Inhibitory activities of indolizine derivatives: a patent review

Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids

(2020) Nina K. Ratmanova et al.   TETRAHEDRON

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues

(2019) Katharigatta Narayanaswamy Venugopala et al.   PLoS One

A Novel Indolizine Derivative Induces Apoptosis Through the Mitochondria p53 Pathway in HepG2 Cells

(2019) Yushuang Liu et al.   Frontiers in Pharmacology

An update on benzofuran inhibitors: a patent review

(2019) Kamal M Dawood   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of novel cage-like heterocyclic hybrids as anti-inflammatory agents through the inhibition of nitrite, PGE2 and TNF-α

(2019) Raju Suresh Kumar et al.   BIOORGANIC CHEMISTRY

Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities

(2019) Khalid M. Attalah et al.   BIOORGANIC CHEMISTRY

Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection

(2019) Osama I. Alwassil et al.   PLoS One

Iodine-Mediated Oxidative Cyclization of 2-(Pyridin-2-yl)acetate Derivatives with Alkynes: Condition-Controlled Selective Synthesis of Multisubstituted Indolizines

(2019) Lisheng He et al.   SYNTHESIS-STUTTGART

Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies

(2019) Venugopala et al.   Biomolecules

Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency

(2019) Ahmed M. Shawky et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Detection of swainsonine-producing endophytes in Patagonian Astragalus species

(2019) Agustin Martinez et al.   TOXICON

Advance of swainsonine biosynthesis

(2018) Xiang-mei Tan et al.   CHINESE CHEMICAL LETTERS

Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition

(2018) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents

(2018) Sujin Park et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-pot microwave assisted synthesis and structural elucidation of novel ethyl 3-substituted-7-methylindolizine-1-carboxylates with larvicidal activity against Anopheles arabiensis

(2018) Sandeep Chandrashekharappa et al.   JOURNAL OF MOLECULAR STRUCTURE

Efficient synthesis and characterization of novel indolizines: exploration of in vitro COX-2 inhibitory activity and molecular modelling studies

(2018) Sandeep Chandrashekharappa et al.   NEW JOURNAL OF CHEMISTRY

Superacid-promoted synthesis of indolizidine derivatives

(2018) Sean Kennedy et al.   TETRAHEDRON LETTERS

Quinoline–galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain

(2018) Kumar Bhaskar Pal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

SAR study on inhibitors of GIIA secreted phospholipase A2 using machine learning methods

(2018) Shengde Zhang et al.   Chemical Biology & Drug Design

Biological evaluation of benzosuberones

(2017) Haider Behbehani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Thiadiazole inhibitors: a patent review

(2017) Kamal M. Dawood et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Design and Synthesis of Novel Indolizine Analogues as COX-2 Inhibitors: Computational Perspective and in vitro Screening

(2017) Chandrashekharappa Sandeep et al.   Indian Journal of Pharmaceutical Education and Research

Molecular modeling studies and anti-TB activity of trisubstituted indolizine analogues; molecular docking and dynamic inputs

(2017) Mohammed A. Khedr et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Antimycobacterial activity of nitrogen heterocycles derivatives: 7-(pyridine-4-yl)-indolizine derivatives. Part VII8–12

(2017) Anda-Mihaela Olaru et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa)

(2017) Santhaseelan Henciya et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

The Biosynthesis Pathway of Swainsonine, a New Anticancer Drug from Three Endophytic Fungi

(2017) Zhenhui Ren et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Lysine-derived Alkaloids: Overview and Update on Biosynthesis and Medicinal Applications with Emphasis on Quinolizidine Alkaloids

(2017) Somnuk Bunsupa et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A simple pH fluorescent probe based on new fluorophore indolizine for imaging of living cells

(2017) Yanqing Ge et al.   SENSORS AND ACTUATORS B-CHEMICAL

Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction

(2017) Jinwoo Kim et al.   TETRAHEDRON

An asymmetric synthesis of (+)-monomorine I

(2017) Masaki Asai et al.   TETRAHEDRON-ASYMMETRY

Synthesis and Characterization of Ethyl 7-Acetyl-2-substituted 3-(substituted benzoyl)indolizine-1-carboxylates for in vitro Anticancer Activity

(2016) C. Sandeep et al.   ASIAN JOURNAL OF CHEMISTRY

New indolizine–chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation

(2016) Iuliana-Monica Moise et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53

(2016) Seong-Hee Moon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway

(2016) Ju Chen et al.   CANCER LETTERS

Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity againstAnopheles arabiensis

(2016) Chandrashekharappa Sandeep et al.   Chemical Biology & Drug Design

The toxicology mechanism of endophytic fungus and swainsonine in locoweed

(2016) Chenchen Wu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists

(2016) Yu Xue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

European medicinal and edible plants associated with subacute and chronic toxicity part II: Plants with hepato-, neuro-, nephro- and immunotoxic effects

(2016) Luka Kristanc et al.   FOOD AND CHEMICAL TOXICOLOGY

Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents

(2016) Liliana Lucescu et al.   Letters in Drug Design & Discovery

Recent advances in the synthesis of indolizines and their π-expanded analogues

(2016) Bartłomiej Sadowski et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG

(2016) Nello Mainolfi et al.   ACS Medicinal Chemistry Letters

α,β-Unsaturated Diazoketones as Useful Platforms in the Synthesis of Nitrogen Heterocycles

(2015) Antonio C. B. Burtoloso et al.   ACCOUNTS OF CHEMICAL RESEARCH

New indolizines with phenanthroline skeleton: Synthesis, structure, antimycobacterial and anticancer evaluation

(2015) Ramona Danac et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase

(2015) Won-Gil Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events

(2015) Liliana Lucescu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Newly synthesized indolizine derivatives – antimicrobial and antimutagenic properties

(2015) Petra Olejníková et al.   CHEMICAL PAPERS

An In silico Approach for Identification of Novel Inhibitors as a Potential Therapeutics Targeting HIV-1 Viral Infectivity Factor

(2015) Chanda Sinha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Studies on indolizines. Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds

(2015) Alina Ghinet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and photophysical properties of 1,2-diphenylindolizine derivatives: fluorescent blue-emitting materials for organic light-emitting device

(2015) Yeong Ran Song et al.   LUMINESCENCE

Synthesis of novel indolizine, diazepinoindolizine and Pyrimidoindolizine derivatives as potent and selective anticancer agents

(2015) Amany Belal et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

(2015) Duncan A. Hay et al.   MedChemComm

Toxicosis by Plant Alkaloids in Humans and Animals in Colombia

(2015) Gonzalo Diaz   Toxins

Facile Access to Benzothiazole-Containing Pyrrolo[1,2-a]quinolines and Pyrrolo[2,1-a]isoquinolinesviaNitrogen Ylides

(2015) Kamal M. Dawood et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists I

(2014) Juan Antonio Alonso et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase

(2014) Carmen Dumea et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Swainsonine-Containing Plants and Their Relationship to Endophytic Fungi

(2014) Daniel Cook et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Indolizine: a biologically active moiety

(2014) Vikas Sharma et al.   MEDICINAL CHEMISTRY RESEARCH

Synthesis of novel indolizine, pyrrolo[1,2-a] quinoline, and 4,5-dihydrothiophene derivatives via nitrogen ylides and their antimicrobial evaluation

(2014) Sobhi M. Gomha et al.   JOURNAL OF CHEMICAL RESEARCH

Indolizine Derivatives as HIV-1 VIF-ElonginC Interaction Inhibitors

(2013) Wenlin Huang et al.   Chemical Biology & Drug Design

α-Trimethylsilylmethylamine Radical Cation in the Synthesis of Cyclic Amines and Beyond

(2013) Ganesh Pandey et al.   CHIMIA

Pathogenesis and preventive treatment for animal disease due to locoweed poisoning

(2013) Wu Chenchen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Synthesis of 3-heteryl substituted pyrrolidine-2,5-diones via catalytic Michael reaction and evaluation of their inhibitory activity against InhA and Mycobacterium tuberculosis

(2013) Tetiana Matviiuk et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antimycobacterial activity of nitrogen heterocycles derivatives: Bipyridine derivatives. Part III [13,14]

(2013) Ramona Danac et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzofuran derivatives: a patent review

(2013) Kamal M Dawood   EXPERT OPINION ON THERAPEUTIC PATENTS

Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-e]pyrrolo[3,4-g]indolizine-4,6(1H,5H)-diones as New Glycogen Synthase Kinase-3β Inhibitors

(2013) Valeria La Pietra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel One-Pot Green Synthesis of Indolizines Biocatalysed by Candida antarctica Lipases

(2013) Rodica Dinica et al.   Marine Drugs

Design, synthesis and biological evaluation of indolizine derivatives as HIV-1 VIF–ElonginC interaction inhibitors

(2013) Wenlin Huang et al.   MOLECULAR DIVERSITY

Synthetic Developments on the Indolizidine Alkaloid, Harmicine

(2013) Samaresh Jana et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis of naturally occurring pyrrolidines, pyrrolizidines and indolizidine alkaloids using proline as a unique chiral synthon

(2013) Chinmay Bhat et al.   RSC Advances

The Molecular Engineering of Organic Sensitizers for Solar-Cell Applications

(2012) Jared H. Delcamp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biochemical Characterization of Selective Inhibitors of Human Group IIA Secreted Phospholipase A2 and Hyaluronic Acid-Linked Inhibitor Conjugates

(2012) Rob C. Oslund et al.   BIOCHEMISTRY

Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists

(2012) Ismet Dorange et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

(2012) Cristina-Maria Abuhaie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of resistance in Mycobacterium smegmatis

(2012) Petra Olejníková et al.   CANADIAN JOURNAL OF MICROBIOLOGY

Multifunctional electron-transporting indolizine derivatives for highly efficient blue fluorescence, orange phosphorescence host and two-color based white OLEDs

(2012) Jing Wan et al.   JOURNAL OF MATERIALS CHEMISTRY

Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Targeting the Interaction between Vif and ElonginC

(2012) T. Zuo et al.   JOURNAL OF VIROLOGY

Indolizidines with ease

(2012) Peter Shapland   Nature Chemistry

Radical azidation reactions and their application in the synthesis of alkaloids

(2012) Guillaume Lapointe et al.   PURE AND APPLIED CHEMISTRY

Synthesis and Properties of Fluoropyrroles and Their Analogues

(2012) Valentine Nenajdenko et al.   SYNTHESIS-STUTTGART

Photochemical Reactions as Key Steps in Natural Product Synthesis

(2011) Thorsten Bach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amberlite–IRA-402 (OH) ion exchange resin mediated synthesis of indolizines, pyrrolo [1,2-a] quinolines and isoquinolines: Antibacterial and antifungal evaluation of the products

(2011) Abhijit Hazra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent progress in synthesis and bioactivity studies of indolizines

(2011) Girija S. Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Total Synthesis of Indolizidine Iminosugars

(2011) In Su Kim et al.   HETEROCYCLES

Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents

(2010) Nam Doo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors

(2010) Andrew F. Donnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition

(2010) Sandrine Gerber-Lemaire et al.   CHIMIA

Synthesis and antiproliferative activity of indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line

(2010) Yong-Miao Shen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Facile three-component domino reactions in the regioselective synthesis and antimycobacterial evaluation of novel indolizines and pyrrolo[2,1-a]isoquinolines

(2010) Sivasubramanian Muthusaravanan et al.   TETRAHEDRON LETTERS

Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure–activity relationship

(2010) Shoujun Chen et al.   MedChemComm

Synthesis and SAR of Benzisothiazole- and Indolizine-β-d-glucopyranoside Inhibitors of SGLT2

(2010) Huiqiang Zhou et al.   ACS Medicinal Chemistry Letters

GDC-0449—A potent inhibitor of the hedgehog pathway

(2009) Kirk D. Robarge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Modulation of carcinogen metabolizing enzymes by new fused heterocycles pendant to 5,6,7,8-tetrahydronaphthalene derivatives

(2009) Nehal A. Hamdy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Some New Indolizine and Pyrrolo[1,2-a]quinoline Derivatives via Nitrogen Ylides

(2009) Kamal M. Dawood et al.   HETEROCYCLES

Synthesis of annulated dihydroisoquinoline heterocycles via their nitrogen ylides

(2008) Tayseer A. Abdallah et al.   TETRAHEDRON

Indolizidine and quinolizidine alkaloids

(2007) Joseph P. Michael   NATURAL PRODUCT REPORTS