Article
Endocrinology & Metabolism
Fei Guo, Zhentao Gong, Taniya Fernando, Lingshan Zhang, Xiaoyong Zhu, Yingli Shi
Summary: This retrospective study examined lipid profiles in women with polycystic ovary syndrome (PCOS) and assessed the correlation between changes in key lipid parameters and PCOS characteristics. The study found a high prevalence of dyslipidemia in Chinese PCOS patients, with different lipid profiles observed in individuals with different PCOS characteristics. The findings suggest a complex relationship between lipid metabolism and PCOS characteristics, which may explain the increased risk of long-term cardiovascular disease. Regular screening of blood lipids is important for PCOS women, and further research is needed to identify optimal subgroups for lipid-lowering treatment and assess therapeutic effectiveness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Endocrinology & Metabolism
Pooja Suresh Poojary, Guruprasad Nayak, Gangotri Panchanan, Arpitha Rao, Sanjna Das Kundapur, Sneha Guruprasad Kalthur, Srinivas Mutalik, Satish Kumar Adiga, Yulian Zhao, Jamie Bakkum-Gamez, Alice Y. Chang, Christopher DeStephano, Mark Sherman, Nagarajan Kannan, Guruprasad Kalthur
Summary: Polycystic ovarian syndrome (PCOS) is a complex health condition associated with metabolic disturbances and infertility. Existing animal models do not fully reflect the features of PCOS, leading to a lack of consensus on appropriate models and inducing agents.
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Michal Kunicki, Anna Calik-Ksepka, Katarzyna Suchta, Anna Duszewska, Katarzyna Smolarczyk, Roman Smolarczyk
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women, characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. The role of Anti-Mullerian Hormone in PCOS still requires further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Lalrawngbawli Annie, Guruswami Gurusubramanian, Vikas Kumar Roy
Summary: Polycystic ovary syndrome is a common reproductive disorder characterized by hyperandrogenism, insulin resistance, cystic ovary and infertility in females. The inhibition of visfatin by FK866 in hyperandrogenised mice shows potential in ameliorating the pathogenesis of PCOS, suggesting a therapeutic role in PCOS management.
Article
Multidisciplinary Sciences
Leili Rahmatnezhad, Lida Moghaddam-Banaem, Tahereh Lak, Afshin Shiva, Javad Rasuli
Summary: This study aimed to determine the levels of free androgen index (FAI) and its association with oxidative stress and insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients. The prevalence of the four PCOS phenotypes in 160 participants was determined, and it was found that phenotype C had the highest FAI levels. In linear regression analysis, PCOS phenotype, follicle-stimulating hormone (FSH) levels, and malondialdehyde (MDA) levels were significantly related to FAI, while homeostatic model assessment for insulin resistance (HOMA-IR) was not associated with FAI.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Enrico Carmina, Rosa Alba Longo
Summary: It is well known that some women with PCOS have excessive adrenal androgen production, which is generally associated with ovarian hyperandrogenism. This study found that adrenal hyperandrogenism is more common in non-classic PCOS phenotypes and is generally part of a generalized higher production of androgens in a subgroup of PCOS patients. However, other factors may increase adrenal androgen production and influence the clinical expression of the syndrome.
Article
Endocrinology & Metabolism
Maria Forslund, Johanna Schmidt, Mats Brannstrom, Kerstin Landin-Wilhelmsen, Eva Dahlgren
Summary: The study found that women with PCOS aged 72 to 91 had lower FSH levels, remained clinically hyperandrogenic, and had similar FAI and body composition as controls. From perimenopausal age until the present age, levels of testosterone and FAI continued to decline in women with PCOS, while SHBG levels continued to increase with age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Mauro S. B. Silva, Laurine Decoster, Gaspard Delpouve, Tori Lhomme, Gaetan Ternier, Vincent Prevot, Paolo Giacobini
Summary: The study manipulated GnRH neurons in adult female mice to investigate the impact of chronic overactivation on PCOS-like hormonal and reproductive impairments. The results showed that hyperactivity of hypothalamic GnRH neurons is a major driver of reproductive and hormonal impairments in PCOS, and antagonizing the aberrant GnRH signaling could be an efficient therapeutic venue for the treatment of PCOS.
Article
Medicine, General & Internal
Gulnar Mammadova, Ceren Ozkul, Selen Yilmaz Isikhan, Aylin Acikgoz, Bulent O. Yildiz
Summary: The gut microbiome of lean PCOS patients with full phenotype showed compositional alterations with similar bacterial richness and diversity compared to controls. Hyperandrogenism is associated with dysbiosis in the gut microbiota of PCOS patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Claire Rodier, Blandine Courbiere, Sara Fernandes, Marie Vermalle, Bretelle Florence, Noemie Resseguier, Thierry Brue, Thomas Cuny
Summary: PCOS and hPRL commonly coexist, with a quarter of cases attributed to microprolactinoma. The metoclopramide test can be helpful in distinguishing etiologies and potentially avoiding unnecessary pituitary MRI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Blazej Meczekalski, Anna Szeliga, Marzena Maciejewska-Jeske, Agnieszka Podfigurna, Paulina Cornetti, Gregory Bala, Eli Y. Adashi
Summary: Hyperthecosis is defined as the presence of nests of luteinized theca cells in the ovarian stroma. It is often described as a severe form of PCOS presenting with symptoms of hyperandrogenism. Treatment involves multi-faceted approach including surgery and medications to alleviate symptoms of elevated androgen levels.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Psychiatry
Han Lin, Mingxing Liu, Dongmei Zhong, Ernest Hung Yu Ng, Jianping Liu, Juan Li, Yu Shi, Chunren Zhang, Xiaohui Wen, Zhefen Mai, Miaoxian Ou, Hongxia Ma
Summary: The study found that the prevalence of anxiety-like and depression-like behaviors among PCOS patients was 26.1% and 52.0%, respectively. These behaviors were associated with factors such as age, body image-related factors, hyperandrogenism-related factors, and metabolic factors. Body image-related factors and hyperandrogenism-related factors were related to both anxiety-like and depression-like behaviors in both infertile and fertile PCOS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Genetics & Heredity
Xinyue Ma, Zhao Wang, Changming Zhang, Yuehong Bian, Xin Zhang, Xin Liu, Yongzhi Cao, Yueran Zhao
Summary: The study revealed associations between certain single-nucleotide polymorphisms in the FKBP5 gene and PCOS with hyperandrogenism, suggesting a potential genetic influence on the development of these conditions.
BMC MEDICAL GENOMICS
(2022)
Review
Genetics & Heredity
Roozbeh Heidarzadehpilehrood, Maryam Pirhoushiaran, Rasoul Abdollahzadeh, Malina Binti Osman, Maryam Sakinah, Norshariza Nordin, Habibah Abdul Hamid
Summary: Polycystic ovary syndrome (PCOS) is a multifactorial condition that can cause infertility and metabolic abnormalities in women of childbearing age. Research suggests that polymorphisms in different ethnicities are associated with the risk of PCOS with infertility.
Article
Medicine, General & Internal
Yan Li, Lihui Hou, Yingji Wang, Liangzhen Xie, Meiwei Zhang, Zimeng Pan, Yangyang Li, Yicheng Ding, Miao Sun, Yufang Qu, Songjiang Liu
Article
Biochemistry & Molecular Biology
Chengji J. Zhou, Yu Ji, Kurt Reynolds, Moira McMahon, Michael A. Garland, Shuwen Zhang, Bo Sun, Ran Gu, Mohammad Islam, Yue Liu, Tianyu Zhao, Grace Hsu, Janet Iwasa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Developmental Biology
Kurt Reynolds, Shuwen Zhang, Bo Sun, Michael A. Garland, Yu Ji, Chengji J. Zhou
BIRTH DEFECTS RESEARCH
(2020)
Review
Developmental Biology
Yu Ji, Michael A. Garland, Bo Sun, Shuwen Zhang, Kurt Reynolds, Moira McMahon, Ratheya Rajakumar, Mohammad S. Islam, Yue Liu, YiPing Chen, Chengji J. Zhou
BIRTH DEFECTS RESEARCH
(2020)
Review
Developmental Biology
Michael A. Garland, Bo Sun, Shuwen Zhang, Kurt Reynolds, Yu Ji, Chengji J. Zhou
BIRTH DEFECTS RESEARCH
(2020)
Article
Endocrinology & Metabolism
Xiaoxuan Zhao, Xiaoling Feng, Xinjie Zhao, Yuepeng Jiang, Xianna Li, Jingyun Niu, Xiaoyu Meng, Jing Wu, Guowang Xu, Lihui Hou, Ying Wang
Summary: The study revealed significant differences in general characteristics, reproductive hormones, and metabolic parameters between the PCOS-MS group, PCOS group, and healthy controls. 40 differential metabolites were identified, involving 23 pathways. 11 of these metabolites showed a correlation coefficient greater than 0.4 with clinical parameters, potentially serving as biomarkers for clinical diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Integrative & Complementary Medicine
Yan Li, Lijia Zhang, Jinjin Gao, Jun Yan, Xue Feng, Xiting He, Hong Jin, Xinyu Li, Zhengyi Cui, Junfei Zhao, Fengyi Liu, Xiaowai Liu, Yongfei Liu, Wan Ren, Songjiang Liu
Summary: This systematic review aimed to determine the efficacy of acupuncture on PCOS in animal preclinical models. Unfortunately, due to the methodological weakness of the included studies and the high heterogeneity, a definite conclusion could not be drawn. Well-designed studies are needed in the future to fill this gap.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Developmental Biology
Ran Gu, Shuwen Zhang, Subbroto Kumar Saha, Yu Ji, Kurt Reynolds, Moira McMahon, Bo Sun, Mohammad Islam, Paul A. Trainor, Yiping Chen, Ying Xu, Yang Chai, Diana Burkart-Waco, Chengji J. Zhou
Summary: This study used mouse genetic and genomic approaches to uncover the mechanisms underlying normal and defective midfacial morphogenesis, revealing that Wls plays a critical role in midfacial development.
Article
Integrative & Complementary Medicine
Yan Li, Changle Peng, Meiwei Zhang, Liangzhen Xie, Jinjin Gao, Yingji Wang, Yuanhe Gao, Lihui Hou
Summary: This pilot study aimed to investigate the potential effects of Tai chi for PCOS patients, and found that in the Tai chi group, BMI, testosterone level, and lipid profile were decreased after 3 months.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemical Research Methods
Yan Wang, Bo Sun, Bradley Shibata, Fuzheng Guo
Summary: This article presents a protocol for assessing myelination at the ultrastructural level using high-resolution transmission electron microscopy. The protocol includes sample preparation from mouse tissue, electron microscopic imaging, and analysis of central nervous system myelination. It is also applicable for analyzing peripheral nervous system myelination in mice.
Article
Multidisciplinary Sciences
Bo Sun, Tommi Vatanen, Thilini N. Jayasinghe, Elizabeth McKenzie, Rinki Murphy, Justin M. O'Sullivan
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Kristina Hubbard, Avik Shome, Bo Sun, Beau Pontre, Ailsa McGregor, Kathleen G. Mountjoy
