Review
Immunology
Tiarne van de Walle, Alessandra Vaccaro, Mohanraj Ramachandran, Ilkka Pietila, Magnus Essand, Anna Dimberg
Summary: Glioblastoma is an aggressive brain tumor with a low prevalence of tumor-reactive T cells, and recent data suggest that naive T cells may be activated within brain tumor-associated tertiary lymphoid structures. Promoting tertiary lymphoid structures could enhance priming of tumor antigen-targeted T cells and sensitize glioblastomas to cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Evan D. Bander, Jonathan P. S. Knisely, Theodore H. Schwartz
Summary: This article discusses the potential indications and advantages of Brachytherapy in the treatment of CNS tumors, while also highlighting the issues with data reliability and predicting future directions.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Engineering, Biomedical
Daniel S. Badali, Yonatan Vainer, Christopher W. Ellenor, Christopher R. Mitchell, Kalman Fishman, Nicolas Soro, Russ Price, Tobias Funk
Summary: The inverse radiation treatment planning algorithm is designed for Sensus Healthcare's Sculptura(TM) electronic brachytherapy system, utilizing simulated annealing to optimize the conformation number (CN). The algorithm achieved high conformal treatment plans with an average CN of 0.79 ± 0.08 and an average gamma passing rate of 0.90 ± 0.10 at 5%/5 mm, demonstrating the potential to reduce treatment time by 20% without sacrificing plan quality. Additionally, downsampling the voxelized volume resulted in a significant speedup of the optimization process without impacting plan quality.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Nalee Kim, Do Hoon Lim, Sang Eun Yoon, Seok Jin Kim, Won Seog Kim
Summary: This study retrospectively analyzed the efficacy of salvage radiotherapy in patients with primary central nervous system lymphoma, showing a higher overall response rate in the sRT group compared to the nRT group, with no significant difference in survival rates. Further studies are needed to identify patient selection criteria for benefiting from salvage radiotherapy.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Review
Neurosciences
Jared Mattingly, Yuchen Li, Ji C. Bihl, Jinju Wang
Summary: Exosomes, secreted by various types of cells, play a crucial role in cell-to-cell communication by delivering proteins and nucleic acids. They are increasingly recognized for their involvement in the pathogenesis of central nervous system diseases and as a promising therapeutic strategy. Research has shown that exosome infusion has beneficial effects on CNS injury animal models, highlighting their potential in neurological medicine.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Kohei Yoshimura, Shinji Kawabata, Hideki Kashiwagi, Yusuke Fukuo, Koji Takeuchi, Gen Futamura, Ryo Hiramatsu, Takushi Takata, Hiroki Tanaka, Tsubasa Watanabe, Minoru Suzuki, Naonori Hu, Shin-Ichi Miyatake, Masahiko Wanibuchi
Summary: The study found that boron neutron capture therapy can be used to treat primary central nervous system lymphoma with promising survival outcomes. The results suggest that BNCT may become a new treatment option for PCNSL.
Review
Biochemistry & Molecular Biology
Carina Marques Coelho, Lia Pereira, Pamela Teubig, Pedro Santos, Filipa Mendes, Silvia Vinals, Daniel Galaviz, Federico Herrera
Summary: Radiotherapy could be a promising treatment for neurodegenerative disorders involving protein misfolding and amyloidogenesis. However, its impact on the central nervous system is still uncertain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemical Research Methods
Md Habibur Rahman, Humayan Kabir Rana, Silong Peng, Xiyuan Hu, Chen Chen, Julian M. W. Quinn, Mohammad Ali Moni
Summary: This study investigates the relationship between central nervous system disorders and glioblastoma by analyzing shared differentially expressed genes and cell signaling pathways. The findings suggest that CNS disorders may influence the progression, growth, or establishment of glioblastoma, and could potentially serve as therapeutic targets. The comparison with gold standard databases offers further support for the identified biomarkers in the pathology underlying the progression of GBM.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Kiyohisa Kamimura, Tsubasa Nakano, Tomohito Hasegawa, Masanori Nakajo, Chihiro Yamada, Yoshiki Kamimura, Kentaro Akune, Fumitaka Ejima, Takuro Ayukawa, Hiroaki Nagano, Koji Takumi, Masatoyo Nakajo, Nayuta Higa, Hajime Yonezawa, Ryosuke Hanaya, Mari Kirishima, Akihide Tanimoto, Takashi Iwanaga, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura
Summary: This study aimed to investigate the impact of effective diffusion time setting on differentiation between PCNSLs and GBMs based on ADC, and to explore the usage of time-dependent diffusion MRI parameters. The results showed that in enhancing regions, PCNSLs had lower ADC values and higher cADC and rcADC values compared to GBMs, while there were no significant differences in peritumoral regions. The use of longer diffusion time resulted in better differentiation performance when evaluating ADC.
Article
Oncology
Nalee Kim, Hoon Do Lim, Sang Eun Yoon, Seok Jin Kim, Won Seog Kim
Summary: Upfront whole-brain radiation therapy (RT) with a reduced dose of 23.4 Gy showed favorable outcomes in patients with stable disease or progressive disease after initial HD-MTX in PCNSL. In addition, upfront RT appears to be an effective treatment for PCNSL when rituximab or stem cell transplantation is not feasible.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yi Zhuo, Yi Zhang, Bing Wang, Shiqi Cheng, Raorao Yuan, Shaowen Liu, Mailin Zhao, Bin Xu, Yan Zhang, Xiaolei Wang
Summary: A new fluorescent probe QAI was synthesized in this study, which could effectively treat MRSA infections in the central nervous system with the help of near-infrared laser and was difficult to develop drug resistance.
APPLIED MATERIALS TODAY
(2022)
Review
Cell Biology
Maria Lalkovicova
Summary: Ionizing radiation can cause irreversible damage to brain cells, leading to serious brain damage and diseases. Current treatments target processes such as cell apoptosis and neuroinflammation. However, the potential side effects and toxicity of these treatments need to be considered. This review focuses on the latest and most effective agents for the treatment and prevention of radiation damage to the central nervous system.
NEURAL REGENERATION RESEARCH
(2022)
Review
Neurosciences
Ziang Geng, Shu Guan, Siqi Wang, Zhongxue Yu, Tiancong Liu, Shaonan Du, Chen Zhu
Summary: This study aims to review the mechanism of mitochondrial transfer in the progress of central nervous system diseases and the possibility of targeted therapy. It found that various types of cells in the central nervous system can transfer mitochondria to each other through different pathways. Additionally, stress signals can trigger the transfer of mitochondria, and various molecular pathways and inhibitors can affect this process. Finally, the study proposes potential targeted pathways and treatment methods for regulating mitochondrial transfer in the treatment of related diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Immunology
Xuan Ying Poh, Fei Kean Loh, Jon S. Friedland, Catherine W. M. Ong
Summary: Tuberculosis (TB) is a major infectious disease worldwide, with central nervous system tuberculosis (CNS-TB) being the most severe form. Neutrophils play a crucial role in CNS-TB by carrying out antimicrobial functions and mediating inflammation and tissue destruction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Matthew S. Peach, Aiden M. Burke, Jasmine Jo, Andrew W. Ju, Kaida Yang
Summary: This case report demonstrates the feasibility of combining GammaTile with dose-matched EBRT volumes for partially resected, recurrent intracranial neoplasms in a reproducible manner.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Oncology
Dominic J. Gessler, Elizabeth C. Neil, Rena Shah, Joseph Levine, James Shanks, Christopher Wilke, Margaret Reynolds, Shunqing Zhang, Can Ozutemiz, Mehmet Gencturk, Mark Folkertsma, W. Robert Bell, Liam Chen, Clara Ferreira, Kathryn Dusenbery, Clark C. Chen
Summary: This study reports the clinical outcomes of using GT brachytherapy platform to treat recurrent glioblastoma patients. The treatment showed good efficacy, survival rates, and local control, with no severe complications observed.
NEURO-ONCOLOGY ADVANCES
(2022)