Article
Biochemistry & Molecular Biology
Keita Adachi, Michiyasu Ishizawa, Shigeyuki Uno, Hitomi Kubota, Takuo Henmi, Tsugumichi Koshinaga, Makoto Makishima, Kenichi Sakurai
Summary: Oral administration of BaP has a protective effect against DSS-induced colitis, reducing inflammation and tissue damage without causing toxic metabolic activation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Hui Xu, Chi Chun Wong, Weilin Li, Yunfei Zhou, Yan Li, Lifu Wang, Lei Liu, Jun Yu
Summary: The study demonstrated that RNF6 promotes colorectal cancer by upregulating SF3B2 transcriptionally, suggesting that the RNF6-SF3B2 axis could be a promising target for CRC therapy. Targeting this axis with SF3B2 inhibitor pladienolide B suppressed CRC cell growth and the combination with 5-fluorouracil showed synergistic effects, leading to tumor regression in xenograft models.
Article
Multidisciplinary Sciences
Ha-Rim Kim, Eun-Mi Noh, Seon-Young Kim
Summary: Ginger has a long history of use in India for both food and medicine and has shown to have strong anti-inflammatory properties. This study aimed to investigate the effects of different derivatives of gingerol and shogaol in a mouse model of colitis. The results showed that these derivatives effectively improved clinical symptoms and intestinal barrier damage and inhibited inflammation through the regulation of NF-kappa B signaling. The compound 10-shogaol was found to be the most effective.
Article
Multidisciplinary Sciences
Jie Xiong, Hongmei Yuan, Shihong Fei, Shengli Yang, Ming You, Li Liu
Summary: In this study, four types of red ginseng were evaluated for their ability to inhibit lung tumor formation and growth. Korean red ginseng B was found to be the most effective in lowering tumor load, and it had the highest level of ginsenoside Rg3. The bioavailability of G-Rg3 was improved when coadministered with verapamil, resulting in increased tumor-preventive abilities.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Yun Luo, Baoqin Zhang, Ningbo Geng, Shuai Sun, Xiaoyao Song, Jiping Chen, Haijun Zhang
Summary: The study investigated the toxicological effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) on human L02 hepatocytes, finding that 6-Cl-B[a]P exhibited stronger toxicity, metabolomic perturbation, and oxidative stress compared to B[a]P. Additionally, 6-Cl-B[a]P caused a wider disruption to metabolic pathways and inhibited mitochondrial electron transport chain activities more significantly than B[a]P. Both compounds also disturbed nucleotide metabolism, glycerophospholipid metabolism, and amino acid metabolism in L02 cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Medicinal
Jeng-Wei Lu, Yuxi Sun, Liang-In Lin, Dong Liu, Zhiyuan Gong
Summary: The study demonstrates the critical role of twist1a and xmrk in HCC metastasis in zebrafish, with inflammatory agents affecting this process. These findings underscore the importance of signaling crosstalk between twist1a and xmrk in regulating HCC metastasis.
Article
Materials Science, Multidisciplinary
Banu Mansuroglu, Kadriye Kizilbey, Fatma Sayan Poyraz, Zuhal Yurttas, Sumeyra Nur Fuerkaiti, Ipek Yagmur Abaoglu, Hatice Nursah Basat
Summary: The study utilized chitosan and dextran sulphate sodium to form a pH-sensitive hydrogel suitable for wound dressing materials, with added vitamin-C and quercetin for accelerating wound healing. Experimental results showed that both loaded and unloaded hydrogels had higher cell viability rates compared to the control group at the end of the 7-day period.
MATERIALS TECHNOLOGY
(2021)
Article
Oncology
Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jeong Eun Yu, Heewon Nho, Eun Shin, Ha-Na Lee, Young-Joon Surh
Summary: The study examined the effects of orchiectomy and testosterone administration on colorectal tumorigenesis in a mouse model. Orchiectomy reduced colitis indices and tumor incidence, which was reversed by testosterone supplementation. Both endogenous and exogenous testosterone were associated with tumor development, supporting a stimulating effect on colorectal carcinogenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joao Martins de Mello-Neto, Gayathiri Elangovan, Edilson Ervolino, Newell Walter Johnson, Anders Gustafsson, Carlos Marcelo da Figueredo
Summary: This study investigated the impact of DSS-induced colitis on periodontal tissues in Wistar rats and found an overexpression of cytokines related to the immune response in gingival tissue.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Shereen E. Elkholy, Shymaa Ahmad Maher, Noura R. Abd El-hamid, Heba A. Elsayed, Wael Abdou Hassan, Asmaa K. K. Abdelmaogood, Samar M. Hussein, Mariusz Jaremko, Samar Zuhair Alshawwa, Hanan M. Alharbi, Samar Imbaby
Summary: Ulcerative colitis (UC) is a chronic autoimmune disease characterized by its relapsing and remitting nature, and it is considered a major healthcare problem. This study evaluated the therapeutic effects of oral probiotics and azithromycin regimens in a rat model of UC, and found that the combination therapy showed the most synergistic beneficial effects in improving histological architecture and reducing inflammation markers in UC tissues. These findings highlight the potential of combining probiotics and azithromycin as a therapeutic approach to enhance the quality of life in UC patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Shuang Pan, Yaming Li, Jinzhao Zhang
Summary: This study investigated the chemopreventive role of 6-shogaol (6-SGL) in BaP-induced lung carcinogenesis by modulating PRDX1-associated oxidative stress, inflammation, and proliferation in mouse models. The results showed that 6-SGL prevented body weight loss, increased lung weight, and the total number of tumors in BaP-exposed mice. Additionally, 6-SGL inhibited lipid peroxidation, restored antioxidant activity, and suppressed MAPK signaling in BaP-exposed mice.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Plant Sciences
Xuan-qing Chen, Xiang-yu Lv, Shi-jia Liu
Summary: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abdalla A. Elbashir, Amira A. Alfadil, FakhrEldin O. Suliman, Ahmed O. Alnajjar
Summary: In this study, the inclusion complexes of cucurbit[n]uril (CB[n], n=6-8) with polyaromatic hydrocarbons (PAHs) Benzo(a)Pyrene (BaP) and fluoranthene (FLT) were examined in aqueous media. The inclusion complexes were characterized and studied using fluorescence and 1H NMR spectroscopy. The 1:1 guest:host complexes were found to be the predominant complexes. Stability constants were determined for the complexes of BaP with CB[6], CB[7], and CB[8] as 2322 +/- 547 M-1, 7281 +/- 689 M-1, and 3566 +/- 473 M-1, respectively. Similarly, stability constants for the complexes of FLT with CB[6], CB[7], and CB[8] were found to be 5900.270 +/- 326 M-1, 726.87 +/- 78 M-1, and 3327.059 +/- 153 M-1, respectively. Molecular dynamics simulations were used to investigate the inclusion process and stability of these complexes in aqueous media. The results showed that stable inclusion complexes were formed between BaP/FLT and CB[7]/CB[8], while CB[6] formed stable exclusion complexes with the PAHs.
Article
Toxicology
L. Wang, J. Xue, F. Wei, G. Zheng, M. Cheng, S. Liu
Summary: The study demonstrated that galangin has a significant anti-tumor effect against BaP-induced stomach carcinogenesis in mice, mainly by inhibiting tumor incidence and volume, reducing lipid peroxidation, and restoring cellular antioxidant status to prevent tumor formation.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Immunology
Priyanka Raju Chougule, Rajendra Sangaraju, Pradeep B. B. Patil, S. S. Y. H. Qadri, Virendra V. V. Panpatil, Sudip Ghosh, Sathish Kumar Mungamuri, Manjula Bhanoori, Sukesh Narayan Sinha
Summary: This study demonstrates the protective effect of ethyl gallate (EG) and propyl gallate (PG) in various combinations on DSS-induced ulcerative colitis in mice. The results show that EG and PG significantly reduce the severity of colitis and improve clinical symptoms. This suggests that the combination of EG and PG has potential as a treatment for inflammatory bowel disease (IBD).
INFLAMMOPHARMACOLOGY
(2023)
