Journal
FUTURE MICROBIOLOGY
Volume 15, Issue 10, Pages 881-896Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2019-0290
Keywords
Acinetobacter baumannii; bacteriophage particles; biohydrogel; choline oleate ionic liquids; transdermal permeation
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo, Brazil)
- FAPESP [2016/08884-3, 2016/12234-4, 2018/05522-9]
- PROSUP-CAPES
- Junior Research contract (CEEC Individual) - Portuguese Foundation for Science and Technology (FCT) [03974/2017]
- CNPq, National Council for Scientific and Technological Development Brazil [306113/2014-7, 308208/2017-0]
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Aim: A sodium alginate-based biohydrogel was prepared integrating choline oleate deep euthetic solvent as facilitator of transdermal delivery and a cocktail of lytic bacteriophages for Acinetobacter baumannii, aiming at treating soft-tissue infections by the aforementioned pathogen. Materials & methods: Two bacteriophages were isolated from a hospital sewage and a wastewater treatment plant sewage in Sorocaba (Brazil), and characterized via SDS-PAGE electrophoresis, transmission electron microscope and evaluation of lytic spectra of the bacteriophage cocktail. The biohydrogel was prepared and characterized by DSC, FTIR, XRD, DESEM, XRT and transdermal permeation of the bacteriophage cocktail. Results & conclusion: The physico-chemical characterization of the biohydrogel produce indicated adequate structural characteristics and ability to promote/facilitate transdermal delivery of bacteriophage particles, thus showing potential for biopharmaceutical applications.
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