Review
Gastroenterology & Hepatology
Alberto Martino, Marco Di Serafino, Luigi Orsini, Francesco Giurazza, Roberto Fiorentino, Enrico Crolla, Severo Campione, Carlo Molino, Luigia Romano, Giovanni Lombardi
Summary: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common and serious medical emergency with high morbidity and mortality. While current guidelines address NVUGIB due to peptic ulcer disease, they do not cover the management of rare and extraordinary rare causes of NVUGIB. It is crucial for all involved clinicians to be familiar with and knowledgeable about these life-threatening conditions, as they often require prompt diagnosis and treatment using a multidisciplinary team approach. The aim of this review is to provide a comprehensive summary of the current evidence regarding the management of such cases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Loren Laine, Ernst J. Kuipers, Alan N. Barkun
Summary: Personalized management strategies should be based on patient characteristics, nature of bleeding lesions, and clinical setting, including available resources.
Article
Gastroenterology & Hepatology
Rapat Pittayanon, Wichitra Khongka, Sittikorn Linlawan, Rattikorn Thungsuk, Surasak Aumkaew, Nicha Teeratorn, Jeerawat Maytapa, Sayamon Kimtrakool, Piyapoom Pakvisal, Natanong Kongtub, Rungsun Rerknimitr, Alan Barkun
Summary: Current guidelines on managing malignant gastrointestinal bleeding vary due to low-quality evidence. This study found that TC-325 hemostatic powder resulted in higher immediate hemostasis rates and lower 30-day rebleeding rates compared to standard endoscopic treatment.
Review
Medicine, General & Internal
Omero Alessandro Paoluzi, Edoardo Troncone, Elena De Cristofaro, Mezia Sibilia, Giovanni Monteleone, Giovanna Del Vecchio Blanco
Summary: Hemostatic powder is a new method for treating gastrointestinal bleeding, which acts as a mechanical barrier or promotes platelet activation and coagulation cascade. However, there are still some unanswered questions regarding its use and efficacy.
MEDICINA-LITHUANIA
(2023)
Review
Gastroenterology & Hepatology
Vikram Kate, Sathasivam Sureshkumar, Balakrishnan Gurushankari, Raja Kalayarasan
Summary: Acute gastrointestinal bleeding is a common surgical emergency associated with high morbidity and mortality. The controversy remains on various management issues, such as appropriate risk stratification, timing of endoscopy, and choosing intervention methods, while drug management also poses a challenge.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Medicine, General & Internal
Pablo Canamares-Orbis, Angel Lanas Arbeloa
Summary: Gastrointestinal bleeding can occur at any point along the mucosa of the gastrointestinal tract. The increasing number of patients suffering from gastrointestinal bleeding is partly due to the extensive use of antiplatelet and anticoagulants drugs. The influence of the microbiome in small bowel bleeding presents a potential therapeutic target for bleeding prevention.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Iulia Ratiu, Raluca Lupusoru, Alina Popescu, Ioan Sporea, Adrian Goldis, Mirela Danila, Bogdan Miutescu, Tudor Moga, Andreea Barbulescu, Roxana Sirli
Summary: This observational retrospective study aimed to investigate the differences and associated factors between variceal and nonvariceal upper gastrointestinal bleeding (UGIB). The results showed that there was a higher rebleeding rate in patients with variceal bleeding.
Article
Medicine, General & Internal
Ah Young Yoo, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Seung Han Kim, Won Shik Kim, Hoon Jai Chun
Summary: Among patients undergoing dual antiplatelet therapy, some may experience recurrent upper gastrointestinal bleeding. These patients are predominantly male, with bleeding mainly from the stomach and peptic ulcers. Age is an important factor for re-bleeding, all-cause mortality, and re-bleeding-related mortality.
Review
Gastroenterology & Hepatology
Ali A. Alali, Alan N. Barkun
Summary: Upper gastrointestinal bleeding (UGIB) is a common gastrointestinal emergency that has significant morbidity and mortality. The epidemiology of UGIB has been changing with a decrease in peptic ulcer disease and an increase in other etiologies. Risk assessment and patient stratification are important for optimal care, with some tools able to identify a low-risk group for outpatient management. Primary care providers play a crucial role in resuscitation, stabilizing patients, providing blood transfusions, and arranging urgent endoscopic assessment and intervention. Managing antithrombotic agents in the acute setting remains challenging.
GASTROENTEROLOGY REPORT
(2023)
Article
Gastroenterology & Hepatology
Boram Cha, Donghyun Lee, Jongbeom Shin, Jin-Seok Park, Gye-Suk Kwon, Hyungkil Kim
Summary: This study evaluated the efficacy of a novel endoscopic hemostatic powder (UI-EWD) in acute lower gastrointestinal bleeding (LGIB) and found that the UI-EWD group had higher success rates in hemostasis and lower re-bleeding rates compared to the conventional treatment group, with no UI-EWD-related adverse events recorded.
BMC GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jongbeom Shin, Boram Cha, Jin-Seok Park, Weonjin Ko, Kye Sook Kwon, Jin-Woo Lee, Hyung Kil Kim, Yong Woon Shin
Summary: The study evaluated the feasibility and efficacy of a new endoscopic hemostatic powder (UI-EWD) in treating tumor bleeding. The results showed that UI-EWD was successful at all tumor bleeding sites, with high immediate hemostasis success rate and low re-bleeding rate within 28 days. UI-EWD as a monotherapy also demonstrated a 100% immediate hemostasis success rate.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Eszter Boros, Zoltan Sipos, Peter Hegyi, Brigitta Teutsch, Levente Frim, Szilard Vancsa, Szabolcs Kiss, Fanni Dembrovszky, Eduard Ostarijas, Andrew Shawyer, Balint Eross
Summary: The study found that among NVUGIB patients, prophylactic transcatheter arterial embolization (PTAE) can reduce the odds of rebleeding and reintervention, with lower mortality rates and surgical requirements.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Won Shik Kim, Seung Han Kim, Moon Kyung Joo, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun
Summary: Objective Non-variceal upper gastrointestinal bleeding (NVUGIB) in patients receiving oral anticoagulants (OACs) may be fatal; however, little is known about re-bleeding and all-cause mortality after successful hemostasis. We investigated the clinical characteristics and risk factors for re-bleeding and death after successful hemostasis. The study found that 30.3% of patients experienced re-bleeding after successful hemostasis, with a mortality rate of 37.5% among these patients, and 2.3% of deaths were related to re-bleeding.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Weam El Hajj, Vincent Quentin, Gaelle Boudoux D'Hautefeuille, Helene Vandamme, Chantal Berger, Mohammed Redha Moussaoui, Aliou Berete, Dominique Louvel, Jean Guy Bertolino, Emmanuel Cuillerier, Quentin Thiebault, Yves Arondel, Sylvie Grimbert, Brigitte Guillou, Isabelle Borel, Pierre Lahmek, Stephane Nahon
Summary: The study reveals that inpatients with variceal and non-variceal upper gastrointestinal bleeding tend to be older and have more comorbidities, leading to higher mortality and rebleeding rates. Independent predictors of mortality include underlying coagulopathy and recurrence of bleeding.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Hong Jae Jeon, Hee Seok Moon, In Sun Kwon, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong
Summary: The study compared the predictive accuracy of several scoring systems for non-variceal upper gastrointestinal bleeding (NVUGIB) patients and found that the new Japanese scoring system, ABC score, and PNED score performed better in predicting 30-day mortality, need for therapeutic intervention, and rebleeding. Factors such as sex, systolic blood pressure, and heart failure were related to outcomes in NVUGIB patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
