Article
Gastroenterology & Hepatology
Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P. Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen G. C. McGregor, Tim Ambrose, Bruce D. George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P. L. Travis, Jack Satsangi
Summary: The changes in acute severe colitis (ASC) management have resulted in improved outcomes. A simple predictive model can be used to identify patients who will not respond to steroids upon admission.
Article
Surgery
J. A. Bunce, B. Doleman, J. N. Lund, G. M. Tierney
Summary: This study investigated the impact of surgeon subspeciality on outcomes after emergency laparotomy for inflammatory bowel disease (IBD). It found that colorectal surgeons had significantly better outcomes in terms of mortality and length of stay for the least urgent category of IBD emergency laparotomies. However, this association was not seen in more urgent cases.
WORLD JOURNAL OF SURGERY
(2023)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
N. M. Daraiseh, A. Black, P. Minar, A. Meisman, M. Saxe, E. A. Lipstein
Summary: Research shows that AYAs need more information about their disease and treatment when managing ulcerative colitis. The development of the iBDecide shared decision-making tool, which includes information on treatment, medication, nutrition, and symptom tracking, aims to promote engagement in shared decision-making among AYAs. The usability test results indicate that AYAs found iBDecide easy to use and expressed willingness to use it, with a mean SUS score of 78.25.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Review
Gastroenterology & Hepatology
Stephane Nancey, Mathurin Fumery, Mathias Faure, Gilles Boschetti, Claire Gay, Laurent Milot, Xavier Roblin
Summary: Cross-sectional magnetic resonance enterography (MRE) and intestinal ultrasonography (IUS) are valuable and noninvasive imaging modalities for the assessment, monitoring, and prediction of disease activity and outcomes in inflammatory bowel disease (IBD) patients. However, the underutilization of IUS in clinical practice is due to the lack of validated indices and trained gastroenterologists and radiologists. Nevertheless, the increasing evidence highlights the importance of both IUS and MRE in aiding clinical decision-making.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Christopher Ma, Jurij Hanzel, Remo Panaccione, William J. Sandborn, Geert R. D'Haens, Vineet Ahuja, Raja Atreya, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert Bryant, Benjamin Cohen, Jean-Frederic Colombel, Silvio Danese, Axel Dignass, Marla C. Dubinsky, Phillip R. Fleshner, Richard B. Gearry, Stephen B. Hanauer, Ailsa Hart, Paulo Gustavo Kotze, Torsten Kucharzik, Peter L. Lakatos, Rupert W. Leong, Fernando Magro, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, Miguel Regueiro, Siddharth Singh, Antonino Spinelli, A. Hillary Steinhart, Simon P. Travis, C. Janneke van der Woude, Bruce Yacyshyn, Takayuki Yamamoto, Matthieu Allez, Willem A. Bemelman, Amy L. Lightner, Edouard Louis, David T. Rubin, Ellen J. Scherl, Corey A. Siegel, Mark S. Silverberg, Severine Vermeire, Claire E. Parker, Stefanie C. McFarlane, Leonardo Guizzetti, Michelle Smith, Niels Vande Casteele, Brian G. Feagan, Vipul Jairath
Summary: This study establishes a core outcome set for randomized controlled trials of CD and UC through a multidisciplinary collaboration involving patients and clinical experts. Candidate outcome domains and measures were generated from literature reviews and patient engagement. The study highlights the importance of harmonizing endpoints for drug development in inflammatory bowel disease.
Article
Gastroenterology & Hepatology
Giuseppe Biscaglia, Anna Latiano, Stefano Castellana, Rosanna Fontana, Annamaria Gentile, Tiziana Latiano, Giuseppe Corritore, Anna Panza, Marianna Nardella, Giuseppina Martino, Fabrizio Bossa, Francesco Perri, Tommaso Mazza, Angelo Andriulli, Orazio Palmieri
Summary: This study investigated germline alterations in patients with inflammatory bowel disease (IBD)-associated colorectal cancer (CRC). The results showed that a significant proportion of IBD patients with CRC had pathogenic variants in cancer-related genes. Those with pathogenic variants had earlier onset of high-grade dysplasia or CRC compared to patients with benign or unidentified variants. Screening for these genes could help identify IBD patients who require more intensive surveillance for early detection of dysplastic changes.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pathology
Zhiyan Fu, Michel Kmeid, Soe Htet Arker, Georgi Lukose, Edward C. Lee, Gregory Y. Lauwers, Hwajeong Lee
Summary: This study aimed to identify histologic features of diverted colon segments in IBD patients and found that severe inflammatory activity, mucosal atrophy, and transmural inflammation were significantly greater in IBD patients compared to non-IBD cases. The inflammatory activity, presence of ulcer(s), IMLAs, TMLAs, and transmural inflammation in diverted colon segments of IBD patients may reflect the severity of underlying IBD.
Article
Gastroenterology & Hepatology
Heather J. Galipeau, Alberto Caminero, Williams Turpin, Miriam Bermudez-Brito, Alba Santiago, Josie Libertucci, Marco Constante, Juan Antonio Raygoza Garay, Gaston Rueda, Sarah Armstrong, Alex Clarizio, Michelle Smith, Michael G. Surette, Premysl Bercik, Kenneth Croitoru, Elena F. Verdu
Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.
Article
Health Care Sciences & Services
Andrew H. Kim, Afaf Girgis, Peter De Cruz, Corey A. Siegel, Neda Karimi, Sasha O. Ruban, Alexandra J. Sechi, Wa Sang Watson Ng, Jane M. Andrews, Susan J. Connor
Summary: This study aims to explore the feasibility and acceptability of myAID, a web-based decision aid, in informing treatment decisions for ulcerative colitis (UC) from the perspectives of Australian patients and clinicians. The study found that myAID was generally acceptable to clinicians as a tool to facilitate shared decision making (SDM) in UC management, but its uptake varied depending on clinicians' approaches to patient education and practice.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Aonghus Lavelle, Stephane Nancey, Jean-Marie Reimund, David Laharie, Philippe Marteau, Xavier Treton, Matthieu Allez, Xavier Roblin, Georgia Malamut, Cyriane Oeuvray, Nathalie Rolhion, Xavier Dray, Dominique Rainteau, Antonin Lamaziere, Emilie Gauliard, Julien Kirchgesner, Laurent Beaugerie, Philippe Seksik, Laurent Peyrin-Biroulet, Harry Sokol
Summary: This study investigated the association between gut microbiota, bile acids, and colorectal cancer in IBD patients. The results found that specific bacterial taxa were associated with cancer, while bile acids were not. Additionally, clustering analysis identified microbiota clusters associated with clinical features.
Letter
Gastroenterology & Hepatology
Charlie W. Lees, Tariq Ahmad, Christopher Andrew Lamb, Nick Powell, Shahida Din, Rachel Cooney, Nicholas A. Kennedy, Rachel Ainley, Ruth Wakeman, Christian Philipp Selinger
Article
Gastroenterology & Hepatology
Nicholas A. Kennedy, Malik Janjua, Neil Chanchlani, Simeng Lin, Claire Bewshea, Rachel Nice, Timothy J. McDonald, Cressida Auckland, Lorna W. Harries, Merlin Davies, Stephen Michell, Klaartje B. Kok, Christopher A. Lamb, Philip J. Smith, Ailsa L. Hart, Richard C. G. Pollok, Charlie W. Lees, Rosemary J. Boyton, Daniel M. Altmann, Shaji Sebastian, Nicholas Powell, James R. Goodhand, Tariq Ahmad
Summary: This study found that a third dose of an mRNA-based vaccine can boost antibody responses and immunity in infliximab-treated patients with IBD. However, these patients had lower antibody concentrations compared to those treated with vedolizumab and were more likely to experience breakthrough infections and reinfections.
Article
Gastroenterology & Hepatology
Eleanor Liu, Robyn Laube, Rupert W. Leong, Aileen Fraser, Christian Selinger, Jimmy K. Limdi
Summary: Objective assessment shows that gastroenterology health care professionals have good knowledge of pregnancy-specific IBD, but there is inconsistency in applying this knowledge in decision-making. Further education for clinicians is needed to provide optimal standardized care for IBD in pregnancy.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Sailish Honap, Peter M. Irving, Mark A. Samaan
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Robin John Dart, Mallika Sekhar, Katie Planche, Martyn Caplin, Charles Murray
Editorial Material
Gastroenterology & Hepatology
Antonia M. D. Churchhouse, Victoria E. L. Moffat, Christian P. Selinger, Christopher A. Lamb, Michelle J. Thornton, Ian Penman, Shahida Din
Review
Gastroenterology & Hepatology
Shaji Sebastian, Jonathan P. Segal, Charlotte Hedin, Gianluca Pellino, Paulo Gustavo Kotze, Michel Adamina, Marjo Campmans-Kuijpers, Justin Davies, Annemarie C. de Vries, Ana Gutierrez Casbas, Alaa El-Hussuna, Pascal Juillerat, Susanna Meade, Monica Millan, Antonino Spinelli
Summary: This article provides expert consensus practice recommendations for peri-operative care in patients with inflammatory bowel diseases (IBD) to optimize surgical outcomes.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Pediatrics
Greg Young, Janet E. Berrington, Stephen Cummings, Jon Dorling, Andrew K. Ewer, Alessandra Frau, Lauren Lett, Chris Probert, Ed Juszczak, John Kirby, Lauren C. Beck, Victoria L. Renwick, Christopher Lamb, Clare Lanyon, William McGuire, Christopher Stewart, Nicholas Embleton
Summary: This study investigated the impact of supplemental bovine lactoferrin on the gut microbiome and metabolome of preterm infants. The results showed minimal impacts of lactoferrin on the microbiome composition, while hospital site and postnatal age had a larger impact. This study provides guidance for future trial design.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Gastroenterology & Hepatology
Matthew J. Lee, ENiGMA CODE collaborators
Summary: The aim of this study was to develop a core descriptor set for reporting Crohn's anal fistula (CAF) research. Through an international modified Delphi process, a consensus was reached on 37 core descriptors within six domains, which may aid in transparent reporting for future studies.
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Richard Pollok, Nishani Jayasooriya, Samantha Baillie, Jonathan Blackwell, Irene Petersen, Alex Bottle, Sonia Saxena, POP IBD Study Grp
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Richard Pollok, Samantha Baillie, Nishani Jayasooriya, Jonathan Blackwell, Irene Petersen, Alex Bottle, Sonia Saxena
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Robyn Laube, Christian P. Selinger, Cynthia H. Seow, Britt Christensen, Emma Flanagan, Debra Kennedy, Reme Mountifield, Sean Seeho, Antonia Shand, Astrid-Jane Williams, Rupert W. Leong
Summary: This study aimed to update consensus statements that guide the clinical management of pregnancy in patients with inflammatory bowel disease (IBD). Through a multidisciplinary working group's discussion and voting, consensus agreements were reached. It is crucial to achieve and maintain IBD remission and engage in a multidisciplinary approach to optimize pregnancy outcomes.
Article
Rheumatology
Rory H. Maclean, Fiza Ahmed, Voon H. Ong, Charles D. Murray, Christopher P. Denton
Summary: In this phenome-wide association study (PheWAS), we investigated the causes and contributors to gastrointestinal dysfunction in systemic sclerosis (SSc) using clinical records data. We found associations between drugs, diagnoses, and antinuclear antibodies (ANA) with important SSc-GI outcomes such as constipation, diarrhea, and gastroesophageal reflux. Our study also identified potential novel risk factors for SSc-GI dysfunction.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Annastazia Learoyd, Lauren Arnold, Fiona Reid, Nicholas Beckley-Hoelscher, Alina Casian, Shirish Sangle, Neil Morton, Louise Nel, Angela Cape, Susan John, Sangmi Kim, Dharshene Shivapatham, Raashid Luqmani, David Jayne, James Galloway, Abdel Douiri, David D'Cruz
Summary: This is a clinical trial that aims to explore the use of hydroxychloroquine as a treatment for patients with non-severe ANCA-associated vasculitis. The trial will assess hydroxychloroquine's efficacy and potential to reduce the need for immunosuppressive treatments, while improving patient outcomes and reducing costs.
Review
Rheumatology
Nikita Arumalla, Chun K. D. Chan, Mark Gibson, Yik L. Man, Maryam A. Adas, Sam Norton, James B. Galloway, Toby Garrood
Summary: This study evaluated the clinical impact of electronic patient-reported outcome measures (ePROMs) on patients with inflammatory arthritides (IAs). The findings showed that ePROM monitoring can reduce disease activity, increase rates of remission/low disease activity, and decrease the need for face-to-face visits, potentially reducing healthcare resource use without detrimental impact on disease outcomes.
ARTHRITIS & RHEUMATOLOGY
(2023)