Editorial Material
Multidisciplinary Sciences
He Zhu
Summary: The Science Popularization and Education Committee of the Chinese Academy of Sciences organized a roundtable discussion on viral infectious diseases, where experts discussed the history and background of viruses, the functioning of the human immune system, and addressed common public concerns regarding COVID vaccines, treatment costs, and the latest monkeypox outbreak.
NATIONAL SCIENCE REVIEW
(2023)
Article
Multidisciplinary Sciences
Pablo Jose Antunez Muinos, Diego Lopez Otero, Ignacio J. Amat-Santos, Javier Lopez Pais, Alvaro Aparisi, Carla E. Cacho Antonio, Pablo Catala, Teba Gonzalez Ferrero, Gonzalo Cabezon, Oscar Otero Garcia, Jose Francisco Gil, Marta Perez Poza, Jordi Candela, Gino Rojas, Victor Jimenez Ramos, Carlos Veras, J. Alberto San Roman, Jose R. Gonzalez-Juanatey
Summary: The study aimed to establish laboratory predictors of mortality in COVID-19 disease in order to identify high-risk patients. By analyzing various laboratory biomarkers, a Covid-19 Lab score was created to predict mortality, with different risk groups identified based on the score. The score was found to be a simple and dynamic tool that could effectively predict mortality in patients with SARS-CoV2 infection.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Fatma Lestari, Abdul Kadir, Attika Puspitasari, Oktomi Suparni, Oktomi J. Wijaya, Herlina J. EL-Matury, Duta Liana, Riza Yosia Sunindijo, Achir Yani Hamid, Fira Azzahra
Summary: This research focuses on hospital preparedness for COVID-19 in Indonesia and assesses the readiness level based on the WHO checklist. The results show that hospitals in Jakarta and Yogyakarta have a higher level of readiness, while hospitals in West Java and North Sumatra vary in their level of readiness.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Xavier Nogues, Francisca Sanchez-Martinez, Xavier Castells, Adolfo Diez-Perez, Rosa Ana Sabate, Irene Petit, Ariadna Brase, Juan Pablo Horcajada, Roberto Guerri-Fernandez, Julio Pascual
Summary: A COVID-19-specific Hospital-at-Home initiative in Barcelona, Spain effectively reduced transmission risk and increased bed capacity, with only a small percentage of cases requiring referral for inpatient care. The results suggest the approach is promising and may be valuable for future outbreaks.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Ninh T. Nguyen, Justine Chinn, Katherine Kirby, Samuel F. Hohmann, Alpesh Amin
Summary: This study analyzed the characteristics and outcomes of adults with COVID-19 who received outpatient management compared to those who required hospitalization in US academic centers. The results showed that compared to hospitalized patients, those managed in an outpatient setting were more likely to be female, white, younger, and had a lower rate of comorbidities. Mortality was significantly lower in the outpatient group, and it increased with increasing age. The rate of hospitalization was lowest for the youngest age group and highest for the oldest age group. Factors associated with outpatient management included female gender, white race, and having commercial insurance.
Article
Health Care Sciences & Services
Karen B. Lasater, Linda H. Aiken, Douglas M. Sloane, Rachel French, Brendan Martin, Kyrani Reneau, Maryann Alexander, Matthew D. McHugh
Summary: Research found that nurse staffing varies across hospitals in New York and Illinois, with the worst mean staffing in New York City. Over half of nurses in both states experienced high burnout. Adjusted data showed that each additional patient per nurse increased the likelihood of nurses and patients giving unfavorable reports.
BMJ QUALITY & SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Fabio Fernandes Neves, Henrique Pott-Junior, Kaori Maria Carolina Yamashita, Sigrid de Sousa Santos, Marcia Regina Cominetti, Caio Cesar de Melo Freire, Anderson Ferreira da Cunha, Alceu Afonso Jordao
Summary: Excessive activation of the immune system in SARSCoV-2 infections leads to increased levels of reactive oxygen species, causing damage to cell structures and directly impacting disease severity and mortality. This cohort study evaluated the potential of plasma oxidative stress biomarkers to predict mortality in COVID-19 patients, accounting for confounding factors. The results showed significant differences in serum levels of alpha-tocopherol, glutathione, superoxide dismutase, and advanced oxidation protein products between survivors and non-survivors. Serum glutathione levels below 327.2 μmol/mL were associated with a significantly higher risk of death in COVID-19 patients, independent of other factors (adjusted hazard ratio = 3.12 [95% CI: 1.83-5.33]).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Elena Salvador, Cristina Mazzi, Nicoletta De Santis, Giulia Bertoli, Antonija Jonjic, Miran Coklo, Marek Majdan, Jose L. Penalvo, Dora Buonfrate
Summary: The study aimed to evaluate whether domiciliary treatment with non-steroidal anti-inflammatory drugs (NSAIDs) influenced the clinical outcome of COVID-19 patients who were hospitalized. The findings showed no association between domiciliary use of NSAIDs and clinical outcome, but older age and male sex were associated with an increased risk of death.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Virology
Toshiki Kuno, Matsuo So, Yoshihisa Miyamoto, Masao Iwagami, Mai Takahashi, Natalia N. Egorova
Summary: The study aimed to explore the association between hospitalizations of patients who tested positive for COVID-19 antibodies and reduced in-hospital mortality. Patients with positive COVID-19 antibody tests showed lower in-hospital mortality compared to those with negative test results after adjustments for patient characteristics and treatments. In conclusion, positive COVID-19 antibody test results were linked to a decreased risk of in-hospital mortality for COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Felicity Cornforth, Lucie Webber, Gabriele Kerr, Hywell Dinsdale, Azeem Majeed, Peter Greengross
Summary: This study aims to examine the impact of COVID-19 vaccination on hospital admissions in England in 2021. The study found that the unvaccinated had higher hospital admission rates compared to the vaccinated. Vaccine effectiveness waned over time, especially in older and at-risk groups. The findings support the continuation of a booster vaccination program, particularly for older people and higher clinical risk groups.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Veronica Cian, Alessandro De Laurenzis, Chiara Siri, Anna Gusmeroli, Margherita Canesi
Summary: This study aims to assess the prevalence of neuropsychological and neuropsychiatric impairment in patients after hospitalization due to COVID-19. The results showed that COVID+ patients exhibited vulnerability in memory and executive functions, while the control group showed higher levels of anxiety.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Engineering, Mechanical
Pedro M. C. L. Pacheco, Marcelo A. Savi, Pedro V. Savi
Summary: This paper describes the dynamics of COVID-19 based on a susceptible-exposed-infectious-removed model, highlighting the importance of social isolation and hospital infrastructure. The results show a strong sensitivity of system dynamics to the transmission rate.
NONLINEAR DYNAMICS
(2021)
Article
Multidisciplinary Sciences
Hagai Rossman, Tomer Meir, Jonathan Somer, Smadar Shilo, Rom Gutman, Asaf Ben Arie, Eran Segal, Uri Shalit, Malka Gorfine
Summary: The study reveals that in Israel, during periods of moderate or high hospital load due to severely ill COVID-19 patients, the in-hospital mortality rates significantly increased, independent of patient characteristics.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Q. Tan, Qing-Jun Liu, Wen-Hui Fan, Xiao-Yan Du, Lin Wu, Hong-Min Gong, Jing Wei, Rui Zhao, Ming Lei, Li-Bo Zhao
Summary: During the COVID-19 pandemic, there was a decrease in the number of acute stroke patients seeking medical care in designated hospitals, but these hospitals were more efficient in providing timely treatment for acute stroke patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Infectious Diseases
Andrew Mutekanga, Edwin Nuwagira, Elias Kumbakumba, Victoria Nyaiteera, Stephen Asiimwe, Medal Gasumuni, Nelson Wandera, Robert Natumanya, Denis Akena, Siraje Senoga, Joseph Kyobe Kiwanuka, George Kateregga, Emmanuel Munyarugero, Fardous Charles Abeya, Paul Stephen Obwoya, Stephen Ttendo, Rose Muhindo
Summary: This study found a high 30-day in-hospital mortality among patients with severe COVID-19 in southwestern Uganda. Factors associated with 30-day in-hospital mortality included age, neutrophil to lymphocyte ratio, and oxygen requirement.
INFECTION AND DRUG RESISTANCE
(2022)
