Journal
EXPERT OPINION ON DRUG SAFETY
Volume 19, Issue 8, Pages 969-979Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14740338.2020.1785427
Keywords
Biologics; pustular psoriasis; acrodermatitis continua of Hallopeau; IL-36RN
Categories
Funding
- National Natural Science Foundation of China [81773331]
- CAMS Initiative for Innovative Medicine [2017-12M3-020]
- National Key Research and Development Program of China [2016YFC0901500]
Ask authors/readers for more resources
Introduction Pustular psoriasis is a group of skin diseases characterized by neutrophil infiltration in the epidermis and formation of sterile pustules. Conventional treatments, such as retinoids and immunosuppressive drugs, have improved the clinical manifestations; however, many patients suffer from drug-related toxicity or are resistant to therapy. Areas covered In this review, the authors focus on the efficacy and safety of these biologics, including anti-IL-1 beta (gevokizumab and canakinumab), anti-IL-1 R (anakinra), anti-IL-36 R (BI 655130), anti-tumor necrosis factor-alpha (etanercept, infliximab, and adalimumab), anti-IL-12/23 (ustekinumab), anti-IL-17A (secukinumab and ixekizumab), anti-IL-17RA (brodalumab), anti-IL-2 R (basiliximab), anti-IL-6 R (tocilizumab), and anti-IL-23 (risankizumab and guselkumab), for treating pustular psoriasis. Expert opinion Patients with pustular psoriasis treated with biologics demonstrated positive responses. Anti-TNF-alpha is the most available biologics for the treatment of pustular psoriasis, and anti-IL-12/23 and anti-IL-17A might be considered as the first- or second-line therapy for moderate-to-severe and refractory pustular psoriasis. Anti-IL-17A can be used in the pustular psoriasis patients who failed to respond to anti-TNF agents and anti-IL-12/23. Therapeutic efficacy of biologics in pustular psoriasis might have no association withIL-36 RNmutation status.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available