSARCC is a rare subtype of renal cell carcinoma characterized by the presence of two different cell populations with distinct morphological and immunophenotypic features. Abnormal expression of CyclinD1 in large cells may be associated with tumor aggressiveness, which is not due to aberration of the CCND1 gene itself.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Pathology
Sophie Ferlicot, Pierre-Alexandre Just, Eva Comperat, Etienne Rouleau, Frederique Tissier, Christophe Vaessen, Stephane Richard
Summary: A rare autosomal dominant disease called Hereditary papillary renal cell carcinoma (HPRCC) is characterized by multiple and bilateral papillary type I renal cell carcinomas caused by activated mutations in the MET proto-oncogene. A case study of a 51-year-old man with HPRCC showed not only papillary tumors but also clear cell renal cell carcinomas. Immunohistochemistry and FISH testing revealed potential links between clear cell RCC and papillary RCC in the context of HPRCC syndrome.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Oncology
Jeroen A. A. van de Pol, Lisa George, Piet A. van den Brandt, Marcella M. L. L. Baldewijns, Leo J. Schouten
Summary: The study found that there are different impacts of body mass index (BMI) and smoking on the risk of clear-cell RCC (ccRCC) and papillary RCC (pRCC), while alcohol consumption is negatively associated with the risk of both. Hypertension is positively associated with the risk of both ccRCC and pRCC. The research also indicates significant differences in BMI, BMI change, and smoking duration among current smokers in terms of ccRCC and pRCC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Oliver Pavlovic, Tvrtko Hudolin, Ivan Miskulin, Stela Bulimbasic, Marijana Coric, Josip Perkovic, Toni Zekulic
Summary: Wnt proteins play an important role in normal kidney development and various kidney diseases, as well as potentially influencing carcinogenesis. This study focused on the immunohistochemical expression of Wnt-4 protein in healthy and tumorous tissue of patients with clear cell renal carcinoma (ccRCC). It was found that Wnt-4 expression was higher in healthy tissue compared to tumor tissue, with a negative correlation between tumor size and Wnt-4 expression. Additionally, patients with suspected metastatic diseases exhibited higher levels of Wnt-4 expression. The study also suggested that tumor progression may require Wnt-4 activation or reactivation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pathology
Sofia Canete-Portillo, Maria del Carmen Rodriguez Pena, Dezhi Wang, Diego F. Sanchez, George J. Netto, Cristina Magi-Galluzzi
Summary: The vascular architecture, microvessel density, and endothelial cell density differ between CCRCC and ccpRCC, which can be utilized as an additional tool for distinguishing the two.
Article
Biochemistry & Molecular Biology
Bin Zheng, Fang Xie, Fajuan Cheng, Jianwei Wang, Zhongshun Yao, Wei He, Zhihong Niu
Summary: This study comprehensively assessed the tumor microenvironment of kidney cancer, identified two immune-related hub genes - IGLL5 and IL2RA, and validated their clinical application value in ccRCC and pRCC. Drug response was also predicted based on selected genes, revealing novel drug candidates for RCC treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Kristian B. Laursen, Qiuying Chen, Francesca Khani, Nabeel Attarwala, Steve S. Gross, Lukas Dow, David M. Nanus, Lorraine J. Gudas
Summary: The study investigated the role of mitochondrial Ndufa4l2 protein in the development of ccRCC using a transgenic mouse model and found that targeted knockdown of Ndufa4l2 can slow down renal lipid accumulation and reduce the expression of ccRCC markers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Ameish Govindarajan, Nicholas J. Salgia, Haiqing Li, Daniela V. Castro, Tamara Mirzapoiazova, Brian Armstrong, Dan Zhao, Benjamin D. Mercier, Nazli Dizman, Neal Chawla, Zeynep Zengin, Luis Meza, Nishita Tripathi, Nicolas Sayegh, Alex Chehrazi-Raffle, Abhishek Tripathi, Sumanta K. Pal
Summary: This study characterizes and compares the immune cell populations of the tumor microenvironment in clear cell and papillary renal cell carcinoma using heavy metal-labeled antibodies. The results show differences in immune cell composition and abundance between the two subtypes.
FRONTIERS IN IMMUNOLOGY
(2023)