Article
Environmental Sciences
Ruiqi Fan, Wanjun Zhang, Lizhong Li, Li Jia, Jun Zhao, Zengming Zhao, Shuangqing Peng, Xiaoyan Yuan, Yiqiang Chen
Summary: The fungicide carbendazim and insecticide chlorpyrifos, used together to protect fruit and vegetable crops in China, have potentially harmful effects on zebrafish embryonic development, both individually and in combination, showing significant synergistic effects. These findings suggest the need for health and environmental risk assessments for various combinations of these agents.
Article
Chemistry, Physical
Ksenia S. Egorova, Alexandra Posvyatenko, Artem N. Fakhrutdinov, Alexey S. Galushko, Marina M. Seitkalieva, Valentine P. Ananikov
Summary: This study applied NMR spectroscopy and scanning electron microscopy to investigate the interactions between ionic liquids and anticancer drugs, revealing synergistic or antagonistic cytotoxic effects in some mixtures. The observed cytotoxic effects were found to be cell type-dependent, with all test substances inducing cell death via necrosis in the CaCo-2 cell line. The study suggests potential benefits of utilizing ionic liquids in drug formulations.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Environmental Sciences
Julieta Peluso, Agustina Furio Lanuza, Cristina S. Perez Coll, Carolina M. Aronzon
Summary: The study found that glyphosate was significantly more toxic to Rhinella arenarum larvae than 2,4-D, with toxicity varying over time. The equitoxic mixture showed additive toxicity at 48 hours and became antagonistic at LC10 and LC50 effect levels after 96 hours. The non-equitoxic mixture exhibited additive toxicity at LC10 effect level from 48 to 168 hours, and synergistic effect from 240 hours.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Bin Cui, Shaozhu Fu, Xin Hao, Dandan Zhou
Summary: In this study, a simultaneous combination of ozonation and biodegradation (SCOB) was proposed to treat coking wastewater. The SCOB system showed higher COD and total phenol removal compared to individual biodegradation and ozonation systems. Ozonation contributed to the oxidation of organics with unsaturated functional groups and soluble microbial products (SMPs), resulting in a decrease in effluent toxicity and chroma. The core of the carrier became the dominant region for biodegradation, leading to the stabilization of COD removal at >80%.
Article
Environmental Sciences
Francisco Rios, Manuela Lechuga, Ismael Lobato-Guarnido, Mercedes Fernandez-Serrano
Summary: The aim of this study is to assess the toxicological effects of three anionic surfactants and three amphoteric surfactants, individually and in binary mixtures, on bacteria and marine microalgae. The results showed that the marine microalgae were more sensitive to the surfactants and mixtures, and the toxic effects of the mixtures were lower than expected.
Article
Environmental Sciences
Tian Yang, Yuting Lu, Yuchen Wang, Liufu Wang, Feng Zhang, Di Ming, Qingsheng Cao, Hui Yang, Yingying Zhang, Wenzhi Wei
Summary: This study investigated the combined toxicity of benzethonium chloride (BEC) and polyhexamethylene guanidine hydrochloride (PHMG-H), widely used sanitizing products during the COVID-19 pandemic. PHMG-H was found to be more toxic than BEC in terms of mortality and genotoxicity. The interaction between the two compounds was evaluated using the concentration addition (CA) model and additive index (AI) method, showing synergistic effects at a 1:9 ratio of BEC + PHMG-H and increased antagonistic effects with increasing BEC concentration over PHMG-H. The findings improve our understanding of how BEC and PHMG-H interact at different mixing ratios and assist in risk assessments for binary mixtures in aquatic ecosystems.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Physical
Dirk Paustian, Marcus Franke, Michael Stelter, Patrick Braeutigam
Summary: Advanced oxidation processes offer promising techniques for water remediation and degradation of micropollutants. The synergistic intensification potential of an ultrasound-assisted photocatalysis (sonophotocatalysis) for bisphenol A degradation was investigated. By adjusting the energy input and photocatalyst dosage, the degradation efficiency can be enhanced.
Article
Environmental Sciences
Jianlong Yan, Yanbin Pan, Junbo He, Xinli Pang, Wenming Shao, Caiping Wang, Rongning Wang, Yaqiong He, Min Zhang, Juheng Ye, Chaolan Lin, Feng Lin, Yongshun Wang, Tangzhiming Li, Yu Lan, Yanbin Guo, Minxian Wang, Mengting Sun, Yun Gong, Mingpei Yuan, Xin Sun, Shaohong Dong
Summary: Polystyrene microplastics are common components of plastic pollution and their impact on vascular toxicity is poorly understood. This study found that patients with vascular calcification had higher levels of polystyrene microplastics in their feces. It was also demonstrated that exposure to polystyrene microplastics induced mild vascular calcification in normal rats and aggravated calcification in rats treated with vitamin D3 and nicotine. Furthermore, polystyrene microplastics disrupted the gut microbiota and caused intestinal inflammation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Chul-Woong Cho, Thi Phuong Thuy Pham, Yufeng Zhao, Stefan Stolte, Yeoung-Sang Yun
Summary: Interest in ionic liquids (ILs) has been growing due to their promising properties, but their actual environmental impact needs careful consideration. ILs may not directly cause atmospheric pollution, but can have adverse effects if leaked into the environment. The toxicity effects of ILs depend on their structure and toxicity testing levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Junguo Ma, Penglin Zhu, Wenhua Wang, Xiaodan Zhang, Panliang Wang, Yousef Sultan, Yuanyuan Li, Weikai Ding, Xiaoyu Li
Summary: This study revealed that chronic exposure to CPF can induce reproductive toxicity in adult zebrafish and transfer CPF from parent fish to offspring. Female fish exposed to CPF showed negative effects on oocyte development and quality, as well as decreased egg production. The larvae, on the other hand, exhibited inhibited heart rate, increased mortality, and disturbance in oxidative balance due to parental CPF exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Yinai Liu, Qianqian Chen, Yaoqi Li, Liuliu Bi, Libo Jin, Renyi Peng
Summary: The large amounts of enriched cadmium in the environment pose serious threats to the aquaculture industry and food processing industry. Studying the toxic effects of cadmium on fish and its possible effects on human health is significant. Research has shown that cadmium accumulation in fish causes tissue differences and damages various physiological systems, including antioxidant defense, reproduction, and immunity.
Article
Environmental Sciences
Haiqing Cai, Yu Bao, Hong Cheng, Xiaoting Ge, Mengdi Zhang, Xiuming Feng, Yuan Zheng, Junxiu He, Yue Wei, Chaoqun Liu, Longman Li, Lulu Huang, Fei Wang, Xing Chen, Pan Chen, Xiaobo Yang
Summary: Heavy metal mixtures can cause nerve damage, but their combined effects are complex and understudied. This study investigated the combined effects of manganese, lead, and arsenic on nerves and the role of zinc homeostasis in metal toxicity. The results showed that certain metal mixtures induced synergistic toxicity, damaging movement, behavior, and neurons, as well as reducing zinc concentration. Zinc supplementation improved zinc homeostasis, restored redox balance, and enhanced nerve function. These findings highlight the importance of considering the interactions between metal mixtures and essential metal homeostasis when assessing metal toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Qingqing Xiang, Ying Zhou, Chengxia Tan
Summary: The enantioselective toxic effects of Prothioconazole (PTC) on Scendesmus obliquus (S. obliquus) were investigated. It was found that R-(-)-PTC had less impact on the growth and photosynthetic pigment contents of S. obliquus compared to Rac-PTC and S-(+)-PTC. This study provides important information for the ecological risk assessment of PTC.
Article
Marine & Freshwater Biology
Yuanyuan Bao, Yuxin Chen, Yixi Zhou, Qian Wang, Zhenghong Zuo, Chunyan Yang
Summary: This study investigated the reproductive toxicity of chronic diflubenzuron exposure in female marine medaka. The results showed that exposure to diflubenzuron resulted in reduced reproductive performance, altered ovarian histopathology, inhibited development of the F1 generation, and changes in hormone levels and gene expression. These findings highlight the importance of investigating the potential environmental risks of diflubenzuron in marine ecosystems.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Peng Huang, Yu Wang, Shu-Shen Liu, Ze-Jun Wang, Ya-Qian Xu
Summary: This study explores the interaction of pesticide mixtures on Caenorhabditis elegans behavioral toxicity endpoint by creating a synergistic-antagonistic heatmap. The results show significant concentration-response relationship and strong synergism among the toxic chemicals. The emergence of synergism raises concerns about these hazardous chemicals.
ENVIRONMENTAL POLLUTION
(2022)
Review
Toxicology
Silvia Vivarelli, Chiara Costa, Michele Teodoro, Federica Giambo, Aristidis Michael Tsatsakis, Concettina Fenga
Summary: Non-communicable diseases (NCDs) are major global causes of mortality and morbidity. Unhealthy lifestyle habits are closely associated with NCDs, and improving these habits may help alleviate symptoms and prolong the life expectancy of affected individuals. Polyphenols (PPLs) derived from plants have shown positive results in preventing and treating NCDs and are considered safe.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
N. V. Tyshko, N. S. Nikitin, S. I. Shestakova, E. O. Sadykova, M. D. Trebukh, G. V. Guseva, N. V. Trusov, I. V. Aksenov, K. S. Golokhvast, A. Tsatsakis, V. A. Tutelyan
Summary: In a chronic model experiment on rats, the liver morphology, intensity of apoptosis, and activity of xenobiotic metabolism enzymes were studied after exposure to a mixture of 6 pesticides and lifelong diets with adequate and insufficient supply of water-soluble vitamins. The dose of each pesticide in the mixture did not exceed the acceptable daily intake (1 ADI). The findings suggest that chronic exposure to low doses of anthropogenic toxicants combined with permanent vitamin deficiency can cause various liver changes, including increased apoptosis activity, depletion of the cytochrome P450 system, steatosis, and inflammatory infiltration, posing a potential health risk.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Gennadiy Onishchenko, Natalia Nikolayeva, Valery Rakitskii, Alexandra Ilnitskaya, Andrey Filin, Aleksei Korolev, Elena Nikitenko, Elena Denisova, Andreas Tsakalof, Ekaterina Guseva, Sergey Kuzmin, Aristidis Tsatsakis
Summary: This study evaluated the health effects of combined or separate exposure to hazardous factors in plasma technology occupational environment on animal models. The results showed that exposure to noise or its combination with chemical factors led to non-specific changes in the CNS, especially in the case of joint exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Magdalena Mititelu, Denisa Ioana Udeanu, Anca Oana Docea, Aristidis Tsatsakis, Daniela Calina, Andreea Letitia Arsene, Mirela Nedelescu, Sorinel Marius Neacsu, Bruno Stefan Velescu, Manuela Ghica
Summary: The release of heavy metals into the natural environment poses problems for ecosystems and human health. Honey can contain heavy metals from agricultural or industrial sources, and consuming contaminated honey can lead to serious health problems. This study aimed to determine the concentrations of heavy metals in honey and soil and assess the associated risks.
ENVIRONMENTAL RESEARCH
(2023)
Review
Food Science & Technology
Ronald Neil Kostoff, Michael Brandon Briggs, Darja Kanduc, Saikat Dewanjee, Ramesh Kandimalla, Yehuda Shoenfeld, Alan L. Porter, Aristidis Tsatsakis
Summary: The severe complications of COVID-19 are a result of the individual's dysfunctional immune response to the initial SARS-CoV-2 infection. Multiple toxic stressors and behaviors contribute to immune system dysfunction which the virus exploits to cause COVID-19. This study identifies eighty modifiable contributing factors that link directly to COVID-19, and shows how each factor contributes to immune system dysfunction, inflammation, coagulation, neural damage, and neurodegeneration. It emphasizes the importance of addressing and eliminating these factors in combatting COVID-19 and similar diseases caused by viral variants.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ourania Anesti, Nafsika Papaioannou, Catherine Gabriel, Achilleas Karakoltzidis, Vazha Dzhedzheia, Ioannis Petridis, Antonios Stratidakis, Mike Dickinson, Milena Horvat, Janja Snoj Tratnik, Aristidis Tsatsakis, Spyros Karakitsios, Dimosthenis A. A. Sarigiannis
Summary: This study presents an integrated approach to investigating the impact of perinatal exposure to metals on child neurodevelopment in two cohorts carried out in Slovenia and Greece. The study found that heavy metal exposure during the perinatal period is associated with impaired mitochondrial respiration and oxidative stress, leading to developmental disorders in children. Additionally, factors such as diet, proximity to pollution sources, and socioeconomic and demographic characteristics also play a role in child neurodevelopment.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Medicinal
Betul Cicek, Ahmet Hacimuftuoglu, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Serhat Hayme, Dimitris Matthaios, Dimitra P. P. Vageli, Sotirios G. G. Doukas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: According to population-based studies, lung cancer is the most common cause of cancer-related deaths worldwide in males, and its incidence among females is also increasing alarmingly. Sorafenib (SOR), a multitargeted protein kinase inhibitor used for the treatment of hepatocellular carcinoma and renal cell carcinoma, has been the subject of interest in preclinical and clinical trials for lung cancer. This study aimed to investigate the effects of SOR in diethylnitrosamine (DEN)-induced lung carcinogenesis and explore its mechanisms of action. The results showed that SOR reduced the levels of SOX-2, TNF-alpha, and IL-1 beta, and alleviated the histopathological damage caused by DEN-induced lung carcinogenesis. Immunohistochemical and immunofluorescence analysis also revealed that SOR treatment decreased the expression of COX-2 and JNK in DEN-intoxicated rats. These findings suggest that SOR inhibits lung precancerous lesions induced by DEN through reducing inflammation and SOX-2 levels.
Article
Environmental Sciences
Konstantin Pikula, Konstantin Kirichenko, Vladimir Chernousov, Sergey Parshin, Alexander Masyutin, Yulia Parshina, Anton Pogodaev, Alexander Gridasov, Aristidis Tsatsakis, Kirill Golokhvast
Summary: This study evaluated the aquatic toxicity of two suspension samples obtained from underwater welding using electrode and flux-cored wire on marine microalgae Attheya ussuriensis and Porphyridium purpureum. The results showed that the suspension obtained from welding with electrode had an acute toxic impact on A. ussuriensis, while both suspensions had chronic toxicity with a 40% growth rate inhibition in this microalga. However, P. purpureum showed tolerance to both suspensions due to the presence of an exopolysaccharide covering that prevented the toxic impact of metal cations.
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Letter
Toxicology
Gio B. Gori, Michael Aschner, Christopher J. Borgert, Samuel M. Cohen, Daniel R. Dietrich, Corrado L. Galli, Helmut Greim, John S. Heslop-Harrison, Sam Kacew, Norbert E. Kaminski, James E. Klaunig, Hans W. J. Marquardt, Olavi Pelkonen, Ruth Roberts, Kai M. Savolainen, Aristidis Tsatsakis, Hiroshi Yamazaki
Summary: The 1958 Delaney amendment banned food additives causing cancer in animals through appropriate tests. However, chronic animal cancer tests have proven to be inconsistent and unreliable in predicting cancer hazards in humans. This poses an existential crisis for regulatory agencies that have relied on such tests to formulate regulations for alleged cancer causing agents.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Toxicology
Viorica Dinca, Anca Oana Docea, Andrei Ioan Drocas, Taxiarchis Konstantinos Nikolouzakis, Polychronis D. Stivaktakis, Dragana Nikitovic, Kirill S. Golokhvast, Antonio F. Hernandez, Daniela Calina, Aristidis Tsatsakis
Summary: The current risk assessment approach for chemicals fails to consider real-life exposure scenarios. The exposure to chemical mixtures in everyday life has become a concern in recent years. This study investigated the long-term effects of exposure to a mixture of 13 chemicals in adult rats and found dose-dependent changes in all examined organs. The main organs involved in biotransformation and clearance consistently presented histopathological changes. Exposure to very low doses of the tested mixture for 18 months induced histopathological lesions and cytotoxic effects in a dose and tissue-dependent manner.
ARCHIVES OF TOXICOLOGY
(2023)
Editorial Material
Substance Abuse
Cornel Radu-Loghin, Karina Mocanu, Hani Al Gouhmani, Constantine Vardavas, Ioanna Lagou, Zinovia Plyta, Aikaterini Papathanasaki, Stella Vogiatzidaki, Alexander Vardavas, Manolis Tzatzarakis, Aristidis Tsatsakis, Filip-pos Filippidis, Christina Kyriakos, Esteve Fernandez, Olena Tigova, Cristina Martinez, Anna Mar Lopez Luque, Marius Eremia, Lucia Maria Lotrean, Antigona Trofor, Thomas Wenzl, Bill Simpson, Pippa Powell, Polina Starchenko, Angeliki Bakou, Eleni Asimaki, Victoria Vivilaki
TOBACCO PREVENTION & CESSATION
(2023)
Article
Chemistry, Medicinal
Sidika Genc, Tarik Yagci, Dimitra P. Vageli, Riza Dundar, Panagiotis G. Doukas, Sotirios G. Doukas, Maria Tolia, Nikolaos Chatzakis, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study found that serum exosomal miR-223, miR-146, and PTEN expression were significantly decreased, while miR-21 expression was significantly increased in LSCC patients. In addition, CRP and vitamin B12 levels were also altered. These results suggest that the expression of serum exosomal miR-223, miR-146, miR-21, as well as the changes in CRP and vitamin B12 levels, may serve as potential indicators of LSCC.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Oncology
Aristidis Tsatsakis, Elisavet Renieri, Dimitris Tsoukalas, Ana Maria Buga, Evangelia Sarandi, Elena Vakonaki, Persefoni Fragkiadaki, Athanasios Alegakis, Dragana Nikitovic, Daniela Calina, Demetrios A. Spandidos, Anca Oana Docea
Summary: This study evaluated the effects of a novel telomerase activator on telomere length and telomerase activity in aged rats. The nutraceutical formulation was found to reduce telomere shortening rate at lower dose and increase telomere length at higher dose. Telomerase activity was also increased in the treated rats.
MOLECULAR MEDICINE REPORTS
(2023)
Correction
Medicine, Research & Experimental
Felician Stancioiu, Georgios Z. Papadakis, George Lazopoulos, Demetrios A. Spandidos, Aristidis Tsatsakis, Marius Floroiu, Corin Badiu
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)