The cytochrome bc1 complex as an antipathogenic target

The cytochromebc(1)complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases andPlasmodium falciparum, which causes human malaria. Cytochromebc(1)is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. Here, we review recent progress in determination of the structure and mechanism of action of cytochromebc(1), and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.