Genetic driver mutations introduced in identical cell‐of‐origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

(2020) David A. Reardon et al.   JAMA Oncology

Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

(2019) Junfei Zhao et al.   NATURE MEDICINE

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(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

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(2019) Kurt A. Schalper et al.   NATURE MEDICINE

Phase II study to evaluate safety and efficacy of MEDI4736 (durvalumab) + radiotherapy in patients with newly diagnosed unmethylated MGMT glioblastoma (new unmeth GBM).

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Does neoadjuvant anti-PD1 therapy improve glioblastoma outcome?

(2019) Anna S. Berghoff et al.   Nature Reviews Neurology

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors

(2019) Ioannis Kaffes et al.   OncoImmunology

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

(2018) Xin Cui et al.   BIOMATERIALS

Concepts for Immunotherapies in Gliomas

(2018) Michael Platten et al.   SEMINARS IN NEUROLOGY

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

(2018) Konrad Gabrusiewicz et al.   OncoImmunology

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(2018) Pakawat Chongsathidkiet et al.   NATURE MEDICINE

Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1

(2018) Zhi-Fa Wen et al.   Journal for ImmunoTherapy of Cancer

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(2018) Massimo Romani et al.   Frontiers in Oncology

Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas

(2017) C. J. Herting et al.   GLIA

Recurrent glioma clinical trial, CheckMate-143: the game is not over yet

(2017) Anna C. Filley et al.   Oncotarget

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

(2017) Yiwen Jiang et al.   Cell Reports

Current Advances in Checkpoint Inhibitors: Lessons from Non-Central Nervous System Cancers and Potential for Glioblastoma

(2017) Natasha Lakin et al.   Frontiers in Oncology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype

(2016) Smitha Sreedharan et al.   CANCER RESEARCH

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid Engraftment in Humanized Mice: Impact of Granulocyte-Colony Stimulating Factor Treatment and Transgenic Mouse Strain

(2016) Alice M. Coughlan et al.   STEM CELLS AND DEVELOPMENT

The Hippo transducer TAZ promotes cell proliferation and tumor formation of glioblastoma cells through EGFR pathway

(2016) Rui Yang et al.   Oncotarget

PD-L1 expression and prognostic impact in glioblastoma

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Differential roles of resident microglia and infiltrating monocytes in murine CNS autoimmunity

(2015) Anat Shemer et al.   Seminars in Immunopathology

Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma

(2014) Tatsuya Ozawa et al.   CANCER CELL

Modeling Adult Gliomas Using RCAS/t-va Technology

(2014) Dolores Hambardzumyan et al.   Translational Oncology

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

(2013) Anat London et al.   Frontiers in Cellular Neuroscience

Bleach gel: A simple agarose gel for analyzing RNA quality

(2012) Patrick S. Aranda et al.   ELECTROPHORESIS

Increased Microglia/Macrophage Gene Expression in a Subset of Adult and Pediatric Astrocytomas

(2012) Jane R. Engler et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

(2010) Noah Saederup et al.   PLoS One

Worse Outcome in Primary Glioblastoma Multiforme With Concurrent Epidermal Growth Factor Receptor and p53 Alteration

(2009) Yolanda Ruano et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

The role of microglia in central nervous system immunity and glioma immunology

(2009) Isaac Yang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

(2009) Haihao Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

(2009) Dan R. Laks et al.   STEM CELLS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE