Review
Biochemistry & Molecular Biology
Qin Niu, Qiannan Sun, Rushui Bai, Yunfan Zhang, Zimeng Zhuang, Xin Zhang, Tianyi Xin, Si Chen, Bing Han
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide with current treatment models presenting limitations. Nanomaterial-based photothermal therapy (PTT) has attracted research attention as a promising alternative. This paper reviews the latest progress in applying biological nanomaterials for PTT in OSCC and discusses different categories of photothermal nanomaterials and drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Biomaterials
Jinzhu Huang, Xiaoyuan Zhang, Kun Fu, Gang Wei, Zhiqiang Su
Summary: Research in the field of cancer treatment is seeking personalized treatment systems, aiming to enhance efficacy by using stimulus-responsive materials combined with non-invasive stimuli. Nanomaterials responsive to physical stimuli like light, ultrasound, magnetic field, and temperature can improve drug delivery, cancer treatment, and tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Pharmacology & Pharmacy
Weirong Kang, Yuwei Liu, Weiping Wang
Summary: Immunotherapy has revolutionized cancer treatments by activating the immune system to effectively inhibit cancer progression. Recent advances in cancer immunotherapy, such as checkpoint blockades and adoptive cellular therapy, have shown remarkable clinical outcomes. However, low response rates and side effects limit the widespread use of immunotherapy. Nanomedicine, specifically light-responsive nanoplatforms, show promise in enhancing immunotherapy by precise drug delivery and modulation of the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Nanoscience & Nanotechnology
Xin Zhang, Xiangbo Bu, Wenyu Jia, Yu Ying, Shanrong Lv, Guan Jiang
Summary: This study developed a novel oxygen-generating nanocomposite through the gas-liquid injection technique, which can enhance the antitumor effect. In vitro and in vivo experiments demonstrated that the nanocomposite efficiently accumulated in tumor tissue and relieved hypoxia, enhancing the efficacy of photodynamic therapy. The combination of photodynamic therapy and photothermal therapy resulted in apoptosis and inhibited tumor growth. This research has significant application value in the treatment of skin tumors.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hanxi Yi, Wangxing Lu, Fan Liu, Guoqing Zhang, Feifan Xie, Wenjie Liu, Lei Wang, Wenhu Zhou, Zeneng Cheng
Summary: Lipo/pB-DOX/ICG is a novel tool for on-demand drug release at tumor sites and a promising candidate for controllable and accurate combinatorial tumor therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hao Hu, Hua Wang, Yuchong Yang, Jiang-Fei Xu, Xi Zhang
Summary: In this study, a cationic porphyrin derivative TMPyP was developed that could be used for specific bacteria-responsive antimicrobial treatment through adaptable photodynamic/photothermal therapy processes. The results showed that TMPyP exhibited strong antimicrobial activity (>99%) through photothermal therapy in hypoxic environments where facultative anaerobes with a strong reducing ability, such as E. coli and S. typhimurium, could reduce TMPyP to phlorin. In aerobic environments with aerobic bacteria, TMPyP functioned as a typical photosensitizer that effectively killed bacteria (>99.9%) through photodynamic therapy. The biocompatibility of TMPyP was significantly improved by forming a host-guest complex with cucurbit[7]uril. This bacteria-responsive porphyrin demonstrates specificity and adaptability in antimicrobial treatment and holds potential in non-invasive treatments of bacterial infections.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Environmental
Yang Yang, Shudi Mo, Ze Zhang, Jingyu Sun, Jinghong Wen, Qilin Yu, Mingyang Liu
Summary: The size of dispersed species of single-atom and cluster catalysts, as well as conventional particulate catalysts, plays a crucial role in their properties, especially in complex systems like photothermal/photodynamic therapy. In this study, carbon black substrates loaded with Cu and Au in varying sizes were examined, revealing different effects on antimicrobial activity. The work contributes to the understanding of the mechanisms behind the properties of single-atom and cluster catalysts and conventional catalysts.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Mengru Chen, Jiaqi Lu, Jun Hou, Yanbao Zhao
Summary: In this study, rod-like biodegradable silica carriers were prepared and loaded with antitumor drug and photosensitizer, demonstrating excellent combined photo-chemotherapy and pH/light responsive release.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Biomaterials
Jie Yu, Xiaoli Zhang, Zhichao Pei, Qi Shuai
Summary: A synergistic phototherapy and hypoxia-activated chemotherapy nanoplatform based on melanin nanoparticles was developed, showing favorable photothermal conversion efficiency, desired cytocompatibility, and excellent synergistic therapeutic efficacy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biotechnology & Applied Microbiology
Beilei Gong, Yuanbing Shen, Huiyan Li, Xiaojun Li, Xia Huan, Jihong Zhou, Yuqing Chen, Jian Wu, Wei Li
Summary: Gold nanoparticles are considered a versatile platform for biomedical applications due to their strong and tunable surface plasmon resonance effect and good biocompatibility. This study designed a new nanoplatform incorporating gold nanorods and indocyanine green to enhance photodynamic/photothermal combination therapy. The polymer shell in the nanoplatform has thermo-responsive characteristics that control drug release at tumour sites, leading to increased drug aggregation and improved therapeutic efficacy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lei Ge, Chenyang Qiao, Yikai Tang, Xiaoke Zhang, Xiqun Jiang
Summary: COFs have been synthesized with hypoxia-responsive azo bonds containing photosensitizers and hypoxia-activated drugs for drug delivery. Upon exposure to hypoxic conditions and NIR light, the COF structure is disrupted, leading to drug release and activation of the hypoxia-activated drug, resulting in effective cancer cell killing and tumor growth inhibition.
Article
Nanoscience & Nanotechnology
Ran Li, Chen Liu, Chaoqiong Wan, Tiantian Liu, Rongrong Zhang, Jie Du, Xiangyu Wang, Xiaofeng Jiao, Ruifang Gao, Bing Li
Summary: This study developed a nano-drug delivery system (NPF@DOX) targeting fibroblast activation protein (FAP) to improve the therapeutic efficacy of combined chemo-photothermal therapy against oral squamous cell carcinoma (OSCC).
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Manlin Qi, Xuan Ren, Wen Li, Yue Sun, Xiaolin Sun, Chunyan Li, Siyao Yu, Lin Xu, Yanmin Zhou, Shuyan Song, Biao Dong, Lin Wang
Summary: This study successfully developed a near-infrared light triggered nanoplatform with dual functions of antibacterial and anti-inflammatory effects. It can effectively treat periodontal disease by killing bacteria and dispersing biofilms, as well as inhibiting inflammation through the release of gas molecules. The nanoplatform shows promising therapeutic potential for periodontal diseases and other refractory infections in deep tissues.
Review
Biochemistry & Molecular Biology
Banendu Sunder Dash, Suprava Das, Jyh-Ping Chen
Summary: PSs have theranostic capabilities for cancer treatment through generating singlet oxygen and/or thermal heat. UV-Vis dyes are used for PDT, but have limited tissue penetration depth. NIR PSs like ICG and its derivatives have been introduced for cancer therapy by combining PTT and/or PDT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Huan Hou, Di Chuan, Min Mu, Zhiyong Liu, Ruichao Liang, Gang Guo, Jianguo Xu
Summary: The development of folic acid functionalized polydopamine nanoparticles for dual delivery of doxorubicin and epigallocatechin-3-gallate has shown promising results in enhancing cellular uptake and anti-tumor efficacy with the assistance of near-infrared light. In vivo studies demonstrate improved drug accumulation, penetration, and retention in tumors, leading to significant suppression of tumor growth and improved survival rates in breast cancer-bearing mice. These nanoparticles have the potential to serve as an effective nanoscale vector for enhanced cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Xin Pang, Hua-yang Fan, Ya-ling Tang, Sha-sha Wang, Ming-xin Cao, Hao-fan Wang, Lu-ling Dai, Ke Wang, Xiang-hua Yu, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang
Review
Biotechnology & Applied Microbiology
Hua-yang Fan, Jian Jiang, Ya-jie Tang, Xin-hua Liang, Ya-ling Tang
ONCOTARGETS AND THERAPY
(2020)
Article
Oncology
Ke Wang, Hua-Yang Fan, Xing Pang, Mei Zhang, Xiang-Hua Yu, Jia-Shun Wu, Bing-Jun Chen, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Summary: High expression of Dll4 is associated with invasive front of SACC, solid tumor type, high TNM grade, and high metastasis and recurrence rates. Notch1 and Dll4 are positively correlated at the invasive front, with leader cells showing high Dll4 expression and follower cells showing high Notch1 expression in a 3D culture model. Silencing Dll4 reduces migration and invasion of SACC cells, but overexpression of Notch1 can rescue these abilities. Dll4/Notch1 signaling pathway may play a role in collective invasion of SACC and could be a potential target for SACC treatment.
Article
Oncology
Jia-shun Wu, Jian Jiang, Bing-jun Chen, Ke Wang, Ya-ling Tang, Xin-hua Liang
Summary: Cancer cell migration and invasion are essential components of metastatic disease, involving various mechanisms and movement strategies. During tumor progression, cancer cells exhibit distinct characteristics and reversible transitions in their motility patterns.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Oncology
Xiao-jie Luo, Min Zheng, Ming-xin Cao, Wei-long Zhang, Mei-chang Huang, Li Dai, Ya-ling Tang, Xin-hua Liang
Summary: The study developed miRNA signatures for both HPV+ and HPV- HNSCC to predict patients' prognosis, and explored their potential biological functions. Combined results suggested that HPV+ HNSCC patients with low signature scores had better immunity and treatment sensitivity, while HPV- HNSCC patients with high scores had poor prognosis due to treatment resistance and cell metabolism dysregulation. Identified signatures for HPV+ and HPV- HNSCC are significant for patient outcomes and may serve as new biomarkers and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang
Summary: This review explores the multifaceted roles of fibroblasts, including normal, senescent, cancer-associated fibroblasts (CAFs), and circulation CAFs, in tumor dormancy, relapse, metastasis, and therapy resistance, aiming to aid in the treatment of cancer metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Mei Zhang, Min Zheng, Li Dai, Wei-long Zhang, Hua-yang Fan, Xiang-hua Yu, Xin Pang, Peng Liao, Bing-jun Chen, Sha-sha Wang, Ming-xin Cao, Xiang-rui Ma, Xin-hua Liang, Ya-ling Tang
Summary: The study revealed that activation of the CXCL12/CXCR4 axis in SACC may promote perineural invasion (PNI) by inducing tumor cells to differentiate towards Schwann-like cells through the Twist/S100A4 axis, accelerating cancer progression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Hua-yang Fan, Zhuo-li Zhu, Hong-chun Xian, Hao-fan Wang, Bing-jun Chen, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang
Summary: Podophyllotoxin (PTOX) is a biologically active compound derived from the podophyllum plant, and its derivatives, such as etoposide and teniposide, show potential for cancer treatment. Studies have revealed that PTOX derivatives exert anticancer effects by inducing cell cycle arrest and DNA/RNA breaks. Despite the development of many derivatives, research on the interactions with downstream cancer-related signaling pathways is still limited.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Oncology
Xin Pang, Sha-Sha Wang, Mei Zhang, Jian Jiang, Hua-Yang Fan, Jia-Shun Wu, Hao-Fan Wang, Xin-Hua Liang, Ya-Ling Tang
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Correction
Oncology
Ke Wang, Hua-Yang Fan, Xing Pang, Mei Zhang, Xiang-Hua Yu, Jia-Shun Wu, Bing-Jun Chen, Jian Jiang, Xin-Hua Liang, Ya-Ling Tang
Review
Pharmacology & Pharmacy
Rong-jia Shi, Hua-yang Fan, Xiang-hua Yu, Ya-ling Tang, Jian Jiang, Xin-hua Liang
Summary: This review focuses on the multidirectional pharmacological properties of Podophyllotoxin (PPT) and its derivatives (PPTs), including the crosstalk with anticancer, anti-inflammatory, immunosuppression, and antiviral effects, as well as the newly uncovered mechanisms and potential of nano delivery.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiang-hua Yu, Jing-biao Wu, Hua-yang Fan, Li Dai, Hong-chun Xian, Bing-jun Chen, Peng Liao, Mei-chang Huang, Xin Pang, Mei Zhang, Xin-hua Liang, Ya-ling Tang
Summary: Artemisinin (ART) may induce vascular normalisation and inhibit tumour growth in oral squamous cell carcinoma (OSCC) through the MIF-signalling pathway.
Article
Oncology
Xin Pang, Sha-sha Wang, Mei Zhang, Jian Jiang, Hua-yang Fan, Jia-shun Wu, Hao-fan Wang, Xin-hua Liang, Ya-ling Tang
Summary: In OSCC samples, higher expression of CMTM6 is associated with higher pathological stage, CD163+ macrophage infiltration, and PD-L1 expression. Knockdown of CMTM6 inhibits proliferative, migrative, and invasive abilities of OSCC cells, and suppresses M2 macrophage polarization in vitro by downregulating PD-L1 expression. Exosomal CMTM6 from OSCC cells promotes M2-like macrophage polarization via ERK1/2 signaling, indicating a novel crosstalk between cancer cells and immune cells in OSCC microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
