Article
Biochemistry & Molecular Biology
Marlene Friedl, Stefan Stoiber, Faris F. Brkic, Lorenz Kadletz-Wanke
Summary: This study assessed the prognostic value of serum albumin in patients with head and neck adenoid-cystic carcinomas. It found that patients in the low albumin group had shorter survival time, particularly in terms of disease-free survival.
Article
Oncology
Wenguang Liu, Xiao Wang, Simin Xie, Weiyin Vivian Liu, Ismail Bilal Masokano, Yu Bai, Juan Chen, Linhui Zhong, Yijing Luo, Gaofeng Zhou, Wenzheng Li, Yigang Pei
Summary: This study assessed the feasibility of three-dimensional chemical exchange saturation transfer (3D CEST) technique in predicting short-term treatment outcomes in nasopharyngeal carcinoma (NPC) patients after chemoradiotherapy (CRT). The results showed that pre-treatment magnetization transfer ratio (MTR) values obtained through 3D CEST demonstrated superior predictive performance compared to amide proton transfer weighted-signal intensity (APTw-SI) and apparent diffusion coefficient (ADC) values.
Article
Oncology
Zhou Liu, Liyan Zou, Qian Yang, Long Qian, Tianran Li, Honghong Luo, Canwen Che, Yuanyuan Lei, Peng Chen, Chunyan Qiu, Xin Liu, Yin Wu, Dehong Luo
Summary: Amide proton transfer (APT) imaging is valuable for early detection and diagnosis of nasopharyngeal carcinoma (NPC). However, baseline APT values are not predictive of short-term treatment response.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qingxu Song, Pengxiang Chen, Xin Chen, Cong Sun, Jianbo Wang, Bingxu Tan, Hong Liu, Yufeng Cheng
Summary: The study investigated the dynamic changes of APT imaging before and after irradiation in NPC mouse models. Results showed that high-dose irradiation led to a significant decrease in tumor APT values, accompanied by necrosis and apoptosis, while low-dose irradiation showed a slight decrease in APT values. APT imaging has the potential to serve as a reliable biomarker for response assessment in NPC.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Article
Oncology
Xiaoxu Ding, Xiangguo Cui, Xiao Cui, Sai Wang
Summary: This meta-analysis compared the efficacy and toxicities of upper-neck irradiation (UNI) and whole-neck irradiation (WNI) in patients with node-negative nasopharyngeal carcinoma. The results showed that UNI had similar efficacy and lower toxicities compared to WNI.
RADIOTHERAPY AND ONCOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Francesca De Felice, Alessandro Vai, Anna Maria Camarda, Nicola Alessandro Iacovelli, Ester Orlandi
Summary: Undifferentiated carcinoma of the nasopharynx (NPC) is rare and mostly occurs in the Asian population. Its anatomical location leads to rich lymph node drainage and a high incidence of cervical node metastasis. Recent innovations in systemic treatments and radiotherapy techniques have improved outcomes and reduced toxicities. Proton therapy is a promising alternative to Intensity Modulated Radiotherapy (IMRT) in managing NPC, especially in reducing side effects for patients with N0-N1-stage disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Rosanne C. Schoonbeek, Julia Zwertbroek, Boudewijn E. C. Plaat, Robert P. Takes, John A. Ridge, Primoz Strojan, Alfio Ferlito, Boukje A. C. van Dijk, Gyorgy B. Halmos
Summary: The study identified race, facility type, type of insurance, and radiotherapy as primary treatment were associated with delays and subsequent inferior survival in the four common sites combined.
Article
Nutrition & Dietetics
Daniel Sat-Munoz, Brenda-Eugenia Martinez-Herrera, Javier-Andres Gonzalez-Rodriguez, Leonardo-Xicotencatl Gutierrez-Rodriguez, Benjamin Trujillo-Hernandez, Luis-Aaron Quiroga-Morales, Aldo-Antonio Alcaraz-Wong, Carlos Davalos-Cobian, Alejandro Solorzano-Melendez, Juan-Daniel Flores-Carlos, Benjamin Rubio-Jurado, Mario Salazar-Paramo, Gabriela-Guadalupe Carrillo-Nunez, Eduardo Gomez-Sanchez, Arnulfo-Hernan Nava-Zavala, Luz-Ma-Adriana Balderas-Pena
Summary: Malnutrition is common in patients with head and neck cancer, and low phase angle is a crucial predictor of survival and a risk factor for death in these patients.
Article
Oncology
Tobias Jagomast, Christian Idel, Luise Klapper, Patrick Kuppler, Anne Offermann, Eva Dreyer, Karl-Ludwig Bruchhage, Julika Ribbat-Idel, Sven Perner
Summary: This study investigated the clinical implications of CDK7 and pMED1 as potential biomarkers in head and neck squamous-cell cancer (HNSCC). The results showed that high levels of CDK7 were associated with lower survival rates and disease-free survival rates in HNSCC patients. Additionally, CDK7 expression was significantly elevated in immune cell infiltrated tumors. In vitro studies also demonstrated the potential of CDK7 inhibition as a therapeutic target.
Article
Medicine, General & Internal
Maria Goncalves, Christina Gsaxner, Andre Ferreira, Jianning Li, Behrus Puladi, Jens Kleesiek, Jan Egger, Victor Alves
Summary: Head and neck cancer, with its complex anatomical structures, can be accurately predicted for prognosis using radiomics and machine learning techniques.
Article
Biotechnology & Applied Microbiology
Ming Shi, Jiangnan Du, Jingjing Shi, Yunchuanxiang Huang, Yan Zhao, Lan Ma
Summary: This study reveals the high expression level of ferroptosis-related factor ATG5 in HNSCC and NPC patients, which is correlated with poor prognosis and the expression of immune checkpoints. HNSCC patients with high expression of ATG5 showed poor response to immune checkpoint blockade therapy. Furthermore, ATG5 is associated with the G2M checkpoint pathway, indicating the potential value of G2M inhibitors in HNSCC/NPC treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Article
Multidisciplinary Sciences
Ji-Hye Choi, Bok-Soon Lee, Jeon Yeob Jang, Yun Sang Lee, Hyo Jeong Kim, Jin Roh, Yoo Seob Shin, Hyun Goo Woo, Chul-Ho Kim
Summary: This study profiles the molecular mechanisms behind the stepwise progression of HNSCC through single-cell RNA-seq analysis. It reveals the role of interactions with the tumor microenvironment in the progression of HNSCC.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Matthias Balk, Robin Rupp, Konstantinos Mantsopoulos, Matti Sievert, Magdalena Gostian, Moritz Allner, Philipp Grundtner, Markus Eckstein, Heinrich Iro, Markus Hecht, Antoniu-Oreste Gostian
Summary: This study assessed the impact of treatment modalities and tumor biology on the oncological outcome of patients with head and neck cancer of unknown primary. The presence of distant metastases and adjuvant treatment with radiation without chemotherapy were significant predictors for overall survival of these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Vijay Maruti Patil, Vanita Noronha, Nandini Menon, Rahul Rai, Atanu Bhattacharjee, Ajay Singh, Kavita Nawale, Shweta Jogdhankar, Rupali Tambe, Sachin Dhumal, Riddhi Sawant, Mitali Alone, Devanshi Karla, Zoya Peelay, Shruti Pathak, Arun Balaji, Suman Kumar, Nilendu Purandare, Archi Agarwal, Ameya Puranik, Abhishek Mahajan, Amit Janu, Gunjesh Kumar Singh, Neha Mittal, Subhash Yadav, Shripad Banavali, Kumar Prabhash
Summary: This study found that only 1%-3% of patients in low- and middle-income countries have access to the approved regimens for treating advanced head and neck squamous cell carcinoma due to cost issues. Previous research has shown that metronomic chemotherapy can improve survival. The study aimed to assess whether the addition of low-dose nivolumab to triple metronomic chemotherapy improved overall survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jing Yuan, Darren M. C. Poon, Gladys Lo
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Oncology
Darren M. C. Poon, Bin Yang, Hui Geng, Oi Lei Wong, Sin Ting Chiu, Kin Yin Cheung, Siu Ki Yu, George Chiu, Jing Yuan
Summary: This study retrospectively analyzed and characterized the online plan adaptation of 1.5T magnetic resonance-guided stereotactic body radiotherapy (MRgSBRT) in prostate cancer patients. The study found significant differences in the adoption frequency of ATS fractions between different treatment fractions, and investigated the rationale and criteria for ATS implementation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jian Hou, Vincent W-S Wong, Yurui Qian, Baiyan Jiang, Anthony W-H Chan, Howard H-W Leung, Grace L-H Wong, Simon C-H Yu, Winnie C-W Chu, Weitian Chen
Summary: This study used MPF-SL technology to measure macromolecule levels in the liver and found that it can detect early-stage liver fibrosis, and is not confounded by liver iron concentration or fat fraction.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rongli Zhang, Ann D. King, Lun M. Wong, Kunwar S. Bhatia, Sahrish Qamar, Frankie K. F. Mo, Alexander C. Vlantis, Qi Yong H. Ai
Summary: This study retrospectively evaluated the diagnostic performances of diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) for distinguishing between benign and malignant salivary gland tumors (SGTs). Significant differences in ADC(mean), D-mean, and D*(mean) were found between SGTs. IVIM showed higher accuracy than DWI in discriminating between benign and malignant SGTs due to its advantage in detecting Warthin's tumors (WTs).
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2023)
Letter
Clinical Neurology
Ann D. King, Qi Yong H. Ai
Review
Medicine, General & Internal
Kuo Feng Hung, Qi Yong H. Ai, Lun M. Wong, Andy Wai Kan Yeung, Dion Tik Shun Li, Yiu Yan Leung
Summary: The increasing use of CT and CBCT in oral and maxillofacial imaging has led to the development of deep learning and radiomics applications for maxillofacial disease diagnosis and management. Deep learning models have been developed for automatic diagnosis, segmentation, and classification of various maxillofacial diseases, while radiomics applications mainly focus on diagnosing occult metastasis and osteoarthritis. These models show high performance and have the potential for clinical use, but challenges in generalizability and reproducibility need to be addressed.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Weitian Chen
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Wang, Weitian Chen, Yurui Qian, Tiffany Y. So
Summary: This study aimed to assess the repeatability of T1rho imaging in normal brain grey and white matter. The results showed high test-retest repeatability of T1rho imaging for whole brain imaging, indicating its reliability for quantitative brain imaging.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2023)
Article
Engineering, Biomedical
Chaoxing Huang, Vincent Wai-Sun Wong, Queenie Chan, Winnie Chiu-Wing Chu, Weitian Chen
Summary: This study proposes a parametric map refinement approach for learning-based T-1 rho mapping. By training the model probabilistically to model uncertainty and utilizing uncertainty maps for weighted training of an improved mapping network, the mapping performance is enhanced and unreliable values are effectively removed. The results demonstrate the potential of this method to provide a trustworthy learning-based quantitative MRI system for T-1 rho mapping of the liver.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Review
Oncology
Kaijing Mao, Lun M. Wong, Rongli Zhang, Tiffany Y. So, Zhiyi Shan, Kuo Feng Hung, Qi Yong H. Ai
Summary: This study systematically evaluated the procedures of radiomics analysis for characterizing salivary gland tumors (SGTs) on MRI. Radiomics analysis showed potential in characterizing SGTs on MRI, but its clinical application is limited due to complex procedures and a lack of standardized methods. This review summarized the procedures of radiomics analysis, focusing on reported methodologies and performances, and proposed potential standards for further development, which may benefit the application of radiomics analysis in characterizing SGTs on MRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Junru Zhong, Yongcheng Yao, Donal G. Cahill, Fan Xiao, Siyue Li, Jack Lee, Kevin Ki-Wai Ho, Michael Tim-Yun Ong, James F. Griffith, Weitian Chen
Summary: This study demonstrates the utility of unsupervised domain adaptation (UDA) for automated osteoarthritis (OA) phenotype classification. By using a large, high-quality source dataset for training, the proposed UDA approach improves the performance of automated OA phenotype classification on small target datasets. This technique is important for improving downstream analysis of locally collected datasets with a small sample size.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Article
Medicine, General & Internal
Christopher C. H. Yip, L. Li, Thomas K. H. Lau, Vicky T. C. Chan, Carol C. H. Kwok, Joyce J. S. Suen, Frankie K. F. Mo, Winnie Yeo
Summary: This retrospective analysis compared the efficacy of olanzapine-based and NEPA-based regimens in controlling chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients receiving AC. The olanzapine group showed higher rates of no rescue therapy and no significant nausea during cycle 1 of AC. However, there were no differences in quality of life between the two groups. Multiple cycle assessment revealed higher rates of total control in the NEPA group in later cycles. These results do not support the superiority of either regimen for breast cancer patients receiving AC.
HONG KONG MEDICAL JOURNAL
(2023)