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Medicine, Research & Experimental
Wanli Duan, Siyuan Pan, Yuyao Zhai, Qian Deng, Wei Ren, Chun Du, Yi Sun
Summary: The function of miR-613 in RCC was investigated and it was confirmed that upregulation of miR-613 can control proliferation, metastasis, and invasion in RCC cells by reducing AXL levels and controlling the PI3K/AKT signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Biotechnology & Applied Microbiology
Xiang Ding, Xu Xu, Xue-Feng He, Ye Yuan, Chuang Chen, Xin-Yu Shen, Sai Su, Zhang Chen, Song-Tao Xu, Yu-Hua Huang
Summary: The study found that MBNL1-AS1 inhibits the progression of Prostate cancer by regulating miR-181a-5p and the PTEN/PI3K/AKT/mTOR signaling pathway.
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Oncology
Yu-Kuei Chen, Ngo Tran My Ngoc, Hsi-Wen Chang, Ying-Fang Su, Chung-Hwan Chen, Yih-Gang Goan, Jeff Yi-Fu Chen, Chun-Wei Tung, Tzyh-Chyuan Hour
Summary: This study found that chlorogenic acid can inhibit the metastasis and invasion ability of esophageal squamous cell carcinoma by affecting the EGFR/p-Akt/Snail pathway.
ANTICANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Yitong Xu, Chenglong Wang, Xizi Jiang, Yao Zhang, Hongbo Su, Jun Jiang, Hongjiu Ren, Xueshan Qiu
Summary: KLHL38 plays a promoting role in non-small cell lung cancer, enhancing cell proliferation, migration, and invasion through activating the Akt signaling pathway, and is closely associated with the malignancy of tumors.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Yazhen Xu, Bingyu Guo, Xiaoyan Liu, Kai Tao
Summary: miR-34a inhibits melanoma growth by targeting ZEB1, suggesting a potential novel target for melanoma treatment.
Article
Cell Biology
Rui Zhao, Yuzhen Ge, Yongjun Gong, Bo Li, Benli Xiao, Shi Zuo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. This study found that low expression of NAP1L5 in HCC was associated with shorter survival and disease-free survival. NAP1L5 inhibited the proliferation, migration, and invasion of hepatoma cells, and induced apoptosis. It also inhibited the growth and metastasis of HCC cells in vivo. Mechanistically, NAP1L5 regulated the PI3K/AKT/mTOR signaling pathway by controlling MYH9 to affect the occurrence and development of HCC. NAP1L5 may be a potential target for liver cancer treatment.
Article
Genetics & Heredity
Binjun He, Kang Zhang, Xiaoliang Han, Chao Su, Jiaming Zhao, Guoxia Wang, Guzong Wang, Liuya Zhang, Wenbin Hu
Summary: This study found that miRNA-105-5p in blood-derived vesicles promotes the development and progression of esophageal squamous cell carcinoma (ESCC) by regulating SPARCL1 and the FAK/Akt signaling pathway. This suggests that serum vesicles could be a novel therapy for ESCC and miRNA-105-5p could be a potential target for ESCC treatment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei, Donghua Zou
Summary: Our study suggests that MDK promotes GBM by activating the PI3K-Akt signaling pathway, and it describes a potential regulatory network involved. MDK is highly expressed in GBM and is associated with poor prognosis, potentially serving as a promising diagnostic and prognostic biomarker for GBM. Overexpression of MDK enhances proliferation, migration, and invasion of GBM cell lines, while suppression of MDK exerts opposite effects. The study also highlights the involvement of MDK in various cancer-related pathways, such as PI3K-Akt signaling, the cell cycle, and VEGF signaling.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Chandra Bhushan Prasad, Deepika Singh, Laxmi Kant Pandey, Satyajit Pradhan, Sunita Singh, Gopeshwar Narayan
Summary: The study reveals that VEGFR2 regulates angiogenesis and epithelial-mesenchymal transition in cervical cancer cells through various signaling pathways. Inhibitors targeting VEGFR showed potential in suppressing metastatic events and cancer-induced angiogenesis. Blocking VEGFR2 signaling altered the formation and growth of cervical tumorspheres, suggesting a potential therapeutic strategy for cervical cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Cell Biology
Jingdian Liu, Junwen Wang, Weidong Tian, Yu Xu, Ran Li, Kai Zhao, Chao You, Yuan Zhu, Joerg Walter Bartsch, Hongquan Niu, Huaqiu Zhang, Kai Shu, Ting Lei
Summary: This study demonstrates for the first time that PDCD10 can induce aggressive behaviors of pituitary adenomas by promoting cellular proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) through the CXCR2-AKT/ERK signaling axis.
Article
Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.