Modeling percutaneous absorption for successful drug discovery and development
Published 2020 View Full Article
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Title
Modeling percutaneous absorption for successful drug discovery and development
Authors
Keywords
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Journal
Expert Opinion on Drug Discovery
Volume -, Issue -, Pages 1-18
Publisher
Informa UK Limited
Online
2020-06-26
DOI
10.1080/17460441.2020.1781085
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Note: Only part of the references are listed.- Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review
- (2019) Siamaque Kazem et al. DRUG DISCOVERY TODAY
- Modelling the intradermal delivery of microneedle array patches for long-acting antiretrovirals using PBPK
- (2019) Rajith K.R. Rajoli et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach
- (2018) Martyn L. Chilton et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
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- (2018) Amber B. Daniel et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Physiologically based pharmacokinetic modelling to guide drug delivery in older people
- (2018) Manoranjenni Chetty et al. ADVANCED DRUG DELIVERY REVIEWS
- Application Of The Tissue Composition-Based Model To Minipig For Predicting The Volume Of Distribution At Steady-State And Dermis-To-Plasma Partition Coefficients Of Drugs Used In The Physiologically-Based Pharmacokinetics Model In Dermatology
- (2018) Patrick Poulin et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Current approaches for choosing feature selection and learning algorithms in quantitative structure–activity relationships (QSAR)
- (2018) Pathan Mohsin Khan et al. Expert Opinion on Drug Discovery
- Quantitative prediction of ionization effect on human skin permeability
- (2017) Hiromi Baba et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Topical and cutaneous delivery using nanosystems
- (2017) MS Roberts et al. JOURNAL OF CONTROLLED RELEASE
- Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study
- (2017) Panayiotis Kattou et al. PHARMACEUTICAL RESEARCH
- Evaluation of in silico tools to predict the skin sensitization potential of chemicals
- (2017) G. R. Verheyen et al. SAR AND QSAR IN ENVIRONMENTAL RESEARCH
- Quantitative structure-skin permeability relationships
- (2017) Ivanka Tsakovska et al. TOXICOLOGY
- Multiscale modelling approaches for assessing cosmetic ingredients safety
- (2017) Frédéric Y. Bois et al. TOXICOLOGY
- Skin toxicity evaluation in patients treated with cetuximab for metastatic colorectal cancer: a new tool for more accurate comprehension of quality of life impacts
- (2017) Michele De Tursi et al. OncoTargets and Therapy
- Evaluation of skin absorption of drugs from topical and transdermal formulations
- (2016) André Luís Morais Ruela et al. Brazilian Journal of Pharmaceutical Sciences
- Be aware of error measures. Further studies on validation of predictive QSAR models
- (2016) Kunal Roy et al. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
- Transdermal toxicity of topically applied anticoagulant rodenticide warfarin in rats
- (2016) Vesna Subota et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization
- (2016) Jeremy M. Fitzpatrick et al. JOURNAL OF APPLIED TOXICOLOGY
- What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis
- (2016) Jeremy M. Fitzpatrick et al. JOURNAL OF APPLIED TOXICOLOGY
- Malathion dermal permeability in relation to dermal load: Assessment by physiologically based pharmacokinetic modeling of in vivo human data
- (2016) Kenneth T. Bogen et al. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
- Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability
- (2016) Gamze Ates et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Development of a human physiologically based pharmacokinetic (PBPK) model for dermal permeability for lindane
- (2016) Megan E. Sawyer et al. TOXICOLOGY LETTERS
- Transdermal patches: history, development and pharmacology
- (2015) Michael N Pastore et al. BRITISH JOURNAL OF PHARMACOLOGY
- Mechanism-Based QSAR Modeling of Skin Sensitization
- (2015) J. C. Dearden et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization
- (2015) Vinicius M. Alves et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration
- (2015) Jeffrey E. Grice et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Impact of Adult Atopic Dermatitis on Topical Drug Penetration: Assessment by Cutaneous Microdialysis and Tape Stripping
- (2014) P Ortiz et al. ACTA DERMATO-VENEREOLOGICA
- Animal models for percutaneous absorption
- (2014) Eui Chang Jung et al. JOURNAL OF APPLIED TOXICOLOGY
- Solute-Vehicle-Skin Interactions in Percutaneous Absorption: The Principles and the People
- (2013) M.S. Roberts SKIN PHARMACOLOGY AND PHYSIOLOGY
- Penetration enhancers
- (2012) Adrian C. Williams et al. ADVANCED DRUG DELIVERY REVIEWS
- Modeling the human skin barrier — Towards a better understanding of dermal absorption
- (2012) Owen G. Jepps et al. ADVANCED DRUG DELIVERY REVIEWS
- Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes
- (2012) Yuri G. Anissimov et al. ADVANCED DRUG DELIVERY REVIEWS
- The influence of lipophilicity in drug discovery and design
- (2012) John A Arnott et al. Expert Opinion on Drug Discovery
- The effect of formulations and experimental conditions on in vitro human skin permeation—Data from updated EDETOX database
- (2012) Eleftherios G. Samaras et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Percutaneous absorption in diseased skin: an overview
- (2012) Audris Chiang et al. JOURNAL OF APPLIED TOXICOLOGY
- Prediction of Concentration–Time Profile and its Inter-Individual Variability following the Dermal Drug Absorption
- (2012) Sebastian Polak et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Estimation of Maximum Transdermal Flux of Nonionized Xenobiotics from Basic Physicochemical Determinants
- (2012) Mikolaj Milewski et al. MOLECULAR PHARMACEUTICS
- Fluorescence Imaging of the Lymph Node Uptake of Proteins in Mice after Subcutaneous Injection: Molecular Weight Dependence
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- Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine-loaded PNIPAM, PLA, PLGA and EC microparticles
- (2011) Anahita Fathi Azarbayjani et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man
- (2011) Xin Liu et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application
- (2011) Yuri Dancik et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The application of discriminant analysis and Machine Learning methods as tools to identify and classify compounds with potential as transdermal enhancers
- (2011) G.P. Moss et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Mathematical models of skin permeability: An overview
- (2011) Samir Mitragotri et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Modelling Dermal Drug Distribution After Topical Application in Human
- (2011) Yuri G. Anissimov et al. PHARMACEUTICAL RESEARCH
- Lipophilicity in drug discovery
- (2010) Michael J Waring Expert Opinion on Drug Discovery
- The Rule of Five for Non-Oral Routes of Drug Delivery: Ophthalmic, Inhalation and Transdermal
- (2010) Young Bin Choy et al. PHARMACEUTICAL RESEARCH
- Enhanced Absorption through Damaged Skin: An Overview of the in vitro Human Model
- (2010) S. Gattu et al. SKIN PHARMACOLOGY AND PHYSIOLOGY
- Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro
- (2009) Jeffrey E. Grice et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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- How not to develop a quantitative structure–activity or structure–property relationship (QSAR/QSPR)
- (2009) J.C. Dearden et al. SAR AND QSAR IN ENVIRONMENTAL RESEARCH
- Biotransformation of Drugs in Human Skin
- (2008) C. K. Svensson DRUG METABOLISM AND DISPOSITION
- Percutaneous permeation modifiers: enhancement versus retardation
- (2008) Diksha Kaushik et al. Expert Opinion on Drug Delivery
- Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment
- (2008) T Bouwman et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- Structure–Permeability Relationship Analysis of the Permeation Barrier Properties of the Stratum Corneum and Viable Epidermis/Dermis of Rat Skin
- (2008) Koji Yamaguchi et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Effect of PBPK Model Structure on Interpretation of In Vivo Human Aqueous Dermal Exposure Trials
- (2008) Anayi M. Norman et al. TOXICOLOGICAL SCIENCES
- In-silico model of skin penetration based on experimentally determined input parameters. Part I: Experimental determination of partition and diffusion coefficients
- (2007) Steffi Hansen et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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