Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype

Mitochondrial dysfunction in age‐related metabolic disorders

(2020) Venkateswaran Natarajan et al.   PROTEOMICS

Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging‐associated tumorigenesis induced by ultraviolet B

(2019) Wen‐Li Hsu et al.   AGING CELL

Oncogene-induced senescence: a double edged sword in cancer

(2018) Xue-ling Liu et al.   ACTA PHARMACOLOGICA SINICA

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

(2018) Marine Warnier et al.   AGING CELL

Calcium signaling and cellular senescence

(2018) Nadine Martin et al.   CELL CALCIUM

Cellular senescence in tissue repair: every cloud has a silver lining

(2018) Maximina H. Yun   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mitochondrial Dynamics in Basal and Stressful Conditions

(2018) Naima Zemirli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging

(2018) Marioly Müller et al.   Frontiers in Neuroscience

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling

(2018) Xingjie Ma et al.   AGING CELL

Elevated [Ca2+]i Levels Occur with Decreased Calpain Activity in Aged Fibroblasts and Their Reversal by Energy-Rich Compounds: New Paradigm for Alzheimer's Disease Prevention

(2018) Huey T. Nguyen et al.   JOURNAL OF ALZHEIMERS DISEASE

Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation

(2018) Xin Hou et al.   Cell Death & Disease

Enhanced inter-compartmental Ca2+ flux modulates mitochondrial metabolism and apoptotic threshold during aging

(2018) Corina T. Madreiter-Sokolowski et al.   Redox Biology

TRPC5 channel modulates endothelial cells senescence

(2017) Zhengtao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain

(2016) Takamasa Ishii et al.   AGING CELL

Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress

(2016) Aleksandra V. Borodkina et al.   Aging-US

Sensing of redox status by TRP channels

(2016) Nozomi Ogawa et al.   CELL CALCIUM

The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis

(2016) Hai-Tao Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype

(2016) Nicolas Malaquin et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner

(2016) Timothy Nacarelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

NF90 coordinately represses the senescence-associated secretory phenotype

(2016) Kumiko Tominaga-Yamanaka et al.   Aging-US

mTOR pathway and Ca2+ stores mobilization in aged smooth muscle cells

(2016) Francisco E Martín-Cano et al.   Aging-US

TORn about SASP regulation

(2015) Nicolás Herranz et al.   CELL CYCLE

Calcium signaling and cell proliferation

(2015) Mauro Cunha Xavier Pinto et al.   CELLULAR SIGNALLING

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: Involvement of TRPM2 and TRPV1 channels

(2015) İ.S. Övey et al.   NEUROSCIENCE

Redox theory of aging

(2015) Dean P. Jones   Redox Biology

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Calcium Signaling Alterations, Oxidative Stress, and Autophagy in Aging

(2014) Rodrigo Portes Ureshino et al.   ANTIOXIDANTS & REDOX SIGNALING

The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na+/Ca2+exchanger and increasing intracellular Ca2+

(2014) M Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Mammalian Target of Rapamycin Complex 2 Signaling Pathway Regulates Transient Receptor Potential Cation Channel 6 in Podocytes

(2014) Fangrui Ding et al.   PLoS One

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

(2014) Clotilde Wiel et al.   Nature Communications

Redox Regulation of Transient Receptor Potential Channels

(2013) Daisuke Kozai et al.   ANTIOXIDANTS & REDOX SIGNALING

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

(2013) Brian Glancy et al.   BIOCHEMISTRY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Roles of transient receptor potential canonical (TRPC) channels and reverse-mode Na+/Ca2+ exchanger on cell proliferation in human cardiac fibroblasts: Effects of transforming growth factor β1

(2013) Kenichi Ikeda et al.   CELL CALCIUM

Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

(2013) Donald A. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension

(2013) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

mTOR-Controlled Autophagy Requires Intracellular Ca2+ Signaling

(2013) Jean-Paul Decuypere et al.   PLoS One

TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma

(2012) Nelson S. Yee et al.   CANCER BIOLOGY & THERAPY

In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo

(2012) Martina C. Meinke et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Genome-Wide Assessment of AU-Rich Elements by the AREScore Algorithm

(2012) Milan Spasic et al.   PLoS Genetics

Abundance of TRPC6 protein in glomerular mesangial cells is decreased by ROS and PKC in diabetes

(2011) Sarabeth Graham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma

(2011) Nelson S. Yee et al.   CANCER LETTERS

Calcium and cell death mechanisms: A perspective from the cell death community

(2011) Boris Zhivotovsky et al.   CELL CALCIUM

Reactive Oxygen Species-mediated TRPC6 Protein Activation in Vascular Myocytes, a Mechanism for Vasoconstrictor-regulated Vascular Tone

(2011) Yanfeng Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders

(2010) Yasemin Erac et al.   AGE

Canonical Transient Receptor Potential 6 (TRPC6), a Redox-regulated Cation Channel

(2010) Sarabeth Graham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies

(2009) Jaya Dasgupta et al.   EXPERIMENTAL GERONTOLOGY

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE